Biosensing with Silicon

Biosensing with Silicon

Author: Enakshi Bhattacharya

Publisher: Springer Nature

Published: 2022-01-01

Total Pages: 115

ISBN-13: 3030927148

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This book discusses two silicon biosensors: an electrochemical sensor – the Electrolyte Insulator Silicon Capacitor (EISCAP), and a mechanical resonant cantilever sensor. The author presents the principle and the technology behind the device fabrication and miniaturization, stable and reproducible functionalization protocols for bioreceptor immobilization, and the measurement and the data analysis for extracting the best performance from these sensors. EISCAP sensors, used for the estimation of triglycerides and urea, have been improved through the use of micromachining processes. The miniaturization brought out advantages as well as challenges which are discussed in this book, resulting in a prototype mini-EISCAP with a readout circuit for fast and accurate estimation of triglycerides. The author also reports on the sensitivity improvements in the estimation of triglycerides and urea obtained with the polycrystalline silicon cantilever and its measurements in liquid media. The book is ideal for materials scientists and engineers working in the field of biosensors and MicroElectroMechanical systems (MEMS) and their optimizations, as well as researchers with biochemical or biomedical expertise, in order to have a fresh and updated review on the last progresses reached with EISCAPs and cantilever sensors.


Book Synopsis Biosensing with Silicon by : Enakshi Bhattacharya

Download or read book Biosensing with Silicon written by Enakshi Bhattacharya and published by Springer Nature. This book was released on 2022-01-01 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses two silicon biosensors: an electrochemical sensor – the Electrolyte Insulator Silicon Capacitor (EISCAP), and a mechanical resonant cantilever sensor. The author presents the principle and the technology behind the device fabrication and miniaturization, stable and reproducible functionalization protocols for bioreceptor immobilization, and the measurement and the data analysis for extracting the best performance from these sensors. EISCAP sensors, used for the estimation of triglycerides and urea, have been improved through the use of micromachining processes. The miniaturization brought out advantages as well as challenges which are discussed in this book, resulting in a prototype mini-EISCAP with a readout circuit for fast and accurate estimation of triglycerides. The author also reports on the sensitivity improvements in the estimation of triglycerides and urea obtained with the polycrystalline silicon cantilever and its measurements in liquid media. The book is ideal for materials scientists and engineers working in the field of biosensors and MicroElectroMechanical systems (MEMS) and their optimizations, as well as researchers with biochemical or biomedical expertise, in order to have a fresh and updated review on the last progresses reached with EISCAPs and cantilever sensors.

Biosensing with Silicon

Biosensing with Silicon

Author: Enakshi Bhattacharya

Publisher:

Published: 2021

Total Pages: 0

ISBN-13: 9783030927158

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This book discusses two silicon biosensors: an electrochemical sensor - the Electrolyte Insulator Silicon Capacitor (EISCAP), and a mechanical resonant cantilever sensor. The author presents the principle and the technology behind the device fabrication and miniaturization, stable and reproducible functionalization protocols for bioreceptor immobilization, and the measurement and the data analysis for extracting the best performance from these sensors. EISCAP sensors, used for the estimation of triglycerides and urea, have been improved through the use of micromachining processes. The miniaturization brought out advantages as well as challenges which are discussed in this book, resulting in a prototype mini-EISCAP with a readout circuit for fast and accurate estimation of triglycerides. The author also reports on the sensitivity improvements in the estimation of triglycerides and urea obtained with the polycrystalline silicon cantilever and its measurements in liquid media. The book is ideal for materials scientists and engineers working in the field of biosensors and MicroElectroMechanical systems (MEMS) and their optimizations, as well as researchers with biochemical or biomedical expertise, in order to have a fresh and updated review on the last progresses reached with EISCAPs and cantilever sensors.


Book Synopsis Biosensing with Silicon by : Enakshi Bhattacharya

Download or read book Biosensing with Silicon written by Enakshi Bhattacharya and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses two silicon biosensors: an electrochemical sensor - the Electrolyte Insulator Silicon Capacitor (EISCAP), and a mechanical resonant cantilever sensor. The author presents the principle and the technology behind the device fabrication and miniaturization, stable and reproducible functionalization protocols for bioreceptor immobilization, and the measurement and the data analysis for extracting the best performance from these sensors. EISCAP sensors, used for the estimation of triglycerides and urea, have been improved through the use of micromachining processes. The miniaturization brought out advantages as well as challenges which are discussed in this book, resulting in a prototype mini-EISCAP with a readout circuit for fast and accurate estimation of triglycerides. The author also reports on the sensitivity improvements in the estimation of triglycerides and urea obtained with the polycrystalline silicon cantilever and its measurements in liquid media. The book is ideal for materials scientists and engineers working in the field of biosensors and MicroElectroMechanical systems (MEMS) and their optimizations, as well as researchers with biochemical or biomedical expertise, in order to have a fresh and updated review on the last progresses reached with EISCAPs and cantilever sensors.

Semiconducting Silicon Nanowires for Biomedical Applications

Semiconducting Silicon Nanowires for Biomedical Applications

Author: Jeffery L. Coffer

Publisher: Woodhead Publishing

Published: 2021-09-14

Total Pages: 442

ISBN-13: 0323851312

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In its second, extensively revised second edition, Semiconducting Silicon Nanowires for Biomedical Applications reviews the fabrication, properties, and biomedical applications of this key material. The book begins by reviewing the basics of growth, characterization, biocompatibility, and surface modification of semiconducting silicon nanowires. Attention then turns to use of these structures for tissue engineering and delivery applications, followed by detection and sensing. Reflecting the evolution of this multidisciplinary subject, several new key topics are highlighted, including our understanding of the cell-nanowire interface, latest advances in associated morphologies (including silicon nanoneedles and nanotubes for therapeutic delivery), and significantly, the status of silicon nanowire commercialization in biotechnology. Semiconducting Silicon Nanowires for Biomedical Applications is a comprehensive resource for biomaterials scientists who are focused on biosensors, drug delivery, and the next generation of nano-biotech platforms that require a detailed understanding of the cell-nanowire interface, along with researchers and developers in industry and academia who are concerned with nanoscale biomaterials, in particular electronically-responsive structures. Reviews the growth, characterization, biocompatibility, and surface modification of semiconducting silicon nanowires Describes silicon nanowires for tissue engineering and delivery applications, including cellular binding & internalization, tissue engineering scaffolds, mediated differentiation of stem cells, and silicon nanoneedles & nanotubes for delivery of small molecule / biologic-based therapeutics Highlights the use of silicon nanowires for detection and sensing Presents a detailed description of our current understanding of the cell-nanowire interface Covers the current status of commercial development of silicon nanowire-based platforms


Book Synopsis Semiconducting Silicon Nanowires for Biomedical Applications by : Jeffery L. Coffer

Download or read book Semiconducting Silicon Nanowires for Biomedical Applications written by Jeffery L. Coffer and published by Woodhead Publishing. This book was released on 2021-09-14 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: In its second, extensively revised second edition, Semiconducting Silicon Nanowires for Biomedical Applications reviews the fabrication, properties, and biomedical applications of this key material. The book begins by reviewing the basics of growth, characterization, biocompatibility, and surface modification of semiconducting silicon nanowires. Attention then turns to use of these structures for tissue engineering and delivery applications, followed by detection and sensing. Reflecting the evolution of this multidisciplinary subject, several new key topics are highlighted, including our understanding of the cell-nanowire interface, latest advances in associated morphologies (including silicon nanoneedles and nanotubes for therapeutic delivery), and significantly, the status of silicon nanowire commercialization in biotechnology. Semiconducting Silicon Nanowires for Biomedical Applications is a comprehensive resource for biomaterials scientists who are focused on biosensors, drug delivery, and the next generation of nano-biotech platforms that require a detailed understanding of the cell-nanowire interface, along with researchers and developers in industry and academia who are concerned with nanoscale biomaterials, in particular electronically-responsive structures. Reviews the growth, characterization, biocompatibility, and surface modification of semiconducting silicon nanowires Describes silicon nanowires for tissue engineering and delivery applications, including cellular binding & internalization, tissue engineering scaffolds, mediated differentiation of stem cells, and silicon nanoneedles & nanotubes for delivery of small molecule / biologic-based therapeutics Highlights the use of silicon nanowires for detection and sensing Presents a detailed description of our current understanding of the cell-nanowire interface Covers the current status of commercial development of silicon nanowire-based platforms

Silicon-Based Hybrid Nanoparticles

Silicon-Based Hybrid Nanoparticles

Author: Sabu Thomas

Publisher: Elsevier

Published: 2021-09-24

Total Pages: 391

ISBN-13: 012824254X

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Silicon-Based Hybrid Nanoparticles: Fundamentals, Properties, and Applications focuses on the fundamental principles and promising applications of silicon-based hybrid nanoparticles in nanoelectronics, energy storage/conversion, catalysis, sensors, biomedicine, environment and imaging. This book is an important reference source for materials scientists and engineers who are seeking to understand more about the major properties and applications of silicon-based hybrid nanoparticles. As the hybridization of silicon nanoparticles with other semiconductors or metal oxides nanoparticles may exhibit superior features, when compared to lone, individual nanoparticles, this book provides the latest insights. In addition, the silicon/iron oxide hybrid nanoparticles also possess excellent fluorescence, super-paramagnetism, and biocompatibility that can be effectively used for the diagnostic imaging system in vivo. Similarly, gold-silicon nanohybrids could be used as highly efficient near-infrared hyperthermia agents for cancer cell destruction. Outlines the major thermal, electrical, optical, magnetic and toxic properties of silicon-based hybrid nanoparticles Describes major applications in energy, environmental science and catalysis Assesses the major challenges to manufacturing silicon-based nanostructured materials on an industrial scale


Book Synopsis Silicon-Based Hybrid Nanoparticles by : Sabu Thomas

Download or read book Silicon-Based Hybrid Nanoparticles written by Sabu Thomas and published by Elsevier. This book was released on 2021-09-24 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: Silicon-Based Hybrid Nanoparticles: Fundamentals, Properties, and Applications focuses on the fundamental principles and promising applications of silicon-based hybrid nanoparticles in nanoelectronics, energy storage/conversion, catalysis, sensors, biomedicine, environment and imaging. This book is an important reference source for materials scientists and engineers who are seeking to understand more about the major properties and applications of silicon-based hybrid nanoparticles. As the hybridization of silicon nanoparticles with other semiconductors or metal oxides nanoparticles may exhibit superior features, when compared to lone, individual nanoparticles, this book provides the latest insights. In addition, the silicon/iron oxide hybrid nanoparticles also possess excellent fluorescence, super-paramagnetism, and biocompatibility that can be effectively used for the diagnostic imaging system in vivo. Similarly, gold-silicon nanohybrids could be used as highly efficient near-infrared hyperthermia agents for cancer cell destruction. Outlines the major thermal, electrical, optical, magnetic and toxic properties of silicon-based hybrid nanoparticles Describes major applications in energy, environmental science and catalysis Assesses the major challenges to manufacturing silicon-based nanostructured materials on an industrial scale

Dual-Mode Electro-photonic Silicon Biosensors

Dual-Mode Electro-photonic Silicon Biosensors

Author: José Juan Colás

Publisher: Springer

Published: 2017-07-18

Total Pages: 159

ISBN-13: 3319605011

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This highly interdisciplinary thesis reports on two innovative photonic biosensors that combine multiple simultaneous measurements to provide unique insights into the activity and structure of surface immobilized biological molecules. In addition, it presents a new silicon photonic biosensor that exploits two cascaded resonant sensors to provide two independent measurements of a biological layer immobilized on the surface. By combining these two measurements, it is possible to unambiguously quantify the density and thickness of the molecular layer; here, the approach’s ability to study molecular conformation and conformational changes in real time is demonstrated. The electrophotonic biosensor integrates silicon photonics with electrochemistry into a single technology. This multi-modal biosensor provides a number of unique capabilities that extend the functionality of conventional silicon photonics. For example, by combining the complementary information revealed by simultaneous electrochemical and photonic measurements, it is possible to provide unique insights into on-surface electrochemical processes. Furthermore, the ability to create electrochemical reactions directly on the silicon surface provides a novel approach for engineering the chemical functionality of the photonic sensors. The electrophotonic biosensor thus represents a critical advance towards the development of very high-density photonic sensor arrays for multiplexed diagnostics.


Book Synopsis Dual-Mode Electro-photonic Silicon Biosensors by : José Juan Colás

Download or read book Dual-Mode Electro-photonic Silicon Biosensors written by José Juan Colás and published by Springer. This book was released on 2017-07-18 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: This highly interdisciplinary thesis reports on two innovative photonic biosensors that combine multiple simultaneous measurements to provide unique insights into the activity and structure of surface immobilized biological molecules. In addition, it presents a new silicon photonic biosensor that exploits two cascaded resonant sensors to provide two independent measurements of a biological layer immobilized on the surface. By combining these two measurements, it is possible to unambiguously quantify the density and thickness of the molecular layer; here, the approach’s ability to study molecular conformation and conformational changes in real time is demonstrated. The electrophotonic biosensor integrates silicon photonics with electrochemistry into a single technology. This multi-modal biosensor provides a number of unique capabilities that extend the functionality of conventional silicon photonics. For example, by combining the complementary information revealed by simultaneous electrochemical and photonic measurements, it is possible to provide unique insights into on-surface electrochemical processes. Furthermore, the ability to create electrochemical reactions directly on the silicon surface provides a novel approach for engineering the chemical functionality of the photonic sensors. The electrophotonic biosensor thus represents a critical advance towards the development of very high-density photonic sensor arrays for multiplexed diagnostics.

Sensing and Biosensing with Optically Active Nanomaterials

Sensing and Biosensing with Optically Active Nanomaterials

Author: Suban K. Sahoo

Publisher: Elsevier

Published: 2021-10-21

Total Pages: 596

ISBN-13: 0323902456

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Sensing and Biosensing with Optically Active Nanomaterials summarizes the potential sensing applications of optically (chromogenic and fluorogenic) active, nano-sized, organic, and inorganic materials for the selective detection of ionic analytes (such as metal ions and anions) in various environmental and biological samples. Sections cover design, synthesis, sensing mechanisms and applications for detecting ionic analytes. Each chapter deals with the sensing applications of one kind of nanomaterial. This book is an important reference source for materials scientists and engineers seeking to increase their understanding on how nanomaterials are being used for sensing applications. Provides information on the various types of optically active inorganic and organic nanomaterials, including quantum dots, SPR active noble metal nanoparticles, metal nanoclusters, organic nanoparticles and carbon dots Summarizes the synthesis, design and development of sensors, along with their mechanisms Explains major sensing applications and manufacturing challenges


Book Synopsis Sensing and Biosensing with Optically Active Nanomaterials by : Suban K. Sahoo

Download or read book Sensing and Biosensing with Optically Active Nanomaterials written by Suban K. Sahoo and published by Elsevier. This book was released on 2021-10-21 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sensing and Biosensing with Optically Active Nanomaterials summarizes the potential sensing applications of optically (chromogenic and fluorogenic) active, nano-sized, organic, and inorganic materials for the selective detection of ionic analytes (such as metal ions and anions) in various environmental and biological samples. Sections cover design, synthesis, sensing mechanisms and applications for detecting ionic analytes. Each chapter deals with the sensing applications of one kind of nanomaterial. This book is an important reference source for materials scientists and engineers seeking to increase their understanding on how nanomaterials are being used for sensing applications. Provides information on the various types of optically active inorganic and organic nanomaterials, including quantum dots, SPR active noble metal nanoparticles, metal nanoclusters, organic nanoparticles and carbon dots Summarizes the synthesis, design and development of sensors, along with their mechanisms Explains major sensing applications and manufacturing challenges

Silicon Nano-biotechnology

Silicon Nano-biotechnology

Author: Yao He

Publisher: Springer Science & Business Media

Published: 2014-04-02

Total Pages: 113

ISBN-13: 3642546684

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This book reviews the latest advances in the development of silicon nano-biotechnology for biological and biomedical applications, which include biosensing, bioimaging, and cancer therapy. In this book, newly developed silicon nano-biotechnology and its biomedical applications are systematically introduced. For instance, fluorescent silicon nanoparticles, serving as novel high-performance biological nanoprobes, are superbly suited to real-time and long-term bioimaging. Silicon nanowire-based sensing platform is especially capable of sensitive, specific, and multiplexed detection of various biological species. Silicon-based nanocarriers with ultra-high drug-loading capacity are highly efficacious for in vitro and in vivo cancer therapies. This book is intended for readers who are interested in the design of functional silicon nanostructures and their biological and biomedical applications. It uses silicon nanoparticles and silicon nanowires as models and discusses topics ranging from their synthesis to their biological applications, the goal being to highlight these exciting achievements as starting points in the field of silicon nano-biotechnology. Yao He is a Professor at Institute of Functional Nano&Soft Materials (FUNSOM), Soochow University, China. Yuanyuan Su is an Associate Professor at Institute of Functional Nano&Soft Materials (FUNSOM), Soochow University, China.


Book Synopsis Silicon Nano-biotechnology by : Yao He

Download or read book Silicon Nano-biotechnology written by Yao He and published by Springer Science & Business Media. This book was released on 2014-04-02 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the latest advances in the development of silicon nano-biotechnology for biological and biomedical applications, which include biosensing, bioimaging, and cancer therapy. In this book, newly developed silicon nano-biotechnology and its biomedical applications are systematically introduced. For instance, fluorescent silicon nanoparticles, serving as novel high-performance biological nanoprobes, are superbly suited to real-time and long-term bioimaging. Silicon nanowire-based sensing platform is especially capable of sensitive, specific, and multiplexed detection of various biological species. Silicon-based nanocarriers with ultra-high drug-loading capacity are highly efficacious for in vitro and in vivo cancer therapies. This book is intended for readers who are interested in the design of functional silicon nanostructures and their biological and biomedical applications. It uses silicon nanoparticles and silicon nanowires as models and discusses topics ranging from their synthesis to their biological applications, the goal being to highlight these exciting achievements as starting points in the field of silicon nano-biotechnology. Yao He is a Professor at Institute of Functional Nano&Soft Materials (FUNSOM), Soochow University, China. Yuanyuan Su is an Associate Professor at Institute of Functional Nano&Soft Materials (FUNSOM), Soochow University, China.

ICOL-2019

ICOL-2019

Author: Kehar Singh

Publisher: Springer Nature

Published: 2021-03-01

Total Pages: 908

ISBN-13: 9811592594

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This book presents peer-reviewed articles from the International Conference on Optics and Electro-optics, ICOL-2019, held at Dehradun in India. It brings together leading researchers and professionals in the field of optics/optical engineering/optical materials and provides a platform to present and establish collaborations in this important area, with the theme “Trends in Electro-optics Instrumentation for Strategic Applications”. Topics covered but not limited to are Optical Engineering, Optical Thin Films, Optical Materials, IR Sensors, Image Processing & Systems, Photonic Band Gap Materials, Adaptive Optics, Optical Image Processing & Holography, Lasers, Fiber Lasers & its Applications, Diffractive Optics, Innovative packaging of Optical Systems, Nanophotonics Devices and Applications, Optical Interferometry & Metrology, Terahertz, Millimeter Wave & Microwave Photonics, Fiber, Integrated & Nonlinear Optics and Optics and Electro-optics for Strategic Applications.


Book Synopsis ICOL-2019 by : Kehar Singh

Download or read book ICOL-2019 written by Kehar Singh and published by Springer Nature. This book was released on 2021-03-01 with total page 908 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents peer-reviewed articles from the International Conference on Optics and Electro-optics, ICOL-2019, held at Dehradun in India. It brings together leading researchers and professionals in the field of optics/optical engineering/optical materials and provides a platform to present and establish collaborations in this important area, with the theme “Trends in Electro-optics Instrumentation for Strategic Applications”. Topics covered but not limited to are Optical Engineering, Optical Thin Films, Optical Materials, IR Sensors, Image Processing & Systems, Photonic Band Gap Materials, Adaptive Optics, Optical Image Processing & Holography, Lasers, Fiber Lasers & its Applications, Diffractive Optics, Innovative packaging of Optical Systems, Nanophotonics Devices and Applications, Optical Interferometry & Metrology, Terahertz, Millimeter Wave & Microwave Photonics, Fiber, Integrated & Nonlinear Optics and Optics and Electro-optics for Strategic Applications.

Label-Free Biosensing

Label-Free Biosensing

Author: Michael J. Schöning

Publisher: Springer

Published: 2018-07-20

Total Pages: 480

ISBN-13: 3319752200

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This volume summarizes the state-of-the-art technologies, key advances and future trends in the field of label-free biosensing. It provides detailed insights into the different types of solid-state, label-free biosensors, their underlying transducer principles, advanced materials utilized, device-fabrication techniques and various applications. The book offers graduate students, academic researchers, and industry professionals a comprehensive source of information on all facets of label-free biosensing and the future trends in this flourishing field. Highlights of the subjects covered include label-free biosensing with: · semiconductor field-effect devices such as nanomaterial-modified capacitive electrolyte-insulator-semiconductor structures, silicon nanowire transistors, III-nitride semiconductor devices and light-addressable potentiometric sensors · impedimetric biosensors using planar and 3D electrodes · nanocavity and solid-state nanopore devices · carbon nanotube and graphene/graphene oxide biosensors · electrochemical biosensors using molecularly imprinted polymers · biomimetic sensors based on acoustic signal transduction · enzyme logic systems and digital biosensors based on the biocomputing concept · heat-transfer as a novel transducer principle · ultrasensitive surface plasmon resonance biosensors · magnetic biosensors and magnetic imaging devices


Book Synopsis Label-Free Biosensing by : Michael J. Schöning

Download or read book Label-Free Biosensing written by Michael J. Schöning and published by Springer. This book was released on 2018-07-20 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume summarizes the state-of-the-art technologies, key advances and future trends in the field of label-free biosensing. It provides detailed insights into the different types of solid-state, label-free biosensors, their underlying transducer principles, advanced materials utilized, device-fabrication techniques and various applications. The book offers graduate students, academic researchers, and industry professionals a comprehensive source of information on all facets of label-free biosensing and the future trends in this flourishing field. Highlights of the subjects covered include label-free biosensing with: · semiconductor field-effect devices such as nanomaterial-modified capacitive electrolyte-insulator-semiconductor structures, silicon nanowire transistors, III-nitride semiconductor devices and light-addressable potentiometric sensors · impedimetric biosensors using planar and 3D electrodes · nanocavity and solid-state nanopore devices · carbon nanotube and graphene/graphene oxide biosensors · electrochemical biosensors using molecularly imprinted polymers · biomimetic sensors based on acoustic signal transduction · enzyme logic systems and digital biosensors based on the biocomputing concept · heat-transfer as a novel transducer principle · ultrasensitive surface plasmon resonance biosensors · magnetic biosensors and magnetic imaging devices

Silicon Photonics Design

Silicon Photonics Design

Author: Lukas Chrostowski

Publisher: Cambridge University Press

Published: 2015-03-12

Total Pages: 439

ISBN-13: 1107085454

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This hands-on introduction to silicon photonics engineering equips students with everything they need to begin creating foundry-ready designs.


Book Synopsis Silicon Photonics Design by : Lukas Chrostowski

Download or read book Silicon Photonics Design written by Lukas Chrostowski and published by Cambridge University Press. This book was released on 2015-03-12 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: This hands-on introduction to silicon photonics engineering equips students with everything they need to begin creating foundry-ready designs.