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Book Synopsis Carbon Black, Titanium Dioxide, and Talc by : IARC Working Group on the Evaluation of Carcinogenic Risks to Humans
Download or read book Carbon Black, Titanium Dioxide, and Talc written by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans and published by . This book was released on 2010 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt:
This volume of the IARC Monographs provides a reassessment of the carcinogenicity of carbon black, titanium dioxide, and talc. All of these agents are poorly soluble particles that are weakly toxic, and were chosen for assessment because evidence suggests that they cause cancer in the respiratory tract of rats through mechanisms similar to those that are operative in people who work in dusty environments (eg. coal mines). An IARC Monographs Working Group reviewed epidemiological evidence, animal bioassays, and mechanistic and other relevant data to reach conclusions as to the carcinogenic hazard of these particles upon inhalation by humans.
Book Synopsis IARC Monographs on the Evaluation of Carcinogenic Risks to Humans by : The International Agency for Research on Cancer
Download or read book IARC Monographs on the Evaluation of Carcinogenic Risks to Humans written by The International Agency for Research on Cancer and published by . This book was released on 2011-02-07 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of the IARC Monographs provides a reassessment of the carcinogenicity of carbon black, titanium dioxide, and talc. All of these agents are poorly soluble particles that are weakly toxic, and were chosen for assessment because evidence suggests that they cause cancer in the respiratory tract of rats through mechanisms similar to those that are operative in people who work in dusty environments (eg. coal mines). An IARC Monographs Working Group reviewed epidemiological evidence, animal bioassays, and mechanistic and other relevant data to reach conclusions as to the carcinogenic hazard of these particles upon inhalation by humans.
Book Synopsis IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Volume 93, Carbon Black, Titanium Dioxide, and Talc by : International Agency for Research on Cancer Working Group on the Evaluation of the Carcinogenic Risks to Humans
Download or read book IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Volume 93, Carbon Black, Titanium Dioxide, and Talc written by International Agency for Research on Cancer Working Group on the Evaluation of the Carcinogenic Risks to Humans and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Particles and Health is an international conference taking place in October 2021 addressing issues in science and regulation. Regulatory initiatives in the European Union (EU) have suggested uniform hazard classifications for all poorly soluble low toxicity particles (PSLTs). Examples of PSLTs include carbon black, titanium dioxide and iron oxide, among others. Approaches have also been proposed for setting workplace exposure limits for PSLTs such as those of the German MAK Commission. The conference will include specific sections over a two day period of about 25 presentations, associated with PSLTs regarding the following major topics: (1) human studies, (2) animal inhalation studies associated with lung cancer,(3) animal and human studies associated with non pulmonary impacts, including reproductive, genetic and cardiac effects, and (4) regulatory application of scientific studies. This conference will include presentations regarding: Definition of PSLT’s with attention to both similarities and differences among these substances. • Address scientific studies regarding human health effects of PSLTs. The value of human studies over animal studies-when human-exposed populations can be studied adequately- will be emphasized. • Address translational toxicology challenges, including the appropriateness of rats as models for human lung pathogenesis (particularly lung cancer) in light of lung overload phenomena and species differences. • Serve as a platform to present current scientific information about PSLTs important for regulatory action. • Publication of pertinent conference presentations in the peer reviewed scientific literature will allow the presentations to live beyond the conference and subsequently be reviewed part of regulatory deliberations. • Establish an interdisciplinary setting for industry, academia and regulatory professionals to interact on an important topic. Such interaction can facilitate enhanced understanding of the science and ideally, more appropriate regulations, appropriate classification and labeling as well as for setting exposure limits, among others. • Recommend areas for further clarifying research regarding the significance of the rat as a model for translation toxicology. The goal of this conference is to present current scientific evidence regarding the numerous dimensions of particles and health and to facilitate interaction and discussions among attendees with expertise in toxicology, epidemiology, occupational and pulmonary medicine and exposure assessment. Interactions between these disciplines will aid in the sound and evidence-based scientific underpinning of regulatory considerations regarding PSLTs. Although regulatory concern regarding PSLTs has focused on lung cancer risk as a result of rat inhalation overload studies, this conference will address all relevant health end points, including genetic and reproductive issues as well, consistent with ECHA guidelines. Sample of Topics related to substances that may be characterized as PSLTs, including carbon black, coal, titanium dioxide, cerium oxide, aluminum oxide barium sulfate and iron oxide, among others. • Defining PSLTs • Epidemiological studies of PSLTs • Inhalation studies evaluating human cellular response to particles • Basic research studies on inflammatory to malignancy pathways • Animal studies, PLSTs and human risk: “New Insights into old data.” • New studies on PSLTs; 2 year carcinogenicity assays • Animal studies and gender specific responses to PSLTs. How does the USA National Cancer Institute (NCI) and National Institute of Environmental Health Sciences (NIEHS) address this challenge of extrapolating rodent data to human risk assessment? • Role of the rodent model in human risk assessment of PSLTs and lung cancer risk • Adverse Outcome Pathways (AOPs) and Modes of Action (MOA): identification and recommendations for closing gaps in knowledge for rodents and humans. • Are there lessons to be learned from how the pharmaceutical industry’s approach to translational science (safety and efficacy) as evolved in recent years? • Setting exposure limits for PSLTs and Translational Toxicology. • Genotoxicity and Reproductive toxicity studies of PSLTs.
Book Synopsis Particles and Health 2021: an International Conference Addressing Issues in Science and Regulation by : Robert McCunney
Download or read book Particles and Health 2021: an International Conference Addressing Issues in Science and Regulation written by Robert McCunney and published by Frontiers Media SA. This book was released on 2023-01-30 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: Particles and Health is an international conference taking place in October 2021 addressing issues in science and regulation. Regulatory initiatives in the European Union (EU) have suggested uniform hazard classifications for all poorly soluble low toxicity particles (PSLTs). Examples of PSLTs include carbon black, titanium dioxide and iron oxide, among others. Approaches have also been proposed for setting workplace exposure limits for PSLTs such as those of the German MAK Commission. The conference will include specific sections over a two day period of about 25 presentations, associated with PSLTs regarding the following major topics: (1) human studies, (2) animal inhalation studies associated with lung cancer,(3) animal and human studies associated with non pulmonary impacts, including reproductive, genetic and cardiac effects, and (4) regulatory application of scientific studies. This conference will include presentations regarding: Definition of PSLT’s with attention to both similarities and differences among these substances. • Address scientific studies regarding human health effects of PSLTs. The value of human studies over animal studies-when human-exposed populations can be studied adequately- will be emphasized. • Address translational toxicology challenges, including the appropriateness of rats as models for human lung pathogenesis (particularly lung cancer) in light of lung overload phenomena and species differences. • Serve as a platform to present current scientific information about PSLTs important for regulatory action. • Publication of pertinent conference presentations in the peer reviewed scientific literature will allow the presentations to live beyond the conference and subsequently be reviewed part of regulatory deliberations. • Establish an interdisciplinary setting for industry, academia and regulatory professionals to interact on an important topic. Such interaction can facilitate enhanced understanding of the science and ideally, more appropriate regulations, appropriate classification and labeling as well as for setting exposure limits, among others. • Recommend areas for further clarifying research regarding the significance of the rat as a model for translation toxicology. The goal of this conference is to present current scientific evidence regarding the numerous dimensions of particles and health and to facilitate interaction and discussions among attendees with expertise in toxicology, epidemiology, occupational and pulmonary medicine and exposure assessment. Interactions between these disciplines will aid in the sound and evidence-based scientific underpinning of regulatory considerations regarding PSLTs. Although regulatory concern regarding PSLTs has focused on lung cancer risk as a result of rat inhalation overload studies, this conference will address all relevant health end points, including genetic and reproductive issues as well, consistent with ECHA guidelines. Sample of Topics related to substances that may be characterized as PSLTs, including carbon black, coal, titanium dioxide, cerium oxide, aluminum oxide barium sulfate and iron oxide, among others. • Defining PSLTs • Epidemiological studies of PSLTs • Inhalation studies evaluating human cellular response to particles • Basic research studies on inflammatory to malignancy pathways • Animal studies, PLSTs and human risk: “New Insights into old data.” • New studies on PSLTs; 2 year carcinogenicity assays • Animal studies and gender specific responses to PSLTs. How does the USA National Cancer Institute (NCI) and National Institute of Environmental Health Sciences (NIEHS) address this challenge of extrapolating rodent data to human risk assessment? • Role of the rodent model in human risk assessment of PSLTs and lung cancer risk • Adverse Outcome Pathways (AOPs) and Modes of Action (MOA): identification and recommendations for closing gaps in knowledge for rodents and humans. • Are there lessons to be learned from how the pharmaceutical industry’s approach to translational science (safety and efficacy) as evolved in recent years? • Setting exposure limits for PSLTs and Translational Toxicology. • Genotoxicity and Reproductive toxicity studies of PSLTs.
An excellent overview of industrial carbon and graphite materials, especially their manufacture, use and applications in industry. Following a short introduction, the main part of this reference deals with industrial forms, their raw materials, properties and manifold applications. Featuring chapters on carbon and graphite materials in energy application, and as catalysts. It covers all important classes of carbon and graphite, from polygranular materials to fullerenes, and from activated carbon to carbon blacks and nanoforms of carbon. Indispensable for chemists and engineers working in such fields as steel, aluminum, electrochemistry, nanotechnology, catalyst, carbon fibres and lightweight composites.
Book Synopsis Industrial Carbon and Graphite Materials by : Hubert Jaeger
Download or read book Industrial Carbon and Graphite Materials written by Hubert Jaeger and published by John Wiley & Sons. This book was released on 2021-06-28 with total page 1008 pages. Available in PDF, EPUB and Kindle. Book excerpt: An excellent overview of industrial carbon and graphite materials, especially their manufacture, use and applications in industry. Following a short introduction, the main part of this reference deals with industrial forms, their raw materials, properties and manifold applications. Featuring chapters on carbon and graphite materials in energy application, and as catalysts. It covers all important classes of carbon and graphite, from polygranular materials to fullerenes, and from activated carbon to carbon blacks and nanoforms of carbon. Indispensable for chemists and engineers working in such fields as steel, aluminum, electrochemistry, nanotechnology, catalyst, carbon fibres and lightweight composites.
Featuring the improved format used in the 5th edition, this updated set presents, in logical groupings, comprehensive toxicological data for industrial compounds, including CAS numbers, physical and chemical properties, exposure limits, and biological tolerance values for occupational exposures, making it essential for toxicologists and industrial hygienists. This edition has about 40% new authors who have brought a new and international perspective to interpreting industrial toxicology, and discusses new subjects such as nanotechnology, flavorings and the food industry, reactive chemical control to comprehensive chemical policy, metalworking fluids, and pharmaceuticals.
Book Synopsis Patty's Toxicology, 6 Volume Set by : Eula Bingham
Download or read book Patty's Toxicology, 6 Volume Set written by Eula Bingham and published by John Wiley & Sons. This book was released on 2012-07-31 with total page 5872 pages. Available in PDF, EPUB and Kindle. Book excerpt: Featuring the improved format used in the 5th edition, this updated set presents, in logical groupings, comprehensive toxicological data for industrial compounds, including CAS numbers, physical and chemical properties, exposure limits, and biological tolerance values for occupational exposures, making it essential for toxicologists and industrial hygienists. This edition has about 40% new authors who have brought a new and international perspective to interpreting industrial toxicology, and discusses new subjects such as nanotechnology, flavorings and the food industry, reactive chemical control to comprehensive chemical policy, metalworking fluids, and pharmaceuticals.
This Special Issue presents studies on the genotoxicity of nanomaterials. Although nanomaterials provide multiple benefits in a wide range of applications, challenges remain in addressing strong concerns about their risks to the environment and human health. As a result of inconsistencies among published results and diverging conclusions, the understanding of nanomaterial exposure and toxicity remains unclear. Determining whether these materials cause DNA damage—the first step in carcinogenesis—must be a priority in testing. In this book, readers will find recent publications on the genotoxic response to a broad range of nanomaterials, the impact of physico-chemical characteristics, safe-by-design and new developed tools.
Book Synopsis From Basic Research to New Tools and Challenges for the Genotoxicity Testing of Nanomaterials by : Valérie Fessard
Download or read book From Basic Research to New Tools and Challenges for the Genotoxicity Testing of Nanomaterials written by Valérie Fessard and published by MDPI. This book was released on 2021-03-24 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Special Issue presents studies on the genotoxicity of nanomaterials. Although nanomaterials provide multiple benefits in a wide range of applications, challenges remain in addressing strong concerns about their risks to the environment and human health. As a result of inconsistencies among published results and diverging conclusions, the understanding of nanomaterial exposure and toxicity remains unclear. Determining whether these materials cause DNA damage—the first step in carcinogenesis—must be a priority in testing. In this book, readers will find recent publications on the genotoxic response to a broad range of nanomaterials, the impact of physico-chemical characteristics, safe-by-design and new developed tools.
Handbook of Nanosafety: Measurement, Exposure and Toxicology, written by leading international experts in nanosafety, provides a comprehensive understanding of engineered nanomaterials (ENM), current international nanosafety regulation, and how ENM can be safely handled in the workplace. Increasingly, the importance of safety needs to be considered when promoting the use of novel technologies like ENM. With its use of case studies and exposure scenarios, Handbook of Nanosafety demonstrates techniques to assess exposure and risks and how these assessments can be applied to improve workers' safety. Topics covered include the effects of ENM on human health, characterization of ENM, aerosol dynamics and measurement, exposure and risk assessment, and safe handling of ENM. Based on outcomes from the NANODEVICE initiative, this is an essential resource for those who need to apply current nanotoxicological thinking in the workplace and anyone who advises on nanosafety, such as professionals in toxicology, occupational safety and risk assessment. Multi-authored book, written by leading researchers in the field of nanotoxicology and nanosafety Features state-of-the-art physical and chemical characterization of engineered nanomaterials (ENM) Develops strategies for exposure assessment, risk assessment and risk management Includes practical case studies and exposure scenarios to demonstrate how you can safely use ENM in the workplace
Book Synopsis Handbook of Nanosafety by : Ulla Vogel
Download or read book Handbook of Nanosafety written by Ulla Vogel and published by Elsevier. This book was released on 2013-12-17 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Nanosafety: Measurement, Exposure and Toxicology, written by leading international experts in nanosafety, provides a comprehensive understanding of engineered nanomaterials (ENM), current international nanosafety regulation, and how ENM can be safely handled in the workplace. Increasingly, the importance of safety needs to be considered when promoting the use of novel technologies like ENM. With its use of case studies and exposure scenarios, Handbook of Nanosafety demonstrates techniques to assess exposure and risks and how these assessments can be applied to improve workers' safety. Topics covered include the effects of ENM on human health, characterization of ENM, aerosol dynamics and measurement, exposure and risk assessment, and safe handling of ENM. Based on outcomes from the NANODEVICE initiative, this is an essential resource for those who need to apply current nanotoxicological thinking in the workplace and anyone who advises on nanosafety, such as professionals in toxicology, occupational safety and risk assessment. Multi-authored book, written by leading researchers in the field of nanotoxicology and nanosafety Features state-of-the-art physical and chemical characterization of engineered nanomaterials (ENM) Develops strategies for exposure assessment, risk assessment and risk management Includes practical case studies and exposure scenarios to demonstrate how you can safely use ENM in the workplace
As the application of nanotechnology in the myriad disciplines of science and engineering--from agriculture, pharmaceuticals, material science, and biotechnology to sensors, electronics, and mechanical and electrical engineering--brings benefits it also can produce serious threats to human health and the environment that must be evaluated. The unique properties of nanomaterials make them different from their bulk counterparts. In addition to such unique properties, the nanometric size of nanomaterials can invite some detrimental effects on the health and well-being of living organisms and the environment. Thus, it is important to distinguish nanomaterials with such ill effects from nanomaterials with no or minimum toxicity. Nanotoxicology: Toxicity Evaluation, Risk Assessment and Management covers issues such as the basic principles of nanotoxicity, methods used for nanotoxicity evaluation, risk assessment and its management for nanomaterial toxicity with a focus on current trends, limitations, challenges, and future directions of nanotoxicity evaluation. Various experts from different countries discuss these issues in detail in this book. This will be helpful to researchers, educators, and students who are interested in research opportunities for avoiding the environmental and health hazards of nanomaterials. This book will also be useful for industrial practitioners, policy makers, and other professionals in the fields of toxicology, medicine, pharmacology, food, drugs, and other regulatory sciences.
Book Synopsis Nanotoxicology by : Vineet Kumar
Download or read book Nanotoxicology written by Vineet Kumar and published by CRC Press. This book was released on 2018-03-12 with total page 654 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the application of nanotechnology in the myriad disciplines of science and engineering--from agriculture, pharmaceuticals, material science, and biotechnology to sensors, electronics, and mechanical and electrical engineering--brings benefits it also can produce serious threats to human health and the environment that must be evaluated. The unique properties of nanomaterials make them different from their bulk counterparts. In addition to such unique properties, the nanometric size of nanomaterials can invite some detrimental effects on the health and well-being of living organisms and the environment. Thus, it is important to distinguish nanomaterials with such ill effects from nanomaterials with no or minimum toxicity. Nanotoxicology: Toxicity Evaluation, Risk Assessment and Management covers issues such as the basic principles of nanotoxicity, methods used for nanotoxicity evaluation, risk assessment and its management for nanomaterial toxicity with a focus on current trends, limitations, challenges, and future directions of nanotoxicity evaluation. Various experts from different countries discuss these issues in detail in this book. This will be helpful to researchers, educators, and students who are interested in research opportunities for avoiding the environmental and health hazards of nanomaterials. This book will also be useful for industrial practitioners, policy makers, and other professionals in the fields of toxicology, medicine, pharmacology, food, drugs, and other regulatory sciences.
An overview of biomedical applications and the toxicity properties of carbon nanomaterials aimed at helping to avoid detrimental health effects while laying the groundwork for further research in this highly relevant field. Summarizing recent research, the book starts with the synthesis and functionalization of carbon nanomaterials, as well as identification and detection in biosystems. It then moves on to the interaction between carbon nanoparticles and biocomponents, focusing on the toxicity and mechanisms to various organs and systems and potential biomedical applications as well. Each section highlights the challenges, outlines unanswered questions, and suggests directions for further research and development efforts.
Book Synopsis Biomedical Applications and Toxicology of Carbon Nanomaterials by : Chunying Chen
Download or read book Biomedical Applications and Toxicology of Carbon Nanomaterials written by Chunying Chen and published by John Wiley & Sons. This book was released on 2016-04-01 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of biomedical applications and the toxicity properties of carbon nanomaterials aimed at helping to avoid detrimental health effects while laying the groundwork for further research in this highly relevant field. Summarizing recent research, the book starts with the synthesis and functionalization of carbon nanomaterials, as well as identification and detection in biosystems. It then moves on to the interaction between carbon nanoparticles and biocomponents, focusing on the toxicity and mechanisms to various organs and systems and potential biomedical applications as well. Each section highlights the challenges, outlines unanswered questions, and suggests directions for further research and development efforts.
