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Book Synopsis Cellular and Molecular Mechanisms of Neurotrophin Function in the Nervous System by : Pedro Bekinschtein
Download or read book Cellular and Molecular Mechanisms of Neurotrophin Function in the Nervous System written by Pedro Bekinschtein and published by Frontiers Media SA. This book was released on 2020-06-15 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt:
The last decades have witnessed a radical change in our views on central nervous system damage and repair. This change is not only due to the emergence of new powerful tools for the analysis of the brain and its reactions to insults, but it also reflects a conceptual change in the way we approach these problems. As an illustration to this development, it is instructive to go back to the proceedings of a meeting at the NIH in 1955 edited by William F. Windle, which summarizes the disillusioned and pessimistic view on CNS regeneration prevailing at the time. While this generation of researchers were well aware of the issues at stake, they felt they had reached the end of the road; the approaches they had pursued had got stuck and the tools available could not take them any further. I can very well imagine that the participants, most of them leaders in the field, left that conference feeling they had heard their field being sentenced to death.
Book Synopsis Neural Cell Specification by : Bernhard H.J. Juurlink
Download or read book Neural Cell Specification written by Bernhard H.J. Juurlink and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last decades have witnessed a radical change in our views on central nervous system damage and repair. This change is not only due to the emergence of new powerful tools for the analysis of the brain and its reactions to insults, but it also reflects a conceptual change in the way we approach these problems. As an illustration to this development, it is instructive to go back to the proceedings of a meeting at the NIH in 1955 edited by William F. Windle, which summarizes the disillusioned and pessimistic view on CNS regeneration prevailing at the time. While this generation of researchers were well aware of the issues at stake, they felt they had reached the end of the road; the approaches they had pursued had got stuck and the tools available could not take them any further. I can very well imagine that the participants, most of them leaders in the field, left that conference feeling they had heard their field being sentenced to death.
Neurons in the nervous system organize into complex networks and their functions are precisely controlled. The most important means for neurons to communicate with each other is transmission through chemical synapses, where the release of neurotransmitters by the presynaptic nerve terminal of one neuron influences the function of a second neuron. Since the discovery of chemical neurotransmission by Otto Loewi in the 1920s, great progress has been made in our understanding of mol- ular mechanisms of neurotransmitter release. The last decade has seen an explosion of knowledge in this field. The aim of Molecular Mechanisms of Neurotransmitter Release is to provide up-to-date, in-depth coverage of essentially all major mole- lar mechanisms of neurotransmitter release. The contributors have made great efforts to write concisely but with sufficient background information, and to use figures/diagrams to present clearly key concepts or experiments. It is hoped that this book may serve as a learning tool for neuroscience students, a solid reference for neuroscientists, and a source of knowledge for people who have a general interest in neuroscience. I was fortunate to be able to gather contributions from a group of outstanding scientists. I thank them for their efforts. In particular, I want to thank Dr. Erik Jorgensen who offered valuable suggestions about the book in addition to contrib- ing an excellent chapter. I thank US National Science Foundation and National Institute of Health for their supports.
Book Synopsis Molecular Mechanisms of Neurotransmitter Release by : Zhao-Wen Wang
Download or read book Molecular Mechanisms of Neurotransmitter Release written by Zhao-Wen Wang and published by Springer Science & Business Media. This book was released on 2010-11-16 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurons in the nervous system organize into complex networks and their functions are precisely controlled. The most important means for neurons to communicate with each other is transmission through chemical synapses, where the release of neurotransmitters by the presynaptic nerve terminal of one neuron influences the function of a second neuron. Since the discovery of chemical neurotransmission by Otto Loewi in the 1920s, great progress has been made in our understanding of mol- ular mechanisms of neurotransmitter release. The last decade has seen an explosion of knowledge in this field. The aim of Molecular Mechanisms of Neurotransmitter Release is to provide up-to-date, in-depth coverage of essentially all major mole- lar mechanisms of neurotransmitter release. The contributors have made great efforts to write concisely but with sufficient background information, and to use figures/diagrams to present clearly key concepts or experiments. It is hoped that this book may serve as a learning tool for neuroscience students, a solid reference for neuroscientists, and a source of knowledge for people who have a general interest in neuroscience. I was fortunate to be able to gather contributions from a group of outstanding scientists. I thank them for their efforts. In particular, I want to thank Dr. Erik Jorgensen who offered valuable suggestions about the book in addition to contrib- ing an excellent chapter. I thank US National Science Foundation and National Institute of Health for their supports.
Intended for use by advanced undergraduate, graduate and medical students, this book presents a study of the unique biochemical and physiological properties of neurons, emphasising the molecular mechanisms that generate and regulate their activity.
Book Synopsis The Neuron by : Irwin B. Levitan
Download or read book The Neuron written by Irwin B. Levitan and published by Oxford University Press, USA. This book was released on 2015 with total page 601 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intended for use by advanced undergraduate, graduate and medical students, this book presents a study of the unique biochemical and physiological properties of neurons, emphasising the molecular mechanisms that generate and regulate their activity.
A central problem in neurobiology concerns mechanisms that generate the pro found diversity and specificity of the nervous system. What is the substance of diversification and specificity at the molecular, cellular, and systems levels? 4 How, for example, do 1011 neurons each form approximately 10 interconnec tions, allowing normal physiological function? How does disruption of these processes result in human disease? These proceedings represent the efforts of molecular biologists, embryologists, neurobiologists, and clinicians to approach these issues. in this volume are grouped by subject to present the varieties The chapters of methods used to approach each individual area. Section I deals with embry ogenesis and morphogenesis of the nervous system. In Chapter 3, Weston and co-workers describe the use of monoclonal antibodies that recognize specific neuronal epitopes (including specific gangliosides) for the purpose of defining heterogeneity in the neural crest, an important model system. Immunocyto chemical analysis reveals the existence of distinct sUbpopulations within the crest at extremely early stages; cells express neuronal or glial binding patterns at the time of migration. Consequently, interactions with the environment may select for predetermined populations. Le Douarin reaches similar conclusions in Chapter 1 by analyzing migratory pathways and developmental potentials in crest of quail-
Book Synopsis Cellular and Molecular Biology of Neuronal Development by : Ira Black
Download or read book Cellular and Molecular Biology of Neuronal Development written by Ira Black and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: A central problem in neurobiology concerns mechanisms that generate the pro found diversity and specificity of the nervous system. What is the substance of diversification and specificity at the molecular, cellular, and systems levels? 4 How, for example, do 1011 neurons each form approximately 10 interconnec tions, allowing normal physiological function? How does disruption of these processes result in human disease? These proceedings represent the efforts of molecular biologists, embryologists, neurobiologists, and clinicians to approach these issues. in this volume are grouped by subject to present the varieties The chapters of methods used to approach each individual area. Section I deals with embry ogenesis and morphogenesis of the nervous system. In Chapter 3, Weston and co-workers describe the use of monoclonal antibodies that recognize specific neuronal epitopes (including specific gangliosides) for the purpose of defining heterogeneity in the neural crest, an important model system. Immunocyto chemical analysis reveals the existence of distinct sUbpopulations within the crest at extremely early stages; cells express neuronal or glial binding patterns at the time of migration. Consequently, interactions with the environment may select for predetermined populations. Le Douarin reaches similar conclusions in Chapter 1 by analyzing migratory pathways and developmental potentials in crest of quail-
The nervous system is an important system of the human body that coordinates its action by transmitting signals from one part of the body to another. It can be divided into the central and the peripheral nervous system. It consists of the brain, spinal cord and the nerves of the body. At the cellular level, the fundamental mechanism is that of the neuron, which transmits signals through axons that trigger the activation of neurotransmitters, which are then released at synapses. This signaling process involves a complicated molecular machinery, which allows the rapid electrical or chemical transmission of signals. Cells that receive a synaptic signal will be excited, inhibited or modulated. The organization of neural pathways, neural circuits and neural networks together build a functioning nervous system. Any abnormality in nervous function can manifest due to a genetic defect, infection, trauma, toxicity, or due to aging. This book provides comprehensive insights into the cellular and molecular basis of the working of the nervous system. It presents researches and studies performed by experts across the globe. It will serve as a reference to a broad spectrum of readers.
Book Synopsis The Nervous System by : Charles Carter
Download or read book The Nervous System written by Charles Carter and published by . This book was released on 2019-06-13 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: The nervous system is an important system of the human body that coordinates its action by transmitting signals from one part of the body to another. It can be divided into the central and the peripheral nervous system. It consists of the brain, spinal cord and the nerves of the body. At the cellular level, the fundamental mechanism is that of the neuron, which transmits signals through axons that trigger the activation of neurotransmitters, which are then released at synapses. This signaling process involves a complicated molecular machinery, which allows the rapid electrical or chemical transmission of signals. Cells that receive a synaptic signal will be excited, inhibited or modulated. The organization of neural pathways, neural circuits and neural networks together build a functioning nervous system. Any abnormality in nervous function can manifest due to a genetic defect, infection, trauma, toxicity, or due to aging. This book provides comprehensive insights into the cellular and molecular basis of the working of the nervous system. It presents researches and studies performed by experts across the globe. It will serve as a reference to a broad spectrum of readers.
Illustrations by Lorie M. Gavulic, MFA Sponsored by the American Society for Neurochemistry.
Book Synopsis Basic Neurochemistry by : George J. Siegel
Download or read book Basic Neurochemistry written by George J. Siegel and published by Lippincott Raven. This book was released on 1999 with total page 1216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Illustrations by Lorie M. Gavulic, MFA Sponsored by the American Society for Neurochemistry.
From Neuron to Brain, Fourth Edition describes how nerve cells go about their business of transmitting signals, how the signals are put together, and how, out of this integration, higher functions emerge. The emphasis, as before, is on experiments, and on the way they are carried out. Elements of format and presentation have been changed -- more headings have been introduced, the paragraphs are shorter, and the illustrations, now in full color, have been clarified. Intended for use in upper-level undergraduate, graduate, psychology, and medical school neuroscience courses, this book will be of interest to anyone who is curious about the workings of the nervous system.
Book Synopsis From Neuron to Brain by : John G. Nicholls
Download or read book From Neuron to Brain written by John G. Nicholls and published by Sinauer Associates, Incorporated. This book was released on 1992 with total page 844 pages. Available in PDF, EPUB and Kindle. Book excerpt: From Neuron to Brain, Fourth Edition describes how nerve cells go about their business of transmitting signals, how the signals are put together, and how, out of this integration, higher functions emerge. The emphasis, as before, is on experiments, and on the way they are carried out. Elements of format and presentation have been changed -- more headings have been introduced, the paragraphs are shorter, and the illustrations, now in full color, have been clarified. Intended for use in upper-level undergraduate, graduate, psychology, and medical school neuroscience courses, this book will be of interest to anyone who is curious about the workings of the nervous system.
This volume collects protocols and procedures utilizing cellular, tissue, and whole animal models that can be applied to the investigation of neurotrophic factors and other agents impacting on these systems. It begins with chapters on the culture of neurons and glia from the central and peripheral nervous systems, neuron-glia and glia-glia co-culture models, oligodendrocytes, and cell-based assays for the evaluation of cell vitality. This revised second edition expands to cover methodology encompassing site-specific direct labeling of neurotrophins and their receptors, angiogenesis assays, stem cells, pancreatic beta-cells, axonal transport, synapse biology, dendritic spine analysis, and brain endothelial cells. Subsequent chapters are dedicated to in vivo lesion models of relevance to nervous system pathology, which can be applied to the investigation of neurotrophic factors and peptides, as well as protocols describing nanofiber- and nanoparticle-based methods for brain delivery of neurotrophic agents. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Neurotrophic Factors: Methods and Protocols, Second Edition is a valuable resource for a wide audience of readers as they explore nervous system function and pathology.
Book Synopsis Neurotrophic Factors by : Stephen D. Skaper
Download or read book Neurotrophic Factors written by Stephen D. Skaper and published by Humana Press. This book was released on 2018-09-05 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume collects protocols and procedures utilizing cellular, tissue, and whole animal models that can be applied to the investigation of neurotrophic factors and other agents impacting on these systems. It begins with chapters on the culture of neurons and glia from the central and peripheral nervous systems, neuron-glia and glia-glia co-culture models, oligodendrocytes, and cell-based assays for the evaluation of cell vitality. This revised second edition expands to cover methodology encompassing site-specific direct labeling of neurotrophins and their receptors, angiogenesis assays, stem cells, pancreatic beta-cells, axonal transport, synapse biology, dendritic spine analysis, and brain endothelial cells. Subsequent chapters are dedicated to in vivo lesion models of relevance to nervous system pathology, which can be applied to the investigation of neurotrophic factors and peptides, as well as protocols describing nanofiber- and nanoparticle-based methods for brain delivery of neurotrophic agents. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Neurotrophic Factors: Methods and Protocols, Second Edition is a valuable resource for a wide audience of readers as they explore nervous system function and pathology.
The world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. This is due to changes in dietary habits and the decrease in physical activity. Exercise is usually part of the prescription, the first line of defense, to prevent or treat metabolic disorders. However, we are still learning how and why exercise provides metabolic benefits in human health. This open access volume focuses on the cellular and molecular pathways that link exercise, muscle biology, hormones and metabolism. This will include novel “myokines” that might act as new therapeutic agents in the future.
Book Synopsis Hormones, Metabolism and the Benefits of Exercise by : Bruce Spiegelman
Download or read book Hormones, Metabolism and the Benefits of Exercise written by Bruce Spiegelman and published by Springer. This book was released on 2018-03-07 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. This is due to changes in dietary habits and the decrease in physical activity. Exercise is usually part of the prescription, the first line of defense, to prevent or treat metabolic disorders. However, we are still learning how and why exercise provides metabolic benefits in human health. This open access volume focuses on the cellular and molecular pathways that link exercise, muscle biology, hormones and metabolism. This will include novel “myokines” that might act as new therapeutic agents in the future.
