Nuclear Oncology

Nuclear Oncology

Author: Cumali Aktolun

Publisher: Lippincott Williams & Wilkins

Published: 2014-09-04

Total Pages: 1964

ISBN-13: 146988349X

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Nuclear Oncology a contemporary narrative of the role of nuclear medicine in oncology with an emphasis on SPECT/CT and PET/CT with additional comments when appropriate on the potential application of PET/MR and to a lesser degree, targeted radionuclide therapy. This book focuses on the use of radionuclides in the diagnosis and treatment of malignant diseases. It describes relevant approved and investigational clinical applications, instrumentation & technology, chemistry and practical clinical issues in nuclear oncology. The basic science and current research topics of nuclear oncology are addressed in separate chapters. Nuclear medicine has become an essential component to all phases of the management of the patient with a malignant tumor and in some cases, even benign neoplasms. The standard of practice for many tumors requires PET/CT imaging at various stages of diagnosis and management. In addition to clinical applications, ongoing investigational efforts, which more and more involve multi-institutional protocols, are also presented. Features: • Focuses on the use of radionuclides in the diagnosis and treatment of malignant diseases • Emphasizes SPECT/CT and PET/CT with additional emphasis on the potential application of PET/MR • Describes relevant approved and investigational clinical applications, instrumentation & technology, chemistry and practical clinical issues in nuclear oncology


Book Synopsis Nuclear Oncology by : Cumali Aktolun

Download or read book Nuclear Oncology written by Cumali Aktolun and published by Lippincott Williams & Wilkins. This book was released on 2014-09-04 with total page 1964 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear Oncology a contemporary narrative of the role of nuclear medicine in oncology with an emphasis on SPECT/CT and PET/CT with additional comments when appropriate on the potential application of PET/MR and to a lesser degree, targeted radionuclide therapy. This book focuses on the use of radionuclides in the diagnosis and treatment of malignant diseases. It describes relevant approved and investigational clinical applications, instrumentation & technology, chemistry and practical clinical issues in nuclear oncology. The basic science and current research topics of nuclear oncology are addressed in separate chapters. Nuclear medicine has become an essential component to all phases of the management of the patient with a malignant tumor and in some cases, even benign neoplasms. The standard of practice for many tumors requires PET/CT imaging at various stages of diagnosis and management. In addition to clinical applications, ongoing investigational efforts, which more and more involve multi-institutional protocols, are also presented. Features: • Focuses on the use of radionuclides in the diagnosis and treatment of malignant diseases • Emphasizes SPECT/CT and PET/CT with additional emphasis on the potential application of PET/MR • Describes relevant approved and investigational clinical applications, instrumentation & technology, chemistry and practical clinical issues in nuclear oncology

Advances in Nuclear Oncology

Advances in Nuclear Oncology

Author: Emilio Bombardieri

Publisher: CRC Press

Published: 2007-10-15

Total Pages: 534

ISBN-13: 0203089677

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The diagnostic and therapeutic achievements in radiopharmaceuticals and nuclear medicine instrumentation - PET, SPECT, MR, CT and their hypbrids PET-CT and SPECT-CT - are the result of the interdisciplinary research efforts of cell-biologists, chemists, pharmacologists, physicists, computer-scientists, engineers, nuclear medicine physicians, a


Book Synopsis Advances in Nuclear Oncology by : Emilio Bombardieri

Download or read book Advances in Nuclear Oncology written by Emilio Bombardieri and published by CRC Press. This book was released on 2007-10-15 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: The diagnostic and therapeutic achievements in radiopharmaceuticals and nuclear medicine instrumentation - PET, SPECT, MR, CT and their hypbrids PET-CT and SPECT-CT - are the result of the interdisciplinary research efforts of cell-biologists, chemists, pharmacologists, physicists, computer-scientists, engineers, nuclear medicine physicians, a

Nuclear Oncology

Nuclear Oncology

Author: Duccio Volterrani

Publisher: Springer Nature

Published: 2022-10-04

Total Pages: 2241

ISBN-13: 3031054946

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This book discusses the role of nuclear medicine in the diagnosis, staging, and treatment of patients with specific cancers. It presents the incidence, pathophysiologic and clinical aspects of the disease, the use of nuclear imaging in diagnosis, staging requirements, management of specific tumors, and surveillance after primary treatment of cancers. It addresses the various diagnostic/therapeutic options that are currently available or are most likely to become available in the near future according to a prioritized approach, thereby keeping to a minimum the number of diagnostic imaging procedures the patient is expected to undergo. Topics include basic science, clinical applications, radionuclide therapy, radioguided surgery, heart disease in the cancer patient, and adverse effects of cancer therapy. Each clinical chapter discusses the radionuclide procedures within an integrated framework, thereby identifying the information required for effective treatment of specific tumors. The book concludes with a series of updated cases that define and expand the didactic material in the clinical application chapters. Thoroughly updated and revised, the third edition incorporates new clinical evidence validating the use of radionuclides for diagnosis and therapy in oncology, new radiotracers, and the growing integration of imaging modalities into different types of hybrid imaging. With contributions from a group of internationally distinguished practitioners, Nuclear Oncology: From Pathophysiology to Clinical Applications, Third Edition, is a valuable reference for nuclear medicine physicians, radiologists, medical and surgical oncologists, and other clinicians involved in the care and management of cancer patients.


Book Synopsis Nuclear Oncology by : Duccio Volterrani

Download or read book Nuclear Oncology written by Duccio Volterrani and published by Springer Nature. This book was released on 2022-10-04 with total page 2241 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the role of nuclear medicine in the diagnosis, staging, and treatment of patients with specific cancers. It presents the incidence, pathophysiologic and clinical aspects of the disease, the use of nuclear imaging in diagnosis, staging requirements, management of specific tumors, and surveillance after primary treatment of cancers. It addresses the various diagnostic/therapeutic options that are currently available or are most likely to become available in the near future according to a prioritized approach, thereby keeping to a minimum the number of diagnostic imaging procedures the patient is expected to undergo. Topics include basic science, clinical applications, radionuclide therapy, radioguided surgery, heart disease in the cancer patient, and adverse effects of cancer therapy. Each clinical chapter discusses the radionuclide procedures within an integrated framework, thereby identifying the information required for effective treatment of specific tumors. The book concludes with a series of updated cases that define and expand the didactic material in the clinical application chapters. Thoroughly updated and revised, the third edition incorporates new clinical evidence validating the use of radionuclides for diagnosis and therapy in oncology, new radiotracers, and the growing integration of imaging modalities into different types of hybrid imaging. With contributions from a group of internationally distinguished practitioners, Nuclear Oncology: From Pathophysiology to Clinical Applications, Third Edition, is a valuable reference for nuclear medicine physicians, radiologists, medical and surgical oncologists, and other clinicians involved in the care and management of cancer patients.

Advances in Radiation Oncology

Advances in Radiation Oncology

Author: Jeffrey Y.C. Wong

Publisher: Springer

Published: 2017-04-20

Total Pages: 271

ISBN-13: 3319532359

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This book concisely reviews important advances in radiation oncology, providing practicing radiation oncologists with a fundamental understanding of each topic and an appreciation of its significance for the future of radiation oncology. It explores in detail the impact of newer imaging modalities, such as multiparametric magnetic resonance imaging (MRI) and positron emission tomography (PET) using fluorodeoxyglucose (FDG) and other novel agents, which deliver improved visualization of the physiologic and phenotypic features of a given cancer, helping oncologists to provide more targeted radiotherapy and assess the response. Due consideration is also given to how advanced technologies for radiation therapy delivery have created new treatment options for patients with localized and metastatic disease, highlighting the increasingly important role of image-guided radiotherapy in treating systemic and oligometastatic disease. Further topics include the potential value of radiotherapy in enhancing immunotherapy thanks to the broader immune-stimulatory effects, how cancer stem cells and the tumor microenvironment influence response, and the application of mathematical and systems biology methods to radiotherapy.


Book Synopsis Advances in Radiation Oncology by : Jeffrey Y.C. Wong

Download or read book Advances in Radiation Oncology written by Jeffrey Y.C. Wong and published by Springer. This book was released on 2017-04-20 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book concisely reviews important advances in radiation oncology, providing practicing radiation oncologists with a fundamental understanding of each topic and an appreciation of its significance for the future of radiation oncology. It explores in detail the impact of newer imaging modalities, such as multiparametric magnetic resonance imaging (MRI) and positron emission tomography (PET) using fluorodeoxyglucose (FDG) and other novel agents, which deliver improved visualization of the physiologic and phenotypic features of a given cancer, helping oncologists to provide more targeted radiotherapy and assess the response. Due consideration is also given to how advanced technologies for radiation therapy delivery have created new treatment options for patients with localized and metastatic disease, highlighting the increasingly important role of image-guided radiotherapy in treating systemic and oligometastatic disease. Further topics include the potential value of radiotherapy in enhancing immunotherapy thanks to the broader immune-stimulatory effects, how cancer stem cells and the tumor microenvironment influence response, and the application of mathematical and systems biology methods to radiotherapy.

Nuclear Oncology

Nuclear Oncology

Author: H. William Strauss

Publisher: Springer Science & Business Media

Published: 2012-11-27

Total Pages: 873

ISBN-13: 0387488944

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This book provides the reader with a comprehensive understanding of both the basic principles and the clinical applications of nuclear oncology imaging techniques. The authors have assembled a distinguished group of leaders in the field who provide valuable insight on the subject. The book also includes major chapters on the cancer patient and the pathophysiology of abnormal tissue, the evaluation of co-existing disease, and the diagnosis and therapy of specific tumors using functional imaging studies. Each chapter is heavily illustrated to assist the reader in understanding the clinical role of nuclear oncology in cancer disease therapy and management.


Book Synopsis Nuclear Oncology by : H. William Strauss

Download or read book Nuclear Oncology written by H. William Strauss and published by Springer Science & Business Media. This book was released on 2012-11-27 with total page 873 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the reader with a comprehensive understanding of both the basic principles and the clinical applications of nuclear oncology imaging techniques. The authors have assembled a distinguished group of leaders in the field who provide valuable insight on the subject. The book also includes major chapters on the cancer patient and the pathophysiology of abnormal tissue, the evaluation of co-existing disease, and the diagnosis and therapy of specific tumors using functional imaging studies. Each chapter is heavily illustrated to assist the reader in understanding the clinical role of nuclear oncology in cancer disease therapy and management.

Nuclear Oncology

Nuclear Oncology

Author:

Publisher:

Published: 1995

Total Pages:

ISBN-13:

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Book Synopsis Nuclear Oncology by :

Download or read book Nuclear Oncology written by and published by . This book was released on 1995 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Therapeutic Nuclear Medicine

Therapeutic Nuclear Medicine

Author: Richard P. Baum

Publisher: Springer

Published: 2014-08-16

Total Pages: 922

ISBN-13: 3540367195

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The recent revolution in molecular biology offers exciting new opportunities for targeted radionuclide therapy. This up-to-date, comprehensive book, written by world-renowned experts, discusses the basic principles of radionuclide therapy, explores in detail the available treatments, explains the regulatory requirements, and examines likely future developments. The full range of clinical applications is considered, including thyroid cancer, hematological malignancies, brain tumors, liver cancer, bone and joint disease, and neuroendocrine tumors. The combination of theoretical background and practical information will provide the reader with all the knowledge required to administer radionuclide therapy safely and effectively in the individual patient. Careful attention is also paid to the role of the therapeutic nuclear physician in coordinating a diverse multidisciplinary team, which is central to the safe provision of treatment.


Book Synopsis Therapeutic Nuclear Medicine by : Richard P. Baum

Download or read book Therapeutic Nuclear Medicine written by Richard P. Baum and published by Springer. This book was released on 2014-08-16 with total page 922 pages. Available in PDF, EPUB and Kindle. Book excerpt: The recent revolution in molecular biology offers exciting new opportunities for targeted radionuclide therapy. This up-to-date, comprehensive book, written by world-renowned experts, discusses the basic principles of radionuclide therapy, explores in detail the available treatments, explains the regulatory requirements, and examines likely future developments. The full range of clinical applications is considered, including thyroid cancer, hematological malignancies, brain tumors, liver cancer, bone and joint disease, and neuroendocrine tumors. The combination of theoretical background and practical information will provide the reader with all the knowledge required to administer radionuclide therapy safely and effectively in the individual patient. Careful attention is also paid to the role of the therapeutic nuclear physician in coordinating a diverse multidisciplinary team, which is central to the safe provision of treatment.

Cancer Biology and the Nuclear Envelope

Cancer Biology and the Nuclear Envelope

Author: Eric C. Schirmer

Publisher: Springer Science & Business Media

Published: 2014-02-22

Total Pages: 610

ISBN-13: 1489980326

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"Nuclear envelope (NE) defects have been linked to cancer biology since the mid-1800s, but it was not until the last few years that we have begun to understand these historical links and to realize that there are myriad ways that the NE impacts on tumorigenesis. The NE is a complex double membrane system that encloses the genome while providing structural support through the intermediate filament lamin polymer and regulating protein/ mRNA trafficking and signaling between the nucleus and cytoplasm via the nuclear pore complexes (NPCs). These functions already provide some mechanisms for NE influences on cancer biology but work in the past few years has elucidated many others. Lamins and many recently identified NE transmembrane proteins (NETs) have been now shown to function in DNA repair, regulation of cell cycle and signaling, apoptosis, cell migration in metastasis and nuclear architecture and morphology. This volume presents a comprehensive overview of the wide range of functions recently identified for NE proteins and their relevance in cancer biology, providing molecular mechanisms and evidence of their value as prognostic and diagnostic markers and suggesting new avenues for the treatment of cancer. Indeed some of these recent links are already yielding promising therapies, such as the current clinical trial of selective inhibitors of the nuclear export factor exportin in certain types of leukemia, melanoma and kidney cancer."


Book Synopsis Cancer Biology and the Nuclear Envelope by : Eric C. Schirmer

Download or read book Cancer Biology and the Nuclear Envelope written by Eric C. Schirmer and published by Springer Science & Business Media. This book was released on 2014-02-22 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Nuclear envelope (NE) defects have been linked to cancer biology since the mid-1800s, but it was not until the last few years that we have begun to understand these historical links and to realize that there are myriad ways that the NE impacts on tumorigenesis. The NE is a complex double membrane system that encloses the genome while providing structural support through the intermediate filament lamin polymer and regulating protein/ mRNA trafficking and signaling between the nucleus and cytoplasm via the nuclear pore complexes (NPCs). These functions already provide some mechanisms for NE influences on cancer biology but work in the past few years has elucidated many others. Lamins and many recently identified NE transmembrane proteins (NETs) have been now shown to function in DNA repair, regulation of cell cycle and signaling, apoptosis, cell migration in metastasis and nuclear architecture and morphology. This volume presents a comprehensive overview of the wide range of functions recently identified for NE proteins and their relevance in cancer biology, providing molecular mechanisms and evidence of their value as prognostic and diagnostic markers and suggesting new avenues for the treatment of cancer. Indeed some of these recent links are already yielding promising therapies, such as the current clinical trial of selective inhibitors of the nuclear export factor exportin in certain types of leukemia, melanoma and kidney cancer."

Advances in Nuclear Data and All-particle Transport for Radiation Oncology

Advances in Nuclear Data and All-particle Transport for Radiation Oncology

Author:

Publisher:

Published: 1994

Total Pages: 6

ISBN-13:

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Fast neutrons have been used to treat over 15,000 cancer patients worldwide and proton therapy is rapidly emerging as a treatment of choice for tumors around critical anatomical structures. Neutron therapy requires evaluated data to (approximately)70 MeV while proton therapy requires data to (approximately)250 MeV. Collaboration between Lawrence Livermore National Laboratory (LLNL) and the medical physics community has revealed limitations in nuclear cross section evaluations and radiation transport capabilities that have prevented neutron and proton radiation therapy centers from using Monte Carlo calculations to accurately predict dose in patients. These evaluations require energy- and angle-dependent cross sections for secondary neutrons, charged-particles and recoil nuclei. We are expanding the LLNL nuclear databases to higher energies for biologically important elements and have developed a three-dimensional, all-particle Monte Carlo radiation transport code that uses computer-assisted-tomography (CT) images as the input mesh. This code, called PEREGRINE calculates dose distributions in the human body and can be used as a tool to determine the dependence of dose on details of the evaluated nuclear data. In this paper, we will review the status of the nuclear data required for neutron and proton therapy, describe the capabilities of the PEREGRINE package, and show the effects of tissue inhomogeneities on dose distribution.


Book Synopsis Advances in Nuclear Data and All-particle Transport for Radiation Oncology by :

Download or read book Advances in Nuclear Data and All-particle Transport for Radiation Oncology written by and published by . This book was released on 1994 with total page 6 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fast neutrons have been used to treat over 15,000 cancer patients worldwide and proton therapy is rapidly emerging as a treatment of choice for tumors around critical anatomical structures. Neutron therapy requires evaluated data to (approximately)70 MeV while proton therapy requires data to (approximately)250 MeV. Collaboration between Lawrence Livermore National Laboratory (LLNL) and the medical physics community has revealed limitations in nuclear cross section evaluations and radiation transport capabilities that have prevented neutron and proton radiation therapy centers from using Monte Carlo calculations to accurately predict dose in patients. These evaluations require energy- and angle-dependent cross sections for secondary neutrons, charged-particles and recoil nuclei. We are expanding the LLNL nuclear databases to higher energies for biologically important elements and have developed a three-dimensional, all-particle Monte Carlo radiation transport code that uses computer-assisted-tomography (CT) images as the input mesh. This code, called PEREGRINE calculates dose distributions in the human body and can be used as a tool to determine the dependence of dose on details of the evaluated nuclear data. In this paper, we will review the status of the nuclear data required for neutron and proton therapy, describe the capabilities of the PEREGRINE package, and show the effects of tissue inhomogeneities on dose distribution.

Nuclear Medicine

Nuclear Medicine

Author: Andreas Buck

Publisher: Springer

Published: 2013-01-01

Total Pages: 1200

ISBN-13: 9783642034770

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This concise reference text summarizes the current knowledge of nuclear medical applications in a wide range of fields, including oncology, cardiology, endocrinology, neurology, gastroenterology, urology, gynecology, and pediatrics. Besides well-established methodologies, recent developments in diagnosis (in particular the hybrid imaging techniques, PET/CT and SPECT/CT) and advances in therapy (radioimmunotherapy, radiopeptide therapies) are presented. Each chapter is introduced by a synopsis summarizing those indications for which a nuclear diagnostic test or therapeutic procedure is superior, comparable, or inferior to competing techniques. Procedure guidelines are briefly described and online references to existing society guidelines, provided. Diagnostic efficacy is carefully appraised and, whenever possible, cost effectiveness is assessed.It is anticipated that this book will become the standard reference both for nuclear medicine physicians and for practitioners in related fields (e.g., oncologists, cardiologists, endocrinologists, and neurologists).


Book Synopsis Nuclear Medicine by : Andreas Buck

Download or read book Nuclear Medicine written by Andreas Buck and published by Springer. This book was released on 2013-01-01 with total page 1200 pages. Available in PDF, EPUB and Kindle. Book excerpt: This concise reference text summarizes the current knowledge of nuclear medical applications in a wide range of fields, including oncology, cardiology, endocrinology, neurology, gastroenterology, urology, gynecology, and pediatrics. Besides well-established methodologies, recent developments in diagnosis (in particular the hybrid imaging techniques, PET/CT and SPECT/CT) and advances in therapy (radioimmunotherapy, radiopeptide therapies) are presented. Each chapter is introduced by a synopsis summarizing those indications for which a nuclear diagnostic test or therapeutic procedure is superior, comparable, or inferior to competing techniques. Procedure guidelines are briefly described and online references to existing society guidelines, provided. Diagnostic efficacy is carefully appraised and, whenever possible, cost effectiveness is assessed.It is anticipated that this book will become the standard reference both for nuclear medicine physicians and for practitioners in related fields (e.g., oncologists, cardiologists, endocrinologists, and neurologists).