Computational Modeling Methods for Neuroscientists

Computational Modeling Methods for Neuroscientists

Author: Erik De Schutter

Publisher: National Geographic Books

Published: 2009-09-04

Total Pages: 0

ISBN-13: 0262013274

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A guide to computational modeling methods in neuroscience, covering a range of modeling scales from molecular reactions to large neural networks. This book offers an introduction to current methods in computational modeling in neuroscience. The book describes realistic modeling methods at levels of complexity ranging from molecular interactions to large neural networks. A “how to” book rather than an analytical account, it focuses on the presentation of methodological approaches, including the selection of the appropriate method and its potential pitfalls. It is intended for experimental neuroscientists and graduate students who have little formal training in mathematical methods, but it will also be useful for scientists with theoretical backgrounds who want to start using data-driven modeling methods. The mathematics needed are kept to an introductory level; the first chapter explains the mathematical methods the reader needs to master to understand the rest of the book. The chapters are written by scientists who have successfully integrated data-driven modeling with experimental work, so all of the material is accessible to experimentalists. The chapters offer comprehensive coverage with little overlap and extensive cross-references, moving from basic building blocks to more complex applications. Contributors Pablo Achard, Haroon Anwar, Upinder S. Bhalla, Michiel Berends, Nicolas Brunel, Ronald L. Calabrese, Brenda Claiborne, Hugo Cornelis, Erik De Schutter, Alain Destexhe, Bard Ermentrout, Kristen Harris, Sean Hill, John R. Huguenard, William R. Holmes, Gwen Jacobs, Gwendal LeMasson, Henry Markram, Reinoud Maex, Astrid A. Prinz, Imad Riachi, John Rinzel, Arnd Roth, Felix Schürmann, Werner Van Geit, Mark C. W. van Rossum, Stefan Wils


Book Synopsis Computational Modeling Methods for Neuroscientists by : Erik De Schutter

Download or read book Computational Modeling Methods for Neuroscientists written by Erik De Schutter and published by National Geographic Books. This book was released on 2009-09-04 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide to computational modeling methods in neuroscience, covering a range of modeling scales from molecular reactions to large neural networks. This book offers an introduction to current methods in computational modeling in neuroscience. The book describes realistic modeling methods at levels of complexity ranging from molecular interactions to large neural networks. A “how to” book rather than an analytical account, it focuses on the presentation of methodological approaches, including the selection of the appropriate method and its potential pitfalls. It is intended for experimental neuroscientists and graduate students who have little formal training in mathematical methods, but it will also be useful for scientists with theoretical backgrounds who want to start using data-driven modeling methods. The mathematics needed are kept to an introductory level; the first chapter explains the mathematical methods the reader needs to master to understand the rest of the book. The chapters are written by scientists who have successfully integrated data-driven modeling with experimental work, so all of the material is accessible to experimentalists. The chapters offer comprehensive coverage with little overlap and extensive cross-references, moving from basic building blocks to more complex applications. Contributors Pablo Achard, Haroon Anwar, Upinder S. Bhalla, Michiel Berends, Nicolas Brunel, Ronald L. Calabrese, Brenda Claiborne, Hugo Cornelis, Erik De Schutter, Alain Destexhe, Bard Ermentrout, Kristen Harris, Sean Hill, John R. Huguenard, William R. Holmes, Gwen Jacobs, Gwendal LeMasson, Henry Markram, Reinoud Maex, Astrid A. Prinz, Imad Riachi, John Rinzel, Arnd Roth, Felix Schürmann, Werner Van Geit, Mark C. W. van Rossum, Stefan Wils


Principles of Computational Modelling in Neuroscience

Principles of Computational Modelling in Neuroscience

Author: David Sterratt

Publisher: Cambridge University Press

Published: 2023-10-05

Total Pages: 553

ISBN-13: 1108483143

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Learn to use computational modelling techniques to understand the nervous system at all levels, from ion channels to networks.


Book Synopsis Principles of Computational Modelling in Neuroscience by : David Sterratt

Download or read book Principles of Computational Modelling in Neuroscience written by David Sterratt and published by Cambridge University Press. This book was released on 2023-10-05 with total page 553 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn to use computational modelling techniques to understand the nervous system at all levels, from ion channels to networks.


Computational Models for Neuroscience

Computational Models for Neuroscience

Author: Robert Hecht-Nielsen

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 311

ISBN-13: 1447100859

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Formal study of neuroscience (broadly defined) has been underway for millennia. For example, writing 2,350 years ago, Aristotle! asserted that association - of which he defined three specific varieties - lies at the center of human cognition. Over the past two centuries, the simultaneous rapid advancements of technology and (conse quently) per capita economic output have fueled an exponentially increasing effort in neuroscience research. Today, thanks to the accumulated efforts of hundreds of thousands of scientists, we possess an enormous body of knowledge about the mind and brain. Unfortunately, much of this knowledge is in the form of isolated factoids. In terms of "big picture" understanding, surprisingly little progress has been made since Aristotle. In some arenas we have probably suffered negative progress because certain neuroscience and neurophilosophy precepts have clouded our self-knowledge; causing us to become largely oblivious to some of the most profound and fundamental aspects of our nature (such as the highly distinctive propensity of all higher mammals to automatically seg ment all aspects of the world into distinct holistic objects and the massive reorganiza tion of large portions of our brains that ensues when we encounter completely new environments and life situations). At this epoch, neuroscience is like a huge collection of small, jagged, jigsaw puz zle pieces piled in a mound in a large warehouse (with neuroscientists going in and tossing more pieces onto the mound every month).


Book Synopsis Computational Models for Neuroscience by : Robert Hecht-Nielsen

Download or read book Computational Models for Neuroscience written by Robert Hecht-Nielsen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: Formal study of neuroscience (broadly defined) has been underway for millennia. For example, writing 2,350 years ago, Aristotle! asserted that association - of which he defined three specific varieties - lies at the center of human cognition. Over the past two centuries, the simultaneous rapid advancements of technology and (conse quently) per capita economic output have fueled an exponentially increasing effort in neuroscience research. Today, thanks to the accumulated efforts of hundreds of thousands of scientists, we possess an enormous body of knowledge about the mind and brain. Unfortunately, much of this knowledge is in the form of isolated factoids. In terms of "big picture" understanding, surprisingly little progress has been made since Aristotle. In some arenas we have probably suffered negative progress because certain neuroscience and neurophilosophy precepts have clouded our self-knowledge; causing us to become largely oblivious to some of the most profound and fundamental aspects of our nature (such as the highly distinctive propensity of all higher mammals to automatically seg ment all aspects of the world into distinct holistic objects and the massive reorganiza tion of large portions of our brains that ensues when we encounter completely new environments and life situations). At this epoch, neuroscience is like a huge collection of small, jagged, jigsaw puz zle pieces piled in a mound in a large warehouse (with neuroscientists going in and tossing more pieces onto the mound every month).


Computational Neuroscience for Advancing Artificial Intelligence: Models, Methods and Applications

Computational Neuroscience for Advancing Artificial Intelligence: Models, Methods and Applications

Author: Alonso, Eduardo

Publisher: IGI Global

Published: 2010-11-30

Total Pages: 396

ISBN-13: 1609600231

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"This book argues that computational models in behavioral neuroscience must be taken with caution, and advocates for the study of mathematical models of existing theories as complementary to neuro-psychological models and computational models"--


Book Synopsis Computational Neuroscience for Advancing Artificial Intelligence: Models, Methods and Applications by : Alonso, Eduardo

Download or read book Computational Neuroscience for Advancing Artificial Intelligence: Models, Methods and Applications written by Alonso, Eduardo and published by IGI Global. This book was released on 2010-11-30 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book argues that computational models in behavioral neuroscience must be taken with caution, and advocates for the study of mathematical models of existing theories as complementary to neuro-psychological models and computational models"--


Computational Neuroscience

Computational Neuroscience

Author: Hanspeter A Mallot

Publisher: Springer Science & Business Media

Published: 2013-05-23

Total Pages: 142

ISBN-13: 3319008617

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Computational Neuroscience - A First Course provides an essential introduction to computational neuroscience and equips readers with a fundamental understanding of modeling the nervous system at the membrane, cellular, and network level. The book, which grew out of a lecture series held regularly for more than ten years to graduate students in neuroscience with backgrounds in biology, psychology and medicine, takes its readers on a journey through three fundamental domains of computational neuroscience: membrane biophysics, systems theory and artificial neural networks. The required mathematical concepts are kept as intuitive and simple as possible throughout the book, making it fully accessible to readers who are less familiar with mathematics. Overall, Computational Neuroscience - A First Course represents an essential reference guide for all neuroscientists who use computational methods in their daily work, as well as for any theoretical scientist approaching the field of computational neuroscience.


Book Synopsis Computational Neuroscience by : Hanspeter A Mallot

Download or read book Computational Neuroscience written by Hanspeter A Mallot and published by Springer Science & Business Media. This book was released on 2013-05-23 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational Neuroscience - A First Course provides an essential introduction to computational neuroscience and equips readers with a fundamental understanding of modeling the nervous system at the membrane, cellular, and network level. The book, which grew out of a lecture series held regularly for more than ten years to graduate students in neuroscience with backgrounds in biology, psychology and medicine, takes its readers on a journey through three fundamental domains of computational neuroscience: membrane biophysics, systems theory and artificial neural networks. The required mathematical concepts are kept as intuitive and simple as possible throughout the book, making it fully accessible to readers who are less familiar with mathematics. Overall, Computational Neuroscience - A First Course represents an essential reference guide for all neuroscientists who use computational methods in their daily work, as well as for any theoretical scientist approaching the field of computational neuroscience.


Principles of Computational Modelling in Neuroscience

Principles of Computational Modelling in Neuroscience

Author: David Sterratt

Publisher: Cambridge University Press

Published: 2011-06-30

Total Pages: 403

ISBN-13: 1139500791

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The nervous system is made up of a large number of interacting elements. To understand how such a complex system functions requires the construction and analysis of computational models at many different levels. This book provides a step-by-step account of how to model the neuron and neural circuitry to understand the nervous system at all levels, from ion channels to networks. Starting with a simple model of the neuron as an electrical circuit, gradually more details are added to include the effects of neuronal morphology, synapses, ion channels and intracellular signalling. The principle of abstraction is explained through chapters on simplifying models, and how simplified models can be used in networks. This theme is continued in a final chapter on modelling the development of the nervous system. Requiring an elementary background in neuroscience and some high school mathematics, this textbook is an ideal basis for a course on computational neuroscience.


Book Synopsis Principles of Computational Modelling in Neuroscience by : David Sterratt

Download or read book Principles of Computational Modelling in Neuroscience written by David Sterratt and published by Cambridge University Press. This book was released on 2011-06-30 with total page 403 pages. Available in PDF, EPUB and Kindle. Book excerpt: The nervous system is made up of a large number of interacting elements. To understand how such a complex system functions requires the construction and analysis of computational models at many different levels. This book provides a step-by-step account of how to model the neuron and neural circuitry to understand the nervous system at all levels, from ion channels to networks. Starting with a simple model of the neuron as an electrical circuit, gradually more details are added to include the effects of neuronal morphology, synapses, ion channels and intracellular signalling. The principle of abstraction is explained through chapters on simplifying models, and how simplified models can be used in networks. This theme is continued in a final chapter on modelling the development of the nervous system. Requiring an elementary background in neuroscience and some high school mathematics, this textbook is an ideal basis for a course on computational neuroscience.


Computational Neuroscience

Computational Neuroscience

Author: Erik De Schutter

Publisher: CRC Press

Published: 2000-11-22

Total Pages: 368

ISBN-13: 9780849320682

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Designed primarily as an introduction to realistic modeling methods, Computational Neuroscience: Realistic Modeling for Experimentalists focuses on methodological approaches, selecting appropriate methods, and identifying potential pitfalls. The author addresses varying levels of complexity, from molecular interactions within single neurons to the processing of information by neural networks. He avoids theoretical mathematics and provides just enough of the basic math used by experimentalists. What makes this resource unique is the inclusion of a CD-ROM that furnishes interactive modeling examples. It contains tutorials and demos, movies and images, and the simulation scripts necessary to run the full simulation described in the chapter examples. Each chapter covers: the theoretical foundation; parameters needed; appropriate software descriptions; evaluation of the model; future directions expected; examples in text boxes linked to the CD-ROM; and references. The first book to bring you cutting-edge developments in neuronal modeling. It provides an introduction to realistic modeling methods at levels of complexity varying from molecular interactions to neural networks. The book and CD-ROM combine to make Computational Neuroscience: Realistic Modeling for Experimentalists the complete package for understanding modeling techniques.


Book Synopsis Computational Neuroscience by : Erik De Schutter

Download or read book Computational Neuroscience written by Erik De Schutter and published by CRC Press. This book was released on 2000-11-22 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designed primarily as an introduction to realistic modeling methods, Computational Neuroscience: Realistic Modeling for Experimentalists focuses on methodological approaches, selecting appropriate methods, and identifying potential pitfalls. The author addresses varying levels of complexity, from molecular interactions within single neurons to the processing of information by neural networks. He avoids theoretical mathematics and provides just enough of the basic math used by experimentalists. What makes this resource unique is the inclusion of a CD-ROM that furnishes interactive modeling examples. It contains tutorials and demos, movies and images, and the simulation scripts necessary to run the full simulation described in the chapter examples. Each chapter covers: the theoretical foundation; parameters needed; appropriate software descriptions; evaluation of the model; future directions expected; examples in text boxes linked to the CD-ROM; and references. The first book to bring you cutting-edge developments in neuronal modeling. It provides an introduction to realistic modeling methods at levels of complexity varying from molecular interactions to neural networks. The book and CD-ROM combine to make Computational Neuroscience: Realistic Modeling for Experimentalists the complete package for understanding modeling techniques.


Computational Models of Brain and Behavior

Computational Models of Brain and Behavior

Author: Ahmed A. Moustafa

Publisher: John Wiley & Sons

Published: 2017-11-13

Total Pages: 586

ISBN-13: 1119159067

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A comprehensive Introduction to the world of brain and behavior computational models This book provides a broad collection of articles covering different aspects of computational modeling efforts in psychology and neuroscience. Specifically, it discusses models that span different brain regions (hippocampus, amygdala, basal ganglia, visual cortex), different species (humans, rats, fruit flies), and different modeling methods (neural network, Bayesian, reinforcement learning, data fitting, and Hodgkin-Huxley models, among others). Computational Models of Brain and Behavior is divided into four sections: (a) Models of brain disorders; (b) Neural models of behavioral processes; (c) Models of neural processes, brain regions and neurotransmitters, and (d) Neural modeling approaches. It provides in-depth coverage of models of psychiatric disorders, including depression, posttraumatic stress disorder (PTSD), schizophrenia, and dyslexia; models of neurological disorders, including Alzheimer’s disease, Parkinson’s disease, and epilepsy; early sensory and perceptual processes; models of olfaction; higher/systems level models and low-level models; Pavlovian and instrumental conditioning; linking information theory to neurobiology; and more. Covers computational approximations to intellectual disability in down syndrome Discusses computational models of pharmacological and immunological treatment in Alzheimer's disease Examines neural circuit models of serotonergic system (from microcircuits to cognition) Educates on information theory, memory, prediction, and timing in associative learning Computational Models of Brain and Behavior is written for advanced undergraduate, Master's and PhD-level students—as well as researchers involved in computational neuroscience modeling research.


Book Synopsis Computational Models of Brain and Behavior by : Ahmed A. Moustafa

Download or read book Computational Models of Brain and Behavior written by Ahmed A. Moustafa and published by John Wiley & Sons. This book was released on 2017-11-13 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive Introduction to the world of brain and behavior computational models This book provides a broad collection of articles covering different aspects of computational modeling efforts in psychology and neuroscience. Specifically, it discusses models that span different brain regions (hippocampus, amygdala, basal ganglia, visual cortex), different species (humans, rats, fruit flies), and different modeling methods (neural network, Bayesian, reinforcement learning, data fitting, and Hodgkin-Huxley models, among others). Computational Models of Brain and Behavior is divided into four sections: (a) Models of brain disorders; (b) Neural models of behavioral processes; (c) Models of neural processes, brain regions and neurotransmitters, and (d) Neural modeling approaches. It provides in-depth coverage of models of psychiatric disorders, including depression, posttraumatic stress disorder (PTSD), schizophrenia, and dyslexia; models of neurological disorders, including Alzheimer’s disease, Parkinson’s disease, and epilepsy; early sensory and perceptual processes; models of olfaction; higher/systems level models and low-level models; Pavlovian and instrumental conditioning; linking information theory to neurobiology; and more. Covers computational approximations to intellectual disability in down syndrome Discusses computational models of pharmacological and immunological treatment in Alzheimer's disease Examines neural circuit models of serotonergic system (from microcircuits to cognition) Educates on information theory, memory, prediction, and timing in associative learning Computational Models of Brain and Behavior is written for advanced undergraduate, Master's and PhD-level students—as well as researchers involved in computational neuroscience modeling research.


Dynamical Systems in Neuroscience

Dynamical Systems in Neuroscience

Author: Eugene M. Izhikevich

Publisher: MIT Press

Published: 2010-01-22

Total Pages: 459

ISBN-13: 0262514206

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Explains the relationship of electrophysiology, nonlinear dynamics, and the computational properties of neurons, with each concept presented in terms of both neuroscience and mathematics and illustrated using geometrical intuition. In order to model neuronal behavior or to interpret the results of modeling studies, neuroscientists must call upon methods of nonlinear dynamics. This book offers an introduction to nonlinear dynamical systems theory for researchers and graduate students in neuroscience. It also provides an overview of neuroscience for mathematicians who want to learn the basic facts of electrophysiology. Dynamical Systems in Neuroscience presents a systematic study of the relationship of electrophysiology, nonlinear dynamics, and computational properties of neurons. It emphasizes that information processing in the brain depends not only on the electrophysiological properties of neurons but also on their dynamical properties. The book introduces dynamical systems, starting with one- and two-dimensional Hodgkin-Huxley-type models and continuing to a description of bursting systems. Each chapter proceeds from the simple to the complex, and provides sample problems at the end. The book explains all necessary mathematical concepts using geometrical intuition; it includes many figures and few equations, making it especially suitable for non-mathematicians. Each concept is presented in terms of both neuroscience and mathematics, providing a link between the two disciplines. Nonlinear dynamical systems theory is at the core of computational neuroscience research, but it is not a standard part of the graduate neuroscience curriculum—or taught by math or physics department in a way that is suitable for students of biology. This book offers neuroscience students and researchers a comprehensive account of concepts and methods increasingly used in computational neuroscience. An additional chapter on synchronization, with more advanced material, can be found at the author's website, www.izhikevich.com.


Book Synopsis Dynamical Systems in Neuroscience by : Eugene M. Izhikevich

Download or read book Dynamical Systems in Neuroscience written by Eugene M. Izhikevich and published by MIT Press. This book was released on 2010-01-22 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explains the relationship of electrophysiology, nonlinear dynamics, and the computational properties of neurons, with each concept presented in terms of both neuroscience and mathematics and illustrated using geometrical intuition. In order to model neuronal behavior or to interpret the results of modeling studies, neuroscientists must call upon methods of nonlinear dynamics. This book offers an introduction to nonlinear dynamical systems theory for researchers and graduate students in neuroscience. It also provides an overview of neuroscience for mathematicians who want to learn the basic facts of electrophysiology. Dynamical Systems in Neuroscience presents a systematic study of the relationship of electrophysiology, nonlinear dynamics, and computational properties of neurons. It emphasizes that information processing in the brain depends not only on the electrophysiological properties of neurons but also on their dynamical properties. The book introduces dynamical systems, starting with one- and two-dimensional Hodgkin-Huxley-type models and continuing to a description of bursting systems. Each chapter proceeds from the simple to the complex, and provides sample problems at the end. The book explains all necessary mathematical concepts using geometrical intuition; it includes many figures and few equations, making it especially suitable for non-mathematicians. Each concept is presented in terms of both neuroscience and mathematics, providing a link between the two disciplines. Nonlinear dynamical systems theory is at the core of computational neuroscience research, but it is not a standard part of the graduate neuroscience curriculum—or taught by math or physics department in a way that is suitable for students of biology. This book offers neuroscience students and researchers a comprehensive account of concepts and methods increasingly used in computational neuroscience. An additional chapter on synchronization, with more advanced material, can be found at the author's website, www.izhikevich.com.


Advanced Data Analysis in Neuroscience

Advanced Data Analysis in Neuroscience

Author: Daniel Durstewitz

Publisher: Springer

Published: 2017-09-15

Total Pages: 292

ISBN-13: 3319599763

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This book is intended for use in advanced graduate courses in statistics / machine learning, as well as for all experimental neuroscientists seeking to understand statistical methods at a deeper level, and theoretical neuroscientists with a limited background in statistics. It reviews almost all areas of applied statistics, from basic statistical estimation and test theory, linear and nonlinear approaches for regression and classification, to model selection and methods for dimensionality reduction, density estimation and unsupervised clustering. Its focus, however, is linear and nonlinear time series analysis from a dynamical systems perspective, based on which it aims to convey an understanding also of the dynamical mechanisms that could have generated observed time series. Further, it integrates computational modeling of behavioral and neural dynamics with statistical estimation and hypothesis testing. This way computational models in neuroscience are not only explanatory frameworks, but become powerful, quantitative data-analytical tools in themselves that enable researchers to look beyond the data surface and unravel underlying mechanisms. Interactive examples of most methods are provided through a package of MatLab routines, encouraging a playful approach to the subject, and providing readers with a better feel for the practical aspects of the methods covered. "Computational neuroscience is essential for integrating and providing a basis for understanding the myriads of remarkable laboratory data on nervous system functions. Daniel Durstewitz has excellently covered the breadth of computational neuroscience from statistical interpretations of data to biophysically based modeling of the neurobiological sources of those data. His presentation is clear, pedagogically sound, and readily useable by experts and beginners alike. It is a pleasure to recommend this very well crafted discussion to experimental neuroscientists as well as mathematically well versed Physicists. The book acts as a window to the issues, to the questions, and to the tools for finding the answers to interesting inquiries about brains and how they function." Henry D. I. Abarbanel Physics and Scripps Institution of Oceanography, University of California, San Diego “This book delivers a clear and thorough introduction to sophisticated analysis approaches useful in computational neuroscience. The models described and the examples provided will help readers develop critical intuitions into what the methods reveal about data. The overall approach of the book reflects the extensive experience Prof. Durstewitz has developed as a leading practitioner of computational neuroscience. “ Bruno B. Averbeck


Book Synopsis Advanced Data Analysis in Neuroscience by : Daniel Durstewitz

Download or read book Advanced Data Analysis in Neuroscience written by Daniel Durstewitz and published by Springer. This book was released on 2017-09-15 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is intended for use in advanced graduate courses in statistics / machine learning, as well as for all experimental neuroscientists seeking to understand statistical methods at a deeper level, and theoretical neuroscientists with a limited background in statistics. It reviews almost all areas of applied statistics, from basic statistical estimation and test theory, linear and nonlinear approaches for regression and classification, to model selection and methods for dimensionality reduction, density estimation and unsupervised clustering. Its focus, however, is linear and nonlinear time series analysis from a dynamical systems perspective, based on which it aims to convey an understanding also of the dynamical mechanisms that could have generated observed time series. Further, it integrates computational modeling of behavioral and neural dynamics with statistical estimation and hypothesis testing. This way computational models in neuroscience are not only explanatory frameworks, but become powerful, quantitative data-analytical tools in themselves that enable researchers to look beyond the data surface and unravel underlying mechanisms. Interactive examples of most methods are provided through a package of MatLab routines, encouraging a playful approach to the subject, and providing readers with a better feel for the practical aspects of the methods covered. "Computational neuroscience is essential for integrating and providing a basis for understanding the myriads of remarkable laboratory data on nervous system functions. Daniel Durstewitz has excellently covered the breadth of computational neuroscience from statistical interpretations of data to biophysically based modeling of the neurobiological sources of those data. His presentation is clear, pedagogically sound, and readily useable by experts and beginners alike. It is a pleasure to recommend this very well crafted discussion to experimental neuroscientists as well as mathematically well versed Physicists. The book acts as a window to the issues, to the questions, and to the tools for finding the answers to interesting inquiries about brains and how they function." Henry D. I. Abarbanel Physics and Scripps Institution of Oceanography, University of California, San Diego “This book delivers a clear and thorough introduction to sophisticated analysis approaches useful in computational neuroscience. The models described and the examples provided will help readers develop critical intuitions into what the methods reveal about data. The overall approach of the book reflects the extensive experience Prof. Durstewitz has developed as a leading practitioner of computational neuroscience. “ Bruno B. Averbeck