Cardiac Energetics

Cardiac Energetics

Author: R. Jacob

Publisher: Springer Science & Business Media

Published: 2013-04-17

Total Pages: 410

ISBN-13: 3662112892

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Assessment of cardiac energetics at the level of ATP-synthesis, chemomechanical energy transformation and whole organ dynamics as a function of haemodynamic load, ventricular configuration and oxygen- and substrates supply is basic to understanding cardiac function under physiological and pathophysiological (hypertrophy, hypoxia, ischaemia and heart failure) conditions. Moreover, cardiac energetics should be an important consideration in the choice and application of drugs especially in the case of vasodilators, inotropic agents and in cardioprotective measures. Only by considering energetics at the subcellular, cellular, and whole-heart level we can arrive at a better understanding of cardiac performance and ultimately better clinical judgement and drug therapy. Quantification of myocardial energetics will also help to determine the optimal time for surgical interventions such as valvular replacement or aneurysm resection. The present volume is the outcome of an international symposium on cardiac energetics held in Gargellen/Montafon (Austria), June 1986. The contributions will certainly help bridge the existing gap between basic research involving isolated structures and that involving the whole organ, on the one hand, and render the results derived from basic research applicable to clinical problems, on the other hand.


Book Synopsis Cardiac Energetics by : R. Jacob

Download or read book Cardiac Energetics written by R. Jacob and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assessment of cardiac energetics at the level of ATP-synthesis, chemomechanical energy transformation and whole organ dynamics as a function of haemodynamic load, ventricular configuration and oxygen- and substrates supply is basic to understanding cardiac function under physiological and pathophysiological (hypertrophy, hypoxia, ischaemia and heart failure) conditions. Moreover, cardiac energetics should be an important consideration in the choice and application of drugs especially in the case of vasodilators, inotropic agents and in cardioprotective measures. Only by considering energetics at the subcellular, cellular, and whole-heart level we can arrive at a better understanding of cardiac performance and ultimately better clinical judgement and drug therapy. Quantification of myocardial energetics will also help to determine the optimal time for surgical interventions such as valvular replacement or aneurysm resection. The present volume is the outcome of an international symposium on cardiac energetics held in Gargellen/Montafon (Austria), June 1986. The contributions will certainly help bridge the existing gap between basic research involving isolated structures and that involving the whole organ, on the one hand, and render the results derived from basic research applicable to clinical problems, on the other hand.

Cardiac Energetics: From Emax to Pressure-Volume Area

Cardiac Energetics: From Emax to Pressure-Volume Area

Author: Martin M. LeWinter

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 291

ISBN-13: 1461520215

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Most of the progress in cardiac energetics in recent years has been spurred by the pressure-volume area concept, the natural extension into energetics of earlier pioneering work delineating the time-varying elastance framework for ventricular contraction. The book draws together a broad spectrum of researchers - basic, applied and clinical - having a shared interest in the energetics of cardiac muscle and ventricle, providing an overview of the current state of the art.


Book Synopsis Cardiac Energetics: From Emax to Pressure-Volume Area by : Martin M. LeWinter

Download or read book Cardiac Energetics: From Emax to Pressure-Volume Area written by Martin M. LeWinter and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most of the progress in cardiac energetics in recent years has been spurred by the pressure-volume area concept, the natural extension into energetics of earlier pioneering work delineating the time-varying elastance framework for ventricular contraction. The book draws together a broad spectrum of researchers - basic, applied and clinical - having a shared interest in the energetics of cardiac muscle and ventricle, providing an overview of the current state of the art.

Cardiac Energetics

Cardiac Energetics

Author: Robert Jacob

Publisher: Springer

Published: 1987-01-01

Total Pages: 425

ISBN-13: 9783798507340

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Book Synopsis Cardiac Energetics by : Robert Jacob

Download or read book Cardiac Energetics written by Robert Jacob and published by Springer. This book was released on 1987-01-01 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cardiac Energetics

Cardiac Energetics

Author: Robert Jacob

Publisher: Springer Verlag

Published: 1987

Total Pages: 425

ISBN-13: 9780387912943

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Book Synopsis Cardiac Energetics by : Robert Jacob

Download or read book Cardiac Energetics written by Robert Jacob and published by Springer Verlag. This book was released on 1987 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cardiac Energy Metabolism in Health and Disease

Cardiac Energy Metabolism in Health and Disease

Author: Gary D. Lopaschuk

Publisher: Springer

Published: 2014-08-22

Total Pages: 301

ISBN-13: 1493912275

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The heart has a very high energy demand but very little energy reserves. In order to sustain contractile function, the heart has to continually produce a large amount of ATP. The heart utilizes free fatty acids mainly and carbohydrates to some extent as substrates for making energy and any change in this energy supply can seriously compromise cardiac function. It has emerged that alterations in cardiac energy metabolism are a major contributor to the development of a number of different forms of heart disease. It is also now known that optimizing energy metabolism in the heart is a viable and important approach to treating various forms of heart disease. Cardiac Energy Metabolism in Health and Disease describes the research advances that have been made in understanding what controls cardiac energy metabolism at molecular, transcriptional and physiological levels. It also describes how alterations in energy metabolism contribute to the development of heart dysfunction and how optimization of energy metabolism can be used to treat heart disease. The topics covered include a discussion of the effects of myocardial ischemia, diabetes, obesity, hypertrophy, heart failure, and genetic disorders of mitochondrial oxidative metabolism on cardiac energetics. The treatment of heart disease by optimizing energy metabolism is also discussed, which includes increasing overall energy production as well as increasing the efficiency of energy production and switching energy substrate preference of the heart. This book will be a valuable source of information to graduate students, postdoctoral fellows, and investigators in the field of experimental cardiology as well as biochemists, physiologists, pharmacologists, cardiologists, cardiovascular surgeons and other health professionals.


Book Synopsis Cardiac Energy Metabolism in Health and Disease by : Gary D. Lopaschuk

Download or read book Cardiac Energy Metabolism in Health and Disease written by Gary D. Lopaschuk and published by Springer. This book was released on 2014-08-22 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: The heart has a very high energy demand but very little energy reserves. In order to sustain contractile function, the heart has to continually produce a large amount of ATP. The heart utilizes free fatty acids mainly and carbohydrates to some extent as substrates for making energy and any change in this energy supply can seriously compromise cardiac function. It has emerged that alterations in cardiac energy metabolism are a major contributor to the development of a number of different forms of heart disease. It is also now known that optimizing energy metabolism in the heart is a viable and important approach to treating various forms of heart disease. Cardiac Energy Metabolism in Health and Disease describes the research advances that have been made in understanding what controls cardiac energy metabolism at molecular, transcriptional and physiological levels. It also describes how alterations in energy metabolism contribute to the development of heart dysfunction and how optimization of energy metabolism can be used to treat heart disease. The topics covered include a discussion of the effects of myocardial ischemia, diabetes, obesity, hypertrophy, heart failure, and genetic disorders of mitochondrial oxidative metabolism on cardiac energetics. The treatment of heart disease by optimizing energy metabolism is also discussed, which includes increasing overall energy production as well as increasing the efficiency of energy production and switching energy substrate preference of the heart. This book will be a valuable source of information to graduate students, postdoctoral fellows, and investigators in the field of experimental cardiology as well as biochemists, physiologists, pharmacologists, cardiologists, cardiovascular surgeons and other health professionals.

The Scientist's Guide to Cardiac Metabolism

The Scientist's Guide to Cardiac Metabolism

Author: Michael Schwarzer

Publisher: Academic Press

Published: 2015-11-04

Total Pages: 240

ISBN-13: 0128026146

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The Scientists Guide to Cardiac Metabolism combines the basic concepts of substrate metabolism, regulation, and interaction within the cell and the organism to provide a comprehensive introduction into the basics of cardiac metabolism. This important reference is the perfect tool for newcomers in cardiac metabolism, providing a basic understanding of the metabolic processes and enabling the newcomer to immediately communicate with the expert as substrate/energy metabolism becomes part of projects. The book is written by established experts in the field, bringing together all the concepts of cardiac metabolism, its regulation, and the impact of disease. Provides a quick and comprehensive introduction into cardiac metabolism Contains an integrated view on cardiac metabolism and its interrelation in metabolism with other organs Presents insights into substrate metabolism in relation to intracellular organization and structure as well as whole organ function Includes historical perspectives that reference important investigators that have contributed to the development of the field


Book Synopsis The Scientist's Guide to Cardiac Metabolism by : Michael Schwarzer

Download or read book The Scientist's Guide to Cardiac Metabolism written by Michael Schwarzer and published by Academic Press. This book was released on 2015-11-04 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Scientists Guide to Cardiac Metabolism combines the basic concepts of substrate metabolism, regulation, and interaction within the cell and the organism to provide a comprehensive introduction into the basics of cardiac metabolism. This important reference is the perfect tool for newcomers in cardiac metabolism, providing a basic understanding of the metabolic processes and enabling the newcomer to immediately communicate with the expert as substrate/energy metabolism becomes part of projects. The book is written by established experts in the field, bringing together all the concepts of cardiac metabolism, its regulation, and the impact of disease. Provides a quick and comprehensive introduction into cardiac metabolism Contains an integrated view on cardiac metabolism and its interrelation in metabolism with other organs Presents insights into substrate metabolism in relation to intracellular organization and structure as well as whole organ function Includes historical perspectives that reference important investigators that have contributed to the development of the field

Heart Perfusion, Energetics, and Ischemia

Heart Perfusion, Energetics, and Ischemia

Author: Leopold Dintenfass

Publisher: Springer Science & Business Media

Published: 2013-03-09

Total Pages: 697

ISBN-13: 1475703937

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The principal purpose of a NATO (North Atlantic Treaty Organization) Advanced Research Workshop, a part of the NATO Advanced Study Institutes Programme, is to: (a) exchange thoughts at the frontiers of knowledge or at the frontiers of two (or more) fields or sectors; (b) review and assess the state of the art; (c) formulate recommendations for future research directions; (d) formulate plans for large international scientific experiments. The aim of the ARW on "Microvascular, rheological, metabolic and heat-transfer aspects of the heart: relation to ischaemia and thrombosis", convened in Chateau de Bonas, July 4-11, 1982, was to describe functions and performance of the heart in an interdisciplin ary effort, involving cardiologists, pathologists, biochemists, haemorheologists, physiologists, pharmacologists and bioengineers; to explore interactions between such subfields as blood rheology, micro circulation and ischaemia of the myocardium, heat transfer, heat work and performance as a pump, effect of -metabolites and ion transfer, mechanism of sudden death, protein synthesis and protein molecular transformations. One of the purposes of the Convenor was to relate clinical haemorheology to the heart energetics and heart metabolism. This was only partly established, as difficulties of communications between different fields, difficulties of semantics and of specialized out looks could not be overcome within a -few days. Nevertheless, a gate was opened for communications interchange in the future. There was even a problem within each specialty, and as is rather common, quite diverse views have been expressed. This, of course, is quite normal in the progress of science.


Book Synopsis Heart Perfusion, Energetics, and Ischemia by : Leopold Dintenfass

Download or read book Heart Perfusion, Energetics, and Ischemia written by Leopold Dintenfass and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 697 pages. Available in PDF, EPUB and Kindle. Book excerpt: The principal purpose of a NATO (North Atlantic Treaty Organization) Advanced Research Workshop, a part of the NATO Advanced Study Institutes Programme, is to: (a) exchange thoughts at the frontiers of knowledge or at the frontiers of two (or more) fields or sectors; (b) review and assess the state of the art; (c) formulate recommendations for future research directions; (d) formulate plans for large international scientific experiments. The aim of the ARW on "Microvascular, rheological, metabolic and heat-transfer aspects of the heart: relation to ischaemia and thrombosis", convened in Chateau de Bonas, July 4-11, 1982, was to describe functions and performance of the heart in an interdisciplin ary effort, involving cardiologists, pathologists, biochemists, haemorheologists, physiologists, pharmacologists and bioengineers; to explore interactions between such subfields as blood rheology, micro circulation and ischaemia of the myocardium, heat transfer, heat work and performance as a pump, effect of -metabolites and ion transfer, mechanism of sudden death, protein synthesis and protein molecular transformations. One of the purposes of the Convenor was to relate clinical haemorheology to the heart energetics and heart metabolism. This was only partly established, as difficulties of communications between different fields, difficulties of semantics and of specialized out looks could not be overcome within a -few days. Nevertheless, a gate was opened for communications interchange in the future. There was even a problem within each specialty, and as is rather common, quite diverse views have been expressed. This, of course, is quite normal in the progress of science.

The Heart's Code

The Heart's Code

Author: Paul P. Pearsall

Publisher: Harmony

Published: 1999-03-10

Total Pages: 304

ISBN-13: 0767999428

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A fascinating synthesis of ancient wisdom, modern medicine, scientific research, and personal experiences that proves that the human heart, not the brain, holds the secrets that link body, mind, and spirit. You know that the heart loves and feels, but did you know that the heart also thinks, remembers, communicates with other hearts, helps regulate immunity, and contains stored information that continually pulses through your body? In The Heart's Code, Dr. Paul Pearsall explains the theory and science behind energy cardiology, the emerging field that is uncovering one of the most significant medical, social, and spiritual discoveries of our time: The heart is more than just a pump; it conducts the cellular symphony that is the very essence of our being. Full of amazing anecdotes and data, The Heart's Code presents the latest research on cellular memory and the power of the heart's energy and explores what these breakthroughs mean about how we should live our lives. By unlocking the heart's code we can discover new ways of understanding human healing and consciousness and create a new model for living that leads to better health, happiness, and self-knowledge.


Book Synopsis The Heart's Code by : Paul P. Pearsall

Download or read book The Heart's Code written by Paul P. Pearsall and published by Harmony. This book was released on 1999-03-10 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: A fascinating synthesis of ancient wisdom, modern medicine, scientific research, and personal experiences that proves that the human heart, not the brain, holds the secrets that link body, mind, and spirit. You know that the heart loves and feels, but did you know that the heart also thinks, remembers, communicates with other hearts, helps regulate immunity, and contains stored information that continually pulses through your body? In The Heart's Code, Dr. Paul Pearsall explains the theory and science behind energy cardiology, the emerging field that is uncovering one of the most significant medical, social, and spiritual discoveries of our time: The heart is more than just a pump; it conducts the cellular symphony that is the very essence of our being. Full of amazing anecdotes and data, The Heart's Code presents the latest research on cellular memory and the power of the heart's energy and explores what these breakthroughs mean about how we should live our lives. By unlocking the heart's code we can discover new ways of understanding human healing and consciousness and create a new model for living that leads to better health, happiness, and self-knowledge.

Novel Concepts in Cardiac Energy Metabolism: From Biology to Disease

Novel Concepts in Cardiac Energy Metabolism: From Biology to Disease

Author: Thomas Pulinilkunnil

Publisher: Frontiers Media SA

Published: 2019-08-08

Total Pages: 89

ISBN-13: 2889459381

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.


Book Synopsis Novel Concepts in Cardiac Energy Metabolism: From Biology to Disease by : Thomas Pulinilkunnil

Download or read book Novel Concepts in Cardiac Energy Metabolism: From Biology to Disease written by Thomas Pulinilkunnil and published by Frontiers Media SA. This book was released on 2019-08-08 with total page 89 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Inotropic Stimulation and Myocardial Energetics

Inotropic Stimulation and Myocardial Energetics

Author: H. Just

Publisher: Springer Science & Business Media

Published: 2013-03-14

Total Pages: 429

ISBN-13: 3662079089

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Inotropic stimulation of the myocardium, as well as vasodilation and diuresis as essential principles in the treatment of congestive heart failure have recently met with considerable criticism and reevaluation. It is generally agreed that unloading of the heart, either through vasodilation and/or diuresis, improves the working conditions of the dilated, failing heart. It reduces myocar dial oxygen consumption through reduction of chamber radius and, thereby, wall tension as the major determinants of myocardial oxygen consumption. Inotropic stimulation, quite in contrast, does not conserve oxygen. It rather consumes energy and that may be disadvantageous in situations of compromised oxygen supply and energy metabolism of the working myocardium. However, under conditions of suf ficient oxygen supply and metabolic support inotropic stimulation may bring about in creased pumping and subsequent improvement of myocardial failure. In recent years it could convincingly be demonstrated that vasodilation leads to symp tomatic improvement of congestive heart failure, improvement of exercise tolerance, and it prolongs life - especially in the case of ACE-inhibitors and the combination of hydra lazine with long-acting nitrates. Quite in contrast, equally beneficial effects could not be demonstrated for inotropic agents in congestive heart failure. Only for the cardiac glyco sides has it been shown that beneficial effects can be achieved, especially if atrial fibril lation with absolute arrhythmia is present. The influence of the cardiac glycosides on the latter represents an effect which is independent of the inotropic action.


Book Synopsis Inotropic Stimulation and Myocardial Energetics by : H. Just

Download or read book Inotropic Stimulation and Myocardial Energetics written by H. Just and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inotropic stimulation of the myocardium, as well as vasodilation and diuresis as essential principles in the treatment of congestive heart failure have recently met with considerable criticism and reevaluation. It is generally agreed that unloading of the heart, either through vasodilation and/or diuresis, improves the working conditions of the dilated, failing heart. It reduces myocar dial oxygen consumption through reduction of chamber radius and, thereby, wall tension as the major determinants of myocardial oxygen consumption. Inotropic stimulation, quite in contrast, does not conserve oxygen. It rather consumes energy and that may be disadvantageous in situations of compromised oxygen supply and energy metabolism of the working myocardium. However, under conditions of suf ficient oxygen supply and metabolic support inotropic stimulation may bring about in creased pumping and subsequent improvement of myocardial failure. In recent years it could convincingly be demonstrated that vasodilation leads to symp tomatic improvement of congestive heart failure, improvement of exercise tolerance, and it prolongs life - especially in the case of ACE-inhibitors and the combination of hydra lazine with long-acting nitrates. Quite in contrast, equally beneficial effects could not be demonstrated for inotropic agents in congestive heart failure. Only for the cardiac glyco sides has it been shown that beneficial effects can be achieved, especially if atrial fibril lation with absolute arrhythmia is present. The influence of the cardiac glycosides on the latter represents an effect which is independent of the inotropic action.