Cardiac Imaging in Electrophysiology

Cardiac Imaging in Electrophysiology

Author: Angelo Auricchio

Publisher: Springer Science & Business Media

Published: 2011-11-15

Total Pages: 332

ISBN-13: 1848824866

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Cardiac arrhythmias are a major cause of death (7 million cases annually worldwide; 400,000 in the U.S. alone) and disability. Yet, a noninvasive imaging modality to identify patients at risk, provide accurate diagnosis and guide therapy is not yet available in clinical practice. Nevertheless, there are various applications of electrophysiologic imaging in humans from ECG/CT reconstructions, MRI to tissue Doppler investigations that provide supplimentary diagnostic data to the cardiologist. EP laboratories are experiencing an increase in volume, for both diagnostic and interventional electrophysiology studies, including mapping, ablation, and pacemaker implants. The equipment requirements for these procedures are stringent, include positioning capabilities, and dose management. This book is designed to review all of the current imaging methodologies that assist in diagnosis within the electrophysiology department.


Book Synopsis Cardiac Imaging in Electrophysiology by : Angelo Auricchio

Download or read book Cardiac Imaging in Electrophysiology written by Angelo Auricchio and published by Springer Science & Business Media. This book was released on 2011-11-15 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac arrhythmias are a major cause of death (7 million cases annually worldwide; 400,000 in the U.S. alone) and disability. Yet, a noninvasive imaging modality to identify patients at risk, provide accurate diagnosis and guide therapy is not yet available in clinical practice. Nevertheless, there are various applications of electrophysiologic imaging in humans from ECG/CT reconstructions, MRI to tissue Doppler investigations that provide supplimentary diagnostic data to the cardiologist. EP laboratories are experiencing an increase in volume, for both diagnostic and interventional electrophysiology studies, including mapping, ablation, and pacemaker implants. The equipment requirements for these procedures are stringent, include positioning capabilities, and dose management. This book is designed to review all of the current imaging methodologies that assist in diagnosis within the electrophysiology department.

Interventional Cardiac Electrophysiology

Interventional Cardiac Electrophysiology

Author: Ralph J. Damiano, Jr., MD, FACC, FACS

Publisher: Cardiotext Publishing

Published: 2015-05-15

Total Pages: 1046

ISBN-13: 193539584X

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Interventional Cardiac Electrophysiology is the first and only comprehensive, state-of-the-art textbook written for practitioners in multiple specialties involved in the care of the arrhythmia patient. Encompassing the entire field of interventional therapy for cardiac rhythm management, from basic science to evidence-based medicine to future directions, topics include: Technology and Therapeutic Techniques – EP techniques; imaging and radiologic technology; device and ablation technology; drug therapy.Interventional Electrophysiologic Procedures – Diagnostic and physiologic EP techniques; mapping in percutaneous catheter and surgical EP procedures; catheter and surgical ablation; device implantation and management.Clinical Indications and Evidence-based Outcomes Standards – For medical and surgical EP interventions for arrhythmias.New Directions in Interventional Electrophysiology – Hybrid therapy for atrial and ventricular arrhythmias and staged therapy. This book will be essential reading for clinicians and researchers that form the health care team for arrhythmia patients: cardiologists, adult and pediatric clinical electrophysiologists, interventional electrophysiologists, cardiac surgeons practicing arrhythmia surgery, allied health care professionals, pharmacologists, radiologists and anesthesiologists evaluating arrhythmia patients, and basic scientists from the biomedical engineering and experimental physiology disciplines. Professor Sanjeev Saksena has been involved in this arena for over three decades and has brought his experience to this textbook, assembling editorial leadership from medical and surgical cardiology to provide a global perspective on fundamentals of medical practice, evidence-based therapeutic practices, and emerging research in this field. This book includes 95 videos.


Book Synopsis Interventional Cardiac Electrophysiology by : Ralph J. Damiano, Jr., MD, FACC, FACS

Download or read book Interventional Cardiac Electrophysiology written by Ralph J. Damiano, Jr., MD, FACC, FACS and published by Cardiotext Publishing. This book was released on 2015-05-15 with total page 1046 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interventional Cardiac Electrophysiology is the first and only comprehensive, state-of-the-art textbook written for practitioners in multiple specialties involved in the care of the arrhythmia patient. Encompassing the entire field of interventional therapy for cardiac rhythm management, from basic science to evidence-based medicine to future directions, topics include: Technology and Therapeutic Techniques – EP techniques; imaging and radiologic technology; device and ablation technology; drug therapy.Interventional Electrophysiologic Procedures – Diagnostic and physiologic EP techniques; mapping in percutaneous catheter and surgical EP procedures; catheter and surgical ablation; device implantation and management.Clinical Indications and Evidence-based Outcomes Standards – For medical and surgical EP interventions for arrhythmias.New Directions in Interventional Electrophysiology – Hybrid therapy for atrial and ventricular arrhythmias and staged therapy. This book will be essential reading for clinicians and researchers that form the health care team for arrhythmia patients: cardiologists, adult and pediatric clinical electrophysiologists, interventional electrophysiologists, cardiac surgeons practicing arrhythmia surgery, allied health care professionals, pharmacologists, radiologists and anesthesiologists evaluating arrhythmia patients, and basic scientists from the biomedical engineering and experimental physiology disciplines. Professor Sanjeev Saksena has been involved in this arena for over three decades and has brought his experience to this textbook, assembling editorial leadership from medical and surgical cardiology to provide a global perspective on fundamentals of medical practice, evidence-based therapeutic practices, and emerging research in this field. This book includes 95 videos.

Electrocardiographic Imaging

Electrocardiographic Imaging

Author: Maria S. Guillem

Publisher: Frontiers Media SA

Published: 2020-04-17

Total Pages: 178

ISBN-13: 2889636712

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Electrical activity in the myocardium coordinates the contraction of the heart, and its knowledge could lead to a better understanding, diagnosis, and treatment of cardiac diseases. This electrical activity generates an electromagnetic field that propagates outside the heart and reaches the human torso surface, where it can be easily measured. Classical electrocardiography aims to interpret the 12-lead electrocardiogram (ECG) to determine cardiac activity and support the diagnosis of cardiac pathologies such as arrhythmias, altered activations, and ischemia. More recently, a higher number of leads is used to reconstruct a more detailed quantitative description of the electrical activity in the heart by solving the so-called inverse problem of electrocardiography. This technique is known as ECG imaging. Today, clinical applications of ECG imaging are showing promising results in guiding a variety of electrophysiological interventions such as catheter ablation of atrial fibrillation and ventricular tachycardia. However, in order to promote the adoption of ECG imaging in the routine clinical practice, further research is required regarding more accurate mathematical methods, further scientific validation under different preclinical scenarios and a more extensive clinical validation


Book Synopsis Electrocardiographic Imaging by : Maria S. Guillem

Download or read book Electrocardiographic Imaging written by Maria S. Guillem and published by Frontiers Media SA. This book was released on 2020-04-17 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: Electrical activity in the myocardium coordinates the contraction of the heart, and its knowledge could lead to a better understanding, diagnosis, and treatment of cardiac diseases. This electrical activity generates an electromagnetic field that propagates outside the heart and reaches the human torso surface, where it can be easily measured. Classical electrocardiography aims to interpret the 12-lead electrocardiogram (ECG) to determine cardiac activity and support the diagnosis of cardiac pathologies such as arrhythmias, altered activations, and ischemia. More recently, a higher number of leads is used to reconstruct a more detailed quantitative description of the electrical activity in the heart by solving the so-called inverse problem of electrocardiography. This technique is known as ECG imaging. Today, clinical applications of ECG imaging are showing promising results in guiding a variety of electrophysiological interventions such as catheter ablation of atrial fibrillation and ventricular tachycardia. However, in order to promote the adoption of ECG imaging in the routine clinical practice, further research is required regarding more accurate mathematical methods, further scientific validation under different preclinical scenarios and a more extensive clinical validation

Echocardiography in Heart Failure and Cardiac Electrophysiology

Echocardiography in Heart Failure and Cardiac Electrophysiology

Author: Umashankar Lakshmanadoss

Publisher: BoD – Books on Demand

Published: 2016-10-19

Total Pages: 220

ISBN-13: 9535127381

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The world of echocardiography continues to be full of exciting new technological developments with an ultimate goal of better patient care. In this book, titled "Echocardiography in Heart Failure and Cardiac Electrophysiology", authors from various parts of the world contributed to the advancement of the field. We have included various chapters about the use of echocardiography and modalities of imaging in various common clinical scenarios - ranging from evaluation of commonly ignored right ventricle, imaging in congestive heart failure, to echocardiographic evaluation of critically ill patients. We have also included topics describing the use of echocardiography in cardiac electrophysiology with special interest to cardiac resynchronization therapy and atrial fibrillation ablation. These topics would be of great interest to the clinicians whether they are trainees, physicians, advanced care providers, or anyone involved in the patient care.


Book Synopsis Echocardiography in Heart Failure and Cardiac Electrophysiology by : Umashankar Lakshmanadoss

Download or read book Echocardiography in Heart Failure and Cardiac Electrophysiology written by Umashankar Lakshmanadoss and published by BoD – Books on Demand. This book was released on 2016-10-19 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world of echocardiography continues to be full of exciting new technological developments with an ultimate goal of better patient care. In this book, titled "Echocardiography in Heart Failure and Cardiac Electrophysiology", authors from various parts of the world contributed to the advancement of the field. We have included various chapters about the use of echocardiography and modalities of imaging in various common clinical scenarios - ranging from evaluation of commonly ignored right ventricle, imaging in congestive heart failure, to echocardiographic evaluation of critically ill patients. We have also included topics describing the use of echocardiography in cardiac electrophysiology with special interest to cardiac resynchronization therapy and atrial fibrillation ablation. These topics would be of great interest to the clinicians whether they are trainees, physicians, advanced care providers, or anyone involved in the patient care.

The ESC Textbook of Cardiovascular Imaging

The ESC Textbook of Cardiovascular Imaging

Author: Jose Luis Zamorano

Publisher: OUP Oxford

Published: 2015-03-26

Total Pages: 661

ISBN-13: 0191008435

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A definitive resource, The ESC Textbook of Cardiovascular Imaging, second edition provides extensive coverage of all cardiovascular imaging modalities. Produced in collaboration with the European Association of Cardiovascular Imaging with contributions from specialists across the globe and edited by a distinguished team of experts, it is a 'state of the art' clinically-orientated imaging reference. Now fully revised and updated with the latest imaging techniques and technology and covering even more conditions than before, it not only discusses the principles of individual modalities but also clearly demonstrates the added value each technique can bring to the treatment of all cardiac diseases. Richly illustrated with colour figures, images, and tables and using a wealth of newly available evidence to link theory to practice, it demonstrates how these techniques can be used in the diagnosis of a range of cardiovascular diseases. Learning how to apply them in practice is made easy with free access to videos and imaging loops online along with the full text so that it is always available, even when on the move. Impressive in scope, The ESC Textbook of Cardiovascular Imaging contains information on cutting-edge technical developments in echocardiography, CT, CMR and hybrid imaging and well imaging's current role in cardiac interventions, such as identifying cardiac structures, helping to guide procedures and exclude possible complications. The application of imaging modalities in conditions such as valvular and coronary heart disease, heart failure, cardiomyopathies, peri-myocardioal disease, adult congenital heart disease and aortic disease, is also extensively considered. From discussion on improved imaging techniques and advances in technology, to guidance and explanation of key practices and theories, this new edition of The ESC Textbook of Cardiovascular Imaging is the ideal reference guide for cardiologists and radiologists alike. This print edition of The ESC Textbook of Cardiovascular Imaging comes with access to the online version on Oxford Medicine Online, for as long as the edition is published by Oxford University Press. By activating your unique access code, you can read and annotate the full text online, follow links from the references to primary research materials, and view, enlarge and download all the figures and tables.


Book Synopsis The ESC Textbook of Cardiovascular Imaging by : Jose Luis Zamorano

Download or read book The ESC Textbook of Cardiovascular Imaging written by Jose Luis Zamorano and published by OUP Oxford. This book was released on 2015-03-26 with total page 661 pages. Available in PDF, EPUB and Kindle. Book excerpt: A definitive resource, The ESC Textbook of Cardiovascular Imaging, second edition provides extensive coverage of all cardiovascular imaging modalities. Produced in collaboration with the European Association of Cardiovascular Imaging with contributions from specialists across the globe and edited by a distinguished team of experts, it is a 'state of the art' clinically-orientated imaging reference. Now fully revised and updated with the latest imaging techniques and technology and covering even more conditions than before, it not only discusses the principles of individual modalities but also clearly demonstrates the added value each technique can bring to the treatment of all cardiac diseases. Richly illustrated with colour figures, images, and tables and using a wealth of newly available evidence to link theory to practice, it demonstrates how these techniques can be used in the diagnosis of a range of cardiovascular diseases. Learning how to apply them in practice is made easy with free access to videos and imaging loops online along with the full text so that it is always available, even when on the move. Impressive in scope, The ESC Textbook of Cardiovascular Imaging contains information on cutting-edge technical developments in echocardiography, CT, CMR and hybrid imaging and well imaging's current role in cardiac interventions, such as identifying cardiac structures, helping to guide procedures and exclude possible complications. The application of imaging modalities in conditions such as valvular and coronary heart disease, heart failure, cardiomyopathies, peri-myocardioal disease, adult congenital heart disease and aortic disease, is also extensively considered. From discussion on improved imaging techniques and advances in technology, to guidance and explanation of key practices and theories, this new edition of The ESC Textbook of Cardiovascular Imaging is the ideal reference guide for cardiologists and radiologists alike. This print edition of The ESC Textbook of Cardiovascular Imaging comes with access to the online version on Oxford Medicine Online, for as long as the edition is published by Oxford University Press. By activating your unique access code, you can read and annotate the full text online, follow links from the references to primary research materials, and view, enlarge and download all the figures and tables.

Practical Intracardiac Echocardiography in Electrophysiology

Practical Intracardiac Echocardiography in Electrophysiology

Author: Jian-Fang Ren

Publisher: John Wiley & Sons

Published: 2008-04-15

Total Pages: 256

ISBN-13: 0470994967

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Tremendous advances in intracardiac echocardiography (ICE) have coincided with the evolution of interventional electrophysiology. This book is designed to provide both the electrophysiologist and echocardiographer with an in-depth view of the role and value of ICE during electrophysiologic procedures. A guide to techniques used for optimal ICE imaging in cardiac electrophysiology is provided. In addition, new and less-recognized uses of ICE in electrophysiological procedures are described and their clinical applications are presented. Illustrated with over 500 images, many of which are in color, the book can also be used as a practical atlas. Readers need not be experts in the field of echocardiography to benefit from this practical approach to intracardiac imaging in electrophysiology.


Book Synopsis Practical Intracardiac Echocardiography in Electrophysiology by : Jian-Fang Ren

Download or read book Practical Intracardiac Echocardiography in Electrophysiology written by Jian-Fang Ren and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tremendous advances in intracardiac echocardiography (ICE) have coincided with the evolution of interventional electrophysiology. This book is designed to provide both the electrophysiologist and echocardiographer with an in-depth view of the role and value of ICE during electrophysiologic procedures. A guide to techniques used for optimal ICE imaging in cardiac electrophysiology is provided. In addition, new and less-recognized uses of ICE in electrophysiological procedures are described and their clinical applications are presented. Illustrated with over 500 images, many of which are in color, the book can also be used as a practical atlas. Readers need not be experts in the field of echocardiography to benefit from this practical approach to intracardiac imaging in electrophysiology.

Anatomy for Cardiac Electrophysiologists: A Practical Handbook

Anatomy for Cardiac Electrophysiologists: A Practical Handbook

Author: S. Yen Ho

Publisher: Cardiotext Publishing

Published: 2012-08

Total Pages: 270

ISBN-13: 193539567X

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This highly visual handbook integrates cardiac anatomy and the state-of-the-art imaging techniques used in today's catheter or electrophysiology laboratory, guiding readers to a comprehensive understanding of both normal cardiac anatomy and the structures associated with complex heart disease. Well organized, easily navigable, and superbly illustrated in a landscape format, this unique text invites the reader on a visual intracardiac journey via stunning images and schematic illustrations, including such imaging modalities as computed tomography, magnetic resonance imaging, ultrasound, radiogra.


Book Synopsis Anatomy for Cardiac Electrophysiologists: A Practical Handbook by : S. Yen Ho

Download or read book Anatomy for Cardiac Electrophysiologists: A Practical Handbook written by S. Yen Ho and published by Cardiotext Publishing. This book was released on 2012-08 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: This highly visual handbook integrates cardiac anatomy and the state-of-the-art imaging techniques used in today's catheter or electrophysiology laboratory, guiding readers to a comprehensive understanding of both normal cardiac anatomy and the structures associated with complex heart disease. Well organized, easily navigable, and superbly illustrated in a landscape format, this unique text invites the reader on a visual intracardiac journey via stunning images and schematic illustrations, including such imaging modalities as computed tomography, magnetic resonance imaging, ultrasound, radiogra.

Cardiac MRI: Guide Book on the Go

Cardiac MRI: Guide Book on the Go

Author: Robert W. Biederman

Publisher: Lippincott Williams & Wilkins

Published: 2011-11-30

Total Pages: 160

ISBN-13: 1451161255

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This pictorial instructional pocket guide, derived from Cardiovascular MRI Tutorial, is a quick reference for MRI technologists, technologist trainees, and radiology or cardiology residents or fellows. Routine cardiac imaging protocols are presented in step-by-step fashion for immediate reference during an MRI examination. Each chapter displays a specific protocol from start to finish, including positioning, anatomy, and sequence terminology, with easy-to-follow illustrative images. Coverage includes protocols for cardiac function; cardiac function/viability; cardiac function/non-ischemic viability; arch; arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C); pulmonary vein electrophysiology (EP) ablation; constrictive pericarditis; atrial or ventricular septal defect (ASD or VSD); anomalous coronaries; and cardiac thalassemia.


Book Synopsis Cardiac MRI: Guide Book on the Go by : Robert W. Biederman

Download or read book Cardiac MRI: Guide Book on the Go written by Robert W. Biederman and published by Lippincott Williams & Wilkins. This book was released on 2011-11-30 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: This pictorial instructional pocket guide, derived from Cardiovascular MRI Tutorial, is a quick reference for MRI technologists, technologist trainees, and radiology or cardiology residents or fellows. Routine cardiac imaging protocols are presented in step-by-step fashion for immediate reference during an MRI examination. Each chapter displays a specific protocol from start to finish, including positioning, anatomy, and sequence terminology, with easy-to-follow illustrative images. Coverage includes protocols for cardiac function; cardiac function/viability; cardiac function/non-ischemic viability; arch; arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C); pulmonary vein electrophysiology (EP) ablation; constrictive pericarditis; atrial or ventricular septal defect (ASD or VSD); anomalous coronaries; and cardiac thalassemia.

Cardiac MRI in Diagnosis, Clinical Management, and Prognosis of Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia

Cardiac MRI in Diagnosis, Clinical Management, and Prognosis of Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia

Author: Aiden Abidov

Publisher: Academic Press

Published: 2016-03-18

Total Pages: 212

ISBN-13: 0128014350

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Cardiac MRI in Diagnosis, Clinical Management and Prognosis of Arrhythmogenic Right Ventricular Cardiomyopathy / Dysplasia provides up-to-date information regarding the most effective diagnostic protocols and CMR sequences for the evaluation of patients with suspected or known ARVC/D. It includes CMR protocol summaries and clinical algorithms presented as flow diagrams, many of which have never been previously published. The book contains case reports from the practice and database of Dr. Frank I. Marcus, world renowned ARVC/D expert; as well as input from imaging experts from a large academic center with unique RV pathology imaging experience. This title is the perfect pocket companion for cardiologists, pediatric cardiologists, cardiac imaging and electrophysiology specialists as well as cardiology researchers. The only comprehensive MRI reference focused and dedicated on the utilization of MRI in screening, diagnosis, therapeutic guidance and prognostic assessment of ARVC/D. Provides evidence based diagnostic and prognostic algorithms for management of patients with known and suspected ARVC/D. Contains concise clinical CMR acquisition protocol and evidence-based summaries of recommendations and multiple practical tips and tricks shared by experts in the field. Includes practical guidelines helping to determine pre-test and post-test likelihood of ARVC/D; as well as CMR evidence of the disease progression. Accompanying website provides complementary videos important for the understanding of ARVC diagnosis.


Book Synopsis Cardiac MRI in Diagnosis, Clinical Management, and Prognosis of Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia by : Aiden Abidov

Download or read book Cardiac MRI in Diagnosis, Clinical Management, and Prognosis of Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia written by Aiden Abidov and published by Academic Press. This book was released on 2016-03-18 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac MRI in Diagnosis, Clinical Management and Prognosis of Arrhythmogenic Right Ventricular Cardiomyopathy / Dysplasia provides up-to-date information regarding the most effective diagnostic protocols and CMR sequences for the evaluation of patients with suspected or known ARVC/D. It includes CMR protocol summaries and clinical algorithms presented as flow diagrams, many of which have never been previously published. The book contains case reports from the practice and database of Dr. Frank I. Marcus, world renowned ARVC/D expert; as well as input from imaging experts from a large academic center with unique RV pathology imaging experience. This title is the perfect pocket companion for cardiologists, pediatric cardiologists, cardiac imaging and electrophysiology specialists as well as cardiology researchers. The only comprehensive MRI reference focused and dedicated on the utilization of MRI in screening, diagnosis, therapeutic guidance and prognostic assessment of ARVC/D. Provides evidence based diagnostic and prognostic algorithms for management of patients with known and suspected ARVC/D. Contains concise clinical CMR acquisition protocol and evidence-based summaries of recommendations and multiple practical tips and tricks shared by experts in the field. Includes practical guidelines helping to determine pre-test and post-test likelihood of ARVC/D; as well as CMR evidence of the disease progression. Accompanying website provides complementary videos important for the understanding of ARVC diagnosis.

Cardiac Electrophysiology Methods and Models

Cardiac Electrophysiology Methods and Models

Author: Daniel C. Sigg

Publisher: Springer Science & Business Media

Published: 2010-09-11

Total Pages: 490

ISBN-13: 1441966587

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Cardiovascular disease is the major cause of mortality and morbidity in the Western Hemisphere. While significant progress has been made in treating a major sub-category of cardiac disease, arrhythmias, significant unmet needs remain. In particular, every day, thousands of patients die because of arrhythmias in the US alone, and atrial fibrillation is the most common arrhythmia affecting millions of patients in the US alone at a given time. Therefore, there is a public need to continue to develop new and better therapies for arrhythmias. Accordingly, an ever increasing number of biomedical, pharmaceutical, and medical personnel is interested in studying various aspects of arrhythmias at a basic, translational, and applied level, both in industry (ie Biotech, Pharmaceutical and device), and in academia. Not only has our overall understanding of molecular bases of disease dramatically increased, but so has the number of available and emerging molecular, pharmacological or device treatment based therapies. This practical, state-of-the art handbook will summarize and review key research methods and protocols, their advantages and pitfalls, with a focus on practical implementation, and collaborative cross-functional research. The volume will include visual and easy-to-use graphics, bulleted summaries, boxed summary paragraphs, links to reference websites, equipment manufacturers where appropriate, photographs of typical experimental setups and so forth, to keep this book very focused on practical methods and implementation, and yet, provide enough theory that the principles are clearly understood and can be easily applied.


Book Synopsis Cardiac Electrophysiology Methods and Models by : Daniel C. Sigg

Download or read book Cardiac Electrophysiology Methods and Models written by Daniel C. Sigg and published by Springer Science & Business Media. This book was released on 2010-09-11 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiovascular disease is the major cause of mortality and morbidity in the Western Hemisphere. While significant progress has been made in treating a major sub-category of cardiac disease, arrhythmias, significant unmet needs remain. In particular, every day, thousands of patients die because of arrhythmias in the US alone, and atrial fibrillation is the most common arrhythmia affecting millions of patients in the US alone at a given time. Therefore, there is a public need to continue to develop new and better therapies for arrhythmias. Accordingly, an ever increasing number of biomedical, pharmaceutical, and medical personnel is interested in studying various aspects of arrhythmias at a basic, translational, and applied level, both in industry (ie Biotech, Pharmaceutical and device), and in academia. Not only has our overall understanding of molecular bases of disease dramatically increased, but so has the number of available and emerging molecular, pharmacological or device treatment based therapies. This practical, state-of-the art handbook will summarize and review key research methods and protocols, their advantages and pitfalls, with a focus on practical implementation, and collaborative cross-functional research. The volume will include visual and easy-to-use graphics, bulleted summaries, boxed summary paragraphs, links to reference websites, equipment manufacturers where appropriate, photographs of typical experimental setups and so forth, to keep this book very focused on practical methods and implementation, and yet, provide enough theory that the principles are clearly understood and can be easily applied.