Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids

Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2000-08-27

Total Pages: 530

ISBN-13: 0309069491

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This volume is the newest release in the authoritative series of quantitative estimates of nutrient intakes to be used for planning and assessing diets for healthy people. Dietary Reference Intakes (DRIs) is the newest framework for an expanded approach developed by U.S. and Canadian scientists. This book discusses in detail the role of vitamin C, vitamin E, selenium, and the carotenoids in human physiology and health. For each nutrient the committee presents what is known about how it functions in the human body, which factors may affect how it works, and how the nutrient may be related to chronic disease. Dietary Reference Intakes provides reference intakes, such as Recommended Dietary Allowances (RDAs), for use in planning nutritionally adequate diets for different groups based on age and gender, along with a new reference intake, the Tolerable Upper Intake Level (UL), designed to assist an individual in knowing how much is "too much" of a nutrient.


Book Synopsis Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids by : Institute of Medicine

Download or read book Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids written by Institute of Medicine and published by National Academies Press. This book was released on 2000-08-27 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is the newest release in the authoritative series of quantitative estimates of nutrient intakes to be used for planning and assessing diets for healthy people. Dietary Reference Intakes (DRIs) is the newest framework for an expanded approach developed by U.S. and Canadian scientists. This book discusses in detail the role of vitamin C, vitamin E, selenium, and the carotenoids in human physiology and health. For each nutrient the committee presents what is known about how it functions in the human body, which factors may affect how it works, and how the nutrient may be related to chronic disease. Dietary Reference Intakes provides reference intakes, such as Recommended Dietary Allowances (RDAs), for use in planning nutritionally adequate diets for different groups based on age and gender, along with a new reference intake, the Tolerable Upper Intake Level (UL), designed to assist an individual in knowing how much is "too much" of a nutrient.


Carotenoids and Retinoids

Carotenoids and Retinoids

Author: Lester Packer

Publisher: AOCS Publishing

Published: 2005-05-30

Total Pages: 350

ISBN-13: 9781893997837

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The presence of carotenoids in the diet and their role in human health has become a subject of unprecedented interest. The chapters in this book represent an account of the information presented at a recent workshop, combined with several additional invited contributions to cover topics more completely that are currently at the cutting edge of research. Some of the highlights of this book include a thorough review of the special role that vitamin A intake plays in the health status of developing countries, the essential role of vitamin A in cell signaling, the molecular targets involved in carotenoid action in smoke-induced lung pathology, and how carotenoids are beneficial in cardiovascular health.


Book Synopsis Carotenoids and Retinoids by : Lester Packer

Download or read book Carotenoids and Retinoids written by Lester Packer and published by AOCS Publishing. This book was released on 2005-05-30 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: The presence of carotenoids in the diet and their role in human health has become a subject of unprecedented interest. The chapters in this book represent an account of the information presented at a recent workshop, combined with several additional invited contributions to cover topics more completely that are currently at the cutting edge of research. Some of the highlights of this book include a thorough review of the special role that vitamin A intake plays in the health status of developing countries, the essential role of vitamin A in cell signaling, the molecular targets involved in carotenoid action in smoke-induced lung pathology, and how carotenoids are beneficial in cardiovascular health.


Nutritional Biochemistry of the Vitamins

Nutritional Biochemistry of the Vitamins

Author: David A. Bender

Publisher: Cambridge University Press

Published: 2003-09-18

Total Pages: 514

ISBN-13: 1139437739

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An authoritative and comprehensive review of our current knowledge of the vitamins, their metabolic functions and the scientific basis for setting recommended intakes for the prevention of deficiency and promotion of optimum health. This publication will be a valuable reference for students and specialists alike in the field of nutritional biochemistry.


Book Synopsis Nutritional Biochemistry of the Vitamins by : David A. Bender

Download or read book Nutritional Biochemistry of the Vitamins written by David A. Bender and published by Cambridge University Press. This book was released on 2003-09-18 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: An authoritative and comprehensive review of our current knowledge of the vitamins, their metabolic functions and the scientific basis for setting recommended intakes for the prevention of deficiency and promotion of optimum health. This publication will be a valuable reference for students and specialists alike in the field of nutritional biochemistry.


Retinoids and Carotenoids in Dermatology

Retinoids and Carotenoids in Dermatology

Author: Anders Vahlquist

Publisher: CRC Press

Published: 2007-06-20

Total Pages: 390

ISBN-13: 1420021184

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This up-to-date reference describes how retinoids and carotenoids function in the skin and how they can be utilized to prevent and treat a wide variety of skin diseases, as well as advance biomedical research in relation to cancer treatment and immunology. Providing an in-depth update on the pharmacology, pharmacodynamics, and new applications of


Book Synopsis Retinoids and Carotenoids in Dermatology by : Anders Vahlquist

Download or read book Retinoids and Carotenoids in Dermatology written by Anders Vahlquist and published by CRC Press. This book was released on 2007-06-20 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: This up-to-date reference describes how retinoids and carotenoids function in the skin and how they can be utilized to prevent and treat a wide variety of skin diseases, as well as advance biomedical research in relation to cancer treatment and immunology. Providing an in-depth update on the pharmacology, pharmacodynamics, and new applications of


Carotenoids and Vitamin A in Translational Medicine

Carotenoids and Vitamin A in Translational Medicine

Author: Olaf Sommerburg

Publisher: CRC Press

Published: 2013-04-24

Total Pages: 439

ISBN-13: 1439855269

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Vitamin A (retinol) is an essential dietary compound with myriad metabolic and regulatory functions. Deficiency can result in vision problems, compromised immune responses, and a host of other medical issues. More than 600 carotenoids have been identified in plants, algae, fungi, and bacteria, and around 50 carotenoids—including β-carotene—can be converted into vitamin A. Carotenoids and Vitamin A in Translational Medicine reviews the medical use of carotenoids and vitamin A in cancer; diseases of the skin, eye, ear, and lung; and inflammatory bowel and metabolic diseases. It also discusses the analytics of carotenoids and the supply of carotenoids and vitamin A in developing countries. Serving a broad community of researchers and practitioners conducting basic and clinical analysis on carotenoids and vitamin A for medical purposes, the book evaluates basic research, epidemiological studies, and clinical trials in the field. It updates information on the worldwide problem of vitamin A deficiency and discusses extensively the pros and cons of carotenoid supplementation in cancer. The authors provide a comprehensive overview of the efforts made in the field of carotenoid research with respect to translational medicine and present the future outlook on carotenoids as new therapeutic agents. It is the editors’ intent through the contributions in this volume to expand this important discussion on therapeutic approaches using carotenoids and retinoids. In doing so, they hope to enhance the quality of research which brings safe, effective, and clinically proven medicines to patients.


Book Synopsis Carotenoids and Vitamin A in Translational Medicine by : Olaf Sommerburg

Download or read book Carotenoids and Vitamin A in Translational Medicine written by Olaf Sommerburg and published by CRC Press. This book was released on 2013-04-24 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vitamin A (retinol) is an essential dietary compound with myriad metabolic and regulatory functions. Deficiency can result in vision problems, compromised immune responses, and a host of other medical issues. More than 600 carotenoids have been identified in plants, algae, fungi, and bacteria, and around 50 carotenoids—including β-carotene—can be converted into vitamin A. Carotenoids and Vitamin A in Translational Medicine reviews the medical use of carotenoids and vitamin A in cancer; diseases of the skin, eye, ear, and lung; and inflammatory bowel and metabolic diseases. It also discusses the analytics of carotenoids and the supply of carotenoids and vitamin A in developing countries. Serving a broad community of researchers and practitioners conducting basic and clinical analysis on carotenoids and vitamin A for medical purposes, the book evaluates basic research, epidemiological studies, and clinical trials in the field. It updates information on the worldwide problem of vitamin A deficiency and discusses extensively the pros and cons of carotenoid supplementation in cancer. The authors provide a comprehensive overview of the efforts made in the field of carotenoid research with respect to translational medicine and present the future outlook on carotenoids as new therapeutic agents. It is the editors’ intent through the contributions in this volume to expand this important discussion on therapeutic approaches using carotenoids and retinoids. In doing so, they hope to enhance the quality of research which brings safe, effective, and clinically proven medicines to patients.


Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc

Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2002-07-19

Total Pages: 804

ISBN-13: 9780309072793

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This volume is the newest release in the authoritative series issued by the National Academy of Sciences on dietary reference intakes (DRIs). This series provides recommended intakes, such as Recommended Dietary Allowances (RDAs), for use in planning nutritionally adequate diets for individuals based on age and gender. In addition, a new reference intake, the Tolerable Upper Intake Level (UL), has also been established to assist an individual in knowing how much is "too much" of a nutrient. Based on the Institute of Medicine's review of the scientific literature regarding dietary micronutrients, recommendations have been formulated regarding vitamins A and K, iron, iodine, chromium, copper, manganese, molybdenum, zinc, and other potentially beneficial trace elements such as boron to determine the roles, if any, they play in health. The book also: Reviews selected components of food that may influence the bioavailability of these compounds. Develops estimates of dietary intake of these compounds that are compatible with good nutrition throughout the life span and that may decrease risk of chronic disease where data indicate they play a role. Determines Tolerable Upper Intake levels for each nutrient reviewed where adequate scientific data are available in specific population subgroups. Identifies research needed to improve knowledge of the role of these micronutrients in human health. This book will be important to professionals in nutrition research and education.


Book Synopsis Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc by : Institute of Medicine

Download or read book Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc written by Institute of Medicine and published by National Academies Press. This book was released on 2002-07-19 with total page 804 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is the newest release in the authoritative series issued by the National Academy of Sciences on dietary reference intakes (DRIs). This series provides recommended intakes, such as Recommended Dietary Allowances (RDAs), for use in planning nutritionally adequate diets for individuals based on age and gender. In addition, a new reference intake, the Tolerable Upper Intake Level (UL), has also been established to assist an individual in knowing how much is "too much" of a nutrient. Based on the Institute of Medicine's review of the scientific literature regarding dietary micronutrients, recommendations have been formulated regarding vitamins A and K, iron, iodine, chromium, copper, manganese, molybdenum, zinc, and other potentially beneficial trace elements such as boron to determine the roles, if any, they play in health. The book also: Reviews selected components of food that may influence the bioavailability of these compounds. Develops estimates of dietary intake of these compounds that are compatible with good nutrition throughout the life span and that may decrease risk of chronic disease where data indicate they play a role. Determines Tolerable Upper Intake levels for each nutrient reviewed where adequate scientific data are available in specific population subgroups. Identifies research needed to improve knowledge of the role of these micronutrients in human health. This book will be important to professionals in nutrition research and education.


Carotenoids and Retinoids in Finnish Foods and the Average Diet

Carotenoids and Retinoids in Finnish Foods and the Average Diet

Author: Marina Heinonen

Publisher:

Published: 1990

Total Pages: 172

ISBN-13:

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Book Synopsis Carotenoids and Retinoids in Finnish Foods and the Average Diet by : Marina Heinonen

Download or read book Carotenoids and Retinoids in Finnish Foods and the Average Diet written by Marina Heinonen and published by . This book was released on 1990 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt:


Vitamin A and Carotenoids

Vitamin A and Carotenoids

Author: Victor R Preedy

Publisher: Royal Society of Chemistry

Published: 2012-08-21

Total Pages: 600

ISBN-13: 1849735506

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Vitamin A has an important role to play in vision, bone growth, reproduction, cell division, and cell differentiation. With the focus on Vitamin A and Carotenoids, this book includes the latest research in these areas and starts with an overview putting the compounds in context with other vitamins, supplementation and discussing the importance of beta-carotene. Details of the chemistry, structure and biochemistry of the compounds begins with nomenclature followed by information on encapsulation, thermal degradation and occurrence. Developments in analytical and bioanalytical techniques concerning these compounds in plant, milk and human tissue systems are covered in detail. Finally, the book covers the extensive functions and effects of Vitamin A on eg developmental growth, immune function, cancer risk, the brain and lungs as well as vision. Delivering high quality information, this book will be of benefit to anyone researching this area of health and nutritional science. It will bridge scientific disciplines so that the information is more meaningful and applicable to health in general. Part of a series of books, it is specifically designed for chemists, analytical scientists, forensic scientists, food scientists, dieticians and health care workers, nutritionists, toxicologists and research academics. Due to its interdisciplinary nature it could also be suitable for lecturers and teachers in food and nutritional sciences and as a college or university library reference guide.


Book Synopsis Vitamin A and Carotenoids by : Victor R Preedy

Download or read book Vitamin A and Carotenoids written by Victor R Preedy and published by Royal Society of Chemistry. This book was released on 2012-08-21 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vitamin A has an important role to play in vision, bone growth, reproduction, cell division, and cell differentiation. With the focus on Vitamin A and Carotenoids, this book includes the latest research in these areas and starts with an overview putting the compounds in context with other vitamins, supplementation and discussing the importance of beta-carotene. Details of the chemistry, structure and biochemistry of the compounds begins with nomenclature followed by information on encapsulation, thermal degradation and occurrence. Developments in analytical and bioanalytical techniques concerning these compounds in plant, milk and human tissue systems are covered in detail. Finally, the book covers the extensive functions and effects of Vitamin A on eg developmental growth, immune function, cancer risk, the brain and lungs as well as vision. Delivering high quality information, this book will be of benefit to anyone researching this area of health and nutritional science. It will bridge scientific disciplines so that the information is more meaningful and applicable to health in general. Part of a series of books, it is specifically designed for chemists, analytical scientists, forensic scientists, food scientists, dieticians and health care workers, nutritionists, toxicologists and research academics. Due to its interdisciplinary nature it could also be suitable for lecturers and teachers in food and nutritional sciences and as a college or university library reference guide.


Metabolism of Biologically Active Retinoids and Provitamin a Carotenoids in Human and Animal Models

Metabolism of Biologically Active Retinoids and Provitamin a Carotenoids in Human and Animal Models

Author: Michael Ryan La Frano

Publisher:

Published: 2012

Total Pages:

ISBN-13: 9781267968722

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Sources of vitamin A, an essential nutrient for growth, healthy vision, and proper immune function, include both retinoids and carotenoids. The vitamin A biological activity these compounds contain and the manner in which they are handled by the body can vary considerably. Knowledge of the metabolism of these sources by the different species that consume them can help better estimate daily requirements, identify where they are stored and used, and assess their impact on health. On a global scale, knowledge of the metabolism of the provitamin A carotenoid beta-carotene in biofortified cassava can help determine its ability to alleviate vitamin A deficiency in populations where it is a staple food. The first chapter discusses the food-based interventions to combat vitamin A deficiency that are currently being tested, while the second chapter describes a human feeding study in which we investigated beta-carotene-biofortified cassava. Cassava is currently being crossbred to increase its beta-carotene content by the non-governmental organization HarvestPlus. However, little is known about the bioavailability and bioconversion of the beta-carotene in biofortified cassava in humans. In a randomized, crossover design study, 10 American women consumed a biofortified cassava porridge containing 2 mg beta-carotene with and without added fat, as well as an unfortified white cassava porridge containing a 0.3 mg retinyl palmitate reference dose. Blood was collected six times from -0.5 - 9.5 hours post-feeding and subsequently analyzed. The results suggest the beta-carotene in biofortified cassava is bioavailable since substantial concentrations of beta-carotene and retinyl palmitate were present in the triacylglycerol-rich lipoprotein plasma fraction after consumption of both biofortified cassava meals. The vitamin A equivalence of both biofortified cassava meals was an average of 4.4 [mu]g beta-carotene : 1 ℗æg retinol (mean ± SD), indicating efficient bioconversion. The following two chapters discuss the provitamin A carotenoid beta-cryptoxanthin. Despite its ability to address vitamin A deficiencies as a source of vitamin A, antioxidant activity, and potential anticarcinogenic effects, little is known about the metabolism of this carotenoid. Although carotenoid metabolism can be investigated in human studies, there are limitations in terms of the tissues that can be tested. Animal studies allow for a full body assessment of carotenoids since entire tissues can be extracted and tested. However, results of these studies are not translatable to humans unless an appropriate animal model for human carotenoid metabolism is used, such as the Mongolian gerbil. We investigated the tissue distribution and dose-response effects after the consumption of varying concentrations of beta-cryptoxanthin in the Mongolian gerbil. In addition, we tested its ability to maintain vitamin A stores. Beta-cryptoxanthin was present in the blood and 12 of the 14 tissues tested, with concentrations being significantly different from baseline in all of the tissues in which it was detected. Beta-cryptoxanthin concentrations increased with higher intakes in most tissues but the increases were nonlinear, suggesting beta-cryptoxanthin absorption may be saturable. Whole organ concentrations of vitamin A in the treatment groups were not significantly different from baseline, indicating beta-cryptoxanthin may be able to sustain vitamin A concentrations when provided as the sole source of vitamin A. The final three chapters focus on lesser known retinoids with vitamin A biological activity, such as dehydroretinol and 3-hydroxyretinol, thought to be uniquely produced in freshwater fish. Knowledge of the concentrations of these retinoids in North American freshwater fish tissues and feed can help better quantify their total vitamin A content. Monitoring vitamin A concentrations can help prevent the negative effects of excess intake. In fact, toxic concentrations of vitamin A can lead to health consequences equally as severe as deficiency such as death and skeletal malformations. Prior to this study, a HPLC method capable of identifying all of our retinoids of interest did not exist. Thus, we developed and validated a HPLC method capable of identifying dehydroretinol, 3-hydroxyretinol, and retinol in a single run. Method validation tests indicated the method had good precision, accuracy, linearity, and sensitivity. In a separate study, we measured the concentrations of retinol, dehydroretinol, and 3-hydroxyretinol in the feed, muscle, and liver of several commercially important species of North-American farm-raised freshwater fish. The concentrations of retinoids within and between fish species and tissues varied dramatically. Interestingly, dehydroretinol concentrations (mean ± SD; 22.1 mg/kg ± 11.3) were lower than retinol (54.4 mg/kg ± 25.0) in fish feed, but often higher (237.2 [mu]g/g ± 292.7) than retinol (81.0 [mu]g/g ± 77.1) in fish liver. As supported by past studies of freshwater fish liver, it appears these fish may preferentially convert retinol to dehydroretinol for storage. Muscle results were dissimilar, with retinol and dehydroretinol nearly equal in concentration. Concentrations of retinol in the feed greatly exceeded recommended levels. 3-hydroxyretinol was detected in relatively low concentrations in the fish liver. To our knowledge, this is the first comparison of dehydroretinol and retinol concentrations in North American farm-raised fish versus fish feed, and the first to detect dehydroretinol concentrations in North American farm-raised fish and commercial fish feed.The results of the above-mentioned studies provide insight into the body's response to the consumption of numerous biologically active retinoids and provitamin A carotenoids and raise awareness about their potential impact in humans and animals. With its high beta-carotene content and efficient bioconversion to vitamin A, biofortified cassava may be an effective component of food-based interventions in vitamin A deficient populations where it is a staple food. The whole-body assessment of beta-cryptoxanthin in the Mongolian gerbil indicated it is stored in numerous tissues and may be capable of sustaining vitamin A concentrations. The high amounts of various vitamin A compounds discovered in the tissues and feed of North American farm-raised fish suggest that vitamin A content from multiple sources should be more closely monitored in the future to ensure fish health.


Book Synopsis Metabolism of Biologically Active Retinoids and Provitamin a Carotenoids in Human and Animal Models by : Michael Ryan La Frano

Download or read book Metabolism of Biologically Active Retinoids and Provitamin a Carotenoids in Human and Animal Models written by Michael Ryan La Frano and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Sources of vitamin A, an essential nutrient for growth, healthy vision, and proper immune function, include both retinoids and carotenoids. The vitamin A biological activity these compounds contain and the manner in which they are handled by the body can vary considerably. Knowledge of the metabolism of these sources by the different species that consume them can help better estimate daily requirements, identify where they are stored and used, and assess their impact on health. On a global scale, knowledge of the metabolism of the provitamin A carotenoid beta-carotene in biofortified cassava can help determine its ability to alleviate vitamin A deficiency in populations where it is a staple food. The first chapter discusses the food-based interventions to combat vitamin A deficiency that are currently being tested, while the second chapter describes a human feeding study in which we investigated beta-carotene-biofortified cassava. Cassava is currently being crossbred to increase its beta-carotene content by the non-governmental organization HarvestPlus. However, little is known about the bioavailability and bioconversion of the beta-carotene in biofortified cassava in humans. In a randomized, crossover design study, 10 American women consumed a biofortified cassava porridge containing 2 mg beta-carotene with and without added fat, as well as an unfortified white cassava porridge containing a 0.3 mg retinyl palmitate reference dose. Blood was collected six times from -0.5 - 9.5 hours post-feeding and subsequently analyzed. The results suggest the beta-carotene in biofortified cassava is bioavailable since substantial concentrations of beta-carotene and retinyl palmitate were present in the triacylglycerol-rich lipoprotein plasma fraction after consumption of both biofortified cassava meals. The vitamin A equivalence of both biofortified cassava meals was an average of 4.4 [mu]g beta-carotene : 1 ℗æg retinol (mean ± SD), indicating efficient bioconversion. The following two chapters discuss the provitamin A carotenoid beta-cryptoxanthin. Despite its ability to address vitamin A deficiencies as a source of vitamin A, antioxidant activity, and potential anticarcinogenic effects, little is known about the metabolism of this carotenoid. Although carotenoid metabolism can be investigated in human studies, there are limitations in terms of the tissues that can be tested. Animal studies allow for a full body assessment of carotenoids since entire tissues can be extracted and tested. However, results of these studies are not translatable to humans unless an appropriate animal model for human carotenoid metabolism is used, such as the Mongolian gerbil. We investigated the tissue distribution and dose-response effects after the consumption of varying concentrations of beta-cryptoxanthin in the Mongolian gerbil. In addition, we tested its ability to maintain vitamin A stores. Beta-cryptoxanthin was present in the blood and 12 of the 14 tissues tested, with concentrations being significantly different from baseline in all of the tissues in which it was detected. Beta-cryptoxanthin concentrations increased with higher intakes in most tissues but the increases were nonlinear, suggesting beta-cryptoxanthin absorption may be saturable. Whole organ concentrations of vitamin A in the treatment groups were not significantly different from baseline, indicating beta-cryptoxanthin may be able to sustain vitamin A concentrations when provided as the sole source of vitamin A. The final three chapters focus on lesser known retinoids with vitamin A biological activity, such as dehydroretinol and 3-hydroxyretinol, thought to be uniquely produced in freshwater fish. Knowledge of the concentrations of these retinoids in North American freshwater fish tissues and feed can help better quantify their total vitamin A content. Monitoring vitamin A concentrations can help prevent the negative effects of excess intake. In fact, toxic concentrations of vitamin A can lead to health consequences equally as severe as deficiency such as death and skeletal malformations. Prior to this study, a HPLC method capable of identifying all of our retinoids of interest did not exist. Thus, we developed and validated a HPLC method capable of identifying dehydroretinol, 3-hydroxyretinol, and retinol in a single run. Method validation tests indicated the method had good precision, accuracy, linearity, and sensitivity. In a separate study, we measured the concentrations of retinol, dehydroretinol, and 3-hydroxyretinol in the feed, muscle, and liver of several commercially important species of North-American farm-raised freshwater fish. The concentrations of retinoids within and between fish species and tissues varied dramatically. Interestingly, dehydroretinol concentrations (mean ± SD; 22.1 mg/kg ± 11.3) were lower than retinol (54.4 mg/kg ± 25.0) in fish feed, but often higher (237.2 [mu]g/g ± 292.7) than retinol (81.0 [mu]g/g ± 77.1) in fish liver. As supported by past studies of freshwater fish liver, it appears these fish may preferentially convert retinol to dehydroretinol for storage. Muscle results were dissimilar, with retinol and dehydroretinol nearly equal in concentration. Concentrations of retinol in the feed greatly exceeded recommended levels. 3-hydroxyretinol was detected in relatively low concentrations in the fish liver. To our knowledge, this is the first comparison of dehydroretinol and retinol concentrations in North American farm-raised fish versus fish feed, and the first to detect dehydroretinol concentrations in North American farm-raised fish and commercial fish feed.The results of the above-mentioned studies provide insight into the body's response to the consumption of numerous biologically active retinoids and provitamin A carotenoids and raise awareness about their potential impact in humans and animals. With its high beta-carotene content and efficient bioconversion to vitamin A, biofortified cassava may be an effective component of food-based interventions in vitamin A deficient populations where it is a staple food. The whole-body assessment of beta-cryptoxanthin in the Mongolian gerbil indicated it is stored in numerous tissues and may be capable of sustaining vitamin A concentrations. The high amounts of various vitamin A compounds discovered in the tissues and feed of North American farm-raised fish suggest that vitamin A content from multiple sources should be more closely monitored in the future to ensure fish health.


Carotenoids and Human Health

Carotenoids and Human Health

Author: Sherry A. Tanumihardjo

Publisher: Springer Science & Business Media

Published: 2012-11-28

Total Pages: 344

ISBN-13: 1627032037

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Carotenoids and Human Health provides an introduction to food sources and metabolism. Written by experts in their fields and including the most up-to-date information, this volume serves as an in-depth guide to studies that have been performed in humans and observations that have been made in population level assessments. Special emphasis is given to associations with disease, as well as the importance of carotenoids internationally, specifically as a source of vitamin A for the world. Comprehensive and easy to use, Carotenoids and Human Health is a very useful resource for nutritionists, registered dieticians, medical students, and graduate students.


Book Synopsis Carotenoids and Human Health by : Sherry A. Tanumihardjo

Download or read book Carotenoids and Human Health written by Sherry A. Tanumihardjo and published by Springer Science & Business Media. This book was released on 2012-11-28 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carotenoids and Human Health provides an introduction to food sources and metabolism. Written by experts in their fields and including the most up-to-date information, this volume serves as an in-depth guide to studies that have been performed in humans and observations that have been made in population level assessments. Special emphasis is given to associations with disease, as well as the importance of carotenoids internationally, specifically as a source of vitamin A for the world. Comprehensive and easy to use, Carotenoids and Human Health is a very useful resource for nutritionists, registered dieticians, medical students, and graduate students.