Design and Analysis of Experiments in the Health Sciences

Design and Analysis of Experiments in the Health Sciences

Author: Gerald van Belle

Publisher: John Wiley & Sons

Published: 2012-07-24

Total Pages: 256

ISBN-13: 0470127279

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An accessible and practical approach to the design and analysis of experiments in the health sciences Design and Analysis of Experiments in the Health Sciences provides a balanced presentation of design and analysis issues relating to data in the health sciences and emphasizes new research areas, the crucial topic of clinical trials, and state-of-the- art applications. Advancing the idea that design drives analysis and analysis reveals the design, the book clearly explains how to apply design and analysis principles in animal, human, and laboratory experiments while illustrating topics with applications and examples from randomized clinical trials and the modern topic of microarrays. The authors outline the following five types of designs that form the basis of most experimental structures: Completely randomized designs Randomized block designs Factorial designs Multilevel experiments Repeated measures designs A related website features a wealth of data sets that are used throughout the book, allowing readers to work hands-on with the material. In addition, an extensive bibliography outlines additional resources for further study of the presented topics. Requiring only a basic background in statistics, Design and Analysis of Experiments in the Health Sciences is an excellent book for introductory courses on experimental design and analysis at the graduate level. The book also serves as a valuable resource for researchers in medicine, dentistry, nursing, epidemiology, statistical genetics, and public health.


Book Synopsis Design and Analysis of Experiments in the Health Sciences by : Gerald van Belle

Download or read book Design and Analysis of Experiments in the Health Sciences written by Gerald van Belle and published by John Wiley & Sons. This book was released on 2012-07-24 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: An accessible and practical approach to the design and analysis of experiments in the health sciences Design and Analysis of Experiments in the Health Sciences provides a balanced presentation of design and analysis issues relating to data in the health sciences and emphasizes new research areas, the crucial topic of clinical trials, and state-of-the- art applications. Advancing the idea that design drives analysis and analysis reveals the design, the book clearly explains how to apply design and analysis principles in animal, human, and laboratory experiments while illustrating topics with applications and examples from randomized clinical trials and the modern topic of microarrays. The authors outline the following five types of designs that form the basis of most experimental structures: Completely randomized designs Randomized block designs Factorial designs Multilevel experiments Repeated measures designs A related website features a wealth of data sets that are used throughout the book, allowing readers to work hands-on with the material. In addition, an extensive bibliography outlines additional resources for further study of the presented topics. Requiring only a basic background in statistics, Design and Analysis of Experiments in the Health Sciences is an excellent book for introductory courses on experimental design and analysis at the graduate level. The book also serves as a valuable resource for researchers in medicine, dentistry, nursing, epidemiology, statistical genetics, and public health.

Design and Analysis of Time Series Experiments

Design and Analysis of Time Series Experiments

Author: Richard McCleary

Publisher: Oxford University Press

Published: 2017

Total Pages: 393

ISBN-13: 0190661569

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Design and Analysis of Time Series Experiments presents the elements of statistical time series analysis while also addressing recent developments in research design and causal modeling. A distinguishing feature of the book is its integration of design and analysis of time series experiments. Drawing examples from criminology, economics, education, pharmacology, public policy, program evaluation, public health, and psychology, Design and Analysis of Time Series Experiments is addressed to researchers and graduate students in a wide range of behavioral, biomedical and social sciences. Readers learn not only how-to skills but, also the underlying rationales for the design features and the analytical methods. ARIMA algebra, Box-Jenkins-Tiao models and model-building strategies, forecasting, and Box-Tiao impact models are developed in separate chapters. The presentation of the models and model-building assumes only exposure to an introductory statistics course, with more difficult mathematical material relegated to appendices. Separate chapters cover threats to statistical conclusion validity, internal validity, construct validity, and external validity with an emphasis on how these threats arise in time series experiments. Design structures for controlling the threats are presented and illustrated through examples. The chapters on statistical conclusion validity and internal validity introduce Bayesian methods, counterfactual causality and synthetic control group designs. Building on the earlier of the authors, Design and Analysis of Time Series Experiments includes more recent developments in modeling, and considers design issues in greater detail than any existing work. Additionally, the book appeals to those who want to conduct or interpret time series experiments, as well as to those interested in research designs for causal inference.--


Book Synopsis Design and Analysis of Time Series Experiments by : Richard McCleary

Download or read book Design and Analysis of Time Series Experiments written by Richard McCleary and published by Oxford University Press. This book was released on 2017 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: Design and Analysis of Time Series Experiments presents the elements of statistical time series analysis while also addressing recent developments in research design and causal modeling. A distinguishing feature of the book is its integration of design and analysis of time series experiments. Drawing examples from criminology, economics, education, pharmacology, public policy, program evaluation, public health, and psychology, Design and Analysis of Time Series Experiments is addressed to researchers and graduate students in a wide range of behavioral, biomedical and social sciences. Readers learn not only how-to skills but, also the underlying rationales for the design features and the analytical methods. ARIMA algebra, Box-Jenkins-Tiao models and model-building strategies, forecasting, and Box-Tiao impact models are developed in separate chapters. The presentation of the models and model-building assumes only exposure to an introductory statistics course, with more difficult mathematical material relegated to appendices. Separate chapters cover threats to statistical conclusion validity, internal validity, construct validity, and external validity with an emphasis on how these threats arise in time series experiments. Design structures for controlling the threats are presented and illustrated through examples. The chapters on statistical conclusion validity and internal validity introduce Bayesian methods, counterfactual causality and synthetic control group designs. Building on the earlier of the authors, Design and Analysis of Time Series Experiments includes more recent developments in modeling, and considers design issues in greater detail than any existing work. Additionally, the book appeals to those who want to conduct or interpret time series experiments, as well as to those interested in research designs for causal inference.--

Design and Analysis of Experiments

Design and Analysis of Experiments

Author: Douglas C. Montgomery

Publisher: Wiley

Published: 2005

Total Pages: 0

ISBN-13: 9780471661597

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This bestselling professional reference has helped over 100,000 engineers and scientists with the success of their experiments. The new edition includes more software examples taken from the three most dominant programs in the field: Minitab, JMP, and SAS. Additional material has also been added in several chapters, including new developments in robust design and factorial designs. New examples and exercises are also presented to illustrate the use of designed experiments in service and transactional organizations. Engineers will be able to apply this information to improve the quality and efficiency of working systems.


Book Synopsis Design and Analysis of Experiments by : Douglas C. Montgomery

Download or read book Design and Analysis of Experiments written by Douglas C. Montgomery and published by Wiley. This book was released on 2005 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This bestselling professional reference has helped over 100,000 engineers and scientists with the success of their experiments. The new edition includes more software examples taken from the three most dominant programs in the field: Minitab, JMP, and SAS. Additional material has also been added in several chapters, including new developments in robust design and factorial designs. New examples and exercises are also presented to illustrate the use of designed experiments in service and transactional organizations. Engineers will be able to apply this information to improve the quality and efficiency of working systems.

Design and Analysis of Experiments with R

Design and Analysis of Experiments with R

Author: John Lawson

Publisher: CRC Press

Published: 2014-12-17

Total Pages: 629

ISBN-13: 1498728480

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Design and Analysis of Experiments with R presents a unified treatment of experimental designs and design concepts commonly used in practice. It connects the objectives of research to the type of experimental design required, describes the process of creating the design and collecting the data, shows how to perform the proper analysis of the data,


Book Synopsis Design and Analysis of Experiments with R by : John Lawson

Download or read book Design and Analysis of Experiments with R written by John Lawson and published by CRC Press. This book was released on 2014-12-17 with total page 629 pages. Available in PDF, EPUB and Kindle. Book excerpt: Design and Analysis of Experiments with R presents a unified treatment of experimental designs and design concepts commonly used in practice. It connects the objectives of research to the type of experimental design required, describes the process of creating the design and collecting the data, shows how to perform the proper analysis of the data,

Introduction to Design and Analysis of Experiments

Introduction to Design and Analysis of Experiments

Author: George W. Cobb

Publisher: Wiley

Published: 2008-06-10

Total Pages: 0

ISBN-13: 9780470412169

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Introduction to Design and Analysis of Experiments explains how to choose sound and suitable design structures and engages students in understanding the interpretive and constructive natures of data analysis and experimental design. Cobb's approach allows students to build a deep understanding of statistical concepts over time as they analyze and design experiments. The field of statistics is presented as a matrix, rather than a hierarchy, of related concepts. Developed over years of classroom use, this text can be used as an introduction to statistics emphasizing experimental design or as an elementary graduate survey course. Widely praised for its exceptional range of intelligent and creative exercises, and for its large number of examples and data sets, Introduction to Design and Analysis of Experiments--now offered in a convenient paperback format--helps students increase their understanding of the material as they come to see the connections between diverse statistical concepts that arise from the experiments around which the text is built.


Book Synopsis Introduction to Design and Analysis of Experiments by : George W. Cobb

Download or read book Introduction to Design and Analysis of Experiments written by George W. Cobb and published by Wiley. This book was released on 2008-06-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to Design and Analysis of Experiments explains how to choose sound and suitable design structures and engages students in understanding the interpretive and constructive natures of data analysis and experimental design. Cobb's approach allows students to build a deep understanding of statistical concepts over time as they analyze and design experiments. The field of statistics is presented as a matrix, rather than a hierarchy, of related concepts. Developed over years of classroom use, this text can be used as an introduction to statistics emphasizing experimental design or as an elementary graduate survey course. Widely praised for its exceptional range of intelligent and creative exercises, and for its large number of examples and data sets, Introduction to Design and Analysis of Experiments--now offered in a convenient paperback format--helps students increase their understanding of the material as they come to see the connections between diverse statistical concepts that arise from the experiments around which the text is built.

Statistical Design and Analysis of Biological Experiments

Statistical Design and Analysis of Biological Experiments

Author: Hans-Michael Kaltenbach

Publisher: Springer Nature

Published: 2021-04-15

Total Pages: 281

ISBN-13: 3030696413

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This richly illustrated book provides an overview of the design and analysis of experiments with a focus on non-clinical experiments in the life sciences, including animal research. It covers the most common aspects of experimental design such as handling multiple treatment factors and improving precision. In addition, it addresses experiments with large numbers of treatment factors and response surface methods for optimizing experimental conditions or biotechnological yields. The book emphasizes the estimation of effect sizes and the principled use of statistical arguments in the broader scientific context. It gradually transitions from classical analysis of variance to modern linear mixed models, and provides detailed information on power analysis and sample size determination, including ‘portable power’ formulas for making quick approximate calculations. In turn, detailed discussions of several real-life examples illustrate the complexities and aberrations that can arise in practice. Chiefly intended for students, teachers and researchers in the fields of experimental biology and biomedicine, the book is largely self-contained and starts with the necessary background on basic statistical concepts. The underlying ideas and necessary mathematics are gradually introduced in increasingly complex variants of a single example. Hasse diagrams serve as a powerful method for visualizing and comparing experimental designs and deriving appropriate models for their analysis. Manual calculations are provided for early examples, allowing the reader to follow the analyses in detail. More complex calculations rely on the statistical software R, but are easily transferable to other software. Though there are few prerequisites for effectively using the book, previous exposure to basic statistical ideas and the software R would be advisable.


Book Synopsis Statistical Design and Analysis of Biological Experiments by : Hans-Michael Kaltenbach

Download or read book Statistical Design and Analysis of Biological Experiments written by Hans-Michael Kaltenbach and published by Springer Nature. This book was released on 2021-04-15 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: This richly illustrated book provides an overview of the design and analysis of experiments with a focus on non-clinical experiments in the life sciences, including animal research. It covers the most common aspects of experimental design such as handling multiple treatment factors and improving precision. In addition, it addresses experiments with large numbers of treatment factors and response surface methods for optimizing experimental conditions or biotechnological yields. The book emphasizes the estimation of effect sizes and the principled use of statistical arguments in the broader scientific context. It gradually transitions from classical analysis of variance to modern linear mixed models, and provides detailed information on power analysis and sample size determination, including ‘portable power’ formulas for making quick approximate calculations. In turn, detailed discussions of several real-life examples illustrate the complexities and aberrations that can arise in practice. Chiefly intended for students, teachers and researchers in the fields of experimental biology and biomedicine, the book is largely self-contained and starts with the necessary background on basic statistical concepts. The underlying ideas and necessary mathematics are gradually introduced in increasingly complex variants of a single example. Hasse diagrams serve as a powerful method for visualizing and comparing experimental designs and deriving appropriate models for their analysis. Manual calculations are provided for early examples, allowing the reader to follow the analyses in detail. More complex calculations rely on the statistical software R, but are easily transferable to other software. Though there are few prerequisites for effectively using the book, previous exposure to basic statistical ideas and the software R would be advisable.

Design and Analysis of Experiments, Introduction to Experimental Design

Design and Analysis of Experiments, Introduction to Experimental Design

Author: Klaus Hinkelmann

Publisher: John Wiley & Sons

Published: 1994-03-22

Total Pages: 528

ISBN-13: 9780471551782

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Design and analysis of experiments/Hinkelmann.-v.1.


Book Synopsis Design and Analysis of Experiments, Introduction to Experimental Design by : Klaus Hinkelmann

Download or read book Design and Analysis of Experiments, Introduction to Experimental Design written by Klaus Hinkelmann and published by John Wiley & Sons. This book was released on 1994-03-22 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Design and analysis of experiments/Hinkelmann.-v.1.

Design and Analysis of Experiments, Volume 1

Design and Analysis of Experiments, Volume 1

Author: Klaus Hinkelmann

Publisher: John Wiley & Sons

Published: 2007-12-04

Total Pages: 640

ISBN-13: 0470191740

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This user-friendly new edition reflects a modern and accessible approach to experimental design and analysis Design and Analysis of Experiments, Volume 1, Second Edition provides a general introduction to the philosophy, theory, and practice of designing scientific comparative experiments and also details the intricacies that are often encountered throughout the design and analysis processes. With the addition of extensive numerical examples and expanded treatment of key concepts, this book further addresses the needs of practitioners and successfully provides a solid understanding of the relationship between the quality of experimental design and the validity of conclusions. This Second Edition continues to provide the theoretical basis of the principles of experimental design in conjunction with the statistical framework within which to apply the fundamental concepts. The difference between experimental studies and observational studies is addressed, along with a discussion of the various components of experimental design: the error-control design, the treatment design, and the observation design. A series of error-control designs are presented based on fundamental design principles, such as randomization, local control (blocking), the Latin square principle, the split-unit principle, and the notion of factorial treatment structure. This book also emphasizes the practical aspects of designing and analyzing experiments and features: Increased coverage of the practical aspects of designing and analyzing experiments, complete with the steps needed to plan and construct an experiment A case study that explores the various types of interaction between both treatment and blocking factors, and numerical and graphical techniques are provided to analyze and interpret these interactions Discussion of the important distinctions between two types of blocking factors and their role in the process of drawing statistical inferences from an experiment A new chapter devoted entirely to repeated measures, highlighting its relationship to split-plot and split-block designs Numerical examples using SAS® to illustrate the analyses of data from various designs and to construct factorial designs that relate the results to the theoretical derivations Design and Analysis of Experiments, Volume 1, Second Edition is an ideal textbook for first-year graduate courses in experimental design and also serves as a practical, hands-on reference for statisticians and researchers across a wide array of subject areas, including biological sciences, engineering, medicine, pharmacology, psychology, and business.


Book Synopsis Design and Analysis of Experiments, Volume 1 by : Klaus Hinkelmann

Download or read book Design and Analysis of Experiments, Volume 1 written by Klaus Hinkelmann and published by John Wiley & Sons. This book was released on 2007-12-04 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: This user-friendly new edition reflects a modern and accessible approach to experimental design and analysis Design and Analysis of Experiments, Volume 1, Second Edition provides a general introduction to the philosophy, theory, and practice of designing scientific comparative experiments and also details the intricacies that are often encountered throughout the design and analysis processes. With the addition of extensive numerical examples and expanded treatment of key concepts, this book further addresses the needs of practitioners and successfully provides a solid understanding of the relationship between the quality of experimental design and the validity of conclusions. This Second Edition continues to provide the theoretical basis of the principles of experimental design in conjunction with the statistical framework within which to apply the fundamental concepts. The difference between experimental studies and observational studies is addressed, along with a discussion of the various components of experimental design: the error-control design, the treatment design, and the observation design. A series of error-control designs are presented based on fundamental design principles, such as randomization, local control (blocking), the Latin square principle, the split-unit principle, and the notion of factorial treatment structure. This book also emphasizes the practical aspects of designing and analyzing experiments and features: Increased coverage of the practical aspects of designing and analyzing experiments, complete with the steps needed to plan and construct an experiment A case study that explores the various types of interaction between both treatment and blocking factors, and numerical and graphical techniques are provided to analyze and interpret these interactions Discussion of the important distinctions between two types of blocking factors and their role in the process of drawing statistical inferences from an experiment A new chapter devoted entirely to repeated measures, highlighting its relationship to split-plot and split-block designs Numerical examples using SAS® to illustrate the analyses of data from various designs and to construct factorial designs that relate the results to the theoretical derivations Design and Analysis of Experiments, Volume 1, Second Edition is an ideal textbook for first-year graduate courses in experimental design and also serves as a practical, hands-on reference for statisticians and researchers across a wide array of subject areas, including biological sciences, engineering, medicine, pharmacology, psychology, and business.

The Design and Analysis of Computer Experiments

The Design and Analysis of Computer Experiments

Author: Thomas J. Santner

Publisher: Springer

Published: 2019-01-08

Total Pages: 436

ISBN-13: 1493988476

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This book describes methods for designing and analyzing experiments that are conducted using a computer code, a computer experiment, and, when possible, a physical experiment. Computer experiments continue to increase in popularity as surrogates for and adjuncts to physical experiments. Since the publication of the first edition, there have been many methodological advances and software developments to implement these new methodologies. The computer experiments literature has emphasized the construction of algorithms for various data analysis tasks (design construction, prediction, sensitivity analysis, calibration among others), and the development of web-based repositories of designs for immediate application. While it is written at a level that is accessible to readers with Masters-level training in Statistics, the book is written in sufficient detail to be useful for practitioners and researchers. New to this revised and expanded edition: • An expanded presentation of basic material on computer experiments and Gaussian processes with additional simulations and examples • A new comparison of plug-in prediction methodologies for real-valued simulator output • An enlarged discussion of space-filling designs including Latin Hypercube designs (LHDs), near-orthogonal designs, and nonrectangular regions • A chapter length description of process-based designs for optimization, to improve good overall fit, quantile estimation, and Pareto optimization • A new chapter describing graphical and numerical sensitivity analysis tools • Substantial new material on calibration-based prediction and inference for calibration parameters • Lists of software that can be used to fit models discussed in the book to aid practitioners


Book Synopsis The Design and Analysis of Computer Experiments by : Thomas J. Santner

Download or read book The Design and Analysis of Computer Experiments written by Thomas J. Santner and published by Springer. This book was released on 2019-01-08 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes methods for designing and analyzing experiments that are conducted using a computer code, a computer experiment, and, when possible, a physical experiment. Computer experiments continue to increase in popularity as surrogates for and adjuncts to physical experiments. Since the publication of the first edition, there have been many methodological advances and software developments to implement these new methodologies. The computer experiments literature has emphasized the construction of algorithms for various data analysis tasks (design construction, prediction, sensitivity analysis, calibration among others), and the development of web-based repositories of designs for immediate application. While it is written at a level that is accessible to readers with Masters-level training in Statistics, the book is written in sufficient detail to be useful for practitioners and researchers. New to this revised and expanded edition: • An expanded presentation of basic material on computer experiments and Gaussian processes with additional simulations and examples • A new comparison of plug-in prediction methodologies for real-valued simulator output • An enlarged discussion of space-filling designs including Latin Hypercube designs (LHDs), near-orthogonal designs, and nonrectangular regions • A chapter length description of process-based designs for optimization, to improve good overall fit, quantile estimation, and Pareto optimization • A new chapter describing graphical and numerical sensitivity analysis tools • Substantial new material on calibration-based prediction and inference for calibration parameters • Lists of software that can be used to fit models discussed in the book to aid practitioners

A First Course in Design and Analysis of Experiments

A First Course in Design and Analysis of Experiments

Author: Gary W. Oehlert

Publisher: W. H. Freeman

Published: 2000-01-19

Total Pages: 600

ISBN-13: 9780716735106

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Oehlert's text is suitable for either a service course for non-statistics graduate students or for statistics majors. Unlike most texts for the one-term grad/upper level course on experimental design, Oehlert's new book offers a superb balance of both analysis and design, presenting three practical themes to students: • when to use various designs • how to analyze the results • how to recognize various design options Also, unlike other older texts, the book is fully oriented toward the use of statistical software in analyzing experiments.


Book Synopsis A First Course in Design and Analysis of Experiments by : Gary W. Oehlert

Download or read book A First Course in Design and Analysis of Experiments written by Gary W. Oehlert and published by W. H. Freeman. This book was released on 2000-01-19 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oehlert's text is suitable for either a service course for non-statistics graduate students or for statistics majors. Unlike most texts for the one-term grad/upper level course on experimental design, Oehlert's new book offers a superb balance of both analysis and design, presenting three practical themes to students: • when to use various designs • how to analyze the results • how to recognize various design options Also, unlike other older texts, the book is fully oriented toward the use of statistical software in analyzing experiments.