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Antibacterial Drug Discovery to Combat MDR

Author: Iqbal Ahmad

Publisher: Springer Nature

Published: 2019-11-09

Total Pages: 680

ISBN-13: 9811398712

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This book compiles the latest information in the field of antibacterial discovery, especially with regard to the looming threat of multi-drug resistance. The respective chapters highlight the discovery of new antibacterial and anti-infective compounds derived from microbes, plants, and other natural sources. The potential applications of nanotechnology to the fields of antibacterial discovery and drug delivery are also discussed, and one section of the book is dedicated to the use of computational tools and metagenomics in antibiotic drug discovery. Techniques for efficient drug delivery are also covered. The book provides a comprehensive overview of the progress made in both antibacterial discovery and delivery, making it a valuable resource for academic researchers, as well as those working in the pharmaceutical industry.

Book Synopsis Antibacterial Drug Discovery to Combat MDR by : Iqbal Ahmad

Download or read book Antibacterial Drug Discovery to Combat MDR written by Iqbal Ahmad and published by Springer Nature. This book was released on 2019-11-09 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book compiles the latest information in the field of antibacterial discovery, especially with regard to the looming threat of multi-drug resistance. The respective chapters highlight the discovery of new antibacterial and anti-infective compounds derived from microbes, plants, and other natural sources. The potential applications of nanotechnology to the fields of antibacterial discovery and drug delivery are also discussed, and one section of the book is dedicated to the use of computational tools and metagenomics in antibiotic drug discovery. Techniques for efficient drug delivery are also covered. The book provides a comprehensive overview of the progress made in both antibacterial discovery and delivery, making it a valuable resource for academic researchers, as well as those working in the pharmaceutical industry.

Drug Discovery Targeting Drug-Resistant Bacteria

Author: Prashant Kesharwani

Publisher: Academic Press

Published: 2020-05-29

Total Pages: 432

ISBN-13: 0128184809

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Drug Discovery Targeting Drug-Resistant Bacteria explores the status and possible future of developments in fighting drug-resistant bacteria. The book covers the majority of microbial diseases and the drugs targeting them. In addition, it discusses the potential targeting strategies and innovative approaches to address drug resistance. It brings together academic and industrial experts working on discovering and developing drugs targeting drug-resistant (DR) bacterial pathogens. New drugs active against drug-resistant pathogens are discussed, along with new strategies being used to discover molecules acting via new modes of action. In addition, alternative therapies such as peptides and phages are included. Pharmaceutical scientists, microbiologists, medical professionals, pathologists, researchers in the field of drug discovery, infectious diseases and microbial drug discovery both in academia and in industrial settings will find this book helpful. Written by scientists with extensive industrial experience in drug discovery Provides a balanced view of the field, including its challenges and future directions Includes a special chapter on the identification and development of drugs against pathogens which exhibit the potential to be used as weapons of war

Book Synopsis Drug Discovery Targeting Drug-Resistant Bacteria by : Prashant Kesharwani

Download or read book Drug Discovery Targeting Drug-Resistant Bacteria written by Prashant Kesharwani and published by Academic Press. This book was released on 2020-05-29 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Discovery Targeting Drug-Resistant Bacteria explores the status and possible future of developments in fighting drug-resistant bacteria. The book covers the majority of microbial diseases and the drugs targeting them. In addition, it discusses the potential targeting strategies and innovative approaches to address drug resistance. It brings together academic and industrial experts working on discovering and developing drugs targeting drug-resistant (DR) bacterial pathogens. New drugs active against drug-resistant pathogens are discussed, along with new strategies being used to discover molecules acting via new modes of action. In addition, alternative therapies such as peptides and phages are included. Pharmaceutical scientists, microbiologists, medical professionals, pathologists, researchers in the field of drug discovery, infectious diseases and microbial drug discovery both in academia and in industrial settings will find this book helpful. Written by scientists with extensive industrial experience in drug discovery Provides a balanced view of the field, including its challenges and future directions Includes a special chapter on the identification and development of drugs against pathogens which exhibit the potential to be used as weapons of war

Drug Discovery Targeting Drug-Resistant Bacteria

Author: Prashant Kesharwani

Publisher: Academic Press

Published: 2020-05-15

Total Pages: 434

ISBN-13: 0128184817

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Book Synopsis Drug Discovery Targeting Drug-Resistant Bacteria by : Prashant Kesharwani

Download or read book Drug Discovery Targeting Drug-Resistant Bacteria written by Prashant Kesharwani and published by Academic Press. This book was released on 2020-05-15 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Discovery Targeting Drug-Resistant Bacteria explores the status and possible future of developments in fighting drug-resistant bacteria. The book covers the majority of microbial diseases and the drugs targeting them. In addition, it discusses the potential targeting strategies and innovative approaches to address drug resistance. It brings together academic and industrial experts working on discovering and developing drugs targeting drug-resistant (DR) bacterial pathogens. New drugs active against drug-resistant pathogens are discussed, along with new strategies being used to discover molecules acting via new modes of action. In addition, alternative therapies such as peptides and phages are included. Pharmaceutical scientists, microbiologists, medical professionals, pathologists, researchers in the field of drug discovery, infectious diseases and microbial drug discovery both in academia and in industrial settings will find this book helpful. Written by scientists with extensive industrial experience in drug discovery Provides a balanced view of the field, including its challenges and future directions Includes a special chapter on the identification and development of drugs against pathogens which exhibit the potential to be used as weapons of war

Treating Infectious Diseases in a Microbial World

Author: National Research Council

Publisher: National Academies Press

Published: 2006-01-03

Total Pages: 102

ISBN-13: 0309180686

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Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.

Book Synopsis Treating Infectious Diseases in a Microbial World by : National Research Council

Download or read book Treating Infectious Diseases in a Microbial World written by National Research Council and published by National Academies Press. This book was released on 2006-01-03 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: Humans coexist with millions of harmless microorganisms, but emerging diseases, resistance to antibiotics, and the threat of bioterrorism are forcing scientists to look for new ways to confront the microbes that do pose a danger. This report identifies innovative approaches to the development of antimicrobial drugs and vaccines based on a greater understanding of how the human immune system interacts with both good and bad microbes. The report concludes that the development of a single superdrug to fight all infectious agents is unrealistic.

Contemporary Approaches to Mitigating Antibacterial Drug Resistance

Author: Grewal, Ajmer Singh

Publisher: IGI Global

Published: 2024-04-01

Total Pages: 384

ISBN-13:

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In infectious disease management, antibacterial agents have long been viewed as pivotal tools in the relentless battle against microorganisms. However, the escalating threat of antibacterial drug resistance has emerged as a formidable challenge to global health. Contemporary Approaches to Mitigating Antibacterial Drug Resistance delves into the heart of this critical issue, exploring the mechanisms, consequences, and innovative strategies to counteract the surge of resistance, a phenomenon becoming increasingly pervasive and threatening worldwide. Antibacterial drug resistance, a pressing public health concern, transcends geographical boundaries. In regions where antibiotic accessibility and overuse prevail, resistance rates soar, giving rise to the ominous "superbugs." This book unravels the intricacies of drug resistance, examining its impact on infectious disease management, healthcare economics, and societal well-being. The exploration begins with a foundational understanding of antibacterial drug resistance, navigating through the intricate mechanisms that drive its rapid proliferation. Environmental and genetic factors, often overlooked, are dissected for their roles in fostering resistance. The book explores the interplay of antibacterial drugs with micro-biodiversity, shedding light on the indirect repercussions on human and environmental ecosystems. The primary audience, encompassing undergraduate and postgraduate students, medical practitioners, academicians, and researchers, will find in-depth insights into emerging therapeutic targets and recent advances in drug development. The secondary audience, including authorities in antibacterial drug resistance and institutional libraries, will discover a valuable resource addressing the multifaceted dimensions of this global menace.

Book Synopsis Contemporary Approaches to Mitigating Antibacterial Drug Resistance by : Grewal, Ajmer Singh

Download or read book Contemporary Approaches to Mitigating Antibacterial Drug Resistance written by Grewal, Ajmer Singh and published by IGI Global. This book was released on 2024-04-01 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: In infectious disease management, antibacterial agents have long been viewed as pivotal tools in the relentless battle against microorganisms. However, the escalating threat of antibacterial drug resistance has emerged as a formidable challenge to global health. Contemporary Approaches to Mitigating Antibacterial Drug Resistance delves into the heart of this critical issue, exploring the mechanisms, consequences, and innovative strategies to counteract the surge of resistance, a phenomenon becoming increasingly pervasive and threatening worldwide. Antibacterial drug resistance, a pressing public health concern, transcends geographical boundaries. In regions where antibiotic accessibility and overuse prevail, resistance rates soar, giving rise to the ominous "superbugs." This book unravels the intricacies of drug resistance, examining its impact on infectious disease management, healthcare economics, and societal well-being. The exploration begins with a foundational understanding of antibacterial drug resistance, navigating through the intricate mechanisms that drive its rapid proliferation. Environmental and genetic factors, often overlooked, are dissected for their roles in fostering resistance. The book explores the interplay of antibacterial drugs with micro-biodiversity, shedding light on the indirect repercussions on human and environmental ecosystems. The primary audience, encompassing undergraduate and postgraduate students, medical practitioners, academicians, and researchers, will find in-depth insights into emerging therapeutic targets and recent advances in drug development. The secondary audience, including authorities in antibacterial drug resistance and institutional libraries, will discover a valuable resource addressing the multifaceted dimensions of this global menace.

Current Developments in the Detection and Control of Multi Drug Resistance

Author: Sanket Kaushik

Publisher: Bentham Science Publishers

Published: 2022-07-26

Total Pages: 181

ISBN-13: 9815049887

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The rise in the incidence of infections is caused by multi drugresistant (MDR) bacteria, it is essential to elucidate the basic mechanism ofantibiotic resistance to discover effective methods for diagnosis and treatmentof infections. The use of pathogen-specific probes offers a faster alternative forpathogen detection and could improve the diagnosis of infection. High resolutionmelting analysis techniques are useful for the detection of multi drugresistant pathogens. Rational Structural Based Drug Design is a common methodto identify a lead compound and take it forward for further developments.This book provides information about recent strategies involved in thediagnosis and treatment of infections caused by MDR bacteria. The volume coversthe use of molecular probes for the quantification of pathogenic bacteria, alongwith other techniques mentioned above. Chapters also cover the use of identificationof novel drug targets from the Lipid A biosynthesis and also from quorum sensingmediated biofilm formation in MDR bacteria. Chapters also cover herbal alternatives for the treatment of MDRbacteria like the use of Cassiaaungustifolia in treatment of various diseases. The reference is suitablefor biomedical students, cellular and molecular biologists.

Book Synopsis Current Developments in the Detection and Control of Multi Drug Resistance by : Sanket Kaushik

Download or read book Current Developments in the Detection and Control of Multi Drug Resistance written by Sanket Kaushik and published by Bentham Science Publishers. This book was released on 2022-07-26 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rise in the incidence of infections is caused by multi drugresistant (MDR) bacteria, it is essential to elucidate the basic mechanism ofantibiotic resistance to discover effective methods for diagnosis and treatmentof infections. The use of pathogen-specific probes offers a faster alternative forpathogen detection and could improve the diagnosis of infection. High resolutionmelting analysis techniques are useful for the detection of multi drugresistant pathogens. Rational Structural Based Drug Design is a common methodto identify a lead compound and take it forward for further developments.This book provides information about recent strategies involved in thediagnosis and treatment of infections caused by MDR bacteria. The volume coversthe use of molecular probes for the quantification of pathogenic bacteria, alongwith other techniques mentioned above. Chapters also cover the use of identificationof novel drug targets from the Lipid A biosynthesis and also from quorum sensingmediated biofilm formation in MDR bacteria. Chapters also cover herbal alternatives for the treatment of MDRbacteria like the use of Cassiaaungustifolia in treatment of various diseases. The reference is suitablefor biomedical students, cellular and molecular biologists.

New Strategies Combating Bacterial Infection

Author: Iqbal Ahmad

Publisher: John Wiley & Sons

Published: 2008-11-21

Total Pages: 322

ISBN-13: 3527622942

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Combating bacterial infections calls for a multidisciplinary approach and this is what is on offer here. Written by an experienced international team of researchers from various fields ranging from biotechnology to traditional medicine, the book provides complete and comprehensive coverage of topics relevant to new antibacterial drugs. This ready reference and handbook adopts a novel approach, focusing on combating multi-drug resistance in bacteria by developing antibacterials with new target sites, using new advances in drug discovery as well as natural products. Divided into three sections, the first describes the problem of drug resistance and the need for new drugs, while the second treats recent trends and new classes of drugs, including relevant developments in transcriptomics and proteomics leading to new antimicrobial drug discovery, and a new generation of antibiotics and non-antibiotics. The third section on natural products discusses the antibacterial action of phytocompounds, plant extracts, essential oils and honey as well as the role of probiotics in bacterial infections. Invaluable to students of medicine, pharmaceutical sciences, phytomedicine and microbiology and all those wanting to know about the possibilities and limitations of new antibacterial drugs. Furthermore, its coverage of plants and other natural products makes this relevant to the pharmaceutical and herbal industries.

Book Synopsis New Strategies Combating Bacterial Infection by : Iqbal Ahmad

Download or read book New Strategies Combating Bacterial Infection written by Iqbal Ahmad and published by John Wiley & Sons. This book was released on 2008-11-21 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Combating bacterial infections calls for a multidisciplinary approach and this is what is on offer here. Written by an experienced international team of researchers from various fields ranging from biotechnology to traditional medicine, the book provides complete and comprehensive coverage of topics relevant to new antibacterial drugs. This ready reference and handbook adopts a novel approach, focusing on combating multi-drug resistance in bacteria by developing antibacterials with new target sites, using new advances in drug discovery as well as natural products. Divided into three sections, the first describes the problem of drug resistance and the need for new drugs, while the second treats recent trends and new classes of drugs, including relevant developments in transcriptomics and proteomics leading to new antimicrobial drug discovery, and a new generation of antibiotics and non-antibiotics. The third section on natural products discusses the antibacterial action of phytocompounds, plant extracts, essential oils and honey as well as the role of probiotics in bacterial infections. Invaluable to students of medicine, pharmaceutical sciences, phytomedicine and microbiology and all those wanting to know about the possibilities and limitations of new antibacterial drugs. Furthermore, its coverage of plants and other natural products makes this relevant to the pharmaceutical and herbal industries.

Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components

Author: Mahendra Rai

Publisher: Academic Press

Published: 2013-05-24

Total Pages: 291

ISBN-13: 0124017088

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Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and their Components offers scientists a single source aimed at fighting specific multidrug-resistant (MDR) microorganisms such as bacteria, protozoans, viruses and fungi using natural products. This essential reference discusses herbal extracts and essential oils used or under investigation to treat MDR infections, as well as those containing antimicrobial activity that could be of potential interest in future studies against MDR microorganisms. The need to combat multidrug-resistant microorganisms is an urgent one and this book provides important coverage of mechanism of action, the advantages and disadvantages of using herbal extracts, essential oils and their components and more to aid researchers in effective antimicrobial drug discovery Addresses the need to develop safe and effective approaches to coping with resistance to all classes of antimicrobial drugs Provides readers with current evidence-based content aimed at using herbal extracts and essential oils in antimicrobial drug development Includes chapters devoted to the activity of herbal products against herpes, AIDS, tuberculosis, drug-resistant cancer cells and more

Book Synopsis Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components by : Mahendra Rai

Download or read book Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and Their Components written by Mahendra Rai and published by Academic Press. This book was released on 2013-05-24 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fighting Multidrug Resistance with Herbal Extracts, Essential Oils and their Components offers scientists a single source aimed at fighting specific multidrug-resistant (MDR) microorganisms such as bacteria, protozoans, viruses and fungi using natural products. This essential reference discusses herbal extracts and essential oils used or under investigation to treat MDR infections, as well as those containing antimicrobial activity that could be of potential interest in future studies against MDR microorganisms. The need to combat multidrug-resistant microorganisms is an urgent one and this book provides important coverage of mechanism of action, the advantages and disadvantages of using herbal extracts, essential oils and their components and more to aid researchers in effective antimicrobial drug discovery Addresses the need to develop safe and effective approaches to coping with resistance to all classes of antimicrobial drugs Provides readers with current evidence-based content aimed at using herbal extracts and essential oils in antimicrobial drug development Includes chapters devoted to the activity of herbal products against herpes, AIDS, tuberculosis, drug-resistant cancer cells and more

Antimicrobial Drug Discovery

Author: G. Tegos

Publisher: CABI

Published: 2012

Total Pages: 369

ISBN-13: 9781780640310

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Drug resistance is increasing among a variety of human pathogenic microorganisms such as Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumaniii, Pseudomonas aeruginosa and Enterobacter spp. (currently dubbed the 'ESKAPE' pathogens), and has emerged as one of the most important clinical challenges of this century. Increased general awareness and fear of these pathogens means there is a growing demand for research to tackle the threat of multidrug resistance. Documenting the latest research in the field, this book discusses current and promising activities to discover new antimicrobials in five key areas: molecular genetics and systems microbiology; synthetic, computational chemistry and chemoinformatics; High Throughput Screening (HTS); non-vertebrate model hosts; and light- and nano-based technologies.

Book Synopsis Antimicrobial Drug Discovery by : G. Tegos

Download or read book Antimicrobial Drug Discovery written by G. Tegos and published by CABI. This book was released on 2012 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug resistance is increasing among a variety of human pathogenic microorganisms such as Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumaniii, Pseudomonas aeruginosa and Enterobacter spp. (currently dubbed the 'ESKAPE' pathogens), and has emerged as one of the most important clinical challenges of this century. Increased general awareness and fear of these pathogens means there is a growing demand for research to tackle the threat of multidrug resistance. Documenting the latest research in the field, this book discusses current and promising activities to discover new antimicrobials in five key areas: molecular genetics and systems microbiology; synthetic, computational chemistry and chemoinformatics; High Throughput Screening (HTS); non-vertebrate model hosts; and light- and nano-based technologies.

Microbial Threats to Health

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2003-08-25

Total Pages: 397

ISBN-13: 0309185548

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Infectious diseases are a global hazard that puts every nation and every person at risk. The recent SARS outbreak is a prime example. Knowing neither geographic nor political borders, often arriving silently and lethally, microbial pathogens constitute a grave threat to the health of humans. Indeed, a majority of countries recently identified the spread of infectious disease as the greatest global problem they confront. Throughout history, humans have struggled to control both the causes and consequences of infectious diseases and we will continue to do so into the foreseeable future. Following up on a high-profile 1992 report from the Institute of Medicine, Microbial Threats to Health examines the current state of knowledge and policy pertaining to emerging and re-emerging infectious diseases from around the globe. It examines the spectrum of microbial threats, factors in disease emergence, and the ultimate capacity of the United States to meet the challenges posed by microbial threats to human health. From the impact of war or technology on disease emergence to the development of enhanced disease surveillance and vaccine strategies, Microbial Threats to Health contains valuable information for researchers, students, health care providers, policymakers, public health officials. and the interested public.

Book Synopsis Microbial Threats to Health by : Institute of Medicine

Download or read book Microbial Threats to Health written by Institute of Medicine and published by National Academies Press. This book was released on 2003-08-25 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious diseases are a global hazard that puts every nation and every person at risk. The recent SARS outbreak is a prime example. Knowing neither geographic nor political borders, often arriving silently and lethally, microbial pathogens constitute a grave threat to the health of humans. Indeed, a majority of countries recently identified the spread of infectious disease as the greatest global problem they confront. Throughout history, humans have struggled to control both the causes and consequences of infectious diseases and we will continue to do so into the foreseeable future. Following up on a high-profile 1992 report from the Institute of Medicine, Microbial Threats to Health examines the current state of knowledge and policy pertaining to emerging and re-emerging infectious diseases from around the globe. It examines the spectrum of microbial threats, factors in disease emergence, and the ultimate capacity of the United States to meet the challenges posed by microbial threats to human health. From the impact of war or technology on disease emergence to the development of enhanced disease surveillance and vaccine strategies, Microbial Threats to Health contains valuable information for researchers, students, health care providers, policymakers, public health officials. and the interested public.