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This book summarizes the recent advances in the knowledge of the structure and physiological functions of the calcium-binding proteins in the central nervous system, describes their cellular distribution and developmental appearance, and discusses their possible association with neurodegenerative disorders and their use as diagnostic tools. This is the first book describing the structure, localization, and functions of calcium-binding proteins in the central nervous system and their involvement in neurodegenerative disorders. It is of great value to neurobiologists, clinicians, pharmacologists, biochemists and molecular biologists.
Book Synopsis Calcium Regulation by Calcium-Binding Proteins in Neurodegenerative Disorders by : Claus W. Heizmann
Download or read book Calcium Regulation by Calcium-Binding Proteins in Neurodegenerative Disorders written by Claus W. Heizmann and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes the recent advances in the knowledge of the structure and physiological functions of the calcium-binding proteins in the central nervous system, describes their cellular distribution and developmental appearance, and discusses their possible association with neurodegenerative disorders and their use as diagnostic tools. This is the first book describing the structure, localization, and functions of calcium-binding proteins in the central nervous system and their involvement in neurodegenerative disorders. It is of great value to neurobiologists, clinicians, pharmacologists, biochemists and molecular biologists.
With the unprecedented identification of new mutation mechanisms in neurodegenerative diseases and the emergence of common mechanisms among diseases that were once considered unrelated, neurobiologists are poised for the development of new therapies based on high throughput screenings and a better understanding of the molecular and cellular mechanisms leading to neurodegeneration. In Molecular Mechanisms of Neurodegenerative Diseases, Marie-Francoise Chesselet, MD, PhD, and a panel of leading researchers and neurologists from industry and academia critically review the most recent advances from different yet complementary points of view. Focusing on Alzheimer's, Parkinson's, and CAG triplet repeat diseases, the authors show how studies of cellular and genetically engineered animal models have enhanced our understanding of the molecular mechanisms of neurodegenerative diseases and may lead to the development of new therapeutics. Topics include the role of Ab toxicity, glial cells, and inflammation in Alzheimer's disease; the formation of abnormal protein fragments across several diseases, the impact of dopamine and mitochondrial dysfunction on neurodegeneration; and the potential of genetics to identify the molecular mechanisms of neurodegenerative diseases. Authoritative and insightful, Molecular Mechanisms of Neurodegenerative Diseases synthesizes the novel ideas and concepts now emerging to create a fresh understanding of neurodegenerative disorders, one that promises to lead to powerful new therapies that prevent, delay the onset, slow the progression, or even cure these cruel diseases.
Book Synopsis Molecular Mechanisms of Neurodegenerative Diseases by : Marie-Francoise Chesselet
Download or read book Molecular Mechanisms of Neurodegenerative Diseases written by Marie-Francoise Chesselet and published by Springer Science & Business Media. This book was released on 2000-10-19 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the unprecedented identification of new mutation mechanisms in neurodegenerative diseases and the emergence of common mechanisms among diseases that were once considered unrelated, neurobiologists are poised for the development of new therapies based on high throughput screenings and a better understanding of the molecular and cellular mechanisms leading to neurodegeneration. In Molecular Mechanisms of Neurodegenerative Diseases, Marie-Francoise Chesselet, MD, PhD, and a panel of leading researchers and neurologists from industry and academia critically review the most recent advances from different yet complementary points of view. Focusing on Alzheimer's, Parkinson's, and CAG triplet repeat diseases, the authors show how studies of cellular and genetically engineered animal models have enhanced our understanding of the molecular mechanisms of neurodegenerative diseases and may lead to the development of new therapeutics. Topics include the role of Ab toxicity, glial cells, and inflammation in Alzheimer's disease; the formation of abnormal protein fragments across several diseases, the impact of dopamine and mitochondrial dysfunction on neurodegeneration; and the potential of genetics to identify the molecular mechanisms of neurodegenerative diseases. Authoritative and insightful, Molecular Mechanisms of Neurodegenerative Diseases synthesizes the novel ideas and concepts now emerging to create a fresh understanding of neurodegenerative disorders, one that promises to lead to powerful new therapies that prevent, delay the onset, slow the progression, or even cure these cruel diseases.
The enormous and varied role of calcium in living systems is now widely appreciated by both cell biologists and clinicians. The identification and characterisation of new calcium binding proteins and regulatory pathways is matched by the recognition of the involvement of calcium binding proteins in a growing number of disease states. This book is intended to introduce clinicians to fundamental biological research, whilst at the same time attracting researchers to the clinical world. The publication of the book coincides with the elucidation of the complete Human Genomic Sequence. As a result of this, scientists now have access to an unprecedented array of data, from which new calcium binding proteins and hence new regulatory pathways will undoubtedly be discovered. It is a further aim of this book to provide a `key' to open the door to the new postgenomic era. The book is in three parts. The first section introduces the reader to the role of calcium in cell biology, providing an appreciation of how this small, simple, non-metabolisable agent can move rapidly and silently through the different cellular compartments, thereby influencing and controlling the fate of the cell. This section also illustrates and dissects the often-complex interplay between calcium and numerous agents in muscle and endocrine cells, neurons, hepatocytes, and platelets. In the second section the reader will discover the role of calcium and its partners in common diseases such as migraine and drug dependence. New classes of diseases such as annexinopathies, channelopathies, calcium-sensing disorders, and citrullinemia are discussed, and the authors give many new insights into the molecular mechanisms of the diseases, thereby explaining how and why they occur. Such information is clearly of primary importance for the pharmaceutical industry. New ideas and concepts of neurodegenerative diseases are introduced, which should stimulate new approaches. Clinicians will also have access, in a comprehensive and authoritative yet highly readable chapter, to data from recent large-scale clinical studies on the numerous and widely prescribed calcium antagonists. The final section gives information on new methods and devices for calcium imaging, and illustrates how calcium movement and change can be monitored and ingeniously utilised as a fast, cheap, and accurate drug screening instrument.
Book Synopsis Calcium: The Molecular Basis of Calcium Action in Biology and Medicine by : R. Pochet
Download or read book Calcium: The Molecular Basis of Calcium Action in Biology and Medicine written by R. Pochet and published by Boom Koninklijke Uitgevers. This book was released on 2000-11-30 with total page 778 pages. Available in PDF, EPUB and Kindle. Book excerpt: The enormous and varied role of calcium in living systems is now widely appreciated by both cell biologists and clinicians. The identification and characterisation of new calcium binding proteins and regulatory pathways is matched by the recognition of the involvement of calcium binding proteins in a growing number of disease states. This book is intended to introduce clinicians to fundamental biological research, whilst at the same time attracting researchers to the clinical world. The publication of the book coincides with the elucidation of the complete Human Genomic Sequence. As a result of this, scientists now have access to an unprecedented array of data, from which new calcium binding proteins and hence new regulatory pathways will undoubtedly be discovered. It is a further aim of this book to provide a `key' to open the door to the new postgenomic era. The book is in three parts. The first section introduces the reader to the role of calcium in cell biology, providing an appreciation of how this small, simple, non-metabolisable agent can move rapidly and silently through the different cellular compartments, thereby influencing and controlling the fate of the cell. This section also illustrates and dissects the often-complex interplay between calcium and numerous agents in muscle and endocrine cells, neurons, hepatocytes, and platelets. In the second section the reader will discover the role of calcium and its partners in common diseases such as migraine and drug dependence. New classes of diseases such as annexinopathies, channelopathies, calcium-sensing disorders, and citrullinemia are discussed, and the authors give many new insights into the molecular mechanisms of the diseases, thereby explaining how and why they occur. Such information is clearly of primary importance for the pharmaceutical industry. New ideas and concepts of neurodegenerative diseases are introduced, which should stimulate new approaches. Clinicians will also have access, in a comprehensive and authoritative yet highly readable chapter, to data from recent large-scale clinical studies on the numerous and widely prescribed calcium antagonists. The final section gives information on new methods and devices for calcium imaging, and illustrates how calcium movement and change can be monitored and ingeniously utilised as a fast, cheap, and accurate drug screening instrument.
The enormous and varied role of calcium in living systems is now widely appreciated by both cell biologists and clinicians. The identification and characterisation of new calcium binding proteins and regulatory pathways is matched by the recognition of the involvement of calcium binding proteins in a growing number of disease states. This book is intended to introduce clinicians to fundamental biological research, whilst at the same time attracting researchers to the clinical world. The publication of the book coincides with the elucidation of the complete Human Genomic Sequence. As a result of this, scientists now have access to an unprecedented array of data, from which new calcium binding proteins and hence new regulatory pathways will undoubtedly be discovered. It is a further aim of this book to provide a `key' to open the door to the new postgenomic era. The book is in three parts. The first section introduces the reader to the role of calcium in cell biology, providing an appreciation of how this small, simple, non-metabolisable agent can move rapidly and silently through the different cellular compartments, thereby influencing and controlling the fate of the cell. This section also illustrates and dissects the often-complex interplay between calcium and numerous agents in muscle and endocrine cells, neurons, hepatocytes, and platelets. In the second section the reader will discover the role of calcium and its partners in common diseases such as migraine and drug dependence. New classes of diseases such as annexinopathies, channelopathies, calcium-sensing disorders, and citrullinemia are discussed, and the authors give many new insights into the molecular mechanisms of the diseases, thereby explaining how and why they occur. Such information is clearly of primary importance for the pharmaceutical industry. New ideas and concepts of neurodegenerative diseases are introduced, which should stimulate new approaches. Clinicians will also have access, in a comprehensive and authoritative yet highly readable chapter, to data from recent large-scale clinical studies on the numerous and widely prescribed calcium antagonists. The final section gives information on new methods and devices for calcium imaging, and illustrates how calcium movement and change can be monitored and ingeniously utilised as a fast, cheap, and accurate drug screening instrument.
Book Synopsis Calcium: The molecular basis of calcium action in biology and medicine by : R. Pochet
Download or read book Calcium: The molecular basis of calcium action in biology and medicine written by R. Pochet and published by Springer Science & Business Media. This book was released on 2011-06-28 with total page 746 pages. Available in PDF, EPUB and Kindle. Book excerpt: The enormous and varied role of calcium in living systems is now widely appreciated by both cell biologists and clinicians. The identification and characterisation of new calcium binding proteins and regulatory pathways is matched by the recognition of the involvement of calcium binding proteins in a growing number of disease states. This book is intended to introduce clinicians to fundamental biological research, whilst at the same time attracting researchers to the clinical world. The publication of the book coincides with the elucidation of the complete Human Genomic Sequence. As a result of this, scientists now have access to an unprecedented array of data, from which new calcium binding proteins and hence new regulatory pathways will undoubtedly be discovered. It is a further aim of this book to provide a `key' to open the door to the new postgenomic era. The book is in three parts. The first section introduces the reader to the role of calcium in cell biology, providing an appreciation of how this small, simple, non-metabolisable agent can move rapidly and silently through the different cellular compartments, thereby influencing and controlling the fate of the cell. This section also illustrates and dissects the often-complex interplay between calcium and numerous agents in muscle and endocrine cells, neurons, hepatocytes, and platelets. In the second section the reader will discover the role of calcium and its partners in common diseases such as migraine and drug dependence. New classes of diseases such as annexinopathies, channelopathies, calcium-sensing disorders, and citrullinemia are discussed, and the authors give many new insights into the molecular mechanisms of the diseases, thereby explaining how and why they occur. Such information is clearly of primary importance for the pharmaceutical industry. New ideas and concepts of neurodegenerative diseases are introduced, which should stimulate new approaches. Clinicians will also have access, in a comprehensive and authoritative yet highly readable chapter, to data from recent large-scale clinical studies on the numerous and widely prescribed calcium antagonists. The final section gives information on new methods and devices for calcium imaging, and illustrates how calcium movement and change can be monitored and ingeniously utilised as a fast, cheap, and accurate drug screening instrument.
Alzheimer’s disease (AD) is the most well-known neurodegenerative disorder, causing dementia. In recent decades, several studies have reported calcium dysregulation in AD occurring through the intervention of several calcium receptors and channels, and affecting different cellular compartments, such as mitochondria, the endoplasmic reticulum, lysosomes, and microdomains within the plasma membrane. Calcium signalling dysregulation is now considered a common proximal cause of dysfunctional neurons and glial supporting cells. This book gathers the newest results and advances in calcium signaling deregulation mechanisms in AD, how they are linked to other players involved in AD, and the potential therapies targeting calcium alterations to treat AD.
Book Synopsis Calcium Signalling in Alzheimer’s Disease by : Mounia Chami
Download or read book Calcium Signalling in Alzheimer’s Disease written by Mounia Chami and published by MDPI. This book was released on 2021-04-22 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer’s disease (AD) is the most well-known neurodegenerative disorder, causing dementia. In recent decades, several studies have reported calcium dysregulation in AD occurring through the intervention of several calcium receptors and channels, and affecting different cellular compartments, such as mitochondria, the endoplasmic reticulum, lysosomes, and microdomains within the plasma membrane. Calcium signalling dysregulation is now considered a common proximal cause of dysfunctional neurons and glial supporting cells. This book gathers the newest results and advances in calcium signaling deregulation mechanisms in AD, how they are linked to other players involved in AD, and the potential therapies targeting calcium alterations to treat AD.
This book focuses on disorders of calcium channels and the use of drugs to treat calcium-related disorders and their associated toxicities. In particular, it discusses the role of various natural products and their attributes in preventing problems associated with calcium imbalances. In addition, the book analyzes trends in the processing of natural products using nanotechnology and their implications in calcium-related disorders. Lastly, it explores some of the most promising aspects of research into calcium signalling disorders – which is especially important, given the wide variety of cellular processes that are controlled by calcium ions – and provides a trustworthy source of up-to-date information in this area of research.
Book Synopsis Calcium Signaling: From Physiology to Diseases by : Senthilkumar Rajagopal
Download or read book Calcium Signaling: From Physiology to Diseases written by Senthilkumar Rajagopal and published by Springer. This book was released on 2017-09-28 with total page 91 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on disorders of calcium channels and the use of drugs to treat calcium-related disorders and their associated toxicities. In particular, it discusses the role of various natural products and their attributes in preventing problems associated with calcium imbalances. In addition, the book analyzes trends in the processing of natural products using nanotechnology and their implications in calcium-related disorders. Lastly, it explores some of the most promising aspects of research into calcium signalling disorders – which is especially important, given the wide variety of cellular processes that are controlled by calcium ions – and provides a trustworthy source of up-to-date information in this area of research.
Book Synopsis Calcium-binding Proteins in Health and Disease by : Anthony W. Norman
Download or read book Calcium-binding Proteins in Health and Disease written by Anthony W. Norman and published by . This book was released on 1987 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Neuronal Calcium Sensors in Health and Disease by : Karl-Wilhelm Koch
Download or read book Neuronal Calcium Sensors in Health and Disease written by Karl-Wilhelm Koch and published by Frontiers Media SA. This book was released on 2020-01-16 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Authors highlight several promising discoveries in the field of calcium signaling that provide new information about both genetic and acquired pathologies. Their discussions will give you new insights into the underlying causes of congenital and acquired diseases and point the way to new, even more promising research and therapies.
Book Synopsis Calcium Signalling and Disease by : Ernesto Carafoli
Download or read book Calcium Signalling and Disease written by Ernesto Carafoli and published by Springer Science & Business Media. This book was released on 2007-09-29 with total page 591 pages. Available in PDF, EPUB and Kindle. Book excerpt: Authors highlight several promising discoveries in the field of calcium signaling that provide new information about both genetic and acquired pathologies. Their discussions will give you new insights into the underlying causes of congenital and acquired diseases and point the way to new, even more promising research and therapies.
Book Synopsis Novel Calcium-binding Proteins by : Claus W. Heizmann
Download or read book Novel Calcium-binding Proteins written by Claus W. Heizmann and published by Springer. This book was released on 1991 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt:
