Multiscale Mechanobiology of Bone Remodeling and Adaptation

Multiscale Mechanobiology of Bone Remodeling and Adaptation

Author: Peter Pivonka

Publisher: Springer

Published: 2017-06-20

Total Pages: 295

ISBN-13: 3319588451

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The book presents state-of-the-art developments in multiscale modeling and latest experimental data on multiscale mechanobiology of bone remodeling and adaptation including fracture healing applications. The multiscale models include musculoskeletal models describing bone-muscle interactions during daily activities such as walking or running, micromechanical models for estimation of bone mechanical properties, bone remodeling and adaptation models, cellular models describing the complex bone-cell interactions taking into account biochemical and biomechanical regulatory factors. Also subcellular processes are covered including arrangement of actin filaments due to mechanical loading and change of receptor configurations.


Book Synopsis Multiscale Mechanobiology of Bone Remodeling and Adaptation by : Peter Pivonka

Download or read book Multiscale Mechanobiology of Bone Remodeling and Adaptation written by Peter Pivonka and published by Springer. This book was released on 2017-06-20 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book presents state-of-the-art developments in multiscale modeling and latest experimental data on multiscale mechanobiology of bone remodeling and adaptation including fracture healing applications. The multiscale models include musculoskeletal models describing bone-muscle interactions during daily activities such as walking or running, micromechanical models for estimation of bone mechanical properties, bone remodeling and adaptation models, cellular models describing the complex bone-cell interactions taking into account biochemical and biomechanical regulatory factors. Also subcellular processes are covered including arrangement of actin filaments due to mechanical loading and change of receptor configurations.

Bone Adaptation

Bone Adaptation

Author: Yoshitaka Kameo

Publisher: Springer

Published: 2018-01-10

Total Pages: 209

ISBN-13: 4431565140

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This book focuses on the systems biomechanics of bone remodeling that provide a multiscale platform for bone adaptation, spanning the cellular, tissue, and organ levels. The mathematical model explained in each section provides concrete examples of in silico approaches for bone adaptation. It will be immensely useful for readers interested in bone morphology and metabolism and will serve as an effective bridge connecting mechanics, cellular and molecular biology, and medical sciences. These in silico approaches towards exploring the mechanisms by which the functioning of dynamic living systems is established and maintained have potential for facilitating the efforts of graduate students and young researchers pioneering new frontiers of biomechanics.


Book Synopsis Bone Adaptation by : Yoshitaka Kameo

Download or read book Bone Adaptation written by Yoshitaka Kameo and published by Springer. This book was released on 2018-01-10 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the systems biomechanics of bone remodeling that provide a multiscale platform for bone adaptation, spanning the cellular, tissue, and organ levels. The mathematical model explained in each section provides concrete examples of in silico approaches for bone adaptation. It will be immensely useful for readers interested in bone morphology and metabolism and will serve as an effective bridge connecting mechanics, cellular and molecular biology, and medical sciences. These in silico approaches towards exploring the mechanisms by which the functioning of dynamic living systems is established and maintained have potential for facilitating the efforts of graduate students and young researchers pioneering new frontiers of biomechanics.

The Mechanical Adaptations of Bones

The Mechanical Adaptations of Bones

Author: John D. Currey

Publisher: Princeton University Press

Published: 2014-07-14

Total Pages: 305

ISBN-13: 1400853729

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This book relates the mechanical and structural properties of bone to its function in man and other vertebrates. John Currey, one of the pioneers of modern bone research, reviews existing information in the field and particularly emphasizes the correlation of the structure of bone with its various uses. Originally published in 1984. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.


Book Synopsis The Mechanical Adaptations of Bones by : John D. Currey

Download or read book The Mechanical Adaptations of Bones written by John D. Currey and published by Princeton University Press. This book was released on 2014-07-14 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book relates the mechanical and structural properties of bone to its function in man and other vertebrates. John Currey, one of the pioneers of modern bone research, reviews existing information in the field and particularly emphasizes the correlation of the structure of bone with its various uses. Originally published in 1984. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

Skeletal Variation and Adaptation in Europeans

Skeletal Variation and Adaptation in Europeans

Author: Christopher B. Ruff

Publisher: John Wiley & Sons

Published: 2018-03-27

Total Pages: 503

ISBN-13: 1118627962

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A comprehensive analysis of changes in body form and skeletal robusticity from the Terminal Pleistocene through the Holocene, leading to the modern European human phenotype. Skeletal Variation and Adaptation in Europeans: Upper Paleolithic to the Twentieth Century brings together for the first time the results of an unprecedented large-scale investigation of European skeletal remains. The study was conducted over ten years by an international research team, and includes more than 2,000 skeletons spanning most of the European continent over the past 30,000 years, from the Early Upper Paleolithic to the 20th century. This time span includes environmental transitions from foraging to food production, small-scale to large-scale urban settlements, increasing social stratification and mechanization of labor, and climatic changes. Alterations in body form and behavior in response to these transitions are reconstructed through osteometric and biomechanical analyses. Divided into four sections, the book includes an introduction to the project and comprehensive descriptions of the methods used; general continent-wide syntheses of major trends in body size, shape, and skeletal robusticity; detailed regional analyses; and a summary of results. It also offers a full data set on an external website. Brings together data from an unprecedented large-scale study of human skeletal and anatomical variations Includes appendix of specific information from each research site Synthesizes data from spatial, temporal, regional, and geographical perspectives Skeletal Variation and Adaptation in Europeans will be a valuable resource for bioarchaeologists, palaeoanthropologists, forensic anthropologists, medical historians, and archaeologists at both the graduate and post-graduate level.


Book Synopsis Skeletal Variation and Adaptation in Europeans by : Christopher B. Ruff

Download or read book Skeletal Variation and Adaptation in Europeans written by Christopher B. Ruff and published by John Wiley & Sons. This book was released on 2018-03-27 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive analysis of changes in body form and skeletal robusticity from the Terminal Pleistocene through the Holocene, leading to the modern European human phenotype. Skeletal Variation and Adaptation in Europeans: Upper Paleolithic to the Twentieth Century brings together for the first time the results of an unprecedented large-scale investigation of European skeletal remains. The study was conducted over ten years by an international research team, and includes more than 2,000 skeletons spanning most of the European continent over the past 30,000 years, from the Early Upper Paleolithic to the 20th century. This time span includes environmental transitions from foraging to food production, small-scale to large-scale urban settlements, increasing social stratification and mechanization of labor, and climatic changes. Alterations in body form and behavior in response to these transitions are reconstructed through osteometric and biomechanical analyses. Divided into four sections, the book includes an introduction to the project and comprehensive descriptions of the methods used; general continent-wide syntheses of major trends in body size, shape, and skeletal robusticity; detailed regional analyses; and a summary of results. It also offers a full data set on an external website. Brings together data from an unprecedented large-scale study of human skeletal and anatomical variations Includes appendix of specific information from each research site Synthesizes data from spatial, temporal, regional, and geographical perspectives Skeletal Variation and Adaptation in Europeans will be a valuable resource for bioarchaeologists, palaeoanthropologists, forensic anthropologists, medical historians, and archaeologists at both the graduate and post-graduate level.

Structure, Function, and Adaptation of Compact Bone

Structure, Function, and Adaptation of Compact Bone

Author: R. Bruce Martin

Publisher:

Published: 1989

Total Pages: 296

ISBN-13:

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Book Synopsis Structure, Function, and Adaptation of Compact Bone by : R. Bruce Martin

Download or read book Structure, Function, and Adaptation of Compact Bone written by R. Bruce Martin and published by . This book was released on 1989 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Bones

Bones

Author: John D. Currey

Publisher: Princeton University Press

Published: 2006-07-23

Total Pages: 456

ISBN-13: 0691128049

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This is a comprehensive and accessible overview of what is known about the structure and mechanics of bone, bones, and teeth. In it, John Currey incorporates critical new concepts and findings from the two decades of research since the publication of his highly regarded The Mechanical Adaptations of Bones. Crucially, Currey shows how bone structure and bone's mechanical properties are intimately bound up with each other and how the mechanical properties of the material interact with the structure of whole bones to produce an adapted structure. For bone tissue, the book discusses stiffness, strength, viscoelasticity, fatigue, and fracture mechanics properties. For whole bones, subjects dealt with include buckling, the optimum hollowness of long bones, impact fracture, and properties of cancellous bone. The effects of mineralization on stiffness and toughness and the role of microcracking in the fracture process receive particular attention. As a zoologist, Currey views bone and bones as solutions to the design problems that vertebrates have faced during their evolution and throughout the book considers what bones have been adapted to do. He covers the full range of bones and bony tissues, as well as dentin and enamel, and uses both human and non-human examples. Copiously illustrated, engagingly written, and assuming little in the way of prior knowledge or mathematical background, Bones is both an ideal introduction to the field and also a reference sure to be frequently consulted by practicing researchers.


Book Synopsis Bones by : John D. Currey

Download or read book Bones written by John D. Currey and published by Princeton University Press. This book was released on 2006-07-23 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a comprehensive and accessible overview of what is known about the structure and mechanics of bone, bones, and teeth. In it, John Currey incorporates critical new concepts and findings from the two decades of research since the publication of his highly regarded The Mechanical Adaptations of Bones. Crucially, Currey shows how bone structure and bone's mechanical properties are intimately bound up with each other and how the mechanical properties of the material interact with the structure of whole bones to produce an adapted structure. For bone tissue, the book discusses stiffness, strength, viscoelasticity, fatigue, and fracture mechanics properties. For whole bones, subjects dealt with include buckling, the optimum hollowness of long bones, impact fracture, and properties of cancellous bone. The effects of mineralization on stiffness and toughness and the role of microcracking in the fracture process receive particular attention. As a zoologist, Currey views bone and bones as solutions to the design problems that vertebrates have faced during their evolution and throughout the book considers what bones have been adapted to do. He covers the full range of bones and bony tissues, as well as dentin and enamel, and uses both human and non-human examples. Copiously illustrated, engagingly written, and assuming little in the way of prior knowledge or mathematical background, Bones is both an ideal introduction to the field and also a reference sure to be frequently consulted by practicing researchers.

Bone Adaptation in Response to Mechanical Loading is Greatest with a Large Initial Deviation in Loading Pattern

Bone Adaptation in Response to Mechanical Loading is Greatest with a Large Initial Deviation in Loading Pattern

Author: Jennifer Lynn Schriefer

Publisher:

Published: 2004

Total Pages: 200

ISBN-13:

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Book Synopsis Bone Adaptation in Response to Mechanical Loading is Greatest with a Large Initial Deviation in Loading Pattern by : Jennifer Lynn Schriefer

Download or read book Bone Adaptation in Response to Mechanical Loading is Greatest with a Large Initial Deviation in Loading Pattern written by Jennifer Lynn Schriefer and published by . This book was released on 2004 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Bone White

Bone White

Author: Ronald Malfi

Publisher: Canelo

Published: 2024-02-08

Total Pages: 417

ISBN-13: 1804366714

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A landscape of frozen darkness. The scrape of bone on bone. ‘Malfi is a modern-day Algernon Blackwood. I'm gonna be talking about this book for years’ Josh Malerman, author of Bird Box Paul Gallo saw the report on the news: a mass murderer leading police to his victims’ graves, in remote Dread’s Hand, Alaska. It’s not even a town; more like the bad memory of a town. The same bit of wilderness where his twin brother went missing a year ago. As the bodies are exhumed, Paul travels to Alaska to get closure and put his grief to rest. But the mystery is only beginning. What Paul finds are superstitious locals who talk of the devil stealing souls, and a line of wooden crosses surrounding the woods. Not to honour the dead, but to keep what’s lurks there from escaping... An edge of your seat thrill ride from a true master of modern horror, perfect for fans of Paul Tremblay, Adam Nevill and T. Kingfisher.


Book Synopsis Bone White by : Ronald Malfi

Download or read book Bone White written by Ronald Malfi and published by Canelo. This book was released on 2024-02-08 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: A landscape of frozen darkness. The scrape of bone on bone. ‘Malfi is a modern-day Algernon Blackwood. I'm gonna be talking about this book for years’ Josh Malerman, author of Bird Box Paul Gallo saw the report on the news: a mass murderer leading police to his victims’ graves, in remote Dread’s Hand, Alaska. It’s not even a town; more like the bad memory of a town. The same bit of wilderness where his twin brother went missing a year ago. As the bodies are exhumed, Paul travels to Alaska to get closure and put his grief to rest. But the mystery is only beginning. What Paul finds are superstitious locals who talk of the devil stealing souls, and a line of wooden crosses surrounding the woods. Not to honour the dead, but to keep what’s lurks there from escaping... An edge of your seat thrill ride from a true master of modern horror, perfect for fans of Paul Tremblay, Adam Nevill and T. Kingfisher.

Mechanical Loading of Bones and Joints

Mechanical Loading of Bones and Joints

Author: Hideaki E. Takahashi

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 314

ISBN-13: 4431658920

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Bones and joints are always under mechanical loading a key concept in understanding bone metabolism. Among the most common diseases of bones and joints in the elderly are osteoporosis and joint osteoarthritis. Dynamic changes in mechanical loading give rise to problems resulting in stenosis of the spinal column at the cervical, thoracic, and lumbar levels. Mechanical loading also accelerates joint destruction caused by inflammation from such conditions as chronic rheumatoid arthritis. An understanding of mechanical loading is essential therefore to clinicians, basic researchers, and engineers working with bones and joints. Providing up-to-date research and clinical findings, the contents of this volume are from the papers, symposia, and special lectures presented at the 12th Annual Meeting of the Orthopaedic Research Meeting of the Japanese Orthopaedic Association in Niigata, in October 1997.


Book Synopsis Mechanical Loading of Bones and Joints by : Hideaki E. Takahashi

Download or read book Mechanical Loading of Bones and Joints written by Hideaki E. Takahashi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bones and joints are always under mechanical loading a key concept in understanding bone metabolism. Among the most common diseases of bones and joints in the elderly are osteoporosis and joint osteoarthritis. Dynamic changes in mechanical loading give rise to problems resulting in stenosis of the spinal column at the cervical, thoracic, and lumbar levels. Mechanical loading also accelerates joint destruction caused by inflammation from such conditions as chronic rheumatoid arthritis. An understanding of mechanical loading is essential therefore to clinicians, basic researchers, and engineers working with bones and joints. Providing up-to-date research and clinical findings, the contents of this volume are from the papers, symposia, and special lectures presented at the 12th Annual Meeting of the Orthopaedic Research Meeting of the Japanese Orthopaedic Association in Niigata, in October 1997.

Basic and Applied Bone Biology

Basic and Applied Bone Biology

Author: David B. Burr

Publisher: Academic Press

Published: 2013-06-11

Total Pages: 390

ISBN-13: 0123914590

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This book provides an overview of skeletal biology from the molecular level to the organ level, including cellular control, interaction and response; adaptive responses to various external stimuli; the interaction of the skeletal system with other metabolic processes in the body; and the effect of various disease processes on the skeleton. The book also includes chapters that address how the skeleton can be evaluated through the use of various imaging technologies, biomechanical testing, histomorphometric analysis, and the use of genetically modified animal models. Presents an in-depth overview of skeletal biology from the molecular to the organ level Offers "refresher" level content for clinicians or researchers outside their areas of expertise Boasts editors and many chapter authors from Indiana and Purdue Universities, two of the broadest and deepest programs in skeletal biology in the US; other chapter authors include clinician scientists from pharmaceutical companies that apply the basics of bone biology


Book Synopsis Basic and Applied Bone Biology by : David B. Burr

Download or read book Basic and Applied Bone Biology written by David B. Burr and published by Academic Press. This book was released on 2013-06-11 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of skeletal biology from the molecular level to the organ level, including cellular control, interaction and response; adaptive responses to various external stimuli; the interaction of the skeletal system with other metabolic processes in the body; and the effect of various disease processes on the skeleton. The book also includes chapters that address how the skeleton can be evaluated through the use of various imaging technologies, biomechanical testing, histomorphometric analysis, and the use of genetically modified animal models. Presents an in-depth overview of skeletal biology from the molecular to the organ level Offers "refresher" level content for clinicians or researchers outside their areas of expertise Boasts editors and many chapter authors from Indiana and Purdue Universities, two of the broadest and deepest programs in skeletal biology in the US; other chapter authors include clinician scientists from pharmaceutical companies that apply the basics of bone biology