Biotransformations in Organic Chemistry

Biotransformations in Organic Chemistry

Author: Kurt Faber

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 329

ISBN-13: 3642974236

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The use of natural catalysts - enzymes - for the transformation of non-natural is not at all new: they have been used for more man-made organic compounds than one hundred years, employed either as whole cells, cell organelles or isolated enzymes [1]. Certainly, the object of most of the early research was totally different from that of the present day. Thus the elucidation of biochemical pathways and enzyme mechanisms was in the foreground of the reasearch some decades ago. It was mainly during the 1980s that the enormous potential of applying natural catalysts to transform non-natural organic compounds was recognized. What started as a trend in the late 1970s could almost be called a fashion in synthetic organic chemistry in the 1990s. Although the early euphoria during the 'gold rush' in this field seems to have eased somewhat, there is still no limit to be seen for the future development of such methods. As a result of this extensive, recent research, there have been an estimated 5000 papers published on the subject [2]. To collate these data as a kind of 'super-review' would clearly be an impossible task and, furthermore, such a hypothetical book would be unpalatable for the non-expert.


Book Synopsis Biotransformations in Organic Chemistry by : Kurt Faber

Download or read book Biotransformations in Organic Chemistry written by Kurt Faber and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of natural catalysts - enzymes - for the transformation of non-natural is not at all new: they have been used for more man-made organic compounds than one hundred years, employed either as whole cells, cell organelles or isolated enzymes [1]. Certainly, the object of most of the early research was totally different from that of the present day. Thus the elucidation of biochemical pathways and enzyme mechanisms was in the foreground of the reasearch some decades ago. It was mainly during the 1980s that the enormous potential of applying natural catalysts to transform non-natural organic compounds was recognized. What started as a trend in the late 1970s could almost be called a fashion in synthetic organic chemistry in the 1990s. Although the early euphoria during the 'gold rush' in this field seems to have eased somewhat, there is still no limit to be seen for the future development of such methods. As a result of this extensive, recent research, there have been an estimated 5000 papers published on the subject [2]. To collate these data as a kind of 'super-review' would clearly be an impossible task and, furthermore, such a hypothetical book would be unpalatable for the non-expert.

Industrial Biotransformations

Industrial Biotransformations

Author: Andreas Liese

Publisher: John Wiley & Sons

Published: 2008-07-11

Total Pages: 428

ISBN-13: 3527614176

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Industrial Biotransformations - a user-friendly and application-oriented up-to-date overview of one-step biotransformations of industrial importance. The data conferring each process is arranged in a convenient format to survey so that the processes can easily be compared. Each set of data is accompanied by key literature citations. As far as flow sheets of the processes are available, these are given reduced to their significant elements. An extensive index classified by substrates, products, enzymes, and companies provides direct access to each process organized in the order of enzyme classes. The reader will find all significant parameters characterizing the biotransformation itself and the process.


Book Synopsis Industrial Biotransformations by : Andreas Liese

Download or read book Industrial Biotransformations written by Andreas Liese and published by John Wiley & Sons. This book was released on 2008-07-11 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Industrial Biotransformations - a user-friendly and application-oriented up-to-date overview of one-step biotransformations of industrial importance. The data conferring each process is arranged in a convenient format to survey so that the processes can easily be compared. Each set of data is accompanied by key literature citations. As far as flow sheets of the processes are available, these are given reduced to their significant elements. An extensive index classified by substrates, products, enzymes, and companies provides direct access to each process organized in the order of enzyme classes. The reader will find all significant parameters characterizing the biotransformation itself and the process.

Biotransformations

Biotransformations

Author: K. Faber

Publisher: Springer Science & Business Media

Published: 2000-02-14

Total Pages: 238

ISBN-13: 9783540669494

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Whereas the hydrolases such as proteases, esterases and lipases are sufficiently well researched to be applied in every standard laboratory, other types of enzymes are still waiting to be discovered with respect to their applicability in organic-chemistry transformations on a preparative scale. This latter point is stressed here, with the focus on the newcomer-enzymes'which show great synthetic potential.


Book Synopsis Biotransformations by : K. Faber

Download or read book Biotransformations written by K. Faber and published by Springer Science & Business Media. This book was released on 2000-02-14 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Whereas the hydrolases such as proteases, esterases and lipases are sufficiently well researched to be applied in every standard laboratory, other types of enzymes are still waiting to be discovered with respect to their applicability in organic-chemistry transformations on a preparative scale. This latter point is stressed here, with the focus on the newcomer-enzymes'which show great synthetic potential.

Biotransformations and Bioprocesses

Biotransformations and Bioprocesses

Author: Mukesh Doble

Publisher: CRC Press

Published: 2004-03-24

Total Pages: 394

ISBN-13: 9780203026373

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From the laboratory to full-scale commercial production, this reference provides a clear and in-depth analysis of bioreactor design and operation and encompasses critical aspects of the biocatalytic manufacturing process. It clarifies principles in reaction and biochemical engineering, synthetic and biotransformation chemistry, and biocell and enzy


Book Synopsis Biotransformations and Bioprocesses by : Mukesh Doble

Download or read book Biotransformations and Bioprocesses written by Mukesh Doble and published by CRC Press. This book was released on 2004-03-24 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the laboratory to full-scale commercial production, this reference provides a clear and in-depth analysis of bioreactor design and operation and encompasses critical aspects of the biocatalytic manufacturing process. It clarifies principles in reaction and biochemical engineering, synthetic and biotransformation chemistry, and biocell and enzy

Biotransformations: A Survey of the Biotransformations of Drugs and Chemicals in Animals

Biotransformations: A Survey of the Biotransformations of Drugs and Chemicals in Animals

Author: D.R. Hawkins

Publisher: Royal Society of Chemistry

Published: 1996-12-31

Total Pages: 528

ISBN-13: 9780854044030

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Now in its seventh outstanding volume, Biotransformations has become established as a unique and important source for those involved in the discovery and development of new compounds. It broadly covers the scientific literature for the period 1987 to 1994. The series provides a complete survey of the biotransformations, in vertebrates, of the following: Pharmaceuticals; agrochemicals; food additives; environmental chemicals; industrial chemicals. Biotransformations provides a ready way of accessing information on the known pathways for the biotransformation of structurally-related compounds. Key functional groups provide an index-related procedure for retrieving information on compounds of interest. A further index allows the retrieval of examples of specific biochemical reactions which may have wider application. Each volume corresponds roughly with the scientific literature published during a calendar year. Each volume contains a review chapter which discusses examples of novel biotransformations, species differences, stereochemical aspects and mechanisms of toxicity associated with specific biotransformations.


Book Synopsis Biotransformations: A Survey of the Biotransformations of Drugs and Chemicals in Animals by : D.R. Hawkins

Download or read book Biotransformations: A Survey of the Biotransformations of Drugs and Chemicals in Animals written by D.R. Hawkins and published by Royal Society of Chemistry. This book was released on 1996-12-31 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its seventh outstanding volume, Biotransformations has become established as a unique and important source for those involved in the discovery and development of new compounds. It broadly covers the scientific literature for the period 1987 to 1994. The series provides a complete survey of the biotransformations, in vertebrates, of the following: Pharmaceuticals; agrochemicals; food additives; environmental chemicals; industrial chemicals. Biotransformations provides a ready way of accessing information on the known pathways for the biotransformation of structurally-related compounds. Key functional groups provide an index-related procedure for retrieving information on compounds of interest. A further index allows the retrieval of examples of specific biochemical reactions which may have wider application. Each volume corresponds roughly with the scientific literature published during a calendar year. Each volume contains a review chapter which discusses examples of novel biotransformations, species differences, stereochemical aspects and mechanisms of toxicity associated with specific biotransformations.

Practical Methods for Biocatalysis and Biotransformations 2

Practical Methods for Biocatalysis and Biotransformations 2

Author: John Whittall

Publisher: John Wiley & Sons

Published: 2012-04-25

Total Pages: 397

ISBN-13: 1118307860

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Biocatalysts are increasingly used by chemists engaged in fine chemical synthesis within both industry and academia. Today, there exists a huge choice of high-tech enzymes and whole cell biocatalysts, which add enormously to the repertoire of synthetic possibilities. Practical Methods for Biocatalysis and Biotransformations 2 is a "how-to" guide that focuses on the practical applications of enzymes and strains of microorganisms that are readily obtained or derived from culture collections. The sources of starting materials and reagents, hints, tips and safety advice (where appropriate) are given to ensure, as far as possible, that the procedures are reproducible. Comparisons to alternative methodology are given and relevant references to the primary literature are cited. This second volume – which can be used on its own or in combination with the first volume - concentrates on new applications and new enzyme families reported since the first volume. Contents include: introduction to recent developments and future needs in biocatalysts and synthetic biology in industry reductive amination enoate reductases for reduction of electron deficient alkenes industrial carbonyl reduction regio- and stereo- selective hydroxylation oxidation of alcohols selective oxidation industrial hydrolases and related enzymes transferases for alkylation, glycosylation and phosphorylation C-C bond formation and decarboxylation halogenation/dehalogenation/heteroatom oxidation tandem and sequential multi-enzymatic syntheses Practical Methods for Biocatalysis and Biotransformations 2 is an essential collection of biocatalytic methods for chemical synthesis which will find a place on the bookshelves of synthetic organic chemists, pharmaceutical chemists, and process R&D chemists in industry and academia.


Book Synopsis Practical Methods for Biocatalysis and Biotransformations 2 by : John Whittall

Download or read book Practical Methods for Biocatalysis and Biotransformations 2 written by John Whittall and published by John Wiley & Sons. This book was released on 2012-04-25 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biocatalysts are increasingly used by chemists engaged in fine chemical synthesis within both industry and academia. Today, there exists a huge choice of high-tech enzymes and whole cell biocatalysts, which add enormously to the repertoire of synthetic possibilities. Practical Methods for Biocatalysis and Biotransformations 2 is a "how-to" guide that focuses on the practical applications of enzymes and strains of microorganisms that are readily obtained or derived from culture collections. The sources of starting materials and reagents, hints, tips and safety advice (where appropriate) are given to ensure, as far as possible, that the procedures are reproducible. Comparisons to alternative methodology are given and relevant references to the primary literature are cited. This second volume – which can be used on its own or in combination with the first volume - concentrates on new applications and new enzyme families reported since the first volume. Contents include: introduction to recent developments and future needs in biocatalysts and synthetic biology in industry reductive amination enoate reductases for reduction of electron deficient alkenes industrial carbonyl reduction regio- and stereo- selective hydroxylation oxidation of alcohols selective oxidation industrial hydrolases and related enzymes transferases for alkylation, glycosylation and phosphorylation C-C bond formation and decarboxylation halogenation/dehalogenation/heteroatom oxidation tandem and sequential multi-enzymatic syntheses Practical Methods for Biocatalysis and Biotransformations 2 is an essential collection of biocatalytic methods for chemical synthesis which will find a place on the bookshelves of synthetic organic chemists, pharmaceutical chemists, and process R&D chemists in industry and academia.

Biotransformations

Biotransformations

Author: D R Hawkins

Publisher: Royal Society of Chemistry

Published: 2007-10-31

Total Pages: 520

ISBN-13: 1847550274

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Now in its seventh outstanding volume, Biotransformations has become established as a unique and important source for those involved in the discovery and development of new compounds. It broadly covers the scientific literature for the period 1987 to 1994. The series provides a complete survey of the biotransformations, in vertebrates, of the following: Pharmaceuticals; agrochemicals; food additives; environmental chemicals; industrial chemicals. Biotransformations provides a ready way of accessing information on the known pathways for the biotransformation of structurally-related compounds. Key functional groups provide an index-related procedure for retrieving information on compounds of interest. A further index allows the retrieval of examples of specific biochemical reactions which may have wider application. Each volume corresponds roughly with the scientific literature published during a calendar year. Each volume contains a review chapter which discusses examples of novel biotransformations, species differences, stereochemical aspects and mechanisms of toxicity associated with specific biotransformations.


Book Synopsis Biotransformations by : D R Hawkins

Download or read book Biotransformations written by D R Hawkins and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its seventh outstanding volume, Biotransformations has become established as a unique and important source for those involved in the discovery and development of new compounds. It broadly covers the scientific literature for the period 1987 to 1994. The series provides a complete survey of the biotransformations, in vertebrates, of the following: Pharmaceuticals; agrochemicals; food additives; environmental chemicals; industrial chemicals. Biotransformations provides a ready way of accessing information on the known pathways for the biotransformation of structurally-related compounds. Key functional groups provide an index-related procedure for retrieving information on compounds of interest. A further index allows the retrieval of examples of specific biochemical reactions which may have wider application. Each volume corresponds roughly with the scientific literature published during a calendar year. Each volume contains a review chapter which discusses examples of novel biotransformations, species differences, stereochemical aspects and mechanisms of toxicity associated with specific biotransformations.

Practical Biotransformations

Practical Biotransformations

Author: Gideon Grogan

Publisher: John Wiley & Sons

Published: 2009-04-01

Total Pages: 256

ISBN-13: 1405193689

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The development of new asymmetric catalytic methods is of fundamental importance to industrial synthetic chemistry. The demand for optically pure synthetic intermediates and the drive to adopt greener methods of synthesis have stimulated a growing interest in biocatalysis as a selective and environmentally benign synthetic technique. Practical Biotransformations: A Beginner's Guide provides an introduction to microbes and enzymes and demonstrates their practical applications in synthetic organic chemistry. Designed as a laboratory manual, this user-friendly guide discusses standard laboratory techniques, with appropriate advice on aspects of microbial practice and associated safety. Topics covered include: An introduction to equipment in a biotransformations laboratory An overview of biocatalyst sources Maintenance and growth of biocatalysts Example biotransformations using commercially available microbes and enzymes Basic gene cloning and the use of ‘designer’ biocatalysts This book will be a valuable resource for synthetic organic chemists with little or no experience of biochemistry or microbiology. It is the author’s hope that this text will inspire readers to consider biocatalytic methods as real alternatives to traditional synthetic solutions.


Book Synopsis Practical Biotransformations by : Gideon Grogan

Download or read book Practical Biotransformations written by Gideon Grogan and published by John Wiley & Sons. This book was released on 2009-04-01 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of new asymmetric catalytic methods is of fundamental importance to industrial synthetic chemistry. The demand for optically pure synthetic intermediates and the drive to adopt greener methods of synthesis have stimulated a growing interest in biocatalysis as a selective and environmentally benign synthetic technique. Practical Biotransformations: A Beginner's Guide provides an introduction to microbes and enzymes and demonstrates their practical applications in synthetic organic chemistry. Designed as a laboratory manual, this user-friendly guide discusses standard laboratory techniques, with appropriate advice on aspects of microbial practice and associated safety. Topics covered include: An introduction to equipment in a biotransformations laboratory An overview of biocatalyst sources Maintenance and growth of biocatalysts Example biotransformations using commercially available microbes and enzymes Basic gene cloning and the use of ‘designer’ biocatalysts This book will be a valuable resource for synthetic organic chemists with little or no experience of biochemistry or microbiology. It is the author’s hope that this text will inspire readers to consider biocatalytic methods as real alternatives to traditional synthetic solutions.

Practical Biotransformations

Practical Biotransformations

Author: Gideon Grogan

Publisher: John Wiley & Sons

Published: 2009-05-18

Total Pages: 352

ISBN-13: 1405193670

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The development of new asymmetric catalytic methods is of fundamental importance to industrial synthetic chemistry. The demand for optically pure synthetic intermediates and the drive to adopt greener methods of synthesis have stimulated a growing interest in biocatalysis as a selective and environmentally benign synthetic technique. Practical Biotransformations: A Beginner's Guide provides an introduction to microbes and enzymes and demonstrates their practical applications in synthetic organic chemistry. Designed as a laboratory manual, this user-friendly guide discusses standard laboratory techniques, with appropriate advice on aspects of microbial practice and associated safety. Topics covered include: An introduction to equipment in a biotransformations laboratory An overview of biocatalyst sources Maintenance and growth of biocatalysts Example biotransformations using commercially available microbes and enzymes Basic gene cloning and the use of ‘designer’ biocatalysts This book will be a valuable resource for synthetic organic chemists with little or no experience of biochemistry or microbiology. It is the author’s hope that this text will inspire readers to consider biocatalytic methods as real alternatives to traditional synthetic solutions.


Book Synopsis Practical Biotransformations by : Gideon Grogan

Download or read book Practical Biotransformations written by Gideon Grogan and published by John Wiley & Sons. This book was released on 2009-05-18 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of new asymmetric catalytic methods is of fundamental importance to industrial synthetic chemistry. The demand for optically pure synthetic intermediates and the drive to adopt greener methods of synthesis have stimulated a growing interest in biocatalysis as a selective and environmentally benign synthetic technique. Practical Biotransformations: A Beginner's Guide provides an introduction to microbes and enzymes and demonstrates their practical applications in synthetic organic chemistry. Designed as a laboratory manual, this user-friendly guide discusses standard laboratory techniques, with appropriate advice on aspects of microbial practice and associated safety. Topics covered include: An introduction to equipment in a biotransformations laboratory An overview of biocatalyst sources Maintenance and growth of biocatalysts Example biotransformations using commercially available microbes and enzymes Basic gene cloning and the use of ‘designer’ biocatalysts This book will be a valuable resource for synthetic organic chemists with little or no experience of biochemistry or microbiology. It is the author’s hope that this text will inspire readers to consider biocatalytic methods as real alternatives to traditional synthetic solutions.

Microbial Enzymes and Biotransformations

Microbial Enzymes and Biotransformations

Author: Jose Luis Barredo

Publisher: Springer Science & Business Media

Published: 2008-02-05

Total Pages: 323

ISBN-13: 1592598463

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Leading experts in enzyme manipulation describe in detail their cutting-edge techniques for the screening, evolution, production, immobilization, and application of enzymes. These readily reproducible methods can be used to improve enzyme function by directed evolution, to covalently immobilize enzymes, to microencapsulate enzymes and cells, and to manufacture enzymes for human health, nutrition, and environmental protection. Overview chapters on microorganisms as a source of metabolic and enzymatic diversity, and on the fast-moving field of enzyme biosensors are presented. Microbial Enzymes and Biotransformations offers laboratory and industrial scientists a wealth of proven enzymatic protocols that show clearly how to go from laboratory results to successful industrial applications.


Book Synopsis Microbial Enzymes and Biotransformations by : Jose Luis Barredo

Download or read book Microbial Enzymes and Biotransformations written by Jose Luis Barredo and published by Springer Science & Business Media. This book was released on 2008-02-05 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading experts in enzyme manipulation describe in detail their cutting-edge techniques for the screening, evolution, production, immobilization, and application of enzymes. These readily reproducible methods can be used to improve enzyme function by directed evolution, to covalently immobilize enzymes, to microencapsulate enzymes and cells, and to manufacture enzymes for human health, nutrition, and environmental protection. Overview chapters on microorganisms as a source of metabolic and enzymatic diversity, and on the fast-moving field of enzyme biosensors are presented. Microbial Enzymes and Biotransformations offers laboratory and industrial scientists a wealth of proven enzymatic protocols that show clearly how to go from laboratory results to successful industrial applications.