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The presence of monotypism in thick atherosclerotic lesions of black females with G-6-PD mosaicism first reported by the Benditts (1973) has been confirmed in two other laboratories. However, we believe that it is premature to conclude that the finding of monotypism necessarily indicates monoclonal origin of athero sclerotic lesions. We have suggested two alternative explanations for the obser vation of monotypism which we believe must be shown to be invalid before accept ing monoclonal origin as the only plausible way to account for the observed G-6-PD monotypism. One of these two alternatives relates to clonal heterogeneity of cell growth potential, i. e. , during the course of progressive growth of a le sion, progeny of one cell may overgrow all others in a portion of the lesion. The other alternative is that one of the G-6-PD alleles may be linked to genes that afford a preferential survival characteristic in the abnormal environment present in atheroscerotic lesions. Thus, cells with one allele may be able to grow better than cells with the other allele, and this characteristic may be unrelated to "A-ness" or "B-ness". We have studied initiation of lesions in He diet-fed swine and demonstrated that all active lesions that were studied were of multiple cell origin (not monoclo nal). We have studied cell growth patterns in developing atherosclerotic lesions in He diet-fed swine and found evidence consistent with clonal heterogeneity in growth potential of lesion cells.
Book Synopsis Atherosclerosis IV by : G. Schettler
Download or read book Atherosclerosis IV written by G. Schettler and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 835 pages. Available in PDF, EPUB and Kindle. Book excerpt: The presence of monotypism in thick atherosclerotic lesions of black females with G-6-PD mosaicism first reported by the Benditts (1973) has been confirmed in two other laboratories. However, we believe that it is premature to conclude that the finding of monotypism necessarily indicates monoclonal origin of athero sclerotic lesions. We have suggested two alternative explanations for the obser vation of monotypism which we believe must be shown to be invalid before accept ing monoclonal origin as the only plausible way to account for the observed G-6-PD monotypism. One of these two alternatives relates to clonal heterogeneity of cell growth potential, i. e. , during the course of progressive growth of a le sion, progeny of one cell may overgrow all others in a portion of the lesion. The other alternative is that one of the G-6-PD alleles may be linked to genes that afford a preferential survival characteristic in the abnormal environment present in atheroscerotic lesions. Thus, cells with one allele may be able to grow better than cells with the other allele, and this characteristic may be unrelated to "A-ness" or "B-ness". We have studied initiation of lesions in He diet-fed swine and demonstrated that all active lesions that were studied were of multiple cell origin (not monoclo nal). We have studied cell growth patterns in developing atherosclerotic lesions in He diet-fed swine and found evidence consistent with clonal heterogeneity in growth potential of lesion cells.
The Social Security Administration (SSA) uses a screening tool called the Listing of Impairments to identify claimants who are so severely impaired that they cannot work at all and thus immediately qualify for benefits. In this report, the IOM makes several recommendations for improving SSA's capacity to determine disability benefits more quickly and efficiently using the Listings.
Book Synopsis Cardiovascular Disability by : Institute of Medicine
Download or read book Cardiovascular Disability written by Institute of Medicine and published by National Academies Press. This book was released on 2010-12-04 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Social Security Administration (SSA) uses a screening tool called the Listing of Impairments to identify claimants who are so severely impaired that they cannot work at all and thus immediately qualify for benefits. In this report, the IOM makes several recommendations for improving SSA's capacity to determine disability benefits more quickly and efficiently using the Listings.
Download or read book Atherosclerosis written by Fujio Numano and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
Book Synopsis Mechanisms of Vascular Disease by : Robert Fitridge
Download or read book Mechanisms of Vascular Disease written by Robert Fitridge and published by University of Adelaide Press. This book was released on 2011 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
The latest basic research on lipid metabolism, vascular biology, cytokines, fibrinolysis, and atherosclerosis is collected in this volume. The most recent treatments for this disorder, including treatment of restenosis by gene therapy, are discussed.
Book Synopsis Atherosclerosis IV by : Fujio Numano
Download or read book Atherosclerosis IV written by Fujio Numano and published by . This book was released on 1997 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: The latest basic research on lipid metabolism, vascular biology, cytokines, fibrinolysis, and atherosclerosis is collected in this volume. The most recent treatments for this disorder, including treatment of restenosis by gene therapy, are discussed.
Download or read book Atherosclerosis 4 written by Fujio Numano and published by . This book was released on 1997 with total page 551 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Atherosclerosis IV by : Fujio Numano
Download or read book Atherosclerosis IV written by Fujio Numano and published by . This book was released on 1997 with total page 551 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Inflammatory Atherosclerosis by : Richard James Frink
Download or read book Inflammatory Atherosclerosis written by Richard James Frink and published by Heart Research Foundation Sacrament. This book was released on 2002 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Atherosclerosis and Its Origin by : Maurice Sandler
Download or read book Atherosclerosis and Its Origin written by Maurice Sandler and published by . This book was released on 1963 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Proceeding of the 6th International Meeting, Bologna, Italy.
Book Synopsis Atherosclerosis and Cardiovascular Diseases by : S. Lenzi
Download or read book Atherosclerosis and Cardiovascular Diseases written by S. Lenzi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceeding of the 6th International Meeting, Bologna, Italy.