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Book Synopsis Allostasis, Homeostasis, and the Costs of Physiological Adaptation by : Jay Schulkin
Download or read book Allostasis, Homeostasis, and the Costs of Physiological Adaptation written by Jay Schulkin and published by Cambridge University Press. This book was released on 2004-10-25 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publisher Description
The concept of homeostasis, the maintenance of the internal physiological environment of an organism within tolerable limits, is well established in medicine and physiology. In contrast, allostasis is a relatively new idea of 'viability through change'. With allostatic regulation by cephalic involvement, the body adapts to potentially diverse and dangerous situations through the activation of neural, hormonal, or immunological mechanisms. Allostasis explains how regulatory events maintain organismic viability, or not, in diverse contexts with varying set points of bodily needs and competing motivations. This 2005 book introduces the concept of allostasis and sets it alongside traditional views of homeostasis. It addresses basic regulatory systems and examines the behavior of bodily regulation under duress. The basic concepts of physiological homeostasis are integrated with disorders like depression, stress, anxiety and addiction. It will therefore appeal to graduate students, medical students and researchers working in physiology, epidemiology, endocrinology, neuroendocrinology, neuroscience, and psychology.
Book Synopsis Allostasis, Homeostasis, and the Costs of Physiological Adaptation by : Jay Schulkin
Download or read book Allostasis, Homeostasis, and the Costs of Physiological Adaptation written by Jay Schulkin and published by Cambridge University Press. This book was released on 2004-10-25 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept of homeostasis, the maintenance of the internal physiological environment of an organism within tolerable limits, is well established in medicine and physiology. In contrast, allostasis is a relatively new idea of 'viability through change'. With allostatic regulation by cephalic involvement, the body adapts to potentially diverse and dangerous situations through the activation of neural, hormonal, or immunological mechanisms. Allostasis explains how regulatory events maintain organismic viability, or not, in diverse contexts with varying set points of bodily needs and competing motivations. This 2005 book introduces the concept of allostasis and sets it alongside traditional views of homeostasis. It addresses basic regulatory systems and examines the behavior of bodily regulation under duress. The basic concepts of physiological homeostasis are integrated with disorders like depression, stress, anxiety and addiction. It will therefore appeal to graduate students, medical students and researchers working in physiology, epidemiology, endocrinology, neuroendocrinology, neuroscience, and psychology.
In contrast to homeostasis, allostasis refers to the relatively new idea of "viability through change." This book addresses basic physiological regulatory systems, and examines bodily regulation under duress. It integrates the basic concepts of physiological homeostasis with disorders such as depression, stress, anxiety and addiction. It will interest graduate students, medical students, and researchers in physiology, epidemiology, endocrinology, neuroendocrinology, neuroscience, and psychology.
Book Synopsis Allostasis, Homeostasis, and the Costs of Physiological Adaptation by : Jay Schulkin
Download or read book Allostasis, Homeostasis, and the Costs of Physiological Adaptation written by Jay Schulkin and published by Cambridge University Press. This book was released on 2012-08-16 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In contrast to homeostasis, allostasis refers to the relatively new idea of "viability through change." This book addresses basic physiological regulatory systems, and examines bodily regulation under duress. It integrates the basic concepts of physiological homeostasis with disorders such as depression, stress, anxiety and addiction. It will interest graduate students, medical students, and researchers in physiology, epidemiology, endocrinology, neuroendocrinology, neuroscience, and psychology.
An overview of allostasis, the process by which the body maintains overall viability under normal and adverse conditions.
Book Synopsis Rethinking Homeostasis by : Jay Schulkin
Download or read book Rethinking Homeostasis written by Jay Schulkin and published by MIT Press. This book was released on 2003 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of allostasis, the process by which the body maintains overall viability under normal and adverse conditions.
The first comprehensive treatment of active inference, an integrative perspective on brain, cognition, and behavior used across multiple disciplines. Active inference is a way of understanding sentient behavior—a theory that characterizes perception, planning, and action in terms of probabilistic inference. Developed by theoretical neuroscientist Karl Friston over years of groundbreaking research, active inference provides an integrated perspective on brain, cognition, and behavior that is increasingly used across multiple disciplines including neuroscience, psychology, and philosophy. Active inference puts the action into perception. This book offers the first comprehensive treatment of active inference, covering theory, applications, and cognitive domains. Active inference is a “first principles” approach to understanding behavior and the brain, framed in terms of a single imperative to minimize free energy. The book emphasizes the implications of the free energy principle for understanding how the brain works. It first introduces active inference both conceptually and formally, contextualizing it within current theories of cognition. It then provides specific examples of computational models that use active inference to explain such cognitive phenomena as perception, attention, memory, and planning.
Book Synopsis Active Inference by : Thomas Parr
Download or read book Active Inference written by Thomas Parr and published by MIT Press. This book was released on 2022-03-29 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first comprehensive treatment of active inference, an integrative perspective on brain, cognition, and behavior used across multiple disciplines. Active inference is a way of understanding sentient behavior—a theory that characterizes perception, planning, and action in terms of probabilistic inference. Developed by theoretical neuroscientist Karl Friston over years of groundbreaking research, active inference provides an integrated perspective on brain, cognition, and behavior that is increasingly used across multiple disciplines including neuroscience, psychology, and philosophy. Active inference puts the action into perception. This book offers the first comprehensive treatment of active inference, covering theory, applications, and cognitive domains. Active inference is a “first principles” approach to understanding behavior and the brain, framed in terms of a single imperative to minimize free energy. The book emphasizes the implications of the free energy principle for understanding how the brain works. It first introduces active inference both conceptually and formally, contextualizing it within current theories of cognition. It then provides specific examples of computational models that use active inference to explain such cognitive phenomena as perception, attention, memory, and planning.
The discovery of the negative feedback of thyroid hormones on pituitary thyroid-stimulating hormone (TSH) secretion, a classical endocrine feedback control system, has shaped diagnosis and treatment of thyroid disease for the last decades. Based on this concept, a unique diagnostic category of subclinical thyroid disorders was introduced, being defined exclusively by an abnormal TSH response in the presence of thyroid hormone concentrations within the reference range. Although this approach was able to deliver a conceptually straightforward disease definition problems surfaced in clinical practice as neither the diagnostic reference range nor the appropriate threshold for initiating substitution treatment are universally agreed upon for subclinical thyroid disorders. The situation is further aggravated by the so-called syndrome T, which comprises a substantial but heterogeneous group of L-T4 treated patients with hypothyroidism with reduced quality of life despite “normal” TSH values. A limited understanding of the physiological relationships between TSH and thyroid hormones may be a main reason for clinical difficulties in dealing with the causes of syndrome T and tailoring substitution therapy for hypothyroid patients with subclinical thyroid disorders. Feedback regulation has recently been shown to be much more complex than previously assumed. The concept of homeostatic control has also been extended to include the lesser known but equally important allostatic thyroid regulation.The latter aims at adaptive homeostasis or stability through changing setpoints and modulating structural parameters of feedback control, as may be appropriate to adapt to a vast array of conditions spanning from fetal life, aging, pregnancy, exercise, starvation, obesity, psychiatric disorders to the severe non-thyroidal illness syndrome. A better understanding of homeostatic and allostatic mechanisms, which govern the behaviour of pituitary-thyroid feedback control, is on the horizon. This promises to improve the diagnostic utility of laboratory methods, laying the foundation for personalised methods to optimise dosage and modality of substitution therapy. The emerging new world of thyroid physiology is reflected on the side of clinical medicine in a new, relational paradigm for diagnosis and treatment. Considerable progress has been made in this respect in the following key areas: • the significance of complementary information processing structures within the feedback loop, in particular ultrashort feedback of TSH on its own secretion and the action of a TSH-T3 shunt unburdening the thyroid from T4 synthesis in imminent thyroid failure, • the unravelling of spatio-temporal dynamics of hormone concentrations ranging from ultradian to circannual rhythms and including hysteresis effects, • the emergence of “non-canonical” mechanisms of thyroid hormone signalling beyond transcriptional control of gene expression, • the physiological actions of thyronine metabolites, which have been previously regarded as biologically inactive, such as thyronamines and iodothyroacetates, • the characterisation of distinct patterns in the adaptive processes to stress and strain and their conclusive explanation through reactions to type 1 and type 2 allostatic load. This collective volume contains the contributions to the Research Topic “Homeostasis and Allostasis of Thyroid Function”, which was originally published by the journal Frontiers in Endocrinology. Authored by an international team of experts from three continents ,the book provides a comprehensive overview on thyroid control from recent research in basic, computational and clinical thyroidology. Many aspects addressed here can be expected to stimulate future research. A more comprehensive view and better integration of in-vitro, in-silico and in-vivo investigations will be invaluable in paving the way to this new world of thyroidology.
Book Synopsis Homeostasis and Allostasis of Thyroid Function by : Johannes W. Dietrich
Download or read book Homeostasis and Allostasis of Thyroid Function written by Johannes W. Dietrich and published by Frontiers Media SA. This book was released on 2018-08-29 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of the negative feedback of thyroid hormones on pituitary thyroid-stimulating hormone (TSH) secretion, a classical endocrine feedback control system, has shaped diagnosis and treatment of thyroid disease for the last decades. Based on this concept, a unique diagnostic category of subclinical thyroid disorders was introduced, being defined exclusively by an abnormal TSH response in the presence of thyroid hormone concentrations within the reference range. Although this approach was able to deliver a conceptually straightforward disease definition problems surfaced in clinical practice as neither the diagnostic reference range nor the appropriate threshold for initiating substitution treatment are universally agreed upon for subclinical thyroid disorders. The situation is further aggravated by the so-called syndrome T, which comprises a substantial but heterogeneous group of L-T4 treated patients with hypothyroidism with reduced quality of life despite “normal” TSH values. A limited understanding of the physiological relationships between TSH and thyroid hormones may be a main reason for clinical difficulties in dealing with the causes of syndrome T and tailoring substitution therapy for hypothyroid patients with subclinical thyroid disorders. Feedback regulation has recently been shown to be much more complex than previously assumed. The concept of homeostatic control has also been extended to include the lesser known but equally important allostatic thyroid regulation.The latter aims at adaptive homeostasis or stability through changing setpoints and modulating structural parameters of feedback control, as may be appropriate to adapt to a vast array of conditions spanning from fetal life, aging, pregnancy, exercise, starvation, obesity, psychiatric disorders to the severe non-thyroidal illness syndrome. A better understanding of homeostatic and allostatic mechanisms, which govern the behaviour of pituitary-thyroid feedback control, is on the horizon. This promises to improve the diagnostic utility of laboratory methods, laying the foundation for personalised methods to optimise dosage and modality of substitution therapy. The emerging new world of thyroid physiology is reflected on the side of clinical medicine in a new, relational paradigm for diagnosis and treatment. Considerable progress has been made in this respect in the following key areas: • the significance of complementary information processing structures within the feedback loop, in particular ultrashort feedback of TSH on its own secretion and the action of a TSH-T3 shunt unburdening the thyroid from T4 synthesis in imminent thyroid failure, • the unravelling of spatio-temporal dynamics of hormone concentrations ranging from ultradian to circannual rhythms and including hysteresis effects, • the emergence of “non-canonical” mechanisms of thyroid hormone signalling beyond transcriptional control of gene expression, • the physiological actions of thyronine metabolites, which have been previously regarded as biologically inactive, such as thyronamines and iodothyroacetates, • the characterisation of distinct patterns in the adaptive processes to stress and strain and their conclusive explanation through reactions to type 1 and type 2 allostatic load. This collective volume contains the contributions to the Research Topic “Homeostasis and Allostasis of Thyroid Function”, which was originally published by the journal Frontiers in Endocrinology. Authored by an international team of experts from three continents ,the book provides a comprehensive overview on thyroid control from recent research in basic, computational and clinical thyroidology. Many aspects addressed here can be expected to stimulate future research. A more comprehensive view and better integration of in-vitro, in-silico and in-vivo investigations will be invaluable in paving the way to this new world of thyroidology.
Stress: Concepts, Cognition, Emotion, and Behavior: Handbook in Stress Series, Volume 1, examines stress and its management in the workplace and is targeted at scientific and clinical researchers in biomedicine, psychology, and some aspects of the social sciences. The audience is appropriate faculty and graduate and undergraduate students interested in stress and its consequences. The format allows access to specific self-contained stress subsections without the need to purchase the whole nine volume Stress handbook series. This makes the publication much more affordable than the previously published four volume Encyclopedia of Stress (Elsevier 2007) in which stress subsections were arranged alphabetically and therefore required purchase of the whole work. This feature will be of special significance for individual scientists and clinicians, as well as laboratories. In this first volume of the series, the primary focus will be on general stress concepts as well as the areas of cognition, emotion, and behavior. Offers chapters with impressive scope, covering topics including the interactions between stress, cognition, emotion and behaviour Features articles carefully selected by eminent stress researchers and prepared by contributors representing outstanding scholarship in the field Includes rich illustrations with explanatory figures and tables Includes boxed call out sections that serve to explain key concepts and methods Allows access to specific self-contained stress subsections without the need to purchase the whole nine volume Stress handbook series
Book Synopsis Stress: Concepts, Cognition, Emotion, and Behavior by : George Fink
Download or read book Stress: Concepts, Cognition, Emotion, and Behavior written by George Fink and published by Academic Press. This book was released on 2016-03-10 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stress: Concepts, Cognition, Emotion, and Behavior: Handbook in Stress Series, Volume 1, examines stress and its management in the workplace and is targeted at scientific and clinical researchers in biomedicine, psychology, and some aspects of the social sciences. The audience is appropriate faculty and graduate and undergraduate students interested in stress and its consequences. The format allows access to specific self-contained stress subsections without the need to purchase the whole nine volume Stress handbook series. This makes the publication much more affordable than the previously published four volume Encyclopedia of Stress (Elsevier 2007) in which stress subsections were arranged alphabetically and therefore required purchase of the whole work. This feature will be of special significance for individual scientists and clinicians, as well as laboratories. In this first volume of the series, the primary focus will be on general stress concepts as well as the areas of cognition, emotion, and behavior. Offers chapters with impressive scope, covering topics including the interactions between stress, cognition, emotion and behaviour Features articles carefully selected by eminent stress researchers and prepared by contributors representing outstanding scholarship in the field Includes rich illustrations with explanatory figures and tables Includes boxed call out sections that serve to explain key concepts and methods Allows access to specific self-contained stress subsections without the need to purchase the whole nine volume Stress handbook series
This work offers a comprehensive re-examination and elaboration of homeostasis, a guiding principle in physiology that has received surprisingly little critical evaluation. Among the key topics addressed are questions concerning the competing demands of different regulatory systems within the body and the problem of maintaining equilibrium in such circumstances. The author makes the important point that the body does not always seek constancy of its internal environment, nor does it always react in ways that prevent change. On the contrary, sometimes physiological mechanisms actively promote change. These changes in regulated levels--termed "rheostasis"--are seen as having an adaptive value beyond a simple failure of homeostasis. This book compares and categorizes examples of rheostasis for a variety of physiological variables, and presents what is known about conflicts between different regulatory systems and their role in promoting the occurrence of rheostasis. Among other topics covered are weight loss during hibernation, calcium storage and reproduction, fever, and rates of fat deposition in adults. The work of an outstanding scholar, this integrative study represents a refreshing and essential new approach to one of the basic concepts in physiological science.
Book Synopsis Rheostasis by : Nicholas Mrosovsky
Download or read book Rheostasis written by Nicholas Mrosovsky and published by New York : Oxford University Press. This book was released on 1990 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work offers a comprehensive re-examination and elaboration of homeostasis, a guiding principle in physiology that has received surprisingly little critical evaluation. Among the key topics addressed are questions concerning the competing demands of different regulatory systems within the body and the problem of maintaining equilibrium in such circumstances. The author makes the important point that the body does not always seek constancy of its internal environment, nor does it always react in ways that prevent change. On the contrary, sometimes physiological mechanisms actively promote change. These changes in regulated levels--termed "rheostasis"--are seen as having an adaptive value beyond a simple failure of homeostasis. This book compares and categorizes examples of rheostasis for a variety of physiological variables, and presents what is known about conflicts between different regulatory systems and their role in promoting the occurrence of rheostasis. Among other topics covered are weight loss during hibernation, calcium storage and reproduction, fever, and rates of fat deposition in adults. The work of an outstanding scholar, this integrative study represents a refreshing and essential new approach to one of the basic concepts in physiological science.
Behavioral medicine emerged in the 1970s as the interdisciplinary field concerned with the integration of behavioral, psychosocial, and biomedical science knowledge relevant to the understanding of health and illness, and the application of this knowledge to prevention, diagnosis, treatment, and rehabilitation. Recent years have witnessed an enormous diversification of behavioral medicine, with new sciences (such as genetics, life course epidemiology) and new technologies (such as neuroimaging) coming into play. This book brings together such new developments by providing an up-to-date compendium of methods and applications drawn from the broad range of behavioral medicine research and practice. The book is divided into 10 sections that address key fields in behavioral medicine. Each section begins with one or two methodological or conceptual chapters, followed by contributions that address substantive topics within that field. Major health problems such as cardiovascular disease, cancer, HIV/AIDs, and obesity are explored from multiple perspectives. The aim is to present behavioral medicine as an integrative discipline, involving diverse methodologies and paradigms that converge on health and well being.
Book Synopsis Handbook of Behavioral Medicine by : Andrew Steptoe
Download or read book Handbook of Behavioral Medicine written by Andrew Steptoe and published by Springer Science & Business Media. This book was released on 2010-09-27 with total page 1054 pages. Available in PDF, EPUB and Kindle. Book excerpt: Behavioral medicine emerged in the 1970s as the interdisciplinary field concerned with the integration of behavioral, psychosocial, and biomedical science knowledge relevant to the understanding of health and illness, and the application of this knowledge to prevention, diagnosis, treatment, and rehabilitation. Recent years have witnessed an enormous diversification of behavioral medicine, with new sciences (such as genetics, life course epidemiology) and new technologies (such as neuroimaging) coming into play. This book brings together such new developments by providing an up-to-date compendium of methods and applications drawn from the broad range of behavioral medicine research and practice. The book is divided into 10 sections that address key fields in behavioral medicine. Each section begins with one or two methodological or conceptual chapters, followed by contributions that address substantive topics within that field. Major health problems such as cardiovascular disease, cancer, HIV/AIDs, and obesity are explored from multiple perspectives. The aim is to present behavioral medicine as an integrative discipline, involving diverse methodologies and paradigms that converge on health and well being.
Cognitive Adaptation: A Pragmatist Perspective argues that there is a fundamental link between cognitive/neural systems and evolution that underlies human activity. One important result is that the line between nature and culture and scientific and humanistic inquiry is quite permeable - the two are fairly continuous with each other. Two concepts figure importantly in our human ascent: agency and animacy. The first is the recognition of another person as having beliefs, desires, and a sense of experience. The second term is the recognition of an object as alive, a piece of biology. Both reflect a predilection in our cognitive architecture that is fundamental to an evolving, but fragile, sense of humanity. The book further argues for a regulative norm of self-corrective inquiry, an appreciation of the hypothetical nature of all knowledge. Schulkin's perspective is rooted in contemporary behavioral and cognitive neuroscience.
Book Synopsis Cognitive Adaptation by : Jay Schulkin
Download or read book Cognitive Adaptation written by Jay Schulkin and published by Cambridge University Press. This book was released on 2014-11-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cognitive Adaptation: A Pragmatist Perspective argues that there is a fundamental link between cognitive/neural systems and evolution that underlies human activity. One important result is that the line between nature and culture and scientific and humanistic inquiry is quite permeable - the two are fairly continuous with each other. Two concepts figure importantly in our human ascent: agency and animacy. The first is the recognition of another person as having beliefs, desires, and a sense of experience. The second term is the recognition of an object as alive, a piece of biology. Both reflect a predilection in our cognitive architecture that is fundamental to an evolving, but fragile, sense of humanity. The book further argues for a regulative norm of self-corrective inquiry, an appreciation of the hypothetical nature of all knowledge. Schulkin's perspective is rooted in contemporary behavioral and cognitive neuroscience.
