Cardiomyocytes in Health and Disease

Cardiomyocytes in Health and Disease

Author: Chandrasekharan C. Kartha

Publisher: Springer Nature

Published: 2021-09-13

Total Pages: 356

ISBN-13: 3030855368

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This book is a treatise on cardiomyocytes, the most important cell for the contractile function of the heart. There has been significant progress in our understanding of the function-related structure, developmental processes and their determinants, mechanisms of cell cycle regulation, post-natal growth, energy metabolism, and reversible and irreversible response of cardiomyocytes to diverse forms of physiological stress and injury. There is also more clarity on the alterations in the biological mechanisms in cardiomyocytes that lead to pathological states and the changes in the cells that occur secondary to disease conditions. Thanks to these advances in knowledge, there have been great gains in attempts to identify disease biomarkers and therapeutic targets for better management of patients with heart diseases. Possibilities to induce regeneration or proliferation of cardiomyocytes and thus repair and or regenerate the damaged heart are also on the horizon.


Book Synopsis Cardiomyocytes in Health and Disease by : Chandrasekharan C. Kartha

Download or read book Cardiomyocytes in Health and Disease written by Chandrasekharan C. Kartha and published by Springer Nature. This book was released on 2021-09-13 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a treatise on cardiomyocytes, the most important cell for the contractile function of the heart. There has been significant progress in our understanding of the function-related structure, developmental processes and their determinants, mechanisms of cell cycle regulation, post-natal growth, energy metabolism, and reversible and irreversible response of cardiomyocytes to diverse forms of physiological stress and injury. There is also more clarity on the alterations in the biological mechanisms in cardiomyocytes that lead to pathological states and the changes in the cells that occur secondary to disease conditions. Thanks to these advances in knowledge, there have been great gains in attempts to identify disease biomarkers and therapeutic targets for better management of patients with heart diseases. Possibilities to induce regeneration or proliferation of cardiomyocytes and thus repair and or regenerate the damaged heart are also on the horizon.

Cardiomyocytes in Health and Disease

Cardiomyocytes in Health and Disease

Author: Chandrasekharan C. Kartha

Publisher:

Published: 2021

Total Pages: 0

ISBN-13: 9783030855376

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This book is a treatise on cardiomyocytes, the most important cell for the contractile function of the heart. There has been significant progress in our understanding of the function-related structure, developmental processes and their determinants, mechanisms of cell cycle regulation, post-natal growth, energy metabolism, and reversible and irreversible response of cardiomyocytes to diverse forms of physiological stress and injury. There is also more clarity on the alterations in the biological mechanisms in cardiomyocytes that lead to pathological states and the changes in the cells that occur secondary to disease conditions. Thanks to these advances in knowledge, there have been great gains in attempts to identify disease biomarkers and therapeutic targets for better management of patients with heart diseases. Possibilities to induce regeneration or proliferation of cardiomyocytes and thus repair and or regenerate the damaged heart are also on the horizon. .


Book Synopsis Cardiomyocytes in Health and Disease by : Chandrasekharan C. Kartha

Download or read book Cardiomyocytes in Health and Disease written by Chandrasekharan C. Kartha and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a treatise on cardiomyocytes, the most important cell for the contractile function of the heart. There has been significant progress in our understanding of the function-related structure, developmental processes and their determinants, mechanisms of cell cycle regulation, post-natal growth, energy metabolism, and reversible and irreversible response of cardiomyocytes to diverse forms of physiological stress and injury. There is also more clarity on the alterations in the biological mechanisms in cardiomyocytes that lead to pathological states and the changes in the cells that occur secondary to disease conditions. Thanks to these advances in knowledge, there have been great gains in attempts to identify disease biomarkers and therapeutic targets for better management of patients with heart diseases. Possibilities to induce regeneration or proliferation of cardiomyocytes and thus repair and or regenerate the damaged heart are also on the horizon. .

Cardiomyocytes – Active Players in Cardiac Disease

Cardiomyocytes – Active Players in Cardiac Disease

Author: Klaus-Dieter Schlüter

Publisher: Springer

Published: 2016-06-28

Total Pages: 286

ISBN-13: 3319312510

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This book summarizes our current understanding about the biology and patho-biology of cardiomyocytes and depicts common techniques for the study of these cells. The book is divided into two parts; the first part provides insight into role and function of cardiomyocytes under normal conditions and describes embryogenesis and differentiation, in the second part the role of cardiomyocytes in aging and disease is discussed and cellular responses under stress conditions illustrated. Cardiomyocytes represent the main mass of the heart, and cellular malfunction directly modifies heart function leading to subsequent heart failure. As such, cardiomyocytes are causative involved in the main reasons of heart failure, such as post-infarct remodeling, hypertensive heart disease, idiopathic heart failure, and interactions with other co-morbidities such as diabetes. On the other hand, cardiomyocytes are necessarily target of therapy. Therefore, a precise understanding of cardiomyocytes biology is a pre-requisite for proper disease treatment and evidence based medicine. The book is written for cell biologists, pharmacologists and biomedical researchers specialized in cardiac and vascular biology.


Book Synopsis Cardiomyocytes – Active Players in Cardiac Disease by : Klaus-Dieter Schlüter

Download or read book Cardiomyocytes – Active Players in Cardiac Disease written by Klaus-Dieter Schlüter and published by Springer. This book was released on 2016-06-28 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes our current understanding about the biology and patho-biology of cardiomyocytes and depicts common techniques for the study of these cells. The book is divided into two parts; the first part provides insight into role and function of cardiomyocytes under normal conditions and describes embryogenesis and differentiation, in the second part the role of cardiomyocytes in aging and disease is discussed and cellular responses under stress conditions illustrated. Cardiomyocytes represent the main mass of the heart, and cellular malfunction directly modifies heart function leading to subsequent heart failure. As such, cardiomyocytes are causative involved in the main reasons of heart failure, such as post-infarct remodeling, hypertensive heart disease, idiopathic heart failure, and interactions with other co-morbidities such as diabetes. On the other hand, cardiomyocytes are necessarily target of therapy. Therefore, a precise understanding of cardiomyocytes biology is a pre-requisite for proper disease treatment and evidence based medicine. The book is written for cell biologists, pharmacologists and biomedical researchers specialized in cardiac and vascular biology.

Cardiac Myocyte-connective Tissue Interactions in Health and Disease

Cardiac Myocyte-connective Tissue Interactions in Health and Disease

Author: Thomas F. Robinson

Publisher: S. Karger AG (Switzerland)

Published: 1990

Total Pages: 168

ISBN-13:

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Book Synopsis Cardiac Myocyte-connective Tissue Interactions in Health and Disease by : Thomas F. Robinson

Download or read book Cardiac Myocyte-connective Tissue Interactions in Health and Disease written by Thomas F. Robinson and published by S. Karger AG (Switzerland). This book was released on 1990 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cardiac Metabolism in Health and Disease

Cardiac Metabolism in Health and Disease

Author: Salah Abdel-aleem

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 192

ISBN-13: 1461556872

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This special issue of Molecular and Cellular Biochemistry contains original research papers as well as invited reviews focused in the field of cardiac metabolism and its regulation under normal and disease conditions. These papers cover many areas under intensive and rapid development such as the regulation of fatty acid oxidation in the heart, the role of cardiac glycogen during ischemia, the role of CPT I isoenzymes, the pathophysiology of diabetic cardiomyopathy, cardiac protection through regulation of energy production, the role of fatty acid binding protein under normal and pathological conditions, and several other important topics in this area of research. We hope that this special issue of Molecular and Cellular Biochemistry provides an up-to-date source of information for scientists and clinicians interested in the mechanism by which cardiac metabolism is regulated in health and disease and the mechanistic relationship between disturbances in cardiac metabolism and the genesis of cardiovascular diseases.


Book Synopsis Cardiac Metabolism in Health and Disease by : Salah Abdel-aleem

Download or read book Cardiac Metabolism in Health and Disease written by Salah Abdel-aleem and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: This special issue of Molecular and Cellular Biochemistry contains original research papers as well as invited reviews focused in the field of cardiac metabolism and its regulation under normal and disease conditions. These papers cover many areas under intensive and rapid development such as the regulation of fatty acid oxidation in the heart, the role of cardiac glycogen during ischemia, the role of CPT I isoenzymes, the pathophysiology of diabetic cardiomyopathy, cardiac protection through regulation of energy production, the role of fatty acid binding protein under normal and pathological conditions, and several other important topics in this area of research. We hope that this special issue of Molecular and Cellular Biochemistry provides an up-to-date source of information for scientists and clinicians interested in the mechanism by which cardiac metabolism is regulated in health and disease and the mechanistic relationship between disturbances in cardiac metabolism and the genesis of cardiovascular diseases.

The Mechanization of the Heart

The Mechanization of the Heart

Author: Thomas Fuchs

Publisher: University Rochester Press

Published: 2001

Total Pages: 286

ISBN-13: 9781580460774

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In Mechanization of the Heart: Harvey and Descartes Thomas Fuchs discusses the similarities and differences of the views of the two seventeenth-century scholars William Harvey and Rene Descartes on the beart and circulationof the blood; Fuch traces the reception of the two views in the medical literature of the time and the influence both views had. In Mechanization of the Heart: Harvey and Descartes Thomas Fuchs begins by comparing the views of William Harvey [1578-1657] and Rene Descartes [1596-1650] on the heart and the circulation of the blood through the body. These two seventeenth-century scholars -- one a British medical doctor, the other a French philosopher and mathemetician -- differed substantially in their beliefs: they both accepted the idea of circulation of the blood, but differed on the action of the heart. Fuchs traces the ways the opposing views were received, revised, rejected, or renewed in succeeding generations by medical writers in various parts of Europe. He then examines Harvey's approach to cardiac and circulatory physiology, mainly through an examination of Harvey's book De motu cordis: he follows with a discussion of the background in Aristotelian philosophy that was the requirement for all studies in medicineand how that affected Harvey's beliefs. Fuchs then turns to Descartes's presentation of Harvey's views and shows how his view, rather than Harvey's, was accepted in Europe at that time. Marjorie Grene brings to the translation herdistinguished background in philosophy and her keen insights into medical philosophy. Thomas Fuchs teaches psychiatry at the Rupert-Karls-Universitat, Heidelberg. MarjorieGrene is Professor Emeritus of Philosophy at the University of California at Davis, and Adjunct Professor and Honorary Distinguished Professor of Philosophy at Virginia Tech University.


Book Synopsis The Mechanization of the Heart by : Thomas Fuchs

Download or read book The Mechanization of the Heart written by Thomas Fuchs and published by University Rochester Press. This book was released on 2001 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Mechanization of the Heart: Harvey and Descartes Thomas Fuchs discusses the similarities and differences of the views of the two seventeenth-century scholars William Harvey and Rene Descartes on the beart and circulationof the blood; Fuch traces the reception of the two views in the medical literature of the time and the influence both views had. In Mechanization of the Heart: Harvey and Descartes Thomas Fuchs begins by comparing the views of William Harvey [1578-1657] and Rene Descartes [1596-1650] on the heart and the circulation of the blood through the body. These two seventeenth-century scholars -- one a British medical doctor, the other a French philosopher and mathemetician -- differed substantially in their beliefs: they both accepted the idea of circulation of the blood, but differed on the action of the heart. Fuchs traces the ways the opposing views were received, revised, rejected, or renewed in succeeding generations by medical writers in various parts of Europe. He then examines Harvey's approach to cardiac and circulatory physiology, mainly through an examination of Harvey's book De motu cordis: he follows with a discussion of the background in Aristotelian philosophy that was the requirement for all studies in medicineand how that affected Harvey's beliefs. Fuchs then turns to Descartes's presentation of Harvey's views and shows how his view, rather than Harvey's, was accepted in Europe at that time. Marjorie Grene brings to the translation herdistinguished background in philosophy and her keen insights into medical philosophy. Thomas Fuchs teaches psychiatry at the Rupert-Karls-Universitat, Heidelberg. MarjorieGrene is Professor Emeritus of Philosophy at the University of California at Davis, and Adjunct Professor and Honorary Distinguished Professor of Philosophy at Virginia Tech University.

Cardiac Mechanobiology in Physiology and Disease

Cardiac Mechanobiology in Physiology and Disease

Author: Markus Hecker

Publisher: Springer

Published: 2024-04-21

Total Pages: 0

ISBN-13: 9783031239670

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This book presents the latest findings in the field of cardiac mechanobiology in health and disease. Cardiac mechanobiology provides knowledge of all aspects of mechanobiology of the heart. Cardiomyogenesis is discussed as well as the mechanobiology of cardiac remodeling and regeneration. The molecular mechanisms of mechanoperception and mechanotransduction in cardiomyocytes are explained, as well as stretch induced differentiation of cardiomyocytes derived from induced pluripotent stem cells. This volume of the series Cardiac and Vascular Biology complements the volume Vascular Mechanobiology in Physiology and Disease (volume 8) published in this series. The book is aimed at clinicians as well as researchers in cardiovascular biology, bioengineering and biophysics, and also represents an educational resource for young researchers and students in these fields.


Book Synopsis Cardiac Mechanobiology in Physiology and Disease by : Markus Hecker

Download or read book Cardiac Mechanobiology in Physiology and Disease written by Markus Hecker and published by Springer. This book was released on 2024-04-21 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the latest findings in the field of cardiac mechanobiology in health and disease. Cardiac mechanobiology provides knowledge of all aspects of mechanobiology of the heart. Cardiomyogenesis is discussed as well as the mechanobiology of cardiac remodeling and regeneration. The molecular mechanisms of mechanoperception and mechanotransduction in cardiomyocytes are explained, as well as stretch induced differentiation of cardiomyocytes derived from induced pluripotent stem cells. This volume of the series Cardiac and Vascular Biology complements the volume Vascular Mechanobiology in Physiology and Disease (volume 8) published in this series. The book is aimed at clinicians as well as researchers in cardiovascular biology, bioengineering and biophysics, and also represents an educational resource for young researchers and students in these fields.

Endocrinology of the Heart in Health and Disease

Endocrinology of the Heart in Health and Disease

Author: Jonathan C. Schisler

Publisher: Academic Press

Published: 2016-10-19

Total Pages: 378

ISBN-13: 0128031123

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Endocrinology of the Heart in Health and Disease: Integrated, Cellular, and Molecular Endocrinology of the Heart covers the traditional concepts of cardio-endocrinology, the role of the various hormone systems, both in health and disease, therapeutic implications, and other recent advances in the various fields represented. The book explores how cardiac hormones are changed in various cardiac pathologies and the recent success that has been uncovered in their therapeutic use. Additional focus is placed on how the heart responds both physiologically and pathophysiologically to a plethora of circulating hormones, reinforcing the importance of the heart as a target of numerous endocrine systems, such as the brain, renal, and adipose. Significant advances have come from basic, clinical, and translational research from a multiplicity of investigators with diverse backgrounds. The book features over 200 photomicrographs, diagrams of molecular relationships, and tables that complement and support the text. It is aimed at a wide audience, including graduate students and post-doctoral fellows in a wide array of biomedical departments and PhD programs (e.g. Pathology, Physiology, Genetics, Pharmacology, Molecular Biology, and Cell Biology) related to the endocrine and cardiovascular sciences curricula, as well as medical residents in pathology, laboratory medicine, internal medicine, and cardiology. Develops the concept of the heart as both an endocrine organ and an endocrine target, exploring the endocrine function of the heart in both health and disease Explains how the levels of several cardiac hormones are changed in various cardiac pathologies and how some hormones can be used therapeutically Offers a single resource on cardio-endocrine disease which collates and curates the wide range of advances being made in the areas of molecular biology, biochemistry, physiology, and pathology


Book Synopsis Endocrinology of the Heart in Health and Disease by : Jonathan C. Schisler

Download or read book Endocrinology of the Heart in Health and Disease written by Jonathan C. Schisler and published by Academic Press. This book was released on 2016-10-19 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocrinology of the Heart in Health and Disease: Integrated, Cellular, and Molecular Endocrinology of the Heart covers the traditional concepts of cardio-endocrinology, the role of the various hormone systems, both in health and disease, therapeutic implications, and other recent advances in the various fields represented. The book explores how cardiac hormones are changed in various cardiac pathologies and the recent success that has been uncovered in their therapeutic use. Additional focus is placed on how the heart responds both physiologically and pathophysiologically to a plethora of circulating hormones, reinforcing the importance of the heart as a target of numerous endocrine systems, such as the brain, renal, and adipose. Significant advances have come from basic, clinical, and translational research from a multiplicity of investigators with diverse backgrounds. The book features over 200 photomicrographs, diagrams of molecular relationships, and tables that complement and support the text. It is aimed at a wide audience, including graduate students and post-doctoral fellows in a wide array of biomedical departments and PhD programs (e.g. Pathology, Physiology, Genetics, Pharmacology, Molecular Biology, and Cell Biology) related to the endocrine and cardiovascular sciences curricula, as well as medical residents in pathology, laboratory medicine, internal medicine, and cardiology. Develops the concept of the heart as both an endocrine organ and an endocrine target, exploring the endocrine function of the heart in both health and disease Explains how the levels of several cardiac hormones are changed in various cardiac pathologies and how some hormones can be used therapeutically Offers a single resource on cardio-endocrine disease which collates and curates the wide range of advances being made in the areas of molecular biology, biochemistry, physiology, and pathology

Cardiac Energy Metabolism in Health and Disease

Cardiac Energy Metabolism in Health and Disease

Author: Gary D. Lopaschuk

Publisher: Springer

Published: 2014-08-22

Total Pages: 301

ISBN-13: 1493912275

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The heart has a very high energy demand but very little energy reserves. In order to sustain contractile function, the heart has to continually produce a large amount of ATP. The heart utilizes free fatty acids mainly and carbohydrates to some extent as substrates for making energy and any change in this energy supply can seriously compromise cardiac function. It has emerged that alterations in cardiac energy metabolism are a major contributor to the development of a number of different forms of heart disease. It is also now known that optimizing energy metabolism in the heart is a viable and important approach to treating various forms of heart disease. Cardiac Energy Metabolism in Health and Disease describes the research advances that have been made in understanding what controls cardiac energy metabolism at molecular, transcriptional and physiological levels. It also describes how alterations in energy metabolism contribute to the development of heart dysfunction and how optimization of energy metabolism can be used to treat heart disease. The topics covered include a discussion of the effects of myocardial ischemia, diabetes, obesity, hypertrophy, heart failure, and genetic disorders of mitochondrial oxidative metabolism on cardiac energetics. The treatment of heart disease by optimizing energy metabolism is also discussed, which includes increasing overall energy production as well as increasing the efficiency of energy production and switching energy substrate preference of the heart. This book will be a valuable source of information to graduate students, postdoctoral fellows, and investigators in the field of experimental cardiology as well as biochemists, physiologists, pharmacologists, cardiologists, cardiovascular surgeons and other health professionals.


Book Synopsis Cardiac Energy Metabolism in Health and Disease by : Gary D. Lopaschuk

Download or read book Cardiac Energy Metabolism in Health and Disease written by Gary D. Lopaschuk and published by Springer. This book was released on 2014-08-22 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: The heart has a very high energy demand but very little energy reserves. In order to sustain contractile function, the heart has to continually produce a large amount of ATP. The heart utilizes free fatty acids mainly and carbohydrates to some extent as substrates for making energy and any change in this energy supply can seriously compromise cardiac function. It has emerged that alterations in cardiac energy metabolism are a major contributor to the development of a number of different forms of heart disease. It is also now known that optimizing energy metabolism in the heart is a viable and important approach to treating various forms of heart disease. Cardiac Energy Metabolism in Health and Disease describes the research advances that have been made in understanding what controls cardiac energy metabolism at molecular, transcriptional and physiological levels. It also describes how alterations in energy metabolism contribute to the development of heart dysfunction and how optimization of energy metabolism can be used to treat heart disease. The topics covered include a discussion of the effects of myocardial ischemia, diabetes, obesity, hypertrophy, heart failure, and genetic disorders of mitochondrial oxidative metabolism on cardiac energetics. The treatment of heart disease by optimizing energy metabolism is also discussed, which includes increasing overall energy production as well as increasing the efficiency of energy production and switching energy substrate preference of the heart. This book will be a valuable source of information to graduate students, postdoctoral fellows, and investigators in the field of experimental cardiology as well as biochemists, physiologists, pharmacologists, cardiologists, cardiovascular surgeons and other health professionals.

Mechanobiology in Health and Disease

Mechanobiology in Health and Disease

Author: Stefaan Verbruggen

Publisher: Academic Press

Published: 2018-08-09

Total Pages: 527

ISBN-13: 0128129530

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Mechanobiology in Health and Disease brings together contributions from leading biologists, clinicians, physicists and engineers in one convenient volume, providing a unified source of information for researchers in this highly multidisciplinary area. Opening chapters provide essential background information on cell mechanotransduction and essential mechanobiology methods and techniques. Other sections focus on the study of mechanobiology in healthy systems, including bone, tendons, muscles, blood vessels, the heart and the skin, as well as mechanobiology studies of pregnancy. Final chapters address the nascent area of mechanobiology in disease, from the study of bone conditions, skin diseases and heart diseases to cancer. A discussion of future perspectives for research completes each chapter in the volume. This is a timely resource for both early-career and established researchers working on mechanobiology. Provides an essential digest of primary research from many fields and disciplines in one convenient volume Covers both experimental approaches and descriptions of mechanobiology problems from mathematical and numerical perspectives Addresses the hot topic of mechanobiology in disease, a particularly dynamic field of frontier science


Book Synopsis Mechanobiology in Health and Disease by : Stefaan Verbruggen

Download or read book Mechanobiology in Health and Disease written by Stefaan Verbruggen and published by Academic Press. This book was released on 2018-08-09 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanobiology in Health and Disease brings together contributions from leading biologists, clinicians, physicists and engineers in one convenient volume, providing a unified source of information for researchers in this highly multidisciplinary area. Opening chapters provide essential background information on cell mechanotransduction and essential mechanobiology methods and techniques. Other sections focus on the study of mechanobiology in healthy systems, including bone, tendons, muscles, blood vessels, the heart and the skin, as well as mechanobiology studies of pregnancy. Final chapters address the nascent area of mechanobiology in disease, from the study of bone conditions, skin diseases and heart diseases to cancer. A discussion of future perspectives for research completes each chapter in the volume. This is a timely resource for both early-career and established researchers working on mechanobiology. Provides an essential digest of primary research from many fields and disciplines in one convenient volume Covers both experimental approaches and descriptions of mechanobiology problems from mathematical and numerical perspectives Addresses the hot topic of mechanobiology in disease, a particularly dynamic field of frontier science