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Book Synopsis Flood on Piney River, November 18-19, 1957, in Vicinity of Spring City, Tennessee by : Tennessee Valley Authority. Division of Water Control Planning
Download or read book Flood on Piney River, November 18-19, 1957, in Vicinity of Spring City, Tennessee written by Tennessee Valley Authority. Division of Water Control Planning and published by . This book was released on 1961 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Positron emission tomography (PET) is a non-invasive imaging method that renders three-dimensional images of tissue that selectively has taken up a radiolabelled organic compound, referred to as a radiotracer. This excellent technique provides clinicians with a tool to monitor disease progression and to evaluate how the patient respond to treatment. The by far most widely employed radiotracer in PET is called 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG), which is often referred to as the golden standard in PET. From a molecular perspective, [18F]FDG is an analogue of glucose where a hydroxyl group has been replaced with a radioactive fluorine atom (18F). It is well known that covalent attachment of carbohydrates (i.e., glycosylation) to biomolecules tend to improve their properties in the body, in terms of; improved pharmacokinetics, increased metabolic stability and faster clearance from blood and other non-specific tissue. It is therefore natural to pursuit the development of a [18F]fluoroglycosylation method where [18F]FDG is chemically conjugated to a ligand with high affinity for a given biological target (e.g., tumors or disease-associated protein aggregates). This thesis describes a novel [18F]fluoroglycosylation method that in a simple and general manner facilitate the conjugation of [18F]FDG to biological ligands using click chemistry. The utility of the developed [18F]fluoroglycosylation method is demonstrated by radiolabelling of curcumin, thus forming a tracer that may be employed for diagnosis of Alzheimer’s disease. Moreover, a set of oligothiophenes were fluoroglycosylated for potential diagnosis of Alzheimer’s disease but also for other much rarer protein misfolding diseases (e.g., Creutzfeldt-Jakob disease and systemic amyloidosis). In addition, the synthesis of a series of 19F-fluoroglycosylated porphyrins is described which exhibited promising properties not only to detect but also to treat melanoma cancer. Lastly, the synthesis of a set of 19F-fluorinated E-stilbenes, structurally based on the antioxidant resveratrol is presented. The E-stilbenes were evaluated for their capacity to spectrally distinguish between native and protofibrillar transthyretin in the pursuit of finding diagnostic markers for the rare but severe disease, transthyretin amyloidosis.
Book Synopsis Synthesis and application of ?-configured [18/19F]FDGs by : Mathias Elgland
Download or read book Synthesis and application of ?-configured [18/19F]FDGs written by Mathias Elgland and published by Linköping University Electronic Press. This book was released on 2018-02-21 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: Positron emission tomography (PET) is a non-invasive imaging method that renders three-dimensional images of tissue that selectively has taken up a radiolabelled organic compound, referred to as a radiotracer. This excellent technique provides clinicians with a tool to monitor disease progression and to evaluate how the patient respond to treatment. The by far most widely employed radiotracer in PET is called 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG), which is often referred to as the golden standard in PET. From a molecular perspective, [18F]FDG is an analogue of glucose where a hydroxyl group has been replaced with a radioactive fluorine atom (18F). It is well known that covalent attachment of carbohydrates (i.e., glycosylation) to biomolecules tend to improve their properties in the body, in terms of; improved pharmacokinetics, increased metabolic stability and faster clearance from blood and other non-specific tissue. It is therefore natural to pursuit the development of a [18F]fluoroglycosylation method where [18F]FDG is chemically conjugated to a ligand with high affinity for a given biological target (e.g., tumors or disease-associated protein aggregates). This thesis describes a novel [18F]fluoroglycosylation method that in a simple and general manner facilitate the conjugation of [18F]FDG to biological ligands using click chemistry. The utility of the developed [18F]fluoroglycosylation method is demonstrated by radiolabelling of curcumin, thus forming a tracer that may be employed for diagnosis of Alzheimer’s disease. Moreover, a set of oligothiophenes were fluoroglycosylated for potential diagnosis of Alzheimer’s disease but also for other much rarer protein misfolding diseases (e.g., Creutzfeldt-Jakob disease and systemic amyloidosis). In addition, the synthesis of a series of 19F-fluoroglycosylated porphyrins is described which exhibited promising properties not only to detect but also to treat melanoma cancer. Lastly, the synthesis of a set of 19F-fluorinated E-stilbenes, structurally based on the antioxidant resveratrol is presented. The E-stilbenes were evaluated for their capacity to spectrally distinguish between native and protofibrillar transthyretin in the pursuit of finding diagnostic markers for the rare but severe disease, transthyretin amyloidosis.
Book Synopsis Vocational and Occupational Education: Hearings held in Washington D.C., February 18, 19, 25, 26 .... vol. 2. Hearings held in Washington, D.C. March 20, 25 26 .... vol. 3. Hearings held in Springfield, Ill., September 15, 1975; Cedar Rapids, Iowa, September 16, 1975 by : United States. Congress. House. Committee on Education and Labor. Subcommittee on Elementary, Secondary, and Vocational Education
Download or read book Vocational and Occupational Education: Hearings held in Washington D.C., February 18, 19, 25, 26 .... vol. 2. Hearings held in Washington, D.C. March 20, 25 26 .... vol. 3. Hearings held in Springfield, Ill., September 15, 1975; Cedar Rapids, Iowa, September 16, 1975 written by United States. Congress. House. Committee on Education and Labor. Subcommittee on Elementary, Secondary, and Vocational Education and published by . This book was released on 1975 with total page 782 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Investigation of the Assassination of President John F. Kennedy: September 18, 19, 20, and 21, 1978 by : United States. Congress. House. Select Committee on Assassinations
Download or read book Investigation of the Assassination of President John F. Kennedy: September 18, 19, 20, and 21, 1978 written by United States. Congress. House. Select Committee on Assassinations and published by . This book was released on 1978 with total page 764 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Forest and Stream written by and published by . This book was released on 1906 with total page 1090 pages. Available in PDF, EPUB and Kindle. Book excerpt:
This book describes the international effort to give order to colours and thus facilitate communication about it, two topics deemed essential to a modernising world that were also recognizably complex. Expert essays will enhance readers' understanding of the struggle to coordinate nature with art at a time when approaches to both were undergoing rapid change. Ordering Colours shows how such seemingly trivial concerns as identifying the basic colours and disseminating appropriate colour diagrams had to meet philosophical, scientific and professional needs across Europe. Contributors detail the many schemes for colour systematization and their real-world applications; questions of concern to both academic- and manufacturing-focused investigators throughout the long 18th century. They bring together original research and new thinking about landmark early modern studies to address important developments as well as neglected historical contributions of European arts, sciences, and economies. This collection is an important addition to the libraries of all who are interested in public culture and manufacturing developments in the early modern period and is aimed at historians of art, technology, philosophy and physics.
Book Synopsis Ordering Colours in 18th and Early 19th Century Europe by : Tanja C. Kleinwächter
Download or read book Ordering Colours in 18th and Early 19th Century Europe written by Tanja C. Kleinwächter and published by Springer Nature. This book was released on 2023-11-05 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the international effort to give order to colours and thus facilitate communication about it, two topics deemed essential to a modernising world that were also recognizably complex. Expert essays will enhance readers' understanding of the struggle to coordinate nature with art at a time when approaches to both were undergoing rapid change. Ordering Colours shows how such seemingly trivial concerns as identifying the basic colours and disseminating appropriate colour diagrams had to meet philosophical, scientific and professional needs across Europe. Contributors detail the many schemes for colour systematization and their real-world applications; questions of concern to both academic- and manufacturing-focused investigators throughout the long 18th century. They bring together original research and new thinking about landmark early modern studies to address important developments as well as neglected historical contributions of European arts, sciences, and economies. This collection is an important addition to the libraries of all who are interested in public culture and manufacturing developments in the early modern period and is aimed at historians of art, technology, philosophy and physics.
Analysis of 18th- and 19th-Century Musical Works in the Classical Tradition is a textbook for upper-level undergraduate and graduate courses in music analysis. It outlines a process of analyzing works in the Classical tradition by uncovering the construction of a piece of music—the formal, harmonic, rhythmic, and voice-leading organizations—as well as its unique features. It develops an in-depth approach that is applied to works by composers including Haydn, Mozart, Beethoven, Schubert, Schumann, and Brahms. The book begins with foundational chapters in music theory, starting with basic diatonic harmony and progressing rapidly to more advanced topics, such as phrase design, phrase expansion, and chromatic harmony. The second part contains analyses of complete musical works and movements. The text features over 150 musical examples, including numerous complete annotated scores. Suggested assignments at the end of each chapter guide students in their own musical analysis.
Book Synopsis Analysis of 18th- and 19th-Century Musical Works in the Classical Tradition by : David Beach
Download or read book Analysis of 18th- and 19th-Century Musical Works in the Classical Tradition written by David Beach and published by Routledge. This book was released on 2012-05-04 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Analysis of 18th- and 19th-Century Musical Works in the Classical Tradition is a textbook for upper-level undergraduate and graduate courses in music analysis. It outlines a process of analyzing works in the Classical tradition by uncovering the construction of a piece of music—the formal, harmonic, rhythmic, and voice-leading organizations—as well as its unique features. It develops an in-depth approach that is applied to works by composers including Haydn, Mozart, Beethoven, Schubert, Schumann, and Brahms. The book begins with foundational chapters in music theory, starting with basic diatonic harmony and progressing rapidly to more advanced topics, such as phrase design, phrase expansion, and chromatic harmony. The second part contains analyses of complete musical works and movements. The text features over 150 musical examples, including numerous complete annotated scores. Suggested assignments at the end of each chapter guide students in their own musical analysis.
Book Synopsis The Metropolitan Building Act, 18th & 19th Victoria, Cap. 122 ... With Notes, Index, and Engravings. By D. G. and R. H. by : David Gibbons
Download or read book The Metropolitan Building Act, 18th & 19th Victoria, Cap. 122 ... With Notes, Index, and Engravings. By D. G. and R. H. written by David Gibbons and published by . This book was released on 1855 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt:
The NIV is the world's best-selling modern translation, with over 150 million copies in print since its first full publication in 1978. This highly accurate and smooth-reading version of the Bible in modern English has the largest library of printed and electronic support material of any modern translation.
Book Synopsis Holy Bible (NIV) by : Various Authors,
Download or read book Holy Bible (NIV) written by Various Authors, and published by Zondervan. This book was released on 2008-09-02 with total page 6637 pages. Available in PDF, EPUB and Kindle. Book excerpt: The NIV is the world's best-selling modern translation, with over 150 million copies in print since its first full publication in 1978. This highly accurate and smooth-reading version of the Bible in modern English has the largest library of printed and electronic support material of any modern translation.
The poor and the sick-poor have always presented a problem to the governments and churches of Europe. Whose responsibility are they? Are they a wilful burden on the honest working population, or are they a necessary presence for the true Christian to live the true Christian life? In the 18th and 19th centuries what happened to the poor and the sick-poor in the north and south of Europe was different. In the north there occurred first the Reformation in the 16th century, which changed attitudes to the poor, and then the advent of industrialisation, with its far-reaching effects of pauperisation of people both in town and countryside. In the Catholic south, where industrialisation did not appear so soon, the Catholic Church introduced a programme of reform at all levels but along traditional lines. This included the founding of new orders dedicated to the care of the poor and sick, of new institutions within which to house and care for them. At all times it was taken for granted that it was a necessary aspect of being a Christian that one should give for the care of the needy, and that this was not the duty of the state or of secular institutions. The secularising movement did however reach the southern countries by way both of the Enlightenment and - more drastically - in the form of the Napoleonic invasions. But after the defeat of Napoleon, the Church reasserted its right to administer and control the support of the poor and sick, and this situation continued until 1900 in most areas. Moreover the effects of industrialisation and the concomitant increase in population did make itself felt in the south in the course of the 19th century, which put great stress on the institutions for poor relief and health care for the poor. All this is still relevant today, since the situations that governments and the Catholic Church found themselves confronted with, and the stark choices they had to make, are being replayed to some extent today. Who is responsible for the poor, who is to blame for their being poor? How should their poverty be relieved, how should the health care of the many be funded? These are still live issues today. While complete in itself the present volume also forms the fourth and last of a four-volume survey of health care and poor relief in Europe between 1500 and 1900, edited by Ole Peter Grell and Andrew Cunningham
Book Synopsis Health Care and Poor Relief in 18th and 19th Century Southern Europe by : Ole Peter Grell
Download or read book Health Care and Poor Relief in 18th and 19th Century Southern Europe written by Ole Peter Grell and published by Routledge. This book was released on 2017-07-05 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: The poor and the sick-poor have always presented a problem to the governments and churches of Europe. Whose responsibility are they? Are they a wilful burden on the honest working population, or are they a necessary presence for the true Christian to live the true Christian life? In the 18th and 19th centuries what happened to the poor and the sick-poor in the north and south of Europe was different. In the north there occurred first the Reformation in the 16th century, which changed attitudes to the poor, and then the advent of industrialisation, with its far-reaching effects of pauperisation of people both in town and countryside. In the Catholic south, where industrialisation did not appear so soon, the Catholic Church introduced a programme of reform at all levels but along traditional lines. This included the founding of new orders dedicated to the care of the poor and sick, of new institutions within which to house and care for them. At all times it was taken for granted that it was a necessary aspect of being a Christian that one should give for the care of the needy, and that this was not the duty of the state or of secular institutions. The secularising movement did however reach the southern countries by way both of the Enlightenment and - more drastically - in the form of the Napoleonic invasions. But after the defeat of Napoleon, the Church reasserted its right to administer and control the support of the poor and sick, and this situation continued until 1900 in most areas. Moreover the effects of industrialisation and the concomitant increase in population did make itself felt in the south in the course of the 19th century, which put great stress on the institutions for poor relief and health care for the poor. All this is still relevant today, since the situations that governments and the Catholic Church found themselves confronted with, and the stark choices they had to make, are being replayed to some extent today. Who is responsible for the poor, who is to blame for their being poor? How should their poverty be relieved, how should the health care of the many be funded? These are still live issues today. While complete in itself the present volume also forms the fourth and last of a four-volume survey of health care and poor relief in Europe between 1500 and 1900, edited by Ole Peter Grell and Andrew Cunningham
