Correlation-based network analysis of cancer metabolism

Correlation-based network analysis of cancer metabolism

Author: Emily G. Armitage

Publisher: Springer

Published: 2014-05-12

Total Pages: 67

ISBN-13: 1493906151

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With the rise of systems biology as an approach in biochemistry research, using high throughput techniques such as mass spectrometry to generate metabolic profiles of cancer metabolism is becoming increasingly popular. There are examples of cancer metabolic profiling studies in the academic literature; however they are often only in journals specific to the metabolomics community. This book will be particularly useful for post-graduate students and post-doctoral researchers using this pioneering technique of network-based correlation analysis. The approach can be adapted to the analysis of any large scale metabolic profiling experiment to answer a range of biological questions in a range of species or for a range of diseases.


Book Synopsis Correlation-based network analysis of cancer metabolism by : Emily G. Armitage

Download or read book Correlation-based network analysis of cancer metabolism written by Emily G. Armitage and published by Springer. This book was released on 2014-05-12 with total page 67 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the rise of systems biology as an approach in biochemistry research, using high throughput techniques such as mass spectrometry to generate metabolic profiles of cancer metabolism is becoming increasingly popular. There are examples of cancer metabolic profiling studies in the academic literature; however they are often only in journals specific to the metabolomics community. This book will be particularly useful for post-graduate students and post-doctoral researchers using this pioneering technique of network-based correlation analysis. The approach can be adapted to the analysis of any large scale metabolic profiling experiment to answer a range of biological questions in a range of species or for a range of diseases.


The Heterogeneity of Cancer Metabolism

The Heterogeneity of Cancer Metabolism

Author: Anne Le

Publisher: Springer

Published: 2018-06-26

Total Pages: 186

ISBN-13: 331977736X

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Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.


Book Synopsis The Heterogeneity of Cancer Metabolism by : Anne Le

Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.


NMR-based Metabolomics

NMR-based Metabolomics

Author: Hector C Keun

Publisher: Royal Society of Chemistry

Published: 2018-01-17

Total Pages: 384

ISBN-13: 184973643X

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This book describes the state of the art in the application of NMR spectroscopy to metabolomics and will be a key title for researchers and practitioners.


Book Synopsis NMR-based Metabolomics by : Hector C Keun

Download or read book NMR-based Metabolomics written by Hector C Keun and published by Royal Society of Chemistry. This book was released on 2018-01-17 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the state of the art in the application of NMR spectroscopy to metabolomics and will be a key title for researchers and practitioners.


Gene Network Inference

Gene Network Inference

Author: Alberto Fuente

Publisher: Springer Science & Business Media

Published: 2014-01-03

Total Pages: 135

ISBN-13: 3642451616

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This book presents recent methods for Systems Genetics (SG) data analysis, applying them to a suite of simulated SG benchmark datasets. Each of the chapter authors received the same datasets to evaluate the performance of their method to better understand which algorithms are most useful for obtaining reliable models from SG datasets. The knowledge gained from this benchmarking study will ultimately allow these algorithms to be used with confidence for SG studies e.g. of complex human diseases or food crop improvement. The book is primarily intended for researchers with a background in the life sciences, not for computer scientists or statisticians.


Book Synopsis Gene Network Inference by : Alberto Fuente

Download or read book Gene Network Inference written by Alberto Fuente and published by Springer Science & Business Media. This book was released on 2014-01-03 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents recent methods for Systems Genetics (SG) data analysis, applying them to a suite of simulated SG benchmark datasets. Each of the chapter authors received the same datasets to evaluate the performance of their method to better understand which algorithms are most useful for obtaining reliable models from SG datasets. The knowledge gained from this benchmarking study will ultimately allow these algorithms to be used with confidence for SG studies e.g. of complex human diseases or food crop improvement. The book is primarily intended for researchers with a background in the life sciences, not for computer scientists or statisticians.


Yeast Systems Biology

Yeast Systems Biology

Author: Juan I. Castrillo

Publisher: Humana Press

Published: 2011-08-23

Total Pages: 0

ISBN-13: 9781617791727

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Systems Biology aims at deciphering the genotype-phenotype relationships at the levels of genes, transcripts (RNAs), peptides, proteins, metabolites, and environmental factors participating in complex cellular networks in order to reveal the mechanisms and principles governing the behavior of complex biological systems. Yeast Systems Biology: Methods and Protocols presents an up-to-date view of the optimal characteristics of the yeast Saccharomyces cerevisiae as a model eukaryote, perspective on the latest experimental and computational techniques for systems biology studies, most of which were first designed for and validated in yeast, and selected examples of yeast systems biology studies and their applications in biotechnology and medicine. These experiments under controlled conditions can uncover the complexity and interplay of biological networks with their dynamics, basic principles of internal organization, and balanced orchestrated functions between organelles in direct interaction with the environment as well as the characterization of short and long-term effects of perturbations and dysregulation of networks that may illuminate the origin of complex human diseases. Written for the highly successful Methods in Molecular BiologyTM series, this volume contains the kind of detailed description and implementation advice that is crucial for getting optimal results. Practical and cutting-edge, Yeast Systems Biology: Methods and Protocols serves researchers interested in comprehensive systems biology strategies in well-defined model systems with specific objectives as well as a better knowledge of the latest post-genomic strategies at all ‘omic levels and computational approaches towards analysis, integration, and modeling of biological systems, from single-celled organisms to higher eukaryotes.


Book Synopsis Yeast Systems Biology by : Juan I. Castrillo

Download or read book Yeast Systems Biology written by Juan I. Castrillo and published by Humana Press. This book was released on 2011-08-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systems Biology aims at deciphering the genotype-phenotype relationships at the levels of genes, transcripts (RNAs), peptides, proteins, metabolites, and environmental factors participating in complex cellular networks in order to reveal the mechanisms and principles governing the behavior of complex biological systems. Yeast Systems Biology: Methods and Protocols presents an up-to-date view of the optimal characteristics of the yeast Saccharomyces cerevisiae as a model eukaryote, perspective on the latest experimental and computational techniques for systems biology studies, most of which were first designed for and validated in yeast, and selected examples of yeast systems biology studies and their applications in biotechnology and medicine. These experiments under controlled conditions can uncover the complexity and interplay of biological networks with their dynamics, basic principles of internal organization, and balanced orchestrated functions between organelles in direct interaction with the environment as well as the characterization of short and long-term effects of perturbations and dysregulation of networks that may illuminate the origin of complex human diseases. Written for the highly successful Methods in Molecular BiologyTM series, this volume contains the kind of detailed description and implementation advice that is crucial for getting optimal results. Practical and cutting-edge, Yeast Systems Biology: Methods and Protocols serves researchers interested in comprehensive systems biology strategies in well-defined model systems with specific objectives as well as a better knowledge of the latest post-genomic strategies at all ‘omic levels and computational approaches towards analysis, integration, and modeling of biological systems, from single-celled organisms to higher eukaryotes.


AACR 2018 Proceedings: Abstracts 3028-5930

AACR 2018 Proceedings: Abstracts 3028-5930

Author: American Association for Cancer Research

Publisher: CTI Meeting Technology

Published: 2018-04-10

Total Pages:

ISBN-13: 1370247702

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Book Synopsis AACR 2018 Proceedings: Abstracts 3028-5930 by : American Association for Cancer Research

Download or read book AACR 2018 Proceedings: Abstracts 3028-5930 written by American Association for Cancer Research and published by CTI Meeting Technology. This book was released on 2018-04-10 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:


Network Theory and Agent-Based Modeling in Economics and Finance

Network Theory and Agent-Based Modeling in Economics and Finance

Author: Anindya S. Chakrabarti

Publisher: Springer Nature

Published: 2019-10-23

Total Pages: 458

ISBN-13: 9811383197

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This book presents the latest findings on network theory and agent-based modeling of economic and financial phenomena. In this context, the economy is depicted as a complex system consisting of heterogeneous agents that interact through evolving networks; the aggregate behavior of the economy arises out of billions of small-scale interactions that take place via countless economic agents. The book focuses on analytical modeling, and on the econometric and statistical analysis of the properties emerging from microscopic interactions. In particular, it highlights the latest empirical and theoretical advances, helping readers understand economic and financial networks, as well as new work on modeling behavior using rich, agent-based frameworks. Innovatively, the book combines observational and theoretical insights in the form of networks and agent-based models, both of which have proved to be extremely valuable in understanding non-linear and evolving complex systems. Given its scope, the book will capture the interest of graduate students and researchers from various disciplines (e.g. economics, computer science, physics, and applied mathematics) whose work involves the domain of complexity theory.


Book Synopsis Network Theory and Agent-Based Modeling in Economics and Finance by : Anindya S. Chakrabarti

Download or read book Network Theory and Agent-Based Modeling in Economics and Finance written by Anindya S. Chakrabarti and published by Springer Nature. This book was released on 2019-10-23 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the latest findings on network theory and agent-based modeling of economic and financial phenomena. In this context, the economy is depicted as a complex system consisting of heterogeneous agents that interact through evolving networks; the aggregate behavior of the economy arises out of billions of small-scale interactions that take place via countless economic agents. The book focuses on analytical modeling, and on the econometric and statistical analysis of the properties emerging from microscopic interactions. In particular, it highlights the latest empirical and theoretical advances, helping readers understand economic and financial networks, as well as new work on modeling behavior using rich, agent-based frameworks. Innovatively, the book combines observational and theoretical insights in the form of networks and agent-based models, both of which have proved to be extremely valuable in understanding non-linear and evolving complex systems. Given its scope, the book will capture the interest of graduate students and researchers from various disciplines (e.g. economics, computer science, physics, and applied mathematics) whose work involves the domain of complexity theory.


Frontiers in Drug Design & Discovery

Frontiers in Drug Design & Discovery

Author: Atta-ur-Rahman

Publisher: Bentham Science Publishers

Published: 2016-05-18

Total Pages: 313

ISBN-13: 1681081652

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Frontiers in Drug Design and Discovery is an eBook series devoted to publishing the latest and the most important advances in drug design and discovery. Eminent scientists have contributed chapters focused on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. This eBook series should prove to be of interest to all pharmaceutical scientists who are involved in research in drug design and discovery and who wish to keep abreast of rapid and important developments in the field. The seventh volume of this series brings together seven reviews covering chemotherapeutic agents, antimicrobials and phytochemicals. Some topics included in this volume are: 1. Metabolic pathways and chemotherapy drugs 2. Cardiotoxicity of cancer chemotherapy 3. Nanotherapeutics for infectious diseases 4. Natural sources of angiogenesis inhibitors …and much more.


Book Synopsis Frontiers in Drug Design & Discovery by : Atta-ur-Rahman

Download or read book Frontiers in Drug Design & Discovery written by Atta-ur-Rahman and published by Bentham Science Publishers. This book was released on 2016-05-18 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Drug Design and Discovery is an eBook series devoted to publishing the latest and the most important advances in drug design and discovery. Eminent scientists have contributed chapters focused on all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, and structure-activity relationships. This eBook series should prove to be of interest to all pharmaceutical scientists who are involved in research in drug design and discovery and who wish to keep abreast of rapid and important developments in the field. The seventh volume of this series brings together seven reviews covering chemotherapeutic agents, antimicrobials and phytochemicals. Some topics included in this volume are: 1. Metabolic pathways and chemotherapy drugs 2. Cardiotoxicity of cancer chemotherapy 3. Nanotherapeutics for infectious diseases 4. Natural sources of angiogenesis inhibitors …and much more.


Progress in Cell Cycle Research

Progress in Cell Cycle Research

Author: Laurent Meijer

Publisher: Springer

Published: 2012-10-08

Total Pages: 0

ISBN-13: 9781461374510

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The latest volume in this highly regarded series covers current advances in the fast-moving field of cell cycle research by gathering reviews otherwise scattered throughout the literature. Contributions encompass fields from cell and molecular biology to biochemistry.


Book Synopsis Progress in Cell Cycle Research by : Laurent Meijer

Download or read book Progress in Cell Cycle Research written by Laurent Meijer and published by Springer. This book was released on 2012-10-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The latest volume in this highly regarded series covers current advances in the fast-moving field of cell cycle research by gathering reviews otherwise scattered throughout the literature. Contributions encompass fields from cell and molecular biology to biochemistry.


Plant Metabolomics

Plant Metabolomics

Author: Kazuki Saito

Publisher: Springer Science & Business Media

Published: 2006-06-29

Total Pages: 351

ISBN-13: 3540297820

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Metabolomics – which deals with all metabolites of an organism – is a rapidly-emerging sector of post-genome research fields. It plays significant roles in a variety of fields from medicine to agriculture and holds a fundamental position in functional genomics studies and their application in plant biotechnology. This volume comprehensively covers plant metabolomics for the first time. The chapters offer cutting-edge information on analytical technology, bioinformatics and applications. They were all written by leading researchers who have been directly involved in plant metabolomics research throughout the world. Up-to-date information and future developments are described, thereby producing a volume which is a landmark of plant metabolomics research and a beneficial guideline to graduate students and researchers in academia, industry, and technology transfer organizations in all plant science fields.


Book Synopsis Plant Metabolomics by : Kazuki Saito

Download or read book Plant Metabolomics written by Kazuki Saito and published by Springer Science & Business Media. This book was released on 2006-06-29 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolomics – which deals with all metabolites of an organism – is a rapidly-emerging sector of post-genome research fields. It plays significant roles in a variety of fields from medicine to agriculture and holds a fundamental position in functional genomics studies and their application in plant biotechnology. This volume comprehensively covers plant metabolomics for the first time. The chapters offer cutting-edge information on analytical technology, bioinformatics and applications. They were all written by leading researchers who have been directly involved in plant metabolomics research throughout the world. Up-to-date information and future developments are described, thereby producing a volume which is a landmark of plant metabolomics research and a beneficial guideline to graduate students and researchers in academia, industry, and technology transfer organizations in all plant science fields.