Delineating Health and Health System: Mechanistic Insights into Covid 19 Complications

Delineating Health and Health System: Mechanistic Insights into Covid 19 Complications

Author: R. C. Sobti

Publisher: Springer Nature

Published: 2021-11-30

Total Pages: 496

ISBN-13: 9811651051

DOWNLOAD EBOOK

This book discusses the organ-specific systemic manifestations of COVID-19. The initial chapters of the book review the origin and evolution of the coronaviruses, followed by pathogenesis and immune response during COVID-19 infection. The book also provides insight into the role of angiotensin-converting enzyme 2 in the onset of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesis. It summarizes the neurological aspects of SARS-CoV2, including transmission pathways, mechanisms of invasion into the nervous system, and mechanisms of neurological disease. It also delineates the association of severe disease with high blood plasma levels of inflammatory cytokines and inflammatory markers in SARS-CoV-2 infection. Lastly, it discusses the perturbation of gut microbiota by SARS-CoV-2 and uncovers the potential risk of virus infection on reproductive health.


Book Synopsis Delineating Health and Health System: Mechanistic Insights into Covid 19 Complications by : R. C. Sobti

Download or read book Delineating Health and Health System: Mechanistic Insights into Covid 19 Complications written by R. C. Sobti and published by Springer Nature. This book was released on 2021-11-30 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the organ-specific systemic manifestations of COVID-19. The initial chapters of the book review the origin and evolution of the coronaviruses, followed by pathogenesis and immune response during COVID-19 infection. The book also provides insight into the role of angiotensin-converting enzyme 2 in the onset of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesis. It summarizes the neurological aspects of SARS-CoV2, including transmission pathways, mechanisms of invasion into the nervous system, and mechanisms of neurological disease. It also delineates the association of severe disease with high blood plasma levels of inflammatory cytokines and inflammatory markers in SARS-CoV-2 infection. Lastly, it discusses the perturbation of gut microbiota by SARS-CoV-2 and uncovers the potential risk of virus infection on reproductive health.

New Advances on Zika Virus Research

New Advances on Zika Virus Research

Author: Luis Martinez-Sobrido

Publisher: MDPI

Published: 2019-04-02

Total Pages: 554

ISBN-13: 3038977640

DOWNLOAD EBOOK

Zika virus (ZIKV) is a mosquito-borne member of the Flaviviridae family that historically has been associated with mild febrile illness. However, the recent outbreaks in Brazil in 2015 and its rapid spread throughout South and Central America and the Caribbean, together with its association with severe neurological disorders—including fetal microcephaly and Guillain-Barré syndrome in adults—have changed the historic perspective of ZIKV. Currently, ZIKV is considered an important public health concern that has the potential to affect millions of people worldwide. The significance of ZIKV in human health and the lack of approved vaccines and/or antiviral drugs to combat ZIKV infection have triggered a global effort to develop effective countermeasures to prevent and/or treat ZIKV infection. In this Special Issue of Viruses, we have assembled a collection of 32 research and review articles that cover the more recent advances on ZIKV molecular biology, replication and transmission, virus–host interactions, pathogenesis, epidemiology, vaccine development, antivirals, and viral diagnosis.


Book Synopsis New Advances on Zika Virus Research by : Luis Martinez-Sobrido

Download or read book New Advances on Zika Virus Research written by Luis Martinez-Sobrido and published by MDPI. This book was released on 2019-04-02 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: Zika virus (ZIKV) is a mosquito-borne member of the Flaviviridae family that historically has been associated with mild febrile illness. However, the recent outbreaks in Brazil in 2015 and its rapid spread throughout South and Central America and the Caribbean, together with its association with severe neurological disorders—including fetal microcephaly and Guillain-Barré syndrome in adults—have changed the historic perspective of ZIKV. Currently, ZIKV is considered an important public health concern that has the potential to affect millions of people worldwide. The significance of ZIKV in human health and the lack of approved vaccines and/or antiviral drugs to combat ZIKV infection have triggered a global effort to develop effective countermeasures to prevent and/or treat ZIKV infection. In this Special Issue of Viruses, we have assembled a collection of 32 research and review articles that cover the more recent advances on ZIKV molecular biology, replication and transmission, virus–host interactions, pathogenesis, epidemiology, vaccine development, antivirals, and viral diagnosis.

Asthma, Health and Society

Asthma, Health and Society

Author: Andrew Harver

Publisher: Springer Science & Business Media

Published: 2010-03-10

Total Pages: 347

ISBN-13: 0387782850

DOWNLOAD EBOOK

Asthma, Health, and Society A Public Health Perspective Edited by Andrew Harver, University of North Carolina at Charlotte, Charlotte Harry Kotses, Ohio University, Athens Asthma, Health, and Society is a comprehensive, current resource on this complex disease—its scope, human costs, and management—from a combined social ecology/public health perspective. This important and unique book proposes a concerted, multifaceted response and sets out the foundation for shaping this response, comprising individual and large-scale assessment, education, advocacy, and multiple forms of intervention. In clear, authoritative detail enhanced by figures, graphs, and references, contributors explain where universal standards need to be set, alliances need to be built (such as among agencies and institutions in a community), and what is currently known about: Pathophysiology, epidemiology, and social impact of asthma. Genetic and environmental factors; protective factors and risk markers. Effects in women, minorities, children, teens, and elders. Medical management, self-management, and home monitoring. Evidence-based interventions at the family, school, and community levels. Screening guidelines, compliance issues, and more. In the absence of a cure or clear-cut causes, Asthma, Health, and Society offers the most robust compilation of practical knowledge on its subject to benefit the range of public health and asthma professionals, researchers, teachers, and students


Book Synopsis Asthma, Health and Society by : Andrew Harver

Download or read book Asthma, Health and Society written by Andrew Harver and published by Springer Science & Business Media. This book was released on 2010-03-10 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: Asthma, Health, and Society A Public Health Perspective Edited by Andrew Harver, University of North Carolina at Charlotte, Charlotte Harry Kotses, Ohio University, Athens Asthma, Health, and Society is a comprehensive, current resource on this complex disease—its scope, human costs, and management—from a combined social ecology/public health perspective. This important and unique book proposes a concerted, multifaceted response and sets out the foundation for shaping this response, comprising individual and large-scale assessment, education, advocacy, and multiple forms of intervention. In clear, authoritative detail enhanced by figures, graphs, and references, contributors explain where universal standards need to be set, alliances need to be built (such as among agencies and institutions in a community), and what is currently known about: Pathophysiology, epidemiology, and social impact of asthma. Genetic and environmental factors; protective factors and risk markers. Effects in women, minorities, children, teens, and elders. Medical management, self-management, and home monitoring. Evidence-based interventions at the family, school, and community levels. Screening guidelines, compliance issues, and more. In the absence of a cure or clear-cut causes, Asthma, Health, and Society offers the most robust compilation of practical knowledge on its subject to benefit the range of public health and asthma professionals, researchers, teachers, and students

Hospital-Based Health Technology Assessment

Hospital-Based Health Technology Assessment

Author: Laura Sampietro-Colom

Publisher: Springer

Published: 2017-01-23

Total Pages: 384

ISBN-13: 3319392050

DOWNLOAD EBOOK

A timely work describing how localized hospital-based health technology assessment (HB-HTA) complements general, ‘arms-length’ HTA agency efforts, and what has been the collective global impact of HB-HTA across the globe. While HB-HTA has gained significant momentum over the past few years, expertise in the field, and information on the operation and organization of HB-HTA, has been scattered. This book serves to bring this information together to inform those who are currently working in the field of HTA at the hospital, regional, national or global level. In addition, this book is intended for decision-makers and policy-makers with a stake in determining the uptake and decommissioning of new and established technologies in the hospital setting. HTA has traditionally been performed at the National/Regional level by HTA Agencies, typically linked to governments. Yet hospitals are the main entry door for most health technologies (HTs). Hospital decision-makers must undertake multiple high stakes investment and disinvestment decisions annually for innovative HTs, usually without adequate information. Despite the existence of arms-length HTA Agencies, inadequate information is available to hospital decision-makers either because relevant HTA reports are not yet released at the time of entry of new technologies to the field, or because even when the report exists, the information contained is insufficient to clarify the contextualized informational needs of hospital decision makers. Therefore, there has recently been a rising trend toward hospital-based HTA units and programs. These units/programs complement the work of National/Regional HTA Agencies by providing the key and relevant evidence needed by hospital decision makers in their specific hospital context, and within required decision-making timelines. The emergence of HB-HTA is creating a comprehensive HTA ecosystem across health care levels, which creates better bridges for knowledge translation through relevance and timeliness.


Book Synopsis Hospital-Based Health Technology Assessment by : Laura Sampietro-Colom

Download or read book Hospital-Based Health Technology Assessment written by Laura Sampietro-Colom and published by Springer. This book was released on 2017-01-23 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: A timely work describing how localized hospital-based health technology assessment (HB-HTA) complements general, ‘arms-length’ HTA agency efforts, and what has been the collective global impact of HB-HTA across the globe. While HB-HTA has gained significant momentum over the past few years, expertise in the field, and information on the operation and organization of HB-HTA, has been scattered. This book serves to bring this information together to inform those who are currently working in the field of HTA at the hospital, regional, national or global level. In addition, this book is intended for decision-makers and policy-makers with a stake in determining the uptake and decommissioning of new and established technologies in the hospital setting. HTA has traditionally been performed at the National/Regional level by HTA Agencies, typically linked to governments. Yet hospitals are the main entry door for most health technologies (HTs). Hospital decision-makers must undertake multiple high stakes investment and disinvestment decisions annually for innovative HTs, usually without adequate information. Despite the existence of arms-length HTA Agencies, inadequate information is available to hospital decision-makers either because relevant HTA reports are not yet released at the time of entry of new technologies to the field, or because even when the report exists, the information contained is insufficient to clarify the contextualized informational needs of hospital decision makers. Therefore, there has recently been a rising trend toward hospital-based HTA units and programs. These units/programs complement the work of National/Regional HTA Agencies by providing the key and relevant evidence needed by hospital decision makers in their specific hospital context, and within required decision-making timelines. The emergence of HB-HTA is creating a comprehensive HTA ecosystem across health care levels, which creates better bridges for knowledge translation through relevance and timeliness.

Replication-Competent Reporter-Expressing Viruses

Replication-Competent Reporter-Expressing Viruses

Author: Luis Martinez-Sobrido

Publisher:

Published: 2016

Total Pages: 322

ISBN-13: 9783038422594

DOWNLOAD EBOOK

Annotation Recombinant viruses expressing reporter fluorescent or bioluminescent proteins are an excellent option to evaluate the dynamics of viral infection progression in both cultured cells and/or validated animal models of viral infection. Reporter proteins are valid surrogates for direct detection of infected cells in vitro and in vivo, without the use of secondary methodologies to identify infected cells. By eliminating the need of secondary labeling, tractable replicating-competent, reporter-expressing viruses provide an ideal approach to monitor viral infections in real time, representing a significant advance in the study of the biology of viruses, to evaluate vaccination approaches, and to identify new therapeutics against viral infections using high-throughput screening settings. In this Special Issue "Replication-Competent Reporter-Expressing Viruses" we review replication-competent, reporter-expressing viruses belonging to different families, methods of characterization, and applications to facilitate the study of in vitro and in vivo viral infections. We also seek to discuss disadvantages and limitations associated with these reporter-expressing viruses. Finally, we provide rational future perspectives and additional avenues for the development, characterization, and applications of recombinant, reporter-expressing, competent viruses.


Book Synopsis Replication-Competent Reporter-Expressing Viruses by : Luis Martinez-Sobrido

Download or read book Replication-Competent Reporter-Expressing Viruses written by Luis Martinez-Sobrido and published by . This book was released on 2016 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annotation Recombinant viruses expressing reporter fluorescent or bioluminescent proteins are an excellent option to evaluate the dynamics of viral infection progression in both cultured cells and/or validated animal models of viral infection. Reporter proteins are valid surrogates for direct detection of infected cells in vitro and in vivo, without the use of secondary methodologies to identify infected cells. By eliminating the need of secondary labeling, tractable replicating-competent, reporter-expressing viruses provide an ideal approach to monitor viral infections in real time, representing a significant advance in the study of the biology of viruses, to evaluate vaccination approaches, and to identify new therapeutics against viral infections using high-throughput screening settings. In this Special Issue "Replication-Competent Reporter-Expressing Viruses" we review replication-competent, reporter-expressing viruses belonging to different families, methods of characterization, and applications to facilitate the study of in vitro and in vivo viral infections. We also seek to discuss disadvantages and limitations associated with these reporter-expressing viruses. Finally, we provide rational future perspectives and additional avenues for the development, characterization, and applications of recombinant, reporter-expressing, competent viruses.

Lumpy Skin Disease

Lumpy Skin Disease

Author: Eeva S. M. Tuppurainen

Publisher: Springer

Published: 2018-07-03

Total Pages: 99

ISBN-13: 3319924117

DOWNLOAD EBOOK

This book provides a comprehensive but concise overview on the economically important emerging cattle pox virus derived Lumpy Skin Disease, including the characteristics of causative agent, description of clinical signs in cattle, pathology and histopathology, immunity, geographical distribution, epidemiology and transmission pathways, control and eradication of the disease. In addition the recent developments in vaccination, mathematical modeling and risk assessment are discussed. Lumpy Skin Disease currently spreads aggressively across the Middle and Near East. The first incursion to the European Union territory occurred in Greece in autumn 2015. The book targets clinicians and field veterinarians in Lumpy Skin Disease affected regions, veterinary authorities as well as advanced students in veterinary medicine and virology.


Book Synopsis Lumpy Skin Disease by : Eeva S. M. Tuppurainen

Download or read book Lumpy Skin Disease written by Eeva S. M. Tuppurainen and published by Springer. This book was released on 2018-07-03 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive but concise overview on the economically important emerging cattle pox virus derived Lumpy Skin Disease, including the characteristics of causative agent, description of clinical signs in cattle, pathology and histopathology, immunity, geographical distribution, epidemiology and transmission pathways, control and eradication of the disease. In addition the recent developments in vaccination, mathematical modeling and risk assessment are discussed. Lumpy Skin Disease currently spreads aggressively across the Middle and Near East. The first incursion to the European Union territory occurred in Greece in autumn 2015. The book targets clinicians and field veterinarians in Lumpy Skin Disease affected regions, veterinary authorities as well as advanced students in veterinary medicine and virology.

Inflammation, 4 Volume Set

Inflammation, 4 Volume Set

Author: Jean-Marc Cavaillon

Publisher: John Wiley & Sons

Published: 2018-02-20

Total Pages: 1818

ISBN-13: 3527338993

DOWNLOAD EBOOK

The leading reference on this topic of increasing medical relevance is unique in offering unparalleled coverage. The editors are among the most respected researchers in inflammation worldwide and here have put together a prestigious team of contributors. Starting with the molecular basis of inflammation, from cytokines via the innate immune system to the different kinds of inflammatory cells, they continue with the function of inflammation in infectious disease before devoting a large section to the relationship between inflammation and chronic diseases. The book concludes with wound and tissue healing and options for therapeutic interventions. A must have for clinicians and biomedical researchers alike.


Book Synopsis Inflammation, 4 Volume Set by : Jean-Marc Cavaillon

Download or read book Inflammation, 4 Volume Set written by Jean-Marc Cavaillon and published by John Wiley & Sons. This book was released on 2018-02-20 with total page 1818 pages. Available in PDF, EPUB and Kindle. Book excerpt: The leading reference on this topic of increasing medical relevance is unique in offering unparalleled coverage. The editors are among the most respected researchers in inflammation worldwide and here have put together a prestigious team of contributors. Starting with the molecular basis of inflammation, from cytokines via the innate immune system to the different kinds of inflammatory cells, they continue with the function of inflammation in infectious disease before devoting a large section to the relationship between inflammation and chronic diseases. The book concludes with wound and tissue healing and options for therapeutic interventions. A must have for clinicians and biomedical researchers alike.

The Coronaviridae

The Coronaviridae

Author: Stuart G. Siddell

Publisher: Springer Science & Business Media

Published: 2013-06-29

Total Pages: 424

ISBN-13: 1489915311

DOWNLOAD EBOOK

Coronaviruses were recognized as a group of enveloped, RNA viruses in 1968 and accepted by the International Committee on the Taxonomy of Viruses as a separate family, the Coronaviridae, in 1975. By 1978, it had become evident that the coronavirus genomic RNA was infectious (i. e. , positive strand), and by 1983, at least the framework of the coronavirus replication strategy had been per ceived. Subsequently, with the application of recombinant DNA techniques, there have been remarkable advances in our understanding of the molecular biology of coronaviruses, and a mass of structural data concerning coronavirus genomes, mRNAs, and pro teins now exists. More recently, attention has been focused on the role of essential and accessory gene products in the coronavirus replication cyde and a molecular analysis of the structure-function relation ships of coronavirus proteins. Nevertheless, there are still large gaps in our knowledge, for instance, in areas such as the genesis of coronavirus subgenomic mRNAs or the function of the coronavirus RNA-dependent RNA polymerase. The diseases caused by coronaviruses have been known for much longer than the agents themselves. Possibly the first coronavirus-related disease to be recorded was feline infectious peritonitis, as early as 1912. The diseases associ ated with infectious bronchitis virus, transmissible gastroenteritis virus, and murine hepatitis virus were all well known before 1950.


Book Synopsis The Coronaviridae by : Stuart G. Siddell

Download or read book The Coronaviridae written by Stuart G. Siddell and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Coronaviruses were recognized as a group of enveloped, RNA viruses in 1968 and accepted by the International Committee on the Taxonomy of Viruses as a separate family, the Coronaviridae, in 1975. By 1978, it had become evident that the coronavirus genomic RNA was infectious (i. e. , positive strand), and by 1983, at least the framework of the coronavirus replication strategy had been per ceived. Subsequently, with the application of recombinant DNA techniques, there have been remarkable advances in our understanding of the molecular biology of coronaviruses, and a mass of structural data concerning coronavirus genomes, mRNAs, and pro teins now exists. More recently, attention has been focused on the role of essential and accessory gene products in the coronavirus replication cyde and a molecular analysis of the structure-function relation ships of coronavirus proteins. Nevertheless, there are still large gaps in our knowledge, for instance, in areas such as the genesis of coronavirus subgenomic mRNAs or the function of the coronavirus RNA-dependent RNA polymerase. The diseases caused by coronaviruses have been known for much longer than the agents themselves. Possibly the first coronavirus-related disease to be recorded was feline infectious peritonitis, as early as 1912. The diseases associ ated with infectious bronchitis virus, transmissible gastroenteritis virus, and murine hepatitis virus were all well known before 1950.

Stigma

Stigma

Author: Gerhard Falk

Publisher: Prometheus Books

Published: 2010-04-06

Total Pages: 376

ISBN-13: 1615923969

DOWNLOAD EBOOK

What is it in human nature that leads us to label some as insiders and stigmatize others as outsiders?Sociologist Gerhard Falk examines the social psychology that motivates this process of exclusion, focusing on the outcasts in contemporary American society and comparing current experience with examples from the past. Referring to the work of Emile Durkheim and Erving Goffman, Falk reviews the whole range of stigmatized people from the mentally ill to ordinary people with unpopular occupations, like undertakers and trash collectors. Amid the wide diversity of stigmatized persons, he finds two basic types of outsiders: the "existential" and the "achieved." The first group comprises those who are stigmatized because of their very existence, regardless of their specific actions: the mentally handicapped, for example. The second group describes those whose actions or life conditions have resulted in stigma: from high achievers (often subject to resentment) to criminals. Falk also looks at the ways in which writers past and present have dramatized stigmatized characters in literature.This fascinating overview of a long-standing and widespread social problem will be of interest to all those concerned about creating a more fair-minded society.


Book Synopsis Stigma by : Gerhard Falk

Download or read book Stigma written by Gerhard Falk and published by Prometheus Books. This book was released on 2010-04-06 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: What is it in human nature that leads us to label some as insiders and stigmatize others as outsiders?Sociologist Gerhard Falk examines the social psychology that motivates this process of exclusion, focusing on the outcasts in contemporary American society and comparing current experience with examples from the past. Referring to the work of Emile Durkheim and Erving Goffman, Falk reviews the whole range of stigmatized people from the mentally ill to ordinary people with unpopular occupations, like undertakers and trash collectors. Amid the wide diversity of stigmatized persons, he finds two basic types of outsiders: the "existential" and the "achieved." The first group comprises those who are stigmatized because of their very existence, regardless of their specific actions: the mentally handicapped, for example. The second group describes those whose actions or life conditions have resulted in stigma: from high achievers (often subject to resentment) to criminals. Falk also looks at the ways in which writers past and present have dramatized stigmatized characters in literature.This fascinating overview of a long-standing and widespread social problem will be of interest to all those concerned about creating a more fair-minded society.

Chronic Kidney Disease and Renal Transplantation

Chronic Kidney Disease and Renal Transplantation

Author: Manisha Sahay

Publisher: BoD – Books on Demand

Published: 2012-02-10

Total Pages: 240

ISBN-13: 9535100033

DOWNLOAD EBOOK

This valuable resource covers inpatient and outpatient approaches to chronic renal disease and renal transplant with clinical practicality. This first section of the book discusses chronic disease under distinct topics, each providing the readers with state-of-the-art information about the disease and its management. It discusses the fresh perspectives on the current state of chronic kidney disease. The text highlights not just the medical aspects but also the psychosocial issues associated with chronic kidney disease. The latest approaches are reviewed through line diagrams that clearly depict recent advances. The second section of the book deals with issues related to transplant. It provides effective and up-to-date insight into caring for your transplant patients.


Book Synopsis Chronic Kidney Disease and Renal Transplantation by : Manisha Sahay

Download or read book Chronic Kidney Disease and Renal Transplantation written by Manisha Sahay and published by BoD – Books on Demand. This book was released on 2012-02-10 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This valuable resource covers inpatient and outpatient approaches to chronic renal disease and renal transplant with clinical practicality. This first section of the book discusses chronic disease under distinct topics, each providing the readers with state-of-the-art information about the disease and its management. It discusses the fresh perspectives on the current state of chronic kidney disease. The text highlights not just the medical aspects but also the psychosocial issues associated with chronic kidney disease. The latest approaches are reviewed through line diagrams that clearly depict recent advances. The second section of the book deals with issues related to transplant. It provides effective and up-to-date insight into caring for your transplant patients.