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Co- and Post-Translational Modifications of Therapeutic Antibodies and Proteins

Author: T. Shantha Raju

Publisher: John Wiley & Sons

Published: 2019-03-15

Total Pages: 293

ISBN-13: 1119053366

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A Comprehensive Guide to Crucial Attributes of Therapeutic Proteins in Biological Pharmaceuticals With this book, Dr. Raju offers a valuable resource for professionals involved in research and development of biopharmaceutical and biosimilar drugs. This is a highly relevant work, as medical practitioners have increasingly turned to biopharmaceutical medicines in their search for safe and reliable treatments for complex diseases, while pharmaceutical researchers seek to expand the availability of biopharmaceuticals and create more affordable biosimilar alternatives. Readers receive a thorough overview of the major co-translational modifications (CTMs) and post-translational modifications (PTMs) of therapeutic proteins relevant to the development of biotherapeutics. The majority of chapters detail individual CTMs and PTMs that may affect the physicochemical, biochemical, biological, pharmacokinetic, immunological, toxicological etc. properties of proteins. In addition, readers are guided on the methodology necessary to analyze and characterize these modifications. Thus, readers gain not only an understanding of CTMs/PTMs, but also the ability to design and assess their own structure-function studies for experimental molecules. Specific features and topics include: Discussion of the research behind and expansion of biopharmaceuticals Twenty chapters detailing relevant CTMs and PTMs of proteins, such as glycosylation, oxidation, phosphorylation, methylation, proteolysis, etc. Each chapter offers an introduction and guide to the mechanisms and biological significance of an individual CTM or PTM, including practical guidance for experiment design and analysis An appendix of biologic pharmaceuticals currently on the market, along with an assessment of their PTMs and overall safety and efficacy This volume will prove a key reference on the shelves of industry and academic researchers involved in the study and development of biochemistry, molecular biology, biopharmaceuticals and proteins in medicine, particularly as biopharmaceuticals and biosimilars become ever more prominent tools in the field of healthcare.

Book Synopsis Co- and Post-Translational Modifications of Therapeutic Antibodies and Proteins by : T. Shantha Raju

Download or read book Co- and Post-Translational Modifications of Therapeutic Antibodies and Proteins written by T. Shantha Raju and published by John Wiley & Sons. This book was released on 2019-03-15 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Comprehensive Guide to Crucial Attributes of Therapeutic Proteins in Biological Pharmaceuticals With this book, Dr. Raju offers a valuable resource for professionals involved in research and development of biopharmaceutical and biosimilar drugs. This is a highly relevant work, as medical practitioners have increasingly turned to biopharmaceutical medicines in their search for safe and reliable treatments for complex diseases, while pharmaceutical researchers seek to expand the availability of biopharmaceuticals and create more affordable biosimilar alternatives. Readers receive a thorough overview of the major co-translational modifications (CTMs) and post-translational modifications (PTMs) of therapeutic proteins relevant to the development of biotherapeutics. The majority of chapters detail individual CTMs and PTMs that may affect the physicochemical, biochemical, biological, pharmacokinetic, immunological, toxicological etc. properties of proteins. In addition, readers are guided on the methodology necessary to analyze and characterize these modifications. Thus, readers gain not only an understanding of CTMs/PTMs, but also the ability to design and assess their own structure-function studies for experimental molecules. Specific features and topics include: Discussion of the research behind and expansion of biopharmaceuticals Twenty chapters detailing relevant CTMs and PTMs of proteins, such as glycosylation, oxidation, phosphorylation, methylation, proteolysis, etc. Each chapter offers an introduction and guide to the mechanisms and biological significance of an individual CTM or PTM, including practical guidance for experiment design and analysis An appendix of biologic pharmaceuticals currently on the market, along with an assessment of their PTMs and overall safety and efficacy This volume will prove a key reference on the shelves of industry and academic researchers involved in the study and development of biochemistry, molecular biology, biopharmaceuticals and proteins in medicine, particularly as biopharmaceuticals and biosimilars become ever more prominent tools in the field of healthcare.

Co- and Post-translational Modification of Proteins

Author: Donald J. Graves

Publisher: Oxford University Press, USA

Published: 1994

Total Pages: 376

ISBN-13:

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This work presents the general biological principles--and the chemical and physical concepts-- needed for an understanding of the post- and co-translational modification of proteins, a fundamental topic in the science of protein biochemistry and molecular biology. Examples of the different types of modification reactions (glycosylation, phosphorylation, prenylation, etc.) are presented to illustrate specific points, and the book is intended to serve as a principles-based guide for studying the subject, whether in the classroom or research laboratory. In addition to its value as a timely overview of a broad, vitally important area, the book can be used in advanced courses on signal transduction, enzymology, and protein chemistry, or as a supplementary text for biochemistry or molecular biology.

Book Synopsis Co- and Post-translational Modification of Proteins by : Donald J. Graves

Download or read book Co- and Post-translational Modification of Proteins written by Donald J. Graves and published by Oxford University Press, USA. This book was released on 1994 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work presents the general biological principles--and the chemical and physical concepts-- needed for an understanding of the post- and co-translational modification of proteins, a fundamental topic in the science of protein biochemistry and molecular biology. Examples of the different types of modification reactions (glycosylation, phosphorylation, prenylation, etc.) are presented to illustrate specific points, and the book is intended to serve as a principles-based guide for studying the subject, whether in the classroom or research laboratory. In addition to its value as a timely overview of a broad, vitally important area, the book can be used in advanced courses on signal transduction, enzymology, and protein chemistry, or as a supplementary text for biochemistry or molecular biology.

Posttranslational Modification of Proteins

Author: Christopher Walsh

Publisher: Roberts and Company Publishers

Published: 2006

Total Pages: 524

ISBN-13: 9780974707730

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Covering the major classes of posttranslational modifications, Posttranslational Modification of Proteins is the first comprehensive treatment of this burgeoning area of proteome diversification.

Book Synopsis Posttranslational Modification of Proteins by : Christopher Walsh

Download or read book Posttranslational Modification of Proteins written by Christopher Walsh and published by Roberts and Company Publishers. This book was released on 2006 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering the major classes of posttranslational modifications, Posttranslational Modification of Proteins is the first comprehensive treatment of this burgeoning area of proteome diversification.

Proteome Research: New Frontiers in Functional Genomics

Author: Marc R. Wilkins

Publisher: Springer Science & Business Media

Published: 2013-03-14

Total Pages: 256

ISBN-13: 366203493X

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Recent advances in two-dimensional electrophoresis, protein microanalysis and bioinformatics have made the large-scale, systematic analysis of proteins and their post-translational modifications from any tissue or organism possible. This approach has acquired the name "Proteome Research", and can be considered as the core of functional genomics. The results of proteome analysis show which genes are expressed, how the protein products are modified, and how they interact, making proteome research of fundamental importance for the biologist, clinician, and pharmaceutical industry.

Book Synopsis Proteome Research: New Frontiers in Functional Genomics by : Marc R. Wilkins

Download or read book Proteome Research: New Frontiers in Functional Genomics written by Marc R. Wilkins and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in two-dimensional electrophoresis, protein microanalysis and bioinformatics have made the large-scale, systematic analysis of proteins and their post-translational modifications from any tissue or organism possible. This approach has acquired the name "Proteome Research", and can be considered as the core of functional genomics. The results of proteome analysis show which genes are expressed, how the protein products are modified, and how they interact, making proteome research of fundamental importance for the biologist, clinician, and pharmaceutical industry.

Post-translational Modifications of Proteins

Author: Christoph Kannicht

Publisher: Humana Press

Published: 2010-11-19

Total Pages: 0

ISBN-13: 9781617377396

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This is a fully up-dated and expanded practical guide to protein structure-function relationships. This important area of research is brought up-to-date by the leading scientists in the field. The compilation of detailed protocols focuses on protein function, proteome research and characterization of pharmaceutical proteins, while following the successful format of the Methods in Molecular BiologyTM series. Comprehensive and cutting edge, the book serves as practical guide for researchers working in the field of protein structure-function relationships and the rapidly growing field of proteomics, as well as scientists in the pharmaceutical industries.

Book Synopsis Post-translational Modifications of Proteins by : Christoph Kannicht

Download or read book Post-translational Modifications of Proteins written by Christoph Kannicht and published by Humana Press. This book was released on 2010-11-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a fully up-dated and expanded practical guide to protein structure-function relationships. This important area of research is brought up-to-date by the leading scientists in the field. The compilation of detailed protocols focuses on protein function, proteome research and characterization of pharmaceutical proteins, while following the successful format of the Methods in Molecular BiologyTM series. Comprehensive and cutting edge, the book serves as practical guide for researchers working in the field of protein structure-function relationships and the rapidly growing field of proteomics, as well as scientists in the pharmaceutical industries.

Posttranslational Modification of Proteins

Author: Christoph Kannicht

Publisher: Springer Science & Business Media

Published: 2008-02-04

Total Pages: 326

ISBN-13: 1592591817

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Christoph Kannicht and a panel of highly experienced researchers describe readily reproducible methods for detecting and analyzing the posttranslational modifications of protein, particularly with regard to protein function, proteome research, and the characterization of pharmaceutical proteins.

Book Synopsis Posttranslational Modification of Proteins by : Christoph Kannicht

Download or read book Posttranslational Modification of Proteins written by Christoph Kannicht and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Christoph Kannicht and a panel of highly experienced researchers describe readily reproducible methods for detecting and analyzing the posttranslational modifications of protein, particularly with regard to protein function, proteome research, and the characterization of pharmaceutical proteins.

Post-Translational Modification of Proteins

Author: Christoph Kannicht

Publisher: Humana

Published: 2019-07-02

Total Pages: 0

ISBN-13: 9781493990535

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The majority of all proteins undergo co- and/or post-translational modifications, crucially altering physical and chemical properties, folding, conformation distribution, stability, activity, and, consequently, the function of the proteins. In Post-Translational Modifications of Proteins: Tools for Functional Proteomics, Third Edition this important area of research is brought up-to-date by the leading scientists in the field. This compilation of detailed protocols focuses on protein function, proteome research and characterization of pharmaceutical proteins, while following the successful format of the Methods in Molecular Biology series. Each chapter provides a brief introduction to the topic, step-by-step laboratory protocols, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting edge, Post-Translational Modifications of Proteins: Tools for Functional Proteomics, Third Edition serves as practical guide for researchers working in the field of protein structure-function relationships and the rapidly growing field of proteomics, as well as scientists in the pharmaceutical industries.

Book Synopsis Post-Translational Modification of Proteins by : Christoph Kannicht

Download or read book Post-Translational Modification of Proteins written by Christoph Kannicht and published by Humana. This book was released on 2019-07-02 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The majority of all proteins undergo co- and/or post-translational modifications, crucially altering physical and chemical properties, folding, conformation distribution, stability, activity, and, consequently, the function of the proteins. In Post-Translational Modifications of Proteins: Tools for Functional Proteomics, Third Edition this important area of research is brought up-to-date by the leading scientists in the field. This compilation of detailed protocols focuses on protein function, proteome research and characterization of pharmaceutical proteins, while following the successful format of the Methods in Molecular Biology series. Each chapter provides a brief introduction to the topic, step-by-step laboratory protocols, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting edge, Post-Translational Modifications of Proteins: Tools for Functional Proteomics, Third Edition serves as practical guide for researchers working in the field of protein structure-function relationships and the rapidly growing field of proteomics, as well as scientists in the pharmaceutical industries.

Post-translational Modifications of Proteins

Author: John J. Harding

Publisher: CRC Press

Published: 1991-12-13

Total Pages: 282

ISBN-13: 9780849341717

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Post-Translational Modifications of Proteins discusses several important topics of interest to researchers and students in protein chemistry and biochemistry, including the occurrence and function of hydroxylated residues and the three enzymes required for their formation; the damaging effects of reactions between sugars and proteins; ADP-riboosylation of proteins outside the nucleus; and Monod, Wyman, and Changeux's concerted model for allosteric control of enzyme activity exemplified by studies on glycogen phosphorylase. The application of Fast Atom Bombardment Mass Spectometry (FAB-MS) to studies on the structure and biosynthesis of various oligosaccharide moieties in protein is examined, and the understanding of the structural diversity and function of glycoprotein oligosaccharides is discussed in this volume.

Book Synopsis Post-translational Modifications of Proteins by : John J. Harding

Download or read book Post-translational Modifications of Proteins written by John J. Harding and published by CRC Press. This book was released on 1991-12-13 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: Post-Translational Modifications of Proteins discusses several important topics of interest to researchers and students in protein chemistry and biochemistry, including the occurrence and function of hydroxylated residues and the three enzymes required for their formation; the damaging effects of reactions between sugars and proteins; ADP-riboosylation of proteins outside the nucleus; and Monod, Wyman, and Changeux's concerted model for allosteric control of enzyme activity exemplified by studies on glycogen phosphorylase. The application of Fast Atom Bombardment Mass Spectometry (FAB-MS) to studies on the structure and biosynthesis of various oligosaccharide moieties in protein is examined, and the understanding of the structural diversity and function of glycoprotein oligosaccharides is discussed in this volume.

Post-Translational Modifications in Health and Disease

Author: Cecilio J. Vidal

Publisher: Springer Science & Business Media

Published: 2010-10-13

Total Pages: 490

ISBN-13: 1441963820

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Post-translational modifications serve many different purposes in several cellular processes such as gene expression, protein folding and transport to appropriate cell compartment, protein-lipid and protein-protein interactions, enzyme regulation, signal transduction, cell proliferation and differentiation, protein stability, recycling and degradation. Although several-hundred different modifications are known, the significance of many of them remains unknown. The enormous versatility of the modifications which frequently alter the physico-chemical properties of the respective proteins represents an extraordinary challenge in understanding their physiological role. Since essential cellular functions are regulated by protein modifications, an improvement of current understanding of their meaning might allow new avenues to prevent and/or alleviate human and animal diseases.

Book Synopsis Post-Translational Modifications in Health and Disease by : Cecilio J. Vidal

Download or read book Post-Translational Modifications in Health and Disease written by Cecilio J. Vidal and published by Springer Science & Business Media. This book was released on 2010-10-13 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Post-translational modifications serve many different purposes in several cellular processes such as gene expression, protein folding and transport to appropriate cell compartment, protein-lipid and protein-protein interactions, enzyme regulation, signal transduction, cell proliferation and differentiation, protein stability, recycling and degradation. Although several-hundred different modifications are known, the significance of many of them remains unknown. The enormous versatility of the modifications which frequently alter the physico-chemical properties of the respective proteins represents an extraordinary challenge in understanding their physiological role. Since essential cellular functions are regulated by protein modifications, an improvement of current understanding of their meaning might allow new avenues to prevent and/or alleviate human and animal diseases.

Novel Cofactors

Author: Judith P. Klinman

Publisher: Gulf Professional Publishing

Published: 2001-10-05

Total Pages: 502

ISBN-13: 9780120342587

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A cofactor is a component part of many enzymes and functions by uniting with another molecule in order to become active. The use of cofactors to supplement the native amino acids of a protein is essential to maintain the chemical capabilities necessary for organisms to survive. This volume focuses on the significant advances of the past decade in identifying and describing new cofactors--either small molecules or those derived posttranslationally.

Book Synopsis Novel Cofactors by : Judith P. Klinman

Download or read book Novel Cofactors written by Judith P. Klinman and published by Gulf Professional Publishing. This book was released on 2001-10-05 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: A cofactor is a component part of many enzymes and functions by uniting with another molecule in order to become active. The use of cofactors to supplement the native amino acids of a protein is essential to maintain the chemical capabilities necessary for organisms to survive. This volume focuses on the significant advances of the past decade in identifying and describing new cofactors--either small molecules or those derived posttranslationally.