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Dynamic Mixed Models for Familial Longitudinal Data

Author: Brajendra C. Sutradhar

Publisher: Springer Science & Business Media

Published: 2011-01-27

Total Pages: 509

ISBN-13: 1441983422

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This book provides a theoretical foundation for the analysis of discrete data such as count and binary data in the longitudinal setup. Unlike the existing books, this book uses a class of auto-correlation structures to model the longitudinal correlations for the repeated discrete data that accommodates all possible Gaussian type auto-correlation models as special cases including the equi-correlation models. This new dynamic modelling approach is utilized to develop theoretically sound inference techniques such as the generalized quasi-likelihood (GQL) technique for consistent and efficient estimation of the underlying regression effects involved in the model, whereas the existing ‘working’ correlations based GEE (generalized estimating equations) approach has serious theoretical limitations both for consistent and efficient estimation, and the existing random effects based correlations approach is not suitable to model the longitudinal correlations. The book has exploited the random effects carefully only to model the correlations of the familial data. Subsequently, this book has modelled the correlations of the longitudinal data collected from the members of a large number of independent families by using the class of auto-correlation structures conditional on the random effects. The book also provides models and inferences for discrete longitudinal data in the adaptive clinical trial set up. The book is mathematically rigorous and provides details for the development of estimation approaches under selected familial and longitudinal models. Further, while the book provides special cares for mathematics behind the correlation models, it also presents the illustrations of the statistical analysis of various real life data. This book will be of interest to the researchers including graduate students in biostatistics and econometrics, among other applied statistics research areas. Brajendra Sutradhar is a University Research Professor at Memorial University in St. John’s, Canada. He is an elected member of the International Statistical Institute and a fellow of the American Statistical Association. He has published about 110 papers in statistics journals in the area of multivariate analysis, time series analysis including forecasting, sampling, survival analysis for correlated failure times, robust inferences in generalized linear mixed models with outliers, and generalized linear longitudinal mixed models with bio-statistical and econometric applications. He has served as an associate editor for six years for Canadian Journal of Statistics and for four years for the Journal of Environmental and Ecological Statistics. He has served for 3 years as a member of the advisory committee on statistical methods in Statistics Canada. Professor Sutradhar was awarded 2007 distinguished service award of Statistics Society of Canada for his many years of services to the society including his special services for society’s annual meetings.

Book Synopsis Dynamic Mixed Models for Familial Longitudinal Data by : Brajendra C. Sutradhar

Download or read book Dynamic Mixed Models for Familial Longitudinal Data written by Brajendra C. Sutradhar and published by Springer Science & Business Media. This book was released on 2011-01-27 with total page 509 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a theoretical foundation for the analysis of discrete data such as count and binary data in the longitudinal setup. Unlike the existing books, this book uses a class of auto-correlation structures to model the longitudinal correlations for the repeated discrete data that accommodates all possible Gaussian type auto-correlation models as special cases including the equi-correlation models. This new dynamic modelling approach is utilized to develop theoretically sound inference techniques such as the generalized quasi-likelihood (GQL) technique for consistent and efficient estimation of the underlying regression effects involved in the model, whereas the existing ‘working’ correlations based GEE (generalized estimating equations) approach has serious theoretical limitations both for consistent and efficient estimation, and the existing random effects based correlations approach is not suitable to model the longitudinal correlations. The book has exploited the random effects carefully only to model the correlations of the familial data. Subsequently, this book has modelled the correlations of the longitudinal data collected from the members of a large number of independent families by using the class of auto-correlation structures conditional on the random effects. The book also provides models and inferences for discrete longitudinal data in the adaptive clinical trial set up. The book is mathematically rigorous and provides details for the development of estimation approaches under selected familial and longitudinal models. Further, while the book provides special cares for mathematics behind the correlation models, it also presents the illustrations of the statistical analysis of various real life data. This book will be of interest to the researchers including graduate students in biostatistics and econometrics, among other applied statistics research areas. Brajendra Sutradhar is a University Research Professor at Memorial University in St. John’s, Canada. He is an elected member of the International Statistical Institute and a fellow of the American Statistical Association. He has published about 110 papers in statistics journals in the area of multivariate analysis, time series analysis including forecasting, sampling, survival analysis for correlated failure times, robust inferences in generalized linear mixed models with outliers, and generalized linear longitudinal mixed models with bio-statistical and econometric applications. He has served as an associate editor for six years for Canadian Journal of Statistics and for four years for the Journal of Environmental and Ecological Statistics. He has served for 3 years as a member of the advisory committee on statistical methods in Statistics Canada. Professor Sutradhar was awarded 2007 distinguished service award of Statistics Society of Canada for his many years of services to the society including his special services for society’s annual meetings.

Mixed Effects Models for Complex Data

Author: Lang Wu

Publisher: CRC Press

Published: 2009-11-11

Total Pages: 431

ISBN-13: 9781420074086

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Although standard mixed effects models are useful in a range of studies, other approaches must often be used in correlation with them when studying complex or incomplete data. Mixed Effects Models for Complex Data discusses commonly used mixed effects models and presents appropriate approaches to address dropouts, missing data, measurement errors, censoring, and outliers. For each class of mixed effects model, the author reviews the corresponding class of regression model for cross-sectional data. An overview of general models and methods, along with motivating examples After presenting real data examples and outlining general approaches to the analysis of longitudinal/clustered data and incomplete data, the book introduces linear mixed effects (LME) models, generalized linear mixed models (GLMMs), nonlinear mixed effects (NLME) models, and semiparametric and nonparametric mixed effects models. It also includes general approaches for the analysis of complex data with missing values, measurement errors, censoring, and outliers. Self-contained coverage of specific topics Subsequent chapters delve more deeply into missing data problems, covariate measurement errors, and censored responses in mixed effects models. Focusing on incomplete data, the book also covers survival and frailty models, joint models of survival and longitudinal data, robust methods for mixed effects models, marginal generalized estimating equation (GEE) models for longitudinal or clustered data, and Bayesian methods for mixed effects models. Background material In the appendix, the author provides background information, such as likelihood theory, the Gibbs sampler, rejection and importance sampling methods, numerical integration methods, optimization methods, bootstrap, and matrix algebra. Failure to properly address missing data, measurement errors, and other issues in statistical analyses can lead to severely biased or misleading results. This book explores the biases that arise when naïve methods are used and shows which approaches should be used to achieve accurate results in longitudinal data analysis.

Book Synopsis Mixed Effects Models for Complex Data by : Lang Wu

Download or read book Mixed Effects Models for Complex Data written by Lang Wu and published by CRC Press. This book was released on 2009-11-11 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although standard mixed effects models are useful in a range of studies, other approaches must often be used in correlation with them when studying complex or incomplete data. Mixed Effects Models for Complex Data discusses commonly used mixed effects models and presents appropriate approaches to address dropouts, missing data, measurement errors, censoring, and outliers. For each class of mixed effects model, the author reviews the corresponding class of regression model for cross-sectional data. An overview of general models and methods, along with motivating examples After presenting real data examples and outlining general approaches to the analysis of longitudinal/clustered data and incomplete data, the book introduces linear mixed effects (LME) models, generalized linear mixed models (GLMMs), nonlinear mixed effects (NLME) models, and semiparametric and nonparametric mixed effects models. It also includes general approaches for the analysis of complex data with missing values, measurement errors, censoring, and outliers. Self-contained coverage of specific topics Subsequent chapters delve more deeply into missing data problems, covariate measurement errors, and censored responses in mixed effects models. Focusing on incomplete data, the book also covers survival and frailty models, joint models of survival and longitudinal data, robust methods for mixed effects models, marginal generalized estimating equation (GEE) models for longitudinal or clustered data, and Bayesian methods for mixed effects models. Background material In the appendix, the author provides background information, such as likelihood theory, the Gibbs sampler, rejection and importance sampling methods, numerical integration methods, optimization methods, bootstrap, and matrix algebra. Failure to properly address missing data, measurement errors, and other issues in statistical analyses can lead to severely biased or misleading results. This book explores the biases that arise when naïve methods are used and shows which approaches should be used to achieve accurate results in longitudinal data analysis.

A Life Course Perspective on Health Trajectories and Transitions

Author: Claudine Burton-Jeangros

Publisher: Springer

Published: 2015-08-11

Total Pages: 213

ISBN-13: 331920484X

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This open access book examines health trajectories and health transitions at different stages of the life course, including childhood, adulthood and later life. It provides findings that assess the role of biological and social transitions on health status over time. The essays examine a wide range of health issues, including the consequences of military service on body mass index, childhood obesity and cardiovascular health, socio-economic inequalities in preventive health care use, depression and anxiety during the child rearing period, health trajectories and transitions in people with cystic fibrosis and oral health over the life course. The book addresses theoretical, empirical and methodological issues as well as examines different national contexts, which help to identify factors of vulnerability and potential resources that support resilience available for specific groups and/or populations. Health reflects the ability of individuals to adapt to their social environment. This book analyzes health as a dynamic experience. It examines how different aspects of individual health unfold over time as a result of aging but also in relation to changing socioeconomic conditions. It also offers readers potential insights into public policies that affect the health status of a population.

Book Synopsis A Life Course Perspective on Health Trajectories and Transitions by : Claudine Burton-Jeangros

Download or read book A Life Course Perspective on Health Trajectories and Transitions written by Claudine Burton-Jeangros and published by Springer. This book was released on 2015-08-11 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book examines health trajectories and health transitions at different stages of the life course, including childhood, adulthood and later life. It provides findings that assess the role of biological and social transitions on health status over time. The essays examine a wide range of health issues, including the consequences of military service on body mass index, childhood obesity and cardiovascular health, socio-economic inequalities in preventive health care use, depression and anxiety during the child rearing period, health trajectories and transitions in people with cystic fibrosis and oral health over the life course. The book addresses theoretical, empirical and methodological issues as well as examines different national contexts, which help to identify factors of vulnerability and potential resources that support resilience available for specific groups and/or populations. Health reflects the ability of individuals to adapt to their social environment. This book analyzes health as a dynamic experience. It examines how different aspects of individual health unfold over time as a result of aging but also in relation to changing socioeconomic conditions. It also offers readers potential insights into public policies that affect the health status of a population.

Longitudinal Categorical Data Analysis

Author: Brajendra C. Sutradhar

Publisher: Springer

Published: 2014-10-30

Total Pages: 387

ISBN-13: 1493921371

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This is the first book in longitudinal categorical data analysis with parametric correlation models developed based on dynamic relationships among repeated categorical responses. This book is a natural generalization of the longitudinal binary data analysis to the multinomial data setup with more than two categories. Thus, unlike the existing books on cross-sectional categorical data analysis using log linear models, this book uses multinomial probability models both in cross-sectional and longitudinal setups. A theoretical foundation is provided for the analysis of univariate multinomial responses, by developing models systematically for the cases with no covariates as well as categorical covariates, both in cross-sectional and longitudinal setups. In the longitudinal setup, both stationary and non-stationary covariates are considered. These models have also been extended to the bivariate multinomial setup along with suitable covariates. For the inferences, the book uses the generalized quasi-likelihood as well as the exact likelihood approaches. The book is technically rigorous, and, it also presents illustrations of the statistical analysis of various real life data involving univariate multinomial responses both in cross-sectional and longitudinal setups. This book is written mainly for the graduate students and researchers in statistics and social sciences, among other applied statistics research areas. However, the rest of the book, specifically the chapters from 1 to 3, may also be used for a senior undergraduate course in statistics.

Book Synopsis Longitudinal Categorical Data Analysis by : Brajendra C. Sutradhar

Download or read book Longitudinal Categorical Data Analysis written by Brajendra C. Sutradhar and published by Springer. This book was released on 2014-10-30 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book in longitudinal categorical data analysis with parametric correlation models developed based on dynamic relationships among repeated categorical responses. This book is a natural generalization of the longitudinal binary data analysis to the multinomial data setup with more than two categories. Thus, unlike the existing books on cross-sectional categorical data analysis using log linear models, this book uses multinomial probability models both in cross-sectional and longitudinal setups. A theoretical foundation is provided for the analysis of univariate multinomial responses, by developing models systematically for the cases with no covariates as well as categorical covariates, both in cross-sectional and longitudinal setups. In the longitudinal setup, both stationary and non-stationary covariates are considered. These models have also been extended to the bivariate multinomial setup along with suitable covariates. For the inferences, the book uses the generalized quasi-likelihood as well as the exact likelihood approaches. The book is technically rigorous, and, it also presents illustrations of the statistical analysis of various real life data involving univariate multinomial responses both in cross-sectional and longitudinal setups. This book is written mainly for the graduate students and researchers in statistics and social sciences, among other applied statistics research areas. However, the rest of the book, specifically the chapters from 1 to 3, may also be used for a senior undergraduate course in statistics.

Longitudinal Data Analysis

Author: Garrett Fitzmaurice

Publisher: CRC Press

Published: 2008-08-11

Total Pages: 633

ISBN-13: 142001157X

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Although many books currently available describe statistical models and methods for analyzing longitudinal data, they do not highlight connections between various research threads in the statistical literature. Responding to this void, Longitudinal Data Analysis provides a clear, comprehensive, and unified overview of state-of-the-art theory

Book Synopsis Longitudinal Data Analysis by : Garrett Fitzmaurice

Download or read book Longitudinal Data Analysis written by Garrett Fitzmaurice and published by CRC Press. This book was released on 2008-08-11 with total page 633 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although many books currently available describe statistical models and methods for analyzing longitudinal data, they do not highlight connections between various research threads in the statistical literature. Responding to this void, Longitudinal Data Analysis provides a clear, comprehensive, and unified overview of state-of-the-art theory

Joint Models for Longitudinal and Time-to-Event Data

Author: Dimitris Rizopoulos

Publisher: CRC Press

Published: 2012-06-22

Total Pages: 279

ISBN-13: 1439872864

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In longitudinal studies it is often of interest to investigate how a marker that is repeatedly measured in time is associated with a time to an event of interest, e.g., prostate cancer studies where longitudinal PSA level measurements are collected in conjunction with the time-to-recurrence. Joint Models for Longitudinal and Time-to-Event Data: With Applications in R provides a full treatment of random effects joint models for longitudinal and time-to-event outcomes that can be utilized to analyze such data. The content is primarily explanatory, focusing on applications of joint modeling, but sufficient mathematical details are provided to facilitate understanding of the key features of these models. All illustrations put forward can be implemented in the R programming language via the freely available package JM written by the author. All the R code used in the book is available at: http://jmr.r-forge.r-project.org/

Book Synopsis Joint Models for Longitudinal and Time-to-Event Data by : Dimitris Rizopoulos

Download or read book Joint Models for Longitudinal and Time-to-Event Data written by Dimitris Rizopoulos and published by CRC Press. This book was released on 2012-06-22 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: In longitudinal studies it is often of interest to investigate how a marker that is repeatedly measured in time is associated with a time to an event of interest, e.g., prostate cancer studies where longitudinal PSA level measurements are collected in conjunction with the time-to-recurrence. Joint Models for Longitudinal and Time-to-Event Data: With Applications in R provides a full treatment of random effects joint models for longitudinal and time-to-event outcomes that can be utilized to analyze such data. The content is primarily explanatory, focusing on applications of joint modeling, but sufficient mathematical details are provided to facilitate understanding of the key features of these models. All illustrations put forward can be implemented in the R programming language via the freely available package JM written by the author. All the R code used in the book is available at: http://jmr.r-forge.r-project.org/

Advances and Challenges in Parametric and Semi-parametric Analysis for Correlated Data

Author: Brajendra C. Sutradhar

Publisher: Springer

Published: 2016-06-15

Total Pages: 256

ISBN-13: 331931260X

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This proceedings volume contains eight selected papers that were presented in the International Symposium in Statistics (ISS) 2015 On Advances in Parametric and Semi-parametric Analysis of Multivariate, Time Series, Spatial-temporal, and Familial-longitudinal Data, held in St. John’s, Canada from July 6 to 8, 2015. The main objective of the ISS-2015 was the discussion on advances and challenges in parametric and semi-parametric analysis for correlated data in both continuous and discrete setups. Thus, as a reflection of the theme of the symposium, the eight papers of this proceedings volume are presented in four parts. Part I is comprised of papers examining Elliptical t Distribution Theory. In Part II, the papers cover spatial and temporal data analysis. Part III is focused on longitudinal multinomial models in parametric and semi-parametric setups. Finally Part IV concludes with a paper on the inferences for longitudinal data subject to a challenge of important covariates selection from a set of large number of covariates available for the individuals in the study.

Book Synopsis Advances and Challenges in Parametric and Semi-parametric Analysis for Correlated Data by : Brajendra C. Sutradhar

Download or read book Advances and Challenges in Parametric and Semi-parametric Analysis for Correlated Data written by Brajendra C. Sutradhar and published by Springer. This book was released on 2016-06-15 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: This proceedings volume contains eight selected papers that were presented in the International Symposium in Statistics (ISS) 2015 On Advances in Parametric and Semi-parametric Analysis of Multivariate, Time Series, Spatial-temporal, and Familial-longitudinal Data, held in St. John’s, Canada from July 6 to 8, 2015. The main objective of the ISS-2015 was the discussion on advances and challenges in parametric and semi-parametric analysis for correlated data in both continuous and discrete setups. Thus, as a reflection of the theme of the symposium, the eight papers of this proceedings volume are presented in four parts. Part I is comprised of papers examining Elliptical t Distribution Theory. In Part II, the papers cover spatial and temporal data analysis. Part III is focused on longitudinal multinomial models in parametric and semi-parametric setups. Finally Part IV concludes with a paper on the inferences for longitudinal data subject to a challenge of important covariates selection from a set of large number of covariates available for the individuals in the study.

Applied Bayesian Modelling

Author: Peter Congdon

Publisher: John Wiley & Sons

Published: 2014-06-25

Total Pages: 684

ISBN-13: 1118895061

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This book provides an accessible approach to Bayesian computing and data analysis, with an emphasis on the interpretation of real data sets. Following in the tradition of the successful first edition, this book aims to make a wide range of statistical modeling applications accessible using tested code that can be readily adapted to the reader's own applications. The second edition has been thoroughly reworked and updated to take account of advances in the field. A new set of worked examples is included. The novel aspect of the first edition was the coverage of statistical modeling using WinBUGS and OPENBUGS. This feature continues in the new edition along with examples using R to broaden appeal and for completeness of coverage.

Book Synopsis Applied Bayesian Modelling by : Peter Congdon

Download or read book Applied Bayesian Modelling written by Peter Congdon and published by John Wiley & Sons. This book was released on 2014-06-25 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an accessible approach to Bayesian computing and data analysis, with an emphasis on the interpretation of real data sets. Following in the tradition of the successful first edition, this book aims to make a wide range of statistical modeling applications accessible using tested code that can be readily adapted to the reader's own applications. The second edition has been thoroughly reworked and updated to take account of advances in the field. A new set of worked examples is included. The novel aspect of the first edition was the coverage of statistical modeling using WinBUGS and OPENBUGS. This feature continues in the new edition along with examples using R to broaden appeal and for completeness of coverage.

ISS-2012 Proceedings Volume On Longitudinal Data Analysis Subject to Measurement Errors, Missing Values, and/or Outliers

Author: Brajendra C. Sutradhar

Publisher: Springer Science & Business Media

Published: 2013-08-13

Total Pages: 224

ISBN-13: 146146871X

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This proceedings volume contains nine selected papers that were presented in the International Symposium in Statistics, 2012 held at Memorial University from July 16 to 18. These nine papers cover three different areas for longitudinal data analysis, four dealing with longitudinal data subject to measurement errors, four on incomplete longitudinal data analysis, and the last one for inferences for longitudinal data subject to outliers. Unlike in the independence setup, the inferences in measurement errors, missing values, and/or outlier models, are not adequately discussed in the longitudinal setup. The papers in the present volume provide details on successes and further challenges in these three areas for longitudinal data analysis. This volume is the first outlet with current research in three important areas in the longitudinal setup. The nine papers presented in three parts clearly reveal the similarities and differences in inference techniques used for three different longitudinal setups. Because the research problems considered in this volume are encountered in many real life studies in biomedical, clinical, epidemiology, socioeconomic, econometrics, and engineering fields, the volume should be useful to the researchers including graduate students in these areas.

Book Synopsis ISS-2012 Proceedings Volume On Longitudinal Data Analysis Subject to Measurement Errors, Missing Values, and/or Outliers by : Brajendra C. Sutradhar

Download or read book ISS-2012 Proceedings Volume On Longitudinal Data Analysis Subject to Measurement Errors, Missing Values, and/or Outliers written by Brajendra C. Sutradhar and published by Springer Science & Business Media. This book was released on 2013-08-13 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: This proceedings volume contains nine selected papers that were presented in the International Symposium in Statistics, 2012 held at Memorial University from July 16 to 18. These nine papers cover three different areas for longitudinal data analysis, four dealing with longitudinal data subject to measurement errors, four on incomplete longitudinal data analysis, and the last one for inferences for longitudinal data subject to outliers. Unlike in the independence setup, the inferences in measurement errors, missing values, and/or outlier models, are not adequately discussed in the longitudinal setup. The papers in the present volume provide details on successes and further challenges in these three areas for longitudinal data analysis. This volume is the first outlet with current research in three important areas in the longitudinal setup. The nine papers presented in three parts clearly reveal the similarities and differences in inference techniques used for three different longitudinal setups. Because the research problems considered in this volume are encountered in many real life studies in biomedical, clinical, epidemiology, socioeconomic, econometrics, and engineering fields, the volume should be useful to the researchers including graduate students in these areas.

Models for Intensive Longitudinal Data

Author: Theodore A. Walls

Publisher: Oxford University Press

Published: 2006-01-19

Total Pages: 320

ISBN-13: 9780198038665

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Rapid technological advances in devices used for data collection have led to the emergence of a new class of longitudinal data: intensive longitudinal data (ILD). Behavioral scientific studies now frequently utilize handheld computers, beepers, web interfaces, and other technological tools for collecting many more data points over time than previously possible. Other protocols, such as those used in fMRI and monitoring of public safety, also produce ILD, hence the statistical models in this volume are applicable to a range of data. The volume features state-of-the-art statistical modeling strategies developed by leading statisticians and methodologists working on ILD in conjunction with behavioral scientists. Chapters present applications from across the behavioral and health sciences, including coverage of substantive topics such as stress, smoking cessation, alcohol use, traffic patterns, educational performance and intimacy. Models for Intensive Longitudinal Data (MILD) is designed for those who want to learn about advanced statistical models for intensive longitudinal data and for those with an interest in selecting and applying a given model. The chapters highlight issues of general concern in modeling these kinds of data, such as a focus on regulatory systems, issues of curve registration, variable frequency and spacing of measurements, complex multivariate patterns of change, and multiple independent series. The extraordinary breadth of coverage makes this an indispensable reference for principal investigators designing new studies that will introduce ILD, applied statisticians working on related models, and methodologists, graduate students, and applied analysts working in a range of fields. A companion Web site at www.oup.com/us/MILD contains program examples and documentation.

Book Synopsis Models for Intensive Longitudinal Data by : Theodore A. Walls

Download or read book Models for Intensive Longitudinal Data written by Theodore A. Walls and published by Oxford University Press. This book was released on 2006-01-19 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rapid technological advances in devices used for data collection have led to the emergence of a new class of longitudinal data: intensive longitudinal data (ILD). Behavioral scientific studies now frequently utilize handheld computers, beepers, web interfaces, and other technological tools for collecting many more data points over time than previously possible. Other protocols, such as those used in fMRI and monitoring of public safety, also produce ILD, hence the statistical models in this volume are applicable to a range of data. The volume features state-of-the-art statistical modeling strategies developed by leading statisticians and methodologists working on ILD in conjunction with behavioral scientists. Chapters present applications from across the behavioral and health sciences, including coverage of substantive topics such as stress, smoking cessation, alcohol use, traffic patterns, educational performance and intimacy. Models for Intensive Longitudinal Data (MILD) is designed for those who want to learn about advanced statistical models for intensive longitudinal data and for those with an interest in selecting and applying a given model. The chapters highlight issues of general concern in modeling these kinds of data, such as a focus on regulatory systems, issues of curve registration, variable frequency and spacing of measurements, complex multivariate patterns of change, and multiple independent series. The extraordinary breadth of coverage makes this an indispensable reference for principal investigators designing new studies that will introduce ILD, applied statisticians working on related models, and methodologists, graduate students, and applied analysts working in a range of fields. A companion Web site at www.oup.com/us/MILD contains program examples and documentation.