Drugs and the Delivery of Oxygen to Tissues

Drugs and the Delivery of Oxygen to Tissues

Author: J. Stuart Fleming

Publisher: CRC Press

Published: 1989-12-31

Total Pages: 298

ISBN-13: 9780849366567

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This rare and unique work consists of a broad overview of hyperviscosity, blood cell deformability, and platelet aggregation. These topics are written in combination with a comprehensive review of drugs bring developed to treat impaired oxygen delivery to tissue. It devotes much attention to the pathophysiology and pharmacology of platelet and red cell involvement. This easy-to-use volume describes in detail techniques for studying microcirculatory functional efficiency, blood cell rheology, and intravascular platelet thrombosis. It also provides the reader with more than 50 figures and nearly 1500 references at a glance. This book is an indispensable resource for all pharmaceutical researchers, physicians, and medical students interested in emerging therapeutic approaches to ischemia.


Book Synopsis Drugs and the Delivery of Oxygen to Tissues by : J. Stuart Fleming

Download or read book Drugs and the Delivery of Oxygen to Tissues written by J. Stuart Fleming and published by CRC Press. This book was released on 1989-12-31 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: This rare and unique work consists of a broad overview of hyperviscosity, blood cell deformability, and platelet aggregation. These topics are written in combination with a comprehensive review of drugs bring developed to treat impaired oxygen delivery to tissue. It devotes much attention to the pathophysiology and pharmacology of platelet and red cell involvement. This easy-to-use volume describes in detail techniques for studying microcirculatory functional efficiency, blood cell rheology, and intravascular platelet thrombosis. It also provides the reader with more than 50 figures and nearly 1500 references at a glance. This book is an indispensable resource for all pharmaceutical researchers, physicians, and medical students interested in emerging therapeutic approaches to ischemia.

Regulation of Tissue Oxygenation, Second Edition

Regulation of Tissue Oxygenation, Second Edition

Author: Roland N. Pittman

Publisher: Biota Publishing

Published: 2016-08-18

Total Pages: 117

ISBN-13: 1615047212

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This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.


Book Synopsis Regulation of Tissue Oxygenation, Second Edition by : Roland N. Pittman

Download or read book Regulation of Tissue Oxygenation, Second Edition written by Roland N. Pittman and published by Biota Publishing. This book was released on 2016-08-18 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt: This presentation describes various aspects of the regulation of tissue oxygenation, including the roles of the circulatory system, respiratory system, and blood, the carrier of oxygen within these components of the cardiorespiratory system. The respiratory system takes oxygen from the atmosphere and transports it by diffusion from the air in the alveoli to the blood flowing through the pulmonary capillaries. The cardiovascular system then moves the oxygenated blood from the heart to the microcirculation of the various organs by convection, where oxygen is released from hemoglobin in the red blood cells and moves to the parenchymal cells of each tissue by diffusion. Oxygen that has diffused into cells is then utilized in the mitochondria to produce adenosine triphosphate (ATP), the energy currency of all cells. The mitochondria are able to produce ATP until the oxygen tension or PO2 on the cell surface falls to a critical level of about 4–5 mm Hg. Thus, in order to meet the energetic needs of cells, it is important to maintain a continuous supply of oxygen to the mitochondria at or above the critical PO2 . In order to accomplish this desired outcome, the cardiorespiratory system, including the blood, must be capable of regulation to ensure survival of all tissues under a wide range of circumstances. The purpose of this presentation is to provide basic information about the operation and regulation of the cardiovascular and respiratory systems, as well as the properties of the blood and parenchymal cells, so that a fundamental understanding of the regulation of tissue oxygenation is achieved.

Drugs and the Delivery of Oxygen to Tissue

Drugs and the Delivery of Oxygen to Tissue

Author:

Publisher:

Published: 1990

Total Pages: 283

ISBN-13:

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Book Synopsis Drugs and the Delivery of Oxygen to Tissue by :

Download or read book Drugs and the Delivery of Oxygen to Tissue written by and published by . This book was released on 1990 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Impact of Vasoactive Drugs on Oxygenation and Tissue Perfusion

The Impact of Vasoactive Drugs on Oxygenation and Tissue Perfusion

Author:

Publisher:

Published: 1992

Total Pages: 101

ISBN-13:

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Nurses caring for critically ill patients, either in the emergency room or intensive care setting, respond to a patient's need for oxygen on a daily basis. The goal of oxygen administration is to provide oxygen to the tissues and cells, thereby preventing anaerobic metabolism (Ahrens, 1987). Sometimes oxygen administration alone is not enough to provide the amounts needed for adequate cellular oxygenation and tissue perfusion. Pharmacological agents may be used to increase oxygen delivery to the cells through increased cardiac output. Frequently these drugs will be vasoactive drugs which constrict or dilate the blood vessels. As the drug act, cardiac output is manipulated for optimum patient response.


Book Synopsis The Impact of Vasoactive Drugs on Oxygenation and Tissue Perfusion by :

Download or read book The Impact of Vasoactive Drugs on Oxygenation and Tissue Perfusion written by and published by . This book was released on 1992 with total page 101 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nurses caring for critically ill patients, either in the emergency room or intensive care setting, respond to a patient's need for oxygen on a daily basis. The goal of oxygen administration is to provide oxygen to the tissues and cells, thereby preventing anaerobic metabolism (Ahrens, 1987). Sometimes oxygen administration alone is not enough to provide the amounts needed for adequate cellular oxygenation and tissue perfusion. Pharmacological agents may be used to increase oxygen delivery to the cells through increased cardiac output. Frequently these drugs will be vasoactive drugs which constrict or dilate the blood vessels. As the drug act, cardiac output is manipulated for optimum patient response.

Oxygen Transport to Tissue XXV

Oxygen Transport to Tissue XXV

Author: Maureen S. Thorniley

Publisher: Springer Science & Business Media

Published: 2003-12-31

Total Pages: 360

ISBN-13: 9780306480355

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The 30th scientific meeting of the International Society on Oxygen Transport to Tissue (ISOTT) was held at the Western Conference Centre, UMIST, Manchester, in August 2002. It was attended by some 96 delegates and accompanying persons and there were 128 presentations.


Book Synopsis Oxygen Transport to Tissue XXV by : Maureen S. Thorniley

Download or read book Oxygen Transport to Tissue XXV written by Maureen S. Thorniley and published by Springer Science & Business Media. This book was released on 2003-12-31 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 30th scientific meeting of the International Society on Oxygen Transport to Tissue (ISOTT) was held at the Western Conference Centre, UMIST, Manchester, in August 2002. It was attended by some 96 delegates and accompanying persons and there were 128 presentations.

Regulation of Coronary Blood Flow

Regulation of Coronary Blood Flow

Author: Michitoshi Inoue

Publisher: Springer Science & Business Media

Published: 2013-11-09

Total Pages: 330

ISBN-13: 4431683674

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Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.


Book Synopsis Regulation of Coronary Blood Flow by : Michitoshi Inoue

Download or read book Regulation of Coronary Blood Flow written by Michitoshi Inoue and published by Springer Science & Business Media. This book was released on 2013-11-09 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.

Tissue Oxygen Utilization

Tissue Oxygen Utilization

Author: Guillermo Gutierrez

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 381

ISBN-13: 3642841694

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Disturbances in peripheral O extraction can be produced in dogs treated with 2 endotoxin and thereby provide an opportunity to test theories for the origin of pathological O supply dependency or to try different treatment modalities. The 2 most serious deficiency in the current animal models is the inability to mimic the increased O demand that is observed in patients at 02 delivery rates in excess of 2 normal. A particular feature of this increased O demand is that it apparently does 2 not stimulate increased 02 extraction, although the limitation in O extraction has 2 not been explored in patients by lowering 02 supply, for obvious reasons. At least two possibilities to account for increased 02 demand could be investigated in animal models, however. The amount of 02 that is utilized in extramitochondrial pathways, which is normally on the order of 10%, may be greatly increased in ARDS and sepsis by O radical formation. There is presently no information 2 concerning how much 02 might be used in this way. Another strong possibility is that mitochondrial injury, perhaps as a result of 02 radical formation, uncouples oxidative phosphorylation. Some evidence presently in the literature supports this idea [19]. Indeed, the association of increased blood lactate levels with higher than expected 02 demands makes uncoupling a very attractive hypothesis that warrants further investigation in animal models using such agents as 2,4-dinitrophenol. References 1.


Book Synopsis Tissue Oxygen Utilization by : Guillermo Gutierrez

Download or read book Tissue Oxygen Utilization written by Guillermo Gutierrez and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: Disturbances in peripheral O extraction can be produced in dogs treated with 2 endotoxin and thereby provide an opportunity to test theories for the origin of pathological O supply dependency or to try different treatment modalities. The 2 most serious deficiency in the current animal models is the inability to mimic the increased O demand that is observed in patients at 02 delivery rates in excess of 2 normal. A particular feature of this increased O demand is that it apparently does 2 not stimulate increased 02 extraction, although the limitation in O extraction has 2 not been explored in patients by lowering 02 supply, for obvious reasons. At least two possibilities to account for increased 02 demand could be investigated in animal models, however. The amount of 02 that is utilized in extramitochondrial pathways, which is normally on the order of 10%, may be greatly increased in ARDS and sepsis by O radical formation. There is presently no information 2 concerning how much 02 might be used in this way. Another strong possibility is that mitochondrial injury, perhaps as a result of 02 radical formation, uncouples oxidative phosphorylation. Some evidence presently in the literature supports this idea [19]. Indeed, the association of increased blood lactate levels with higher than expected 02 demands makes uncoupling a very attractive hypothesis that warrants further investigation in animal models using such agents as 2,4-dinitrophenol. References 1.

Human Hemoglobins

Human Hemoglobins

Author: Howard Franklin Bunn

Publisher: W.B. Saunders Company

Published: 1977

Total Pages: 456

ISBN-13:

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Since the dawn of the era of molecular biology, hemoglobin has been subjected to more scrutiny than any other protein, and Bunn, Forget, and Ranney can each lay claim to major contributions to the saga of hemoglobin. Their well-organized, comprehensive, and superbly illustrated work is an excellent review of the abnormal hemoglobin field. Early chapters deal with the structure and function of human hemoglobin and the way in which this is modified in various disease states. Later sections deal with the various structural hemoglobin variants and their associated clinical manifestations, the thalassaemias, and the acquired disorders of hemoglobin. The sections that deal with the modification of hemoglobin function in various disease states are particularly good. The book contains an extensive and up-to-date bibliography and is remarkably free from errors of fact or type--the best standard of reference on the subject as of the year 1977.


Book Synopsis Human Hemoglobins by : Howard Franklin Bunn

Download or read book Human Hemoglobins written by Howard Franklin Bunn and published by W.B. Saunders Company. This book was released on 1977 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the dawn of the era of molecular biology, hemoglobin has been subjected to more scrutiny than any other protein, and Bunn, Forget, and Ranney can each lay claim to major contributions to the saga of hemoglobin. Their well-organized, comprehensive, and superbly illustrated work is an excellent review of the abnormal hemoglobin field. Early chapters deal with the structure and function of human hemoglobin and the way in which this is modified in various disease states. Later sections deal with the various structural hemoglobin variants and their associated clinical manifestations, the thalassaemias, and the acquired disorders of hemoglobin. The sections that deal with the modification of hemoglobin function in various disease states are particularly good. The book contains an extensive and up-to-date bibliography and is remarkably free from errors of fact or type--the best standard of reference on the subject as of the year 1977.

The Cerebral Circulation

The Cerebral Circulation

Author: Marilyn J. Cipolla

Publisher: Biota Publishing

Published: 2016-07-28

Total Pages: 82

ISBN-13: 1615047239

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This e-book will review special features of the cerebral circulation and how they contribute to the physiology of the brain. It describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain microcirculation such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death.


Book Synopsis The Cerebral Circulation by : Marilyn J. Cipolla

Download or read book The Cerebral Circulation written by Marilyn J. Cipolla and published by Biota Publishing. This book was released on 2016-07-28 with total page 82 pages. Available in PDF, EPUB and Kindle. Book excerpt: This e-book will review special features of the cerebral circulation and how they contribute to the physiology of the brain. It describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain microcirculation such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death.

Basic Physiology for Anaesthetists

Basic Physiology for Anaesthetists

Author: David Chambers

Publisher: Cambridge University Press

Published: 2019-07-25

Total Pages: 469

ISBN-13: 1108463991

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Easily understood, up-to-date and clinically relevant, this book provides junior anaesthetists with an essential physiology resource.


Book Synopsis Basic Physiology for Anaesthetists by : David Chambers

Download or read book Basic Physiology for Anaesthetists written by David Chambers and published by Cambridge University Press. This book was released on 2019-07-25 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: Easily understood, up-to-date and clinically relevant, this book provides junior anaesthetists with an essential physiology resource.