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Advances in genomics and combinatorial chemistry during the past two decades inspired innovative technologies and changes in the discovery and pre-clinical development paradigm with the goal of accelerating the process of bringing therapeutic drugs to market. Written by William Kisaalita, one of the foremost experts in this field, 3D Cell-Based Bio
Book Synopsis 3D Cell-Based Biosensors in Drug Discovery Programs by : William S. Kisaalita
Download or read book 3D Cell-Based Biosensors in Drug Discovery Programs written by William S. Kisaalita and published by CRC Press. This book was released on 2010-06-22 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in genomics and combinatorial chemistry during the past two decades inspired innovative technologies and changes in the discovery and pre-clinical development paradigm with the goal of accelerating the process of bringing therapeutic drugs to market. Written by William Kisaalita, one of the foremost experts in this field, 3D Cell-Based Bio
In the 21st century, we are witnessing the integration of two dynamic disciplines electronics and biology. As a result bioelectronics and biosensors have become of particular interest to engineers and researchers working in related biomedical areas. Written by recognized experts the field, this leading-edge resource is the first book to systematically introduce the concept, technology, and development of cell-based biosensors. Readers find details on the latest cell-based biosensor models and novel micro-structure biosensor techniques. Taking an interdisciplinary approach, this unique volume presents the latest innovative applications of cell-based biosensors in a variety of biomedical fields. The book also explores future trends of cell-based biosensors, including integrated chips, nanotechnology and microfluidics. Over 140 illustrations help clarify key topics throughout the book.
Book Synopsis Cell-based Biosensors by : Ping Wang
Download or read book Cell-based Biosensors written by Ping Wang and published by Artech House Publishers. This book was released on 2010 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the 21st century, we are witnessing the integration of two dynamic disciplines electronics and biology. As a result bioelectronics and biosensors have become of particular interest to engineers and researchers working in related biomedical areas. Written by recognized experts the field, this leading-edge resource is the first book to systematically introduce the concept, technology, and development of cell-based biosensors. Readers find details on the latest cell-based biosensor models and novel micro-structure biosensor techniques. Taking an interdisciplinary approach, this unique volume presents the latest innovative applications of cell-based biosensors in a variety of biomedical fields. The book also explores future trends of cell-based biosensors, including integrated chips, nanotechnology and microfluidics. Over 140 illustrations help clarify key topics throughout the book.
This volume explores label-free biosensors, advantageous in part because this technology bypasses the need of labels, reporters, and cell engineering, all of which are common to labeled techniques but may introduce artifacts in assay results. Addressing several fundamental and practical aspects as to how to implement label-free methods in the drug discovery process, this book covers a wide range of topics, including binding kinetics determination, fragment screening, antibody epitope mapping, protein-protein interaction profiling and screening, receptor pathway deconvolution, drug pharmacology profiling and screening, target identification, drug toxicity assessment, and physical phenotype profiling and diagnostics based on various cellular processes such as cell adhesion, migration, invasion, infection, and inflammation. As part of the Methods in Pharmacology and Toxicology series, chapters aim to provide key detail and implementation advice to aid with progress in the lab. Practical and thorough, Label-Free Biosensor Methods in Drug Discovery provides a new avenue for rapid access to a focused collection of highly regarded contributions in the field.
Book Synopsis Label-Free Biosensor Methods in Drug Discovery by : Ye Fang
Download or read book Label-Free Biosensor Methods in Drug Discovery written by Ye Fang and published by Humana. This book was released on 2016-10-05 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores label-free biosensors, advantageous in part because this technology bypasses the need of labels, reporters, and cell engineering, all of which are common to labeled techniques but may introduce artifacts in assay results. Addressing several fundamental and practical aspects as to how to implement label-free methods in the drug discovery process, this book covers a wide range of topics, including binding kinetics determination, fragment screening, antibody epitope mapping, protein-protein interaction profiling and screening, receptor pathway deconvolution, drug pharmacology profiling and screening, target identification, drug toxicity assessment, and physical phenotype profiling and diagnostics based on various cellular processes such as cell adhesion, migration, invasion, infection, and inflammation. As part of the Methods in Pharmacology and Toxicology series, chapters aim to provide key detail and implementation advice to aid with progress in the lab. Practical and thorough, Label-Free Biosensor Methods in Drug Discovery provides a new avenue for rapid access to a focused collection of highly regarded contributions in the field.
Book Synopsis Multiplexed Biosensors for Drug Discovery Applications by : Jahnavi Jha
Download or read book Multiplexed Biosensors for Drug Discovery Applications written by Jahnavi Jha and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Development of a Living Cell-based Biosensor by : Xiaojun Feng
Download or read book Development of a Living Cell-based Biosensor written by Xiaojun Feng and published by . This book was released on 2006 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Development of Whole Cell-based Biosensor in 3D Environment for Nanoparticles Cytotoxicity Detection by : Monika Dubiak-Szepietowska
Download or read book Development of Whole Cell-based Biosensor in 3D Environment for Nanoparticles Cytotoxicity Detection written by Monika Dubiak-Szepietowska and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biosensors for Drug Discovery Applications by : Nikhil Bhalla
Download or read book Biosensors for Drug Discovery Applications written by Nikhil Bhalla and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis La Vie quotidienne en Normandie by :
Download or read book La Vie quotidienne en Normandie written by and published by . This book was released on 1976 with total page 34 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Abstract: Based on three-dimensional (3-D) cultures of GFP-expressing mammalian cells, a novel microbiorector array capable of online monitoring of biological activities was developed. The 3-D microbioreactor array can afford parallel, automated, and long-term (over one month) cell bioactivity assays. It can also increase signal to noise ratio (SNR) by at least one order of magnitude as compared to the conventional 2-D culture system and at the same time remove most of the detection interference caused by cell activities. It used inexpensive materials and proven tissue engineering principles, and can be used for fast cell culture media development and cytotoxicity assays for drug screening. Toxicity of embryotoxic reference chemicals and anti-cancer drugs was measured in the 3-D multicellular models and the predicted toxicity was compared to that from monolayer cultures. It showed that the 3-D system was a more realistic pharmacotoxicological test system than 2-D monolayer cultures. With the 3-D system, acquired tissue resistance in the treatment of bulky tumor tissues could be revealed in a high-throughput manner. As a bridge over the gap between monolayer cell cultures and animal models, this 3-D system can improve the drug discovery process when being applied in toxicity and efficacy tests prior to animal experiments. Besides high-throughput toxicity screening, autofluorescence detection of 3-D tissue cultures could also be extended to immobilized cell culture process development. Butyrate treatment was used as a case study to demonstrate the performance of the new system. The microbioreactor array developed was used for high-throughput cell process development to improve monoclonal antibody (MAb) production in a fibrous bed bioreactor (FBB) using CHO cells. A novel online fluorescence probe was developed and used in spinner flasks and a lab-scale perfusion fibrous bed bioreactor to non-invasively quantify cell growth and MAb productivity. The results from this study showed that GFP fluorescence could indicate recombinant protein production and thus provide a fast, reliable and robust platform for cell culture process development to optimize target protein productivity without cell counting or protein analysis.
Book Synopsis 3-D Cell-based High-throughput Screening for Drug Discovery and Cell Culture Process Development by : Xudong Zhang
Download or read book 3-D Cell-based High-throughput Screening for Drug Discovery and Cell Culture Process Development written by Xudong Zhang and published by . This book was released on 2008 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Based on three-dimensional (3-D) cultures of GFP-expressing mammalian cells, a novel microbiorector array capable of online monitoring of biological activities was developed. The 3-D microbioreactor array can afford parallel, automated, and long-term (over one month) cell bioactivity assays. It can also increase signal to noise ratio (SNR) by at least one order of magnitude as compared to the conventional 2-D culture system and at the same time remove most of the detection interference caused by cell activities. It used inexpensive materials and proven tissue engineering principles, and can be used for fast cell culture media development and cytotoxicity assays for drug screening. Toxicity of embryotoxic reference chemicals and anti-cancer drugs was measured in the 3-D multicellular models and the predicted toxicity was compared to that from monolayer cultures. It showed that the 3-D system was a more realistic pharmacotoxicological test system than 2-D monolayer cultures. With the 3-D system, acquired tissue resistance in the treatment of bulky tumor tissues could be revealed in a high-throughput manner. As a bridge over the gap between monolayer cell cultures and animal models, this 3-D system can improve the drug discovery process when being applied in toxicity and efficacy tests prior to animal experiments. Besides high-throughput toxicity screening, autofluorescence detection of 3-D tissue cultures could also be extended to immobilized cell culture process development. Butyrate treatment was used as a case study to demonstrate the performance of the new system. The microbioreactor array developed was used for high-throughput cell process development to improve monoclonal antibody (MAb) production in a fibrous bed bioreactor (FBB) using CHO cells. A novel online fluorescence probe was developed and used in spinner flasks and a lab-scale perfusion fibrous bed bioreactor to non-invasively quantify cell growth and MAb productivity. The results from this study showed that GFP fluorescence could indicate recombinant protein production and thus provide a fast, reliable and robust platform for cell culture process development to optimize target protein productivity without cell counting or protein analysis.
Book Synopsis Creation of Whole-cell Biosensors for High Throughput Drug Screening and Toxin Detection by : Laura J. Itle
Download or read book Creation of Whole-cell Biosensors for High Throughput Drug Screening and Toxin Detection written by Laura J. Itle and published by . This book was released on 2005 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt:
