Chimera Research

Chimera Research

Author: Insoo Hyun

Publisher: Humana

Published: 2020-08-14

Total Pages: 234

ISBN-13: 9781493995264

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This volume addresses challenging new questions surrounding stem cell-based chimera research. This book is organized into three parts: Part One provides readers with a summary of different human donor cell types. The chapters in this section discuss ways to evaluate new types of pluripotent stem cells; the derivation of naïve and primed pluripotent stem cells from mouse preimplantation embryos; and the ethical and regulatory complexities of informed consent for the procurement of somatic cells. Part Two discusses methods for generating chimeras. The chapters here look at chick models and human-chick organizer grafts; generating human-pig interspecies chimeras; and techniques for transplanting mouse neural stem cells into a mouse disease model for stroke. Part Three concludes the book with a look at ongoing ethical controversies and new scientific directions. Chapters in this part cover the ethics of crossing the xenobarrier; animal welfare; experimentation with spermatogonial stem cells; and cautious approaches to human-monkey chimera studies to further understand complex human brain disorders. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Chimera Research: Methods and Protocols is a valuable resource for scientists interesting in using chimeras as a research tool while also taking into consideration their complex ethical scopes.


Book Synopsis Chimera Research by : Insoo Hyun

Download or read book Chimera Research written by Insoo Hyun and published by Humana. This book was released on 2020-08-14 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume addresses challenging new questions surrounding stem cell-based chimera research. This book is organized into three parts: Part One provides readers with a summary of different human donor cell types. The chapters in this section discuss ways to evaluate new types of pluripotent stem cells; the derivation of naïve and primed pluripotent stem cells from mouse preimplantation embryos; and the ethical and regulatory complexities of informed consent for the procurement of somatic cells. Part Two discusses methods for generating chimeras. The chapters here look at chick models and human-chick organizer grafts; generating human-pig interspecies chimeras; and techniques for transplanting mouse neural stem cells into a mouse disease model for stroke. Part Three concludes the book with a look at ongoing ethical controversies and new scientific directions. Chapters in this part cover the ethics of crossing the xenobarrier; animal welfare; experimentation with spermatogonial stem cells; and cautious approaches to human-monkey chimera studies to further understand complex human brain disorders. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Chimera Research: Methods and Protocols is a valuable resource for scientists interesting in using chimeras as a research tool while also taking into consideration their complex ethical scopes.

Chimera Research

Chimera Research

Author: Insoo Hyun

Publisher: Humana

Published: 2019-06-08

Total Pages: 234

ISBN-13: 9781493995233

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This volume addresses challenging new questions surrounding stem cell-based chimera research. This book is organized into three parts: Part One provides readers with a summary of different human donor cell types. The chapters in this section discuss ways to evaluate new types of pluripotent stem cells; the derivation of naïve and primed pluripotent stem cells from mouse preimplantation embryos; and the ethical and regulatory complexities of informed consent for the procurement of somatic cells. Part Two discusses methods for generating chimeras. The chapters here look at chick models and human-chick organizer grafts; generating human-pig interspecies chimeras; and techniques for transplanting mouse neural stem cells into a mouse disease model for stroke. Part Three concludes the book with a look at ongoing ethical controversies and new scientific directions. Chapters in this part cover the ethics of crossing the xenobarrier; animal welfare; experimentation with spermatogonial stem cells; and cautious approaches to human-monkey chimera studies to further understand complex human brain disorders. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Chimera Research: Methods and Protocols is a valuable resource for scientists interesting in using chimeras as a research tool while also taking into consideration their complex ethical scopes.


Book Synopsis Chimera Research by : Insoo Hyun

Download or read book Chimera Research written by Insoo Hyun and published by Humana. This book was released on 2019-06-08 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume addresses challenging new questions surrounding stem cell-based chimera research. This book is organized into three parts: Part One provides readers with a summary of different human donor cell types. The chapters in this section discuss ways to evaluate new types of pluripotent stem cells; the derivation of naïve and primed pluripotent stem cells from mouse preimplantation embryos; and the ethical and regulatory complexities of informed consent for the procurement of somatic cells. Part Two discusses methods for generating chimeras. The chapters here look at chick models and human-chick organizer grafts; generating human-pig interspecies chimeras; and techniques for transplanting mouse neural stem cells into a mouse disease model for stroke. Part Three concludes the book with a look at ongoing ethical controversies and new scientific directions. Chapters in this part cover the ethics of crossing the xenobarrier; animal welfare; experimentation with spermatogonial stem cells; and cautious approaches to human-monkey chimera studies to further understand complex human brain disorders. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Chimera Research: Methods and Protocols is a valuable resource for scientists interesting in using chimeras as a research tool while also taking into consideration their complex ethical scopes.

CHIMBRIDS - Chimeras and Hybrids in Comparative European and International Research

CHIMBRIDS - Chimeras and Hybrids in Comparative European and International Research

Author: Jochen Taupitz

Publisher: Springer Science & Business Media

Published: 2009-10-15

Total Pages: 1032

ISBN-13: 3540938699

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National, European and international concepts and strategies concerning the legal and ethical framework of chimera and hybrid research are still largely missing, even though they are absolutely necessary in order to use the potential of chimera and hybrid research effectively and efficiently for the benefit of science and society. The outcome of the CHIMBRIDS-Project successfully sheds light on the chances and risks of this research and provides legal solutions to existing problems in order to help decision-makers fulfil their tasks in an informed and efficient manner. This comprehensive volume details the complete results, contributed by 40 scholars from 10 member states of the European Union, Canada, China, Israel, Japan, Switzerland and the US, with descriptive reports of the legal situation in specific countries and in-depth analysis of all scientific, medical, ethical and legal implications of chimera and hybrid research.


Book Synopsis CHIMBRIDS - Chimeras and Hybrids in Comparative European and International Research by : Jochen Taupitz

Download or read book CHIMBRIDS - Chimeras and Hybrids in Comparative European and International Research written by Jochen Taupitz and published by Springer Science & Business Media. This book was released on 2009-10-15 with total page 1032 pages. Available in PDF, EPUB and Kindle. Book excerpt: National, European and international concepts and strategies concerning the legal and ethical framework of chimera and hybrid research are still largely missing, even though they are absolutely necessary in order to use the potential of chimera and hybrid research effectively and efficiently for the benefit of science and society. The outcome of the CHIMBRIDS-Project successfully sheds light on the chances and risks of this research and provides legal solutions to existing problems in order to help decision-makers fulfil their tasks in an informed and efficient manner. This comprehensive volume details the complete results, contributed by 40 scholars from 10 member states of the European Union, Canada, China, Israel, Japan, Switzerland and the US, with descriptive reports of the legal situation in specific countries and in-depth analysis of all scientific, medical, ethical and legal implications of chimera and hybrid research.

Dictionary of Global Bioethics

Dictionary of Global Bioethics

Author: Henk ten Have

Publisher: Springer Nature

Published: 2021-05-26

Total Pages: 1063

ISBN-13: 3030541614

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This Dictionary presents a broad range of topics relevant in present-day global bioethics. With more than 500 entries, this dictionary covers organizations working in the field of global bioethics, international documents concerning bioethics, personalities that have played a role in the development of global bioethics, as well as specific topics in the field.The book is not only useful for students and professionals in global health activities, but can also serve as a basic tool that explains relevant ethical notions and terms. The dictionary furthers the ideals of cosmopolitanism: solidarity, equality, respect for difference and concern with what human beings- and specifically patients - have in common, regardless of their backgrounds, hometowns, religions, gender, etc. Global problems such as pandemic diseases, disasters, lack of care and medication, homelessness and displacement call for global responses.This book demonstrates that a moral vision of global health is necessary and it helps to quickly understand the basic ideas of global bioethics.


Book Synopsis Dictionary of Global Bioethics by : Henk ten Have

Download or read book Dictionary of Global Bioethics written by Henk ten Have and published by Springer Nature. This book was released on 2021-05-26 with total page 1063 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Dictionary presents a broad range of topics relevant in present-day global bioethics. With more than 500 entries, this dictionary covers organizations working in the field of global bioethics, international documents concerning bioethics, personalities that have played a role in the development of global bioethics, as well as specific topics in the field.The book is not only useful for students and professionals in global health activities, but can also serve as a basic tool that explains relevant ethical notions and terms. The dictionary furthers the ideals of cosmopolitanism: solidarity, equality, respect for difference and concern with what human beings- and specifically patients - have in common, regardless of their backgrounds, hometowns, religions, gender, etc. Global problems such as pandemic diseases, disasters, lack of care and medication, homelessness and displacement call for global responses.This book demonstrates that a moral vision of global health is necessary and it helps to quickly understand the basic ideas of global bioethics.

Chimeras, Hybrids, and Interspecies Research

Chimeras, Hybrids, and Interspecies Research

Author: Andrea L. Bonnicksen

Publisher: Georgetown University Press

Published: 2009-09-21

Total Pages: 182

ISBN-13: 1589017196

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In his 2006 State of the Union speech, President George W. Bush asked the U.S. Congress to prohibit the "most egregious abuses of medical research," such as the "creation of animal–human hybrids." The president's message echoed that of a 2004 report by the President's Council on Bioethics, which recommended that hybrid human–animal embryos be banned by Congress. Discussions of early interspecies research, in which cells or DNA are interchanged between humans and nonhumans at early stages of development, can often devolve into sweeping statements, colorful imagery, and confusing policy. Although today's policy advisory groups are becoming more informed, debate is still limited by the interchangeable use of terms such as chimeras and hybrids, a tendency to treat all forms of interspecies alike, the failure to distinguish between laboratory research and procreation, and not enough serious policy justification. Andrea Bonnicksen seeks to understand reasons behind support of and disdain for interspecies research in such areas as chimerism, hybridization, interspecies nuclear transfer, cross-species embryo transfer, and transgenics. She highlights two claims critics make against early interspecies studies: that the research will violate human dignity and that it can lead to procreation. Are these claims sufficient to justify restrictive policy? Bonnicksen carefully illustrates the challenges of making policy for sensitive and often sensationalized research—research that touches deep-seated values and that probes the boundary between human and nonhuman animals.


Book Synopsis Chimeras, Hybrids, and Interspecies Research by : Andrea L. Bonnicksen

Download or read book Chimeras, Hybrids, and Interspecies Research written by Andrea L. Bonnicksen and published by Georgetown University Press. This book was released on 2009-09-21 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: In his 2006 State of the Union speech, President George W. Bush asked the U.S. Congress to prohibit the "most egregious abuses of medical research," such as the "creation of animal–human hybrids." The president's message echoed that of a 2004 report by the President's Council on Bioethics, which recommended that hybrid human–animal embryos be banned by Congress. Discussions of early interspecies research, in which cells or DNA are interchanged between humans and nonhumans at early stages of development, can often devolve into sweeping statements, colorful imagery, and confusing policy. Although today's policy advisory groups are becoming more informed, debate is still limited by the interchangeable use of terms such as chimeras and hybrids, a tendency to treat all forms of interspecies alike, the failure to distinguish between laboratory research and procreation, and not enough serious policy justification. Andrea Bonnicksen seeks to understand reasons behind support of and disdain for interspecies research in such areas as chimerism, hybridization, interspecies nuclear transfer, cross-species embryo transfer, and transgenics. She highlights two claims critics make against early interspecies studies: that the research will violate human dignity and that it can lead to procreation. Are these claims sufficient to justify restrictive policy? Bonnicksen carefully illustrates the challenges of making policy for sensitive and often sensationalized research—research that touches deep-seated values and that probes the boundary between human and nonhuman animals.

Chimerism

Chimerism

Author: Nicole L. Draper

Publisher: Springer

Published: 2018-06-21

Total Pages: 200

ISBN-13: 3319898663

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This text provides a comprehensive, up-to-date review of chimerism. The first part of the volume presents the causes of chimerism, specifically focusing on fertilization and early embryonic errors, pregnancy and multiple gestations, and transplantation and transfusion. The second part of the volume outlines clinical identification and consequences of chimerism. Chapters in this section focus on the effects of chimerism on testing in relationship determination and forensics, prenatal genetic testing and screening, and blood and HLA typing. This part also reviews new data concerning matching donors and recipients for transplantation, while outlining the risks of transplantation, such as graft-vs-host disease and passenger lymphocyte syndrome. Additionally, evidence on the role of chimerism in autoimmune disease and cancer is presented. Written by experts in the field, Chimerism: A Clinical Guide is a valuable resource for clinicians and researchers that will help guide patient management and stimulate investigative efforts.


Book Synopsis Chimerism by : Nicole L. Draper

Download or read book Chimerism written by Nicole L. Draper and published by Springer. This book was released on 2018-06-21 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text provides a comprehensive, up-to-date review of chimerism. The first part of the volume presents the causes of chimerism, specifically focusing on fertilization and early embryonic errors, pregnancy and multiple gestations, and transplantation and transfusion. The second part of the volume outlines clinical identification and consequences of chimerism. Chapters in this section focus on the effects of chimerism on testing in relationship determination and forensics, prenatal genetic testing and screening, and blood and HLA typing. This part also reviews new data concerning matching donors and recipients for transplantation, while outlining the risks of transplantation, such as graft-vs-host disease and passenger lymphocyte syndrome. Additionally, evidence on the role of chimerism in autoimmune disease and cancer is presented. Written by experts in the field, Chimerism: A Clinical Guide is a valuable resource for clinicians and researchers that will help guide patient management and stimulate investigative efforts.

Chimera Patterns in Networks

Chimera Patterns in Networks

Author: Anna Zakharova

Publisher: Springer Nature

Published: 2020-03-09

Total Pages: 243

ISBN-13: 3030217140

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This is the first book devoted to chimera states - peculiar partial synchronization patterns in networks. Providing an overview of the state of the art in research on this topic, it explores how these hybrid states, which are composed of spatially separated domains of synchronized and desynchronized behavior, arise surprisingly in networks of identical units and symmetric coupling topologies. The book not only describes various types of chimeras, but also discusses the role of time delay, stochasticity, and network topology for these synchronization-desynchronization patterns. Moreover, it addresses the question of robustness and control of chimera states, which have various applications in physics, biology, chemistry, and engineering. This book is intended for researchers with a background in physics, applied mathematics, or engineering. Of great interest to specialists working on related problems, it is also a valuable resource for newcomers to the field and other scientists working on the control of spatio-temporal patterns.


Book Synopsis Chimera Patterns in Networks by : Anna Zakharova

Download or read book Chimera Patterns in Networks written by Anna Zakharova and published by Springer Nature. This book was released on 2020-03-09 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book devoted to chimera states - peculiar partial synchronization patterns in networks. Providing an overview of the state of the art in research on this topic, it explores how these hybrid states, which are composed of spatially separated domains of synchronized and desynchronized behavior, arise surprisingly in networks of identical units and symmetric coupling topologies. The book not only describes various types of chimeras, but also discusses the role of time delay, stochasticity, and network topology for these synchronization-desynchronization patterns. Moreover, it addresses the question of robustness and control of chimera states, which have various applications in physics, biology, chemistry, and engineering. This book is intended for researchers with a background in physics, applied mathematics, or engineering. Of great interest to specialists working on related problems, it is also a valuable resource for newcomers to the field and other scientists working on the control of spatio-temporal patterns.

The Chimera Principle

The Chimera Principle

Author: Carlo Severi

Publisher: Hau

Published: 2015

Total Pages: 0

ISBN-13: 9780990505051

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Using philosophical and ethnographic theory, presents new approaches to ritual and memory, relating them to visual and sound images as acts of communication.


Book Synopsis The Chimera Principle by : Carlo Severi

Download or read book The Chimera Principle written by Carlo Severi and published by Hau. This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using philosophical and ethnographic theory, presents new approaches to ritual and memory, relating them to visual and sound images as acts of communication.

The Great Kanto Earthquake and the Chimera of National Reconstruction in Japan

The Great Kanto Earthquake and the Chimera of National Reconstruction in Japan

Author: J. Charles Schenking

Publisher: Columbia University Press

Published: 2013-07-09

Total Pages: 400

ISBN-13: 0231162189

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In September 1923, a magnitude 7.9 earthquake devastated eastern Japan, killing more than 120,000 people and leaving two million homeless. Using a rich array of source material, J. Charles Schencking tells for the first time the graphic tale of Tokyo's destruction and rebirth. In emotive prose, he documents how the citizens of Tokyo experienced this unprecedented calamity and explores the ways in which it rattled people's deep-seated anxieties about modernity. While explaining how and why the disaster compelled people to reflect on Japanese society, he also examines how reconstruction encouraged the capital's inhabitants to entertain new types of urbanism as they rebuilt their world. Some residents hoped that a grandiose metropolis, reflecting new values, would rise from the ashes of disaster-ravaged Tokyo. Many, however, desired a quick return of the city they once called home. Opportunistic elites advocated innovative state infrastructure to better manage the daily lives of Tokyo residents. Others focused on rejuvenating society--morally, economically, and spiritually--to combat the perceived degeneration of Japan. Schencking explores the inspiration behind these dreams and the extent to which they were realized. He investigates why Japanese citizens from all walks of life responded to overtures for renewal with varying degrees of acceptance, ambivalence, and resistance. His research not only sheds light on Japan's experience with and interpretation of the earthquake but challenges widespread assumptions that disasters unite stricken societies, creating a "blank slate" for radical transformation. National reconstruction in the wake of the Great Kanto Earthquake, Schencking demonstrates, proved to be illusive.


Book Synopsis The Great Kanto Earthquake and the Chimera of National Reconstruction in Japan by : J. Charles Schenking

Download or read book The Great Kanto Earthquake and the Chimera of National Reconstruction in Japan written by J. Charles Schenking and published by Columbia University Press. This book was released on 2013-07-09 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: In September 1923, a magnitude 7.9 earthquake devastated eastern Japan, killing more than 120,000 people and leaving two million homeless. Using a rich array of source material, J. Charles Schencking tells for the first time the graphic tale of Tokyo's destruction and rebirth. In emotive prose, he documents how the citizens of Tokyo experienced this unprecedented calamity and explores the ways in which it rattled people's deep-seated anxieties about modernity. While explaining how and why the disaster compelled people to reflect on Japanese society, he also examines how reconstruction encouraged the capital's inhabitants to entertain new types of urbanism as they rebuilt their world. Some residents hoped that a grandiose metropolis, reflecting new values, would rise from the ashes of disaster-ravaged Tokyo. Many, however, desired a quick return of the city they once called home. Opportunistic elites advocated innovative state infrastructure to better manage the daily lives of Tokyo residents. Others focused on rejuvenating society--morally, economically, and spiritually--to combat the perceived degeneration of Japan. Schencking explores the inspiration behind these dreams and the extent to which they were realized. He investigates why Japanese citizens from all walks of life responded to overtures for renewal with varying degrees of acceptance, ambivalence, and resistance. His research not only sheds light on Japan's experience with and interpretation of the earthquake but challenges widespread assumptions that disasters unite stricken societies, creating a "blank slate" for radical transformation. National reconstruction in the wake of the Great Kanto Earthquake, Schencking demonstrates, proved to be illusive.

The Emerging Field of Human Neural Organoids, Transplants, and Chimeras

The Emerging Field of Human Neural Organoids, Transplants, and Chimeras

Author: National Academies of Sciences Engineering and Medicine

Publisher:

Published: 2022-01-08

Total Pages: 144

ISBN-13: 9780309303361

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The United States military is arguably the most intensely technological, complex enterprise in existence. When compared to the gross domestic products of other countries, the Department of Defense (DoD) budget ranks above all but about 20 nations. If viewed as a company, it would be the largest globally with the most employees. Major investments in weapons systems using advanced technologies provide an advantage over competing systems. Each weapon, platform, vehicle, and person in an operating force is a node in one or more advanced networks that provide the ability to rapidly form a coherent force from a large number of broadly distributed elements. DoD's ability to create and operate forces of this nature demands a competent understanding by its workforce of the composition, acquisition, and employment of its technology-enabled forces. Review of Specialized Degree-Granting Graduate Programs of the Department of Defense in STEM and Management focuses on the graduate science, technology, engineering, mathematics and management (STEM+M) education issues of the Air Force, Navy, and Marines. This report assesses the cost, benefits, and organizational placement of DoD institutions that grant degrees in STEM+M and evaluates alternative ways - for example, civilian institutions and distance learning - to ensure adequate numbers and high-quality education outcomes for DoD personnel."--Publisher's description.


Book Synopsis The Emerging Field of Human Neural Organoids, Transplants, and Chimeras by : National Academies of Sciences Engineering and Medicine

Download or read book The Emerging Field of Human Neural Organoids, Transplants, and Chimeras written by National Academies of Sciences Engineering and Medicine and published by . This book was released on 2022-01-08 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: The United States military is arguably the most intensely technological, complex enterprise in existence. When compared to the gross domestic products of other countries, the Department of Defense (DoD) budget ranks above all but about 20 nations. If viewed as a company, it would be the largest globally with the most employees. Major investments in weapons systems using advanced technologies provide an advantage over competing systems. Each weapon, platform, vehicle, and person in an operating force is a node in one or more advanced networks that provide the ability to rapidly form a coherent force from a large number of broadly distributed elements. DoD's ability to create and operate forces of this nature demands a competent understanding by its workforce of the composition, acquisition, and employment of its technology-enabled forces. Review of Specialized Degree-Granting Graduate Programs of the Department of Defense in STEM and Management focuses on the graduate science, technology, engineering, mathematics and management (STEM+M) education issues of the Air Force, Navy, and Marines. This report assesses the cost, benefits, and organizational placement of DoD institutions that grant degrees in STEM+M and evaluates alternative ways - for example, civilian institutions and distance learning - to ensure adequate numbers and high-quality education outcomes for DoD personnel."--Publisher's description.