Antioxidants and Stem Cells for Coronary Heart Disease

Antioxidants and Stem Cells for Coronary Heart Disease

Author: Philip B Oliva

Publisher: World Scientific

Published: 2014-01-22

Total Pages: 632

ISBN-13: 9814602345

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This book covers two known controversial topics — antioxidants and stem cells as therapies to treat coronary heart disease. Aiming to provide college-educated but not scientifically trained readership with a wealth of information about these two cutting-edge technologies, Antioxidants and Stem Cells for Coronary Heart Disease is written with minimum scientific terminology. Basic science studies and clinical trials regarding stem cells and antioxidants are discussed and peppered with anecdotes to make them understandable and entertaining to the laymen. Contents:Part I:The French ParadoxLDL Oxidation — BrieflyAcetylation of LDLFree RadicalsThe Oxygen ParadoxRetrolental Fibroplasia from 1956 to 1972: The Quiet TimeThe Second Epidemic of Retrolental Fibroplasia: 1972–20??Cytokines and ChemokinesLDL Oxidation by Free Radicals — In DetailTwo Other Ways to Oxidize LDL: Lipoxygenase and Nitric OxideWhat is the Raison d'être for Oxidized LDL?Fatty Streaks and Foam CellsEmbryonic Stem CellsAdult Stem CellsTransgenic MicePart II:Treatment of Coronary Heart Disease with Antioxidants: An IntroductionThe Mediterranean DietAcute Myocardial Infarctions in Japan and Norway from 1910 to 1950Wine, Beer, and Spirits as AntioxidantsA Perspective on Antioxidant Vitamins for the Treatment of Coronary Heart DiseaseVitamin AThe Thalidomide SagaVitamin CVitamin EDo Combinations of Antioxidant Vitamins Work Better than Individual Vitamins in Patients with Coronary Heart Disease?A RequiemMolecular Markers, Reporter Genes and Suicide GenesStem Cells for the Heart: Hype or Hope?The PrizefightBrainbowCre/Lox: A Cut-and-Paste Method of Gene Swapping Without a Mac or PC and a New Scientific Term with Vast SignificanceBacteriophage, Transgenic Mice and Transgenic MarmosetsPhage Geometry and Soccer BallsEuler's FormulaE = mc2 and Einstein's BrainThe Manhattan Project and Its Connection with Albert EinsteinA Gadget, a Little Boy and a Fat ManCamillo Golgi and Santiago Ramón Y Cajal: Bitter Rivals to The End Readership: College-educated general public and non-scientists who are interested in the topic of antioxidants and stem cells. Key Features:The book is written in plain English and scientific jargons are explained in laymen terms“Hot topics” such as embryonic stem cells, adult stem cells and antioxidants are discussedA well-researched and colourfully illustrated book for readers of the general publicKeywords:Stem Cells;Antioxidants;Coronary Heart Disease


Book Synopsis Antioxidants and Stem Cells for Coronary Heart Disease by : Philip B Oliva

Download or read book Antioxidants and Stem Cells for Coronary Heart Disease written by Philip B Oliva and published by World Scientific. This book was released on 2014-01-22 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers two known controversial topics — antioxidants and stem cells as therapies to treat coronary heart disease. Aiming to provide college-educated but not scientifically trained readership with a wealth of information about these two cutting-edge technologies, Antioxidants and Stem Cells for Coronary Heart Disease is written with minimum scientific terminology. Basic science studies and clinical trials regarding stem cells and antioxidants are discussed and peppered with anecdotes to make them understandable and entertaining to the laymen. Contents:Part I:The French ParadoxLDL Oxidation — BrieflyAcetylation of LDLFree RadicalsThe Oxygen ParadoxRetrolental Fibroplasia from 1956 to 1972: The Quiet TimeThe Second Epidemic of Retrolental Fibroplasia: 1972–20??Cytokines and ChemokinesLDL Oxidation by Free Radicals — In DetailTwo Other Ways to Oxidize LDL: Lipoxygenase and Nitric OxideWhat is the Raison d'être for Oxidized LDL?Fatty Streaks and Foam CellsEmbryonic Stem CellsAdult Stem CellsTransgenic MicePart II:Treatment of Coronary Heart Disease with Antioxidants: An IntroductionThe Mediterranean DietAcute Myocardial Infarctions in Japan and Norway from 1910 to 1950Wine, Beer, and Spirits as AntioxidantsA Perspective on Antioxidant Vitamins for the Treatment of Coronary Heart DiseaseVitamin AThe Thalidomide SagaVitamin CVitamin EDo Combinations of Antioxidant Vitamins Work Better than Individual Vitamins in Patients with Coronary Heart Disease?A RequiemMolecular Markers, Reporter Genes and Suicide GenesStem Cells for the Heart: Hype or Hope?The PrizefightBrainbowCre/Lox: A Cut-and-Paste Method of Gene Swapping Without a Mac or PC and a New Scientific Term with Vast SignificanceBacteriophage, Transgenic Mice and Transgenic MarmosetsPhage Geometry and Soccer BallsEuler's FormulaE = mc2 and Einstein's BrainThe Manhattan Project and Its Connection with Albert EinsteinA Gadget, a Little Boy and a Fat ManCamillo Golgi and Santiago Ramón Y Cajal: Bitter Rivals to The End Readership: College-educated general public and non-scientists who are interested in the topic of antioxidants and stem cells. Key Features:The book is written in plain English and scientific jargons are explained in laymen terms“Hot topics” such as embryonic stem cells, adult stem cells and antioxidants are discussedA well-researched and colourfully illustrated book for readers of the general publicKeywords:Stem Cells;Antioxidants;Coronary Heart Disease

Stem Cell and Gene Therapy for Cardiovascular Disease

Stem Cell and Gene Therapy for Cardiovascular Disease

Author: Emerson C. Perin

Publisher: Academic Press

Published: 2015-08-21

Total Pages: 538

ISBN-13: 0128018631

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Stem Cell and Gene Therapy for Cardiovascular Disease is a state-of-the-art reference that combines, in one place, the breadth and depth of information available on the topic. As stem cell and gene therapies are the most cutting-edge therapies currently available for patients with heart failure, each section of the book provides information on medical trials from contributors and specialists from around the world, including not only what has been completed, but also what is planned for future research and trials. Cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals will find this book an invaluable resource for further study on the topic. Provides information on stem and gene therapy medical trials from contributors and specialists around the world, including not only what has been completed, but also what is planned for future research and trials Presents topics that can be applied to allogeneic cells, mesenchymal cells, gene therapy, cardiomyoctyes, iPS cells, MAPC's, and organogenesis Covers the three areas with the greatest clinical trials to date: chronic limb ischemia, chronic angina, and acute MI Covers the prevailing opinions on how to harness the body’s natural repair mechanisms Ideal resource for cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals


Book Synopsis Stem Cell and Gene Therapy for Cardiovascular Disease by : Emerson C. Perin

Download or read book Stem Cell and Gene Therapy for Cardiovascular Disease written by Emerson C. Perin and published by Academic Press. This book was released on 2015-08-21 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem Cell and Gene Therapy for Cardiovascular Disease is a state-of-the-art reference that combines, in one place, the breadth and depth of information available on the topic. As stem cell and gene therapies are the most cutting-edge therapies currently available for patients with heart failure, each section of the book provides information on medical trials from contributors and specialists from around the world, including not only what has been completed, but also what is planned for future research and trials. Cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals will find this book an invaluable resource for further study on the topic. Provides information on stem and gene therapy medical trials from contributors and specialists around the world, including not only what has been completed, but also what is planned for future research and trials Presents topics that can be applied to allogeneic cells, mesenchymal cells, gene therapy, cardiomyoctyes, iPS cells, MAPC's, and organogenesis Covers the three areas with the greatest clinical trials to date: chronic limb ischemia, chronic angina, and acute MI Covers the prevailing opinions on how to harness the body’s natural repair mechanisms Ideal resource for cardiology researchers, basic science clinicians, fellows, residents, students, and industry professionals

Antioxidants and Cardiovascular Disease

Antioxidants and Cardiovascular Disease

Author: R. Nath

Publisher: Alpha Science Int'l Ltd.

Published: 2004

Total Pages: 322

ISBN-13: 9788173195143

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Authored by leading investigators in the field of cardiovascular research and practicing clinicians across the globe, this book details the scientific evidence for the heath effect of vitamins, antioxidants and functional food, specifically, their role in the cardiovascular system and provides recommendations in cardiovascular nutrition.


Book Synopsis Antioxidants and Cardiovascular Disease by : R. Nath

Download or read book Antioxidants and Cardiovascular Disease written by R. Nath and published by Alpha Science Int'l Ltd.. This book was released on 2004 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Authored by leading investigators in the field of cardiovascular research and practicing clinicians across the globe, this book details the scientific evidence for the heath effect of vitamins, antioxidants and functional food, specifically, their role in the cardiovascular system and provides recommendations in cardiovascular nutrition.

Stem Cells and Myocardial Regeneration

Stem Cells and Myocardial Regeneration

Author: Marc S. Penn

Publisher: Springer Science & Business Media

Published: 2007-11-06

Total Pages: 314

ISBN-13: 1597452726

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Over the past 5 years there has been great excitement and controversy in the scientific, financial, and lay literature for the potential of stem cell-based strategies for the prev- tion and treatment of chronic heart failure (CHF). Not that long ago we believed we were born with a set number of cardiac myocytes and that once damaged there was no hope to replace them. The interest in the field stems from the magnitude of cardiovascular disease in the world. Our ability to treat and help patients survive acute myocardial infarction (MI) has resulted in a near epidemic of CHF. There are more than 5 million Americans who currently carry the diagnosis of CHF. With more than 1 million MIs a year in the United States, there are approx 500,000 new cases of CHF diagnosed each year. The goal of Stem Cells and Myocardial Regeneration is to present, in a coherent manner, the current state of knowledge of stem cell-based therapies for cardiac dysfunction, including current findings in both the laboratory and the clinic trials. The first section of this Stem Cells and Myocardial Regeneration focuses on the magnitude of the problem and the successes and failures of what we consider optimal medical therapy. It is on this background that stem cell-based therapy needs to build.


Book Synopsis Stem Cells and Myocardial Regeneration by : Marc S. Penn

Download or read book Stem Cells and Myocardial Regeneration written by Marc S. Penn and published by Springer Science & Business Media. This book was released on 2007-11-06 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past 5 years there has been great excitement and controversy in the scientific, financial, and lay literature for the potential of stem cell-based strategies for the prev- tion and treatment of chronic heart failure (CHF). Not that long ago we believed we were born with a set number of cardiac myocytes and that once damaged there was no hope to replace them. The interest in the field stems from the magnitude of cardiovascular disease in the world. Our ability to treat and help patients survive acute myocardial infarction (MI) has resulted in a near epidemic of CHF. There are more than 5 million Americans who currently carry the diagnosis of CHF. With more than 1 million MIs a year in the United States, there are approx 500,000 new cases of CHF diagnosed each year. The goal of Stem Cells and Myocardial Regeneration is to present, in a coherent manner, the current state of knowledge of stem cell-based therapies for cardiac dysfunction, including current findings in both the laboratory and the clinic trials. The first section of this Stem Cells and Myocardial Regeneration focuses on the magnitude of the problem and the successes and failures of what we consider optimal medical therapy. It is on this background that stem cell-based therapy needs to build.

Studies on Cardiovascular Disorders

Studies on Cardiovascular Disorders

Author: Heinrich Sauer

Publisher: Springer Science & Business Media

Published: 2010-09-11

Total Pages: 587

ISBN-13: 1607616009

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This collection of articles on oxidative stress in clinical practice surveys essential current research in what is a rapidly evolving field. As well as giving the reader a mechanistic overview of how oxidative stress affects cardiovascular disease, it analyzes the potential of a number of therapeutic options that target these pathways. Understanding the complexity of the cellular redox system could lead to the development of better targeted interventions that facilitate patient recovery. Even as large-scale clinical trials of so-called ‘simple’ antioxidant approaches such as vitamins C and E show that significant benefits for cardiovascular patients remain elusive, Studies on Cardiovascular Disorders demonstrates that such approaches are too simplistic. Beginning with a summary of redox signaling models that could induce the progression of redox-associated cardiovascular disorders, the volume moves on to examine redox-mediated protein modification under physiological and pathophysiological conditions. It provides an outline of the signaling pathways in cardiovascular development during embryogenesis, and what impact these might have in the differentiation process of resident cardiac and blastocyst derived stem cells. Further chapters detail our current knowledge of the influence the sensory nervous system exerts on the cardiovascular system, and the paradoxical role of mitochondria-derived ROS in cardiac protection. In all, almost 30 contributions cover issues as diverse as the antioxidant properties of statins in the heart and the oxidative risk factors for cardiovascular disease in women. A range of medical practitioners will find the contents of Studies on Cardiovascular Disorders provides illuminating insight into the Janus-faced role of ROS in the cardiovascular system.


Book Synopsis Studies on Cardiovascular Disorders by : Heinrich Sauer

Download or read book Studies on Cardiovascular Disorders written by Heinrich Sauer and published by Springer Science & Business Media. This book was released on 2010-09-11 with total page 587 pages. Available in PDF, EPUB and Kindle. Book excerpt: This collection of articles on oxidative stress in clinical practice surveys essential current research in what is a rapidly evolving field. As well as giving the reader a mechanistic overview of how oxidative stress affects cardiovascular disease, it analyzes the potential of a number of therapeutic options that target these pathways. Understanding the complexity of the cellular redox system could lead to the development of better targeted interventions that facilitate patient recovery. Even as large-scale clinical trials of so-called ‘simple’ antioxidant approaches such as vitamins C and E show that significant benefits for cardiovascular patients remain elusive, Studies on Cardiovascular Disorders demonstrates that such approaches are too simplistic. Beginning with a summary of redox signaling models that could induce the progression of redox-associated cardiovascular disorders, the volume moves on to examine redox-mediated protein modification under physiological and pathophysiological conditions. It provides an outline of the signaling pathways in cardiovascular development during embryogenesis, and what impact these might have in the differentiation process of resident cardiac and blastocyst derived stem cells. Further chapters detail our current knowledge of the influence the sensory nervous system exerts on the cardiovascular system, and the paradoxical role of mitochondria-derived ROS in cardiac protection. In all, almost 30 contributions cover issues as diverse as the antioxidant properties of statins in the heart and the oxidative risk factors for cardiovascular disease in women. A range of medical practitioners will find the contents of Studies on Cardiovascular Disorders provides illuminating insight into the Janus-faced role of ROS in the cardiovascular system.

Heart Regeneration

Heart Regeneration

Author:

Publisher:

Published:

Total Pages:

ISBN-13: 9814465259

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Book Synopsis Heart Regeneration by :

Download or read book Heart Regeneration written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Regenerating the Heart

Regenerating the Heart

Author: Ira S. Cohen

Publisher: Springer Science & Business Media

Published: 2011-03-23

Total Pages: 555

ISBN-13: 1617790214

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Medical research made huge strides in treating heart disease in the 20th century, from drug-eluding stents to automatic internal defibrillators. Public awareness of the dangers of heart disease has never been more pervasive. Now, though, ten years into a new millennium, scientists are gearing up for the next great challenges in tackling this pervasive condition. Cell therapy is going to be a key weapon in the fight against heart disease. It has the potential to address many cardiovascular conditions. From heart failure to atrioventricular nodal dysfunction, the young but promising field of cell therapy is set to play a significant role in developing the cures that the upcoming decades of hard work will yield. Regenerating the Heart: Stem Cells and the Cardiovascular System organizes the field into a digestible body of knowledge. Its four sections cover mechanical regeneration, electrical regeneration, cardiac tissues and in vivo stem cell therapies. An array of talented researchers share the fruits of their labors, with chapters covering such crucial issues as the cardiogenic potential of varying stem cell types, the ways in which they might be used to tackle arrhythmias, their possible application to biological replacements for cardiac tissues such as valves, and the varying approaches used in the in vivo evaluation of stem cell therapies, including methods of delivering stem cells to the myocardium. This comprehensive survey of an area of research with such exciting potential is an invaluable resource both for veteran stem cell researchers who need to monitor fresh developments, and for newly minted investigators seeking inspirational examples.


Book Synopsis Regenerating the Heart by : Ira S. Cohen

Download or read book Regenerating the Heart written by Ira S. Cohen and published by Springer Science & Business Media. This book was released on 2011-03-23 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical research made huge strides in treating heart disease in the 20th century, from drug-eluding stents to automatic internal defibrillators. Public awareness of the dangers of heart disease has never been more pervasive. Now, though, ten years into a new millennium, scientists are gearing up for the next great challenges in tackling this pervasive condition. Cell therapy is going to be a key weapon in the fight against heart disease. It has the potential to address many cardiovascular conditions. From heart failure to atrioventricular nodal dysfunction, the young but promising field of cell therapy is set to play a significant role in developing the cures that the upcoming decades of hard work will yield. Regenerating the Heart: Stem Cells and the Cardiovascular System organizes the field into a digestible body of knowledge. Its four sections cover mechanical regeneration, electrical regeneration, cardiac tissues and in vivo stem cell therapies. An array of talented researchers share the fruits of their labors, with chapters covering such crucial issues as the cardiogenic potential of varying stem cell types, the ways in which they might be used to tackle arrhythmias, their possible application to biological replacements for cardiac tissues such as valves, and the varying approaches used in the in vivo evaluation of stem cell therapies, including methods of delivering stem cells to the myocardium. This comprehensive survey of an area of research with such exciting potential is an invaluable resource both for veteran stem cell researchers who need to monitor fresh developments, and for newly minted investigators seeking inspirational examples.

Cardiovascular Regeneration and Stem Cell Therapy

Cardiovascular Regeneration and Stem Cell Therapy

Author: Annarosa Leri

Publisher: John Wiley & Sons

Published: 2008-04-15

Total Pages: 248

ISBN-13: 0470994304

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This book is the definitive reference on two of the most exciting areas of cardiovascular research – myocardial regeneration and stem cell therapy – for the treatment of disease. Edited by pioneers in the area, with contributions from every major investigator worldwide, it covers: The biology of stem cells The actions of stem cells from the bone marrow, the heart, and embryos on the normal restorative and repair functions of the heart and blood vessels How stem cells could contribute to myocardial recovery in the face of injury and aging How adjuvant therapy with growth factors might enhance stem cell activity in regeneration and repair Clinical applications and clinical experiences This fully referenced publication presents the current state of knowledge in both basic science and clinical practice, and is an essential reference for scientists, students, and clinicians.


Book Synopsis Cardiovascular Regeneration and Stem Cell Therapy by : Annarosa Leri

Download or read book Cardiovascular Regeneration and Stem Cell Therapy written by Annarosa Leri and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the definitive reference on two of the most exciting areas of cardiovascular research – myocardial regeneration and stem cell therapy – for the treatment of disease. Edited by pioneers in the area, with contributions from every major investigator worldwide, it covers: The biology of stem cells The actions of stem cells from the bone marrow, the heart, and embryos on the normal restorative and repair functions of the heart and blood vessels How stem cells could contribute to myocardial recovery in the face of injury and aging How adjuvant therapy with growth factors might enhance stem cell activity in regeneration and repair Clinical applications and clinical experiences This fully referenced publication presents the current state of knowledge in both basic science and clinical practice, and is an essential reference for scientists, students, and clinicians.

Oxidative Stress in Heart Diseases

Oxidative Stress in Heart Diseases

Author: Sajal Chakraborti

Publisher: Springer Nature

Published: 2019-11-06

Total Pages: 596

ISBN-13: 9811382735

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This book bridges the gap between fundamental and translational research in the area of heart disease. It describes a multidisciplinary approach, and demonstrates biochemical mechanisms associated with dysregulation of redox signaling, which leads heart disease. Presenting recent studies on improved forms of ROS scavenging enzymes; specific inhibitors for different ROS generating enzymes; and oxidant induced signaling pathways and their antagonists that allow subtle modulation of redox signaling, it also discusses the spatial and temporal aspects of oxidative stress in the cardiovascular system, which are of vital importance in developing better strategies for treating heart disease. Each chapter offers researchers valuable insights into identifying targets for drug development for different types of heart disease.


Book Synopsis Oxidative Stress in Heart Diseases by : Sajal Chakraborti

Download or read book Oxidative Stress in Heart Diseases written by Sajal Chakraborti and published by Springer Nature. This book was released on 2019-11-06 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book bridges the gap between fundamental and translational research in the area of heart disease. It describes a multidisciplinary approach, and demonstrates biochemical mechanisms associated with dysregulation of redox signaling, which leads heart disease. Presenting recent studies on improved forms of ROS scavenging enzymes; specific inhibitors for different ROS generating enzymes; and oxidant induced signaling pathways and their antagonists that allow subtle modulation of redox signaling, it also discusses the spatial and temporal aspects of oxidative stress in the cardiovascular system, which are of vital importance in developing better strategies for treating heart disease. Each chapter offers researchers valuable insights into identifying targets for drug development for different types of heart disease.

Handbook of Cardiac Stem Cell Therapy

Handbook of Cardiac Stem Cell Therapy

Author: Ioannis Dimarakis

Publisher: Imperial College Press

Published: 2009-01-01

Total Pages: 306

ISBN-13: 184816257X

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This book is an impressive compilation of contributions on the hot topic of cardiac stem cell therapy from leading groups all over the world. In the assembly of chapters, a structured approach is adopted; starting from the clinician's perspective, all developments in both the experimental and clinical research areas are covered. This journey will take the reader from the bench-top to the bedside, with all chapters written by leading authorities in their respective fields, including data still in press with medical journals.


Book Synopsis Handbook of Cardiac Stem Cell Therapy by : Ioannis Dimarakis

Download or read book Handbook of Cardiac Stem Cell Therapy written by Ioannis Dimarakis and published by Imperial College Press. This book was released on 2009-01-01 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an impressive compilation of contributions on the hot topic of cardiac stem cell therapy from leading groups all over the world. In the assembly of chapters, a structured approach is adopted; starting from the clinician's perspective, all developments in both the experimental and clinical research areas are covered. This journey will take the reader from the bench-top to the bedside, with all chapters written by leading authorities in their respective fields, including data still in press with medical journals.