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Download or read book Current Research on Calcium-regulating Hormones written by Cary Wayne Cooper and published by . This book was released on 1987 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author: D. D. Bikle
Publisher: Springer Science & Business Media
Published: 2012-12-06
Total Pages: 399
ISBN-13: 1461255538
DOWNLOAD EBOOKThe ability to measure accurately the hormones regulating calcium homeosta sis is the fundamental first step toward understanding the roles these hormones play in health and disease. Techniques for such measurements have only been available for the past 10 years or so and remain in a state of rapid development. Sensitive parathyroid hormone (PTH) radioimmunoassays appeared in the early 1970s, and with them came a whole new appreciation for the prevalence and implications of hyperparathyroidism, primary or secondary, in the popu lation. The calcitonin (CT) radioimmunoassay came later and achieved rapid success in the. diagnosis of a previously poorly understood cancer, medullary carcinoma of the thyroid, frequently associated with the familial multiple endo crine neoplasia type 2 syndromes (a and b). As the sensitivity of the calcitonin radioimmunoassay has improved, our understanding of the role of calcitonin in normal physiological processes has increased. The knowledge that vitamin D must be metabolized to produce its biologic effects is only 15 years old. This has had profound implications in our understanding of a variety of metabolic bone, kidney, and gastrointestinal diseases. Assays to measure the major cir culating form of vitamin D, 25-hydroxyvitamin D, were described 10 years ago. Assays for the other metabolites, in particular, 1,25-dihydroxyvitamin D, were described even more recently. As of today, we know of many vitamin D metabolites and have developed the techniques to measure most of them; how ever, many questions remain concerning their physiological role.
Download or read book Assay of Calcium-regulating Hormones written by D. D. Bikle and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ability to measure accurately the hormones regulating calcium homeosta sis is the fundamental first step toward understanding the roles these hormones play in health and disease. Techniques for such measurements have only been available for the past 10 years or so and remain in a state of rapid development. Sensitive parathyroid hormone (PTH) radioimmunoassays appeared in the early 1970s, and with them came a whole new appreciation for the prevalence and implications of hyperparathyroidism, primary or secondary, in the popu lation. The calcitonin (CT) radioimmunoassay came later and achieved rapid success in the. diagnosis of a previously poorly understood cancer, medullary carcinoma of the thyroid, frequently associated with the familial multiple endo crine neoplasia type 2 syndromes (a and b). As the sensitivity of the calcitonin radioimmunoassay has improved, our understanding of the role of calcitonin in normal physiological processes has increased. The knowledge that vitamin D must be metabolized to produce its biologic effects is only 15 years old. This has had profound implications in our understanding of a variety of metabolic bone, kidney, and gastrointestinal diseases. Assays to measure the major cir culating form of vitamin D, 25-hydroxyvitamin D, were described 10 years ago. Assays for the other metabolites, in particular, 1,25-dihydroxyvitamin D, were described even more recently. As of today, we know of many vitamin D metabolites and have developed the techniques to measure most of them; how ever, many questions remain concerning their physiological role.
Author: M.F. Crass, III
Publisher: CRC Press
Published: 1994-12-27
Total Pages: 344
ISBN-13: 9780849386619
DOWNLOAD EBOOKThis is the first book to exclusively address the actions of calcium-regulating hormones and peptides in the cardiovascular system. With 111 illustrations and 13 tables, this comprehensive volume includes: An extensive and critical review of present knowledge of the structure, synthesis, secretion, metabolism, receptors, signal transduction, and actions on classical target cells of each of the calcium-regulating hormones and peptides Discussions on parathyroid hormone and calcitonin, parathyroid hormone-related protein, parathyroid hypertensive factor, 1,25 dihydroxyvitamin D3, calcitonin gene-related peptide, and certain steroid hormones in terms of vascular biology and cardiac function The integrated physiology of calcium-regulating hormones in terms of blood pressure regulation in normotensive and hypertensive settings State-of-the-art electrophysiological techniques used by leading cardiovascular biologists to assess calciotropic hormone effects on calcium channel currents in both vascular smooth muscle and cardiac myocytes Studies on the regulation of hormone and receptor gene expression in the context of possible regulation of local and systemic blood flow and cardiac function by calcium-regulating hormones and peptides
Download or read book Calcium-Regulating Hormones and Cardiovascular Function written by M.F. Crass, III and published by CRC Press. This book was released on 1994-12-27 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book to exclusively address the actions of calcium-regulating hormones and peptides in the cardiovascular system. With 111 illustrations and 13 tables, this comprehensive volume includes: An extensive and critical review of present knowledge of the structure, synthesis, secretion, metabolism, receptors, signal transduction, and actions on classical target cells of each of the calcium-regulating hormones and peptides Discussions on parathyroid hormone and calcitonin, parathyroid hormone-related protein, parathyroid hypertensive factor, 1,25 dihydroxyvitamin D3, calcitonin gene-related peptide, and certain steroid hormones in terms of vascular biology and cardiac function The integrated physiology of calcium-regulating hormones in terms of blood pressure regulation in normotensive and hypertensive settings State-of-the-art electrophysiological techniques used by leading cardiovascular biologists to assess calciotropic hormone effects on calcium channel currents in both vascular smooth muscle and cardiac myocytes Studies on the regulation of hormone and receptor gene expression in the context of possible regulation of local and systemic blood flow and cardiac function by calcium-regulating hormones and peptides
Author: Heinrich Schmidt-Gayk
Publisher: Springer Science & Business Media
Published: 2012-12-06
Total Pages: 336
ISBN-13: 3662004062
DOWNLOAD EBOOKCalcium metabolism is regulated by three specific hormones: parathor- mone, calciferol metabolites, and calcitonin. Cyclic AMP also plays an important part in calcium regulation, and its concentration in urine can be taken as a measure of parathyroid function. Methods for quantitative measurement of, e.g. calcium-regulating hormones and vitamin D metabolites as well as of cAMP are absolutely necessary for safe differential diagnosis of diseases of the parathyroid like hypo- and hyperparathyroidism. In this monograph all presently available methods are summarized as to whether they can already be obtained as test kits or are still being tested. Radioimmunoassays for the various peptide fragments such as 53-84, 44-68, 28-48, and 1-34 are described, as are immunochemiluminescence methods and adenylate cyclase bioassays. The same is true for the vitamin D metabolites, where the various assays for calcidiol and calcitriol such as HPLC, protein-binding assay with second antibody separation, and double antibody RIA are deA scribed. Finally, determination of calcitonin and cAMP is discussed in detail. This is a practically and clinically oriented monograph for working in the fields of internal medicine, endocrinology, and laboratory medicine.
Download or read book Calcium Regulating Hormones, Vitamin D Metabolites, and Cyclic AMP Assays and Their Clinical Application written by Heinrich Schmidt-Gayk and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Calcium metabolism is regulated by three specific hormones: parathor- mone, calciferol metabolites, and calcitonin. Cyclic AMP also plays an important part in calcium regulation, and its concentration in urine can be taken as a measure of parathyroid function. Methods for quantitative measurement of, e.g. calcium-regulating hormones and vitamin D metabolites as well as of cAMP are absolutely necessary for safe differential diagnosis of diseases of the parathyroid like hypo- and hyperparathyroidism. In this monograph all presently available methods are summarized as to whether they can already be obtained as test kits or are still being tested. Radioimmunoassays for the various peptide fragments such as 53-84, 44-68, 28-48, and 1-34 are described, as are immunochemiluminescence methods and adenylate cyclase bioassays. The same is true for the vitamin D metabolites, where the various assays for calcidiol and calcitriol such as HPLC, protein-binding assay with second antibody separation, and double antibody RIA are deA scribed. Finally, determination of calcitonin and cAMP is discussed in detail. This is a practically and clinically oriented monograph for working in the fields of internal medicine, endocrinology, and laboratory medicine.
Author: Masayoshi Yamaguchi
Publisher:
Published: 2014
Total Pages: 186
ISBN-13: 9781629486048
DOWNLOAD EBOOKThe calcium metabolism in the living body is skillfully regulated through calcium-regulating hormones, including the parathyroid hormone, active vitamin D3 metabolite and calcitonin. The blood calcium concentration is ten thousand-fold compared with the levels in cells. Cells use extracellular calcium to regulate cell function efficiently. Intracellular calcium homeostasis is exactly regulated through the mechanism related to various calcium transport systems in cells. Signal transduction plays a pivotal role in cellular regulation. Calcium signaling is probably the most ubiquitous cellular signal that mediates the action of many hormones, cytokines, and neurotransmitters. Calcium regulates the activity of numerous calcium-dependent proteins including protein kinases, protein phosphatases, protease and other calcium-regulating factors involved in calcium signaling. Calcium signaling plays a pivotal role in the regulation of manifold cellular functions including cell proliferation, apoptosis and gene expression. This book focuses on recent topics in calcium signaling and its related diseases.
Download or read book New Developments in Calcium Signaling Research written by Masayoshi Yamaguchi and published by . This book was released on 2014 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: The calcium metabolism in the living body is skillfully regulated through calcium-regulating hormones, including the parathyroid hormone, active vitamin D3 metabolite and calcitonin. The blood calcium concentration is ten thousand-fold compared with the levels in cells. Cells use extracellular calcium to regulate cell function efficiently. Intracellular calcium homeostasis is exactly regulated through the mechanism related to various calcium transport systems in cells. Signal transduction plays a pivotal role in cellular regulation. Calcium signaling is probably the most ubiquitous cellular signal that mediates the action of many hormones, cytokines, and neurotransmitters. Calcium regulates the activity of numerous calcium-dependent proteins including protein kinases, protein phosphatases, protease and other calcium-regulating factors involved in calcium signaling. Calcium signaling plays a pivotal role in the regulation of manifold cellular functions including cell proliferation, apoptosis and gene expression. This book focuses on recent topics in calcium signaling and its related diseases.
Author:
Publisher: Academic Press
Published: 2013-07-24
Total Pages: 307
ISBN-13: 0124079385
DOWNLOAD EBOOKStore-operated calcium channels are found in most animal cells and regulate many cellular functions including cell division, growth, differentiation, and cell death. This volume provides a concise and informative overview of the principles of store-operated calcium entry and the key developments in the field from researchers who have led these advances. The overall goal of the volume is to provide interested students and investigators with sufficient information to enable a broad understanding of the progress and current excitement in the field. The volume contains a wealth of information that even experienced investigators in the field will find useful. The volume provides a comprehensive overview of the mechanisms and functions of store-operated calcium channels Contributors are authoritative researchers who have produced important advances in the field The volume is well-illustrated with cartoons and data to facilitate easy comprehension of the subject
Download or read book Store-Operated Calcium Channels written by and published by Academic Press. This book was released on 2013-07-24 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Store-operated calcium channels are found in most animal cells and regulate many cellular functions including cell division, growth, differentiation, and cell death. This volume provides a concise and informative overview of the principles of store-operated calcium entry and the key developments in the field from researchers who have led these advances. The overall goal of the volume is to provide interested students and investigators with sufficient information to enable a broad understanding of the progress and current excitement in the field. The volume contains a wealth of information that even experienced investigators in the field will find useful. The volume provides a comprehensive overview of the mechanisms and functions of store-operated calcium channels Contributors are authoritative researchers who have produced important advances in the field The volume is well-illustrated with cartoons and data to facilitate easy comprehension of the subject
Download or read book Hormonal Control of Calcium Metabolism written by David V. Cohn and published by . This book was released on 1981 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author: Hirotoshi Morii
Publisher:
Published: 1991
Total Pages: 168
ISBN-13: 9783805553728
DOWNLOAD EBOOKDownload or read book Calcium-regulating Hormones written by Hirotoshi Morii and published by . This book was released on 1991 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Calcium-regulating Hormones: Role in disease and aging written by Hirotoshi Morii and published by . This book was released on 1991 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author: Christopher G. Dacke
Publisher: Society for Endocrinology
Published: 1996
Total Pages: 240
ISBN-13:
DOWNLOAD EBOOKThis text provides an overview of contemporary research in the area of comparative endocrinology of calcium and bone metabolism. It contains a collection of papers reviewing each main area of research: invertebrates, fish/amphibia, birds, and mammals. The papers were presented at a satellite workshop to the International Conference on Calcium Regulating Hormones held in Melbourne, Australia in February 1995. The book gives a comprehensive coverage of calcium regulation and includes topics as diverse as molluscan and dinosaur calcium metabolism. It includes the latest research on calcitonin gene-related and parathyroid hormone-related peptide function and the evolution of these hormones in lower vertebrates and invertebrates. The molecular biology of receptors to these peptides and to active metabolites of vitamin D also feature strongly.
Download or read book The Comparative Endocrinology of Calcium Regulation written by Christopher G. Dacke and published by Society for Endocrinology. This book was released on 1996 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text provides an overview of contemporary research in the area of comparative endocrinology of calcium and bone metabolism. It contains a collection of papers reviewing each main area of research: invertebrates, fish/amphibia, birds, and mammals. The papers were presented at a satellite workshop to the International Conference on Calcium Regulating Hormones held in Melbourne, Australia in February 1995. The book gives a comprehensive coverage of calcium regulation and includes topics as diverse as molluscan and dinosaur calcium metabolism. It includes the latest research on calcitonin gene-related and parathyroid hormone-related peptide function and the evolution of these hormones in lower vertebrates and invertebrates. The molecular biology of receptors to these peptides and to active metabolites of vitamin D also feature strongly.
