Dynamic Systems Biology Modeling and Simulation

Dynamic Systems Biology Modeling and Simulation

Author: Joseph DiStefano III

Publisher: Academic Press

Published: 2015-01-10

Total Pages: 884

ISBN-13: 0124104932

DOWNLOAD EBOOK

Dynamic Systems Biology Modeling and Simuation consolidates and unifies classical and contemporary multiscale methodologies for mathematical modeling and computer simulation of dynamic biological systems – from molecular/cellular, organ-system, on up to population levels. The book pedagogy is developed as a well-annotated, systematic tutorial – with clearly spelled-out and unified nomenclature – derived from the author’s own modeling efforts, publications and teaching over half a century. Ambiguities in some concepts and tools are clarified and others are rendered more accessible and practical. The latter include novel qualitative theory and methodologies for recognizing dynamical signatures in data using structural (multicompartmental and network) models and graph theory; and analyzing structural and measurement (data) models for quantification feasibility. The level is basic-to-intermediate, with much emphasis on biomodeling from real biodata, for use in real applications. Introductory coverage of core mathematical concepts such as linear and nonlinear differential and difference equations, Laplace transforms, linear algebra, probability, statistics and stochastics topics; PLUS ....... The pertinent biology, biochemistry, biophysics or pharmacology for modeling are provided, to support understanding the amalgam of “math modeling” with life sciences. Strong emphasis on quantifying as well as building and analyzing biomodels: includes methodology and computational tools for parameter identifiability and sensitivity analysis; parameter estimation from real data; model distinguishability and simplification; and practical bioexperiment design and optimization. Companion website provides solutions and program code for examples and exercises using Matlab, Simulink, VisSim, SimBiology, SAAMII, AMIGO, Copasi and SBML-coded models. A full set of PowerPoint slides are available from the author for teaching from his textbook. He uses them to teach a 10 week quarter upper division course at UCLA, which meets twice a week, so there are 20 lectures. They can easily be augmented or stretched for a 15 week semester course. Importantly, the slides are editable, so they can be readily adapted to a lecturer’s personal style and course content needs. The lectures are based on excerpts from 12 of the first 13 chapters of DSBMS. They are designed to highlight the key course material, as a study guide and structure for students following the full text content. The complete PowerPoint slide package (~25 MB) can be obtained by instructors (or prospective instructors) by emailing the author directly, at: [email protected]


Book Synopsis Dynamic Systems Biology Modeling and Simulation by : Joseph DiStefano III

Download or read book Dynamic Systems Biology Modeling and Simulation written by Joseph DiStefano III and published by Academic Press. This book was released on 2015-01-10 with total page 884 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dynamic Systems Biology Modeling and Simuation consolidates and unifies classical and contemporary multiscale methodologies for mathematical modeling and computer simulation of dynamic biological systems – from molecular/cellular, organ-system, on up to population levels. The book pedagogy is developed as a well-annotated, systematic tutorial – with clearly spelled-out and unified nomenclature – derived from the author’s own modeling efforts, publications and teaching over half a century. Ambiguities in some concepts and tools are clarified and others are rendered more accessible and practical. The latter include novel qualitative theory and methodologies for recognizing dynamical signatures in data using structural (multicompartmental and network) models and graph theory; and analyzing structural and measurement (data) models for quantification feasibility. The level is basic-to-intermediate, with much emphasis on biomodeling from real biodata, for use in real applications. Introductory coverage of core mathematical concepts such as linear and nonlinear differential and difference equations, Laplace transforms, linear algebra, probability, statistics and stochastics topics; PLUS ....... The pertinent biology, biochemistry, biophysics or pharmacology for modeling are provided, to support understanding the amalgam of “math modeling” with life sciences. Strong emphasis on quantifying as well as building and analyzing biomodels: includes methodology and computational tools for parameter identifiability and sensitivity analysis; parameter estimation from real data; model distinguishability and simplification; and practical bioexperiment design and optimization. Companion website provides solutions and program code for examples and exercises using Matlab, Simulink, VisSim, SimBiology, SAAMII, AMIGO, Copasi and SBML-coded models. A full set of PowerPoint slides are available from the author for teaching from his textbook. He uses them to teach a 10 week quarter upper division course at UCLA, which meets twice a week, so there are 20 lectures. They can easily be augmented or stretched for a 15 week semester course. Importantly, the slides are editable, so they can be readily adapted to a lecturer’s personal style and course content needs. The lectures are based on excerpts from 12 of the first 13 chapters of DSBMS. They are designed to highlight the key course material, as a study guide and structure for students following the full text content. The complete PowerPoint slide package (~25 MB) can be obtained by instructors (or prospective instructors) by emailing the author directly, at: [email protected]

Systems Biology

Systems Biology

Author: Jinzhi Lei

Publisher: Springer

Published: 2021-05-14

Total Pages: 308

ISBN-13: 9783030730321

DOWNLOAD EBOOK

This book discusses the mathematical simulation of biological systems, with a focus on the modeling of gene expression, gene regulatory networks and stem cell regeneration. The diffusion of morphogens is addressed by introducing various reaction-diffusion equations based on different hypotheses concerning the process of morphogen gradient formation. The robustness of steady-state gradients is also covered through boundary value problems. The introduction gives an overview of the relevant biological concepts (cells, DNA, organism development) and provides the requisite mathematical preliminaries on continuous dynamics and stochastic modeling. A basic understanding of calculus is assumed. The techniques described in this book encompass a wide range of mechanisms, from molecular behavior to population dynamics, and the inclusion of recent developments in the literature together with first-hand results make it an ideal reference for both new students and experienced researchers in the field of systems biology and applied mathematics.


Book Synopsis Systems Biology by : Jinzhi Lei

Download or read book Systems Biology written by Jinzhi Lei and published by Springer. This book was released on 2021-05-14 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the mathematical simulation of biological systems, with a focus on the modeling of gene expression, gene regulatory networks and stem cell regeneration. The diffusion of morphogens is addressed by introducing various reaction-diffusion equations based on different hypotheses concerning the process of morphogen gradient formation. The robustness of steady-state gradients is also covered through boundary value problems. The introduction gives an overview of the relevant biological concepts (cells, DNA, organism development) and provides the requisite mathematical preliminaries on continuous dynamics and stochastic modeling. A basic understanding of calculus is assumed. The techniques described in this book encompass a wide range of mechanisms, from molecular behavior to population dynamics, and the inclusion of recent developments in the literature together with first-hand results make it an ideal reference for both new students and experienced researchers in the field of systems biology and applied mathematics.

Systems Biology

Systems Biology

Author: Jinzhi Lei

Publisher: Springer Nature

Published: 2021-05-13

Total Pages: 308

ISBN-13: 3030730336

DOWNLOAD EBOOK

This book discusses the mathematical simulation of biological systems, with a focus on the modeling of gene expression, gene regulatory networks and stem cell regeneration. The diffusion of morphogens is addressed by introducing various reaction-diffusion equations based on different hypotheses concerning the process of morphogen gradient formation. The robustness of steady-state gradients is also covered through boundary value problems. The introduction gives an overview of the relevant biological concepts (cells, DNA, organism development) and provides the requisite mathematical preliminaries on continuous dynamics and stochastic modeling. A basic understanding of calculus is assumed. The techniques described in this book encompass a wide range of mechanisms, from molecular behavior to population dynamics, and the inclusion of recent developments in the literature together with first-hand results make it an ideal reference for both new students and experienced researchers in the field of systems biology and applied mathematics.


Book Synopsis Systems Biology by : Jinzhi Lei

Download or read book Systems Biology written by Jinzhi Lei and published by Springer Nature. This book was released on 2021-05-13 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the mathematical simulation of biological systems, with a focus on the modeling of gene expression, gene regulatory networks and stem cell regeneration. The diffusion of morphogens is addressed by introducing various reaction-diffusion equations based on different hypotheses concerning the process of morphogen gradient formation. The robustness of steady-state gradients is also covered through boundary value problems. The introduction gives an overview of the relevant biological concepts (cells, DNA, organism development) and provides the requisite mathematical preliminaries on continuous dynamics and stochastic modeling. A basic understanding of calculus is assumed. The techniques described in this book encompass a wide range of mechanisms, from molecular behavior to population dynamics, and the inclusion of recent developments in the literature together with first-hand results make it an ideal reference for both new students and experienced researchers in the field of systems biology and applied mathematics.

Dynamic Biosystem Modeling & Simulation Methodology - Integrated & Accessible

Dynamic Biosystem Modeling & Simulation Methodology - Integrated & Accessible

Author: Joseph Distefano, 3rd

Publisher:

Published: 2019-09-16

Total Pages: 354

ISBN-13: 9781733495004

DOWNLOAD EBOOK

This textbook is uniquely crafted for use in teaching undergraduate students in the life, math, computer and other sciences and engineering. It is INTRODUCTORY LEVEL, for students who have taken or are currently completing their undergraduate math requirements, and are acquiring analytical-thinking and doing skills, along with introductory biology, chemistry and physics subject matter. It's about learning HOW to model and simulate dynamic biological systems, which also makes it useful for graduate students and professional researchers who want a more rigorous treatment of introductory life science math modeling, integrated with the biology. It brings together the multidisciplinary pedagogy of these subjects into a SINGLE INTRODUCTORY MODELING METHODOLOGY COURSE, crystalizing the experience of an author who has been teaching dynamic biosystems modeling and simulation methodology for the life sciences for more than 50 years. DiStefano maximizes accessibility and "systems-math-biology" integration - without diminishing conceptual rigor. Minimally essential applied math and SYSTEMS ENGINEERING METHODS are included, along with a synopsis of the biology and physiology underlying dynamic biosystem modeling, all in a modeling pedagogy context. This textbook fills a major need in the training of contemporary biology students.Dynamic biosystems modeling methodology is presented over 12 distinctive chapters, primarily with systems diagrams and simple differential equations and algebra for expressing them quantitatively, integrated with the biology. Solving and analyzing (quantifying) the biomodels are then accomplished by simulation, using a facile control system simulation language Simulink, a GUI/Matlab toolbox that emulates control systems diagramming, rather than by "coding" the model in a standard computer programming language. Students see and work with the system model - not the code - a big plus. Higher math and complex analytical solutions are avoided.Each chapter begins with a list of LEARNING GOALS, to help with both perspective for the chapter material, and retrospective, to measure learning. EXERCISES for the student at the end of each chapter are designed to test and reinforce learning. A SOLUTIONS MANUAL for chapter exercises is available to qualified instructors from the author, as are LECTURE SLIDES and LAB ASSIGNMENTS AND SOLUTIONS, for courses that adopt the textbook for student use.


Book Synopsis Dynamic Biosystem Modeling & Simulation Methodology - Integrated & Accessible by : Joseph Distefano, 3rd

Download or read book Dynamic Biosystem Modeling & Simulation Methodology - Integrated & Accessible written by Joseph Distefano, 3rd and published by . This book was released on 2019-09-16 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook is uniquely crafted for use in teaching undergraduate students in the life, math, computer and other sciences and engineering. It is INTRODUCTORY LEVEL, for students who have taken or are currently completing their undergraduate math requirements, and are acquiring analytical-thinking and doing skills, along with introductory biology, chemistry and physics subject matter. It's about learning HOW to model and simulate dynamic biological systems, which also makes it useful for graduate students and professional researchers who want a more rigorous treatment of introductory life science math modeling, integrated with the biology. It brings together the multidisciplinary pedagogy of these subjects into a SINGLE INTRODUCTORY MODELING METHODOLOGY COURSE, crystalizing the experience of an author who has been teaching dynamic biosystems modeling and simulation methodology for the life sciences for more than 50 years. DiStefano maximizes accessibility and "systems-math-biology" integration - without diminishing conceptual rigor. Minimally essential applied math and SYSTEMS ENGINEERING METHODS are included, along with a synopsis of the biology and physiology underlying dynamic biosystem modeling, all in a modeling pedagogy context. This textbook fills a major need in the training of contemporary biology students.Dynamic biosystems modeling methodology is presented over 12 distinctive chapters, primarily with systems diagrams and simple differential equations and algebra for expressing them quantitatively, integrated with the biology. Solving and analyzing (quantifying) the biomodels are then accomplished by simulation, using a facile control system simulation language Simulink, a GUI/Matlab toolbox that emulates control systems diagramming, rather than by "coding" the model in a standard computer programming language. Students see and work with the system model - not the code - a big plus. Higher math and complex analytical solutions are avoided.Each chapter begins with a list of LEARNING GOALS, to help with both perspective for the chapter material, and retrospective, to measure learning. EXERCISES for the student at the end of each chapter are designed to test and reinforce learning. A SOLUTIONS MANUAL for chapter exercises is available to qualified instructors from the author, as are LECTURE SLIDES and LAB ASSIGNMENTS AND SOLUTIONS, for courses that adopt the textbook for student use.

Simulation of Dynamic Systems with MATLAB® and Simulink®

Simulation of Dynamic Systems with MATLAB® and Simulink®

Author: Harold Klee

Publisher: CRC Press

Published: 2018-02-02

Total Pages: 852

ISBN-13: 1498787789

DOWNLOAD EBOOK

Continuous-system simulation is an increasingly important tool for optimizing the performance of real-world systems. The book presents an integrated treatment of continuous simulation with all the background and essential prerequisites in one setting. It features updated chapters and two new sections on Black Swan and the Stochastic Information Packet (SIP) and Stochastic Library Units with Relationships Preserved (SLURP) Standard. The new edition includes basic concepts, mathematical tools, and the common principles of various simulation models for different phenomena, as well as an abundance of case studies, real-world examples, homework problems, and equations to develop a practical understanding of concepts.


Book Synopsis Simulation of Dynamic Systems with MATLAB® and Simulink® by : Harold Klee

Download or read book Simulation of Dynamic Systems with MATLAB® and Simulink® written by Harold Klee and published by CRC Press. This book was released on 2018-02-02 with total page 852 pages. Available in PDF, EPUB and Kindle. Book excerpt: Continuous-system simulation is an increasingly important tool for optimizing the performance of real-world systems. The book presents an integrated treatment of continuous simulation with all the background and essential prerequisites in one setting. It features updated chapters and two new sections on Black Swan and the Stochastic Information Packet (SIP) and Stochastic Library Units with Relationships Preserved (SLURP) Standard. The new edition includes basic concepts, mathematical tools, and the common principles of various simulation models for different phenomena, as well as an abundance of case studies, real-world examples, homework problems, and equations to develop a practical understanding of concepts.

Modeling Dynamic Biological Systems

Modeling Dynamic Biological Systems

Author: Bruce Hannon

Publisher: Springer

Published: 2014-07-05

Total Pages: 419

ISBN-13: 3319056158

DOWNLOAD EBOOK

Many biologists and ecologists have developed models that find widespread use in theoretical investigations and in applications to organism behavior, disease control, population and metapopulation theory, ecosystem dynamics, and environmental management. This book captures and extends the process of model development by concentrating on the dynamic aspects of these processes and by providing the tools such that virtually anyone with basic knowledge in the Life Sciences can develop meaningful dynamic models. Examples of the systems modeled in the book range from models of cell development, the beating heart, the growth and spread of insects, spatial competition and extinction, to the spread and control of epidemics, including the conditions for the development of chaos. Key features: - easy-to-learn and easy-to-use software - examples from many subdisciplines of biology, covering models of cells, organisms, populations, and metapopulations - no prior computer or programming experience required Key benefits: - learn how to develop modeling skills and system thinking on your own rather than use models developed by others - be able to easily run models under alternative assumptions and investigate the implications of these assumptions for the dynamics of the biological system being modeled - develop skills to assess the dynamics of biological systems


Book Synopsis Modeling Dynamic Biological Systems by : Bruce Hannon

Download or read book Modeling Dynamic Biological Systems written by Bruce Hannon and published by Springer. This book was released on 2014-07-05 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many biologists and ecologists have developed models that find widespread use in theoretical investigations and in applications to organism behavior, disease control, population and metapopulation theory, ecosystem dynamics, and environmental management. This book captures and extends the process of model development by concentrating on the dynamic aspects of these processes and by providing the tools such that virtually anyone with basic knowledge in the Life Sciences can develop meaningful dynamic models. Examples of the systems modeled in the book range from models of cell development, the beating heart, the growth and spread of insects, spatial competition and extinction, to the spread and control of epidemics, including the conditions for the development of chaos. Key features: - easy-to-learn and easy-to-use software - examples from many subdisciplines of biology, covering models of cells, organisms, populations, and metapopulations - no prior computer or programming experience required Key benefits: - learn how to develop modeling skills and system thinking on your own rather than use models developed by others - be able to easily run models under alternative assumptions and investigate the implications of these assumptions for the dynamics of the biological system being modeled - develop skills to assess the dynamics of biological systems

Measurements, Modelling and Simulation of Dynamic Systems

Measurements, Modelling and Simulation of Dynamic Systems

Author: Edward Layer

Publisher: Springer Science & Business Media

Published: 2009-12-30

Total Pages: 165

ISBN-13: 364204588X

DOWNLOAD EBOOK

The development and use of models of various objects is becoming a more common practice in recent days. This is due to the ease with which models can be developed and examined through the use of computers and appropriate software. Of those two, the former - high-speed computers - are easily accessible nowadays, and the latter - existing programs - are being updated almost continuously, and at the same time new powerful software is being developed. Usually a model represents correlations between some processes and their interactions, with better or worse quality of representation. It details and characterizes a part of the real world taking into account a structure of phenomena, as well as quantitative and qualitative relations. There are a great variety of models. Modelling is carried out in many diverse fields. All types of natural phenomena in the area of biology, ecology and medicine are possible subjects for modelling. Models stand for and represent technical objects in physics, chemistry, engineering, social events and behaviours in sociology, financial matters, investments and stock markets in economy, strategy and tactics, defence, security and safety in military fields. There is one common point for all models. We expect them to fulfil the validity of prediction. It means that through the analysis of models it is possible to predict phenomena, which may occur in a fragment of the real world represented by a given model. We also expect to be able to predict future reactions to signals from the outside world.


Book Synopsis Measurements, Modelling and Simulation of Dynamic Systems by : Edward Layer

Download or read book Measurements, Modelling and Simulation of Dynamic Systems written by Edward Layer and published by Springer Science & Business Media. This book was released on 2009-12-30 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development and use of models of various objects is becoming a more common practice in recent days. This is due to the ease with which models can be developed and examined through the use of computers and appropriate software. Of those two, the former - high-speed computers - are easily accessible nowadays, and the latter - existing programs - are being updated almost continuously, and at the same time new powerful software is being developed. Usually a model represents correlations between some processes and their interactions, with better or worse quality of representation. It details and characterizes a part of the real world taking into account a structure of phenomena, as well as quantitative and qualitative relations. There are a great variety of models. Modelling is carried out in many diverse fields. All types of natural phenomena in the area of biology, ecology and medicine are possible subjects for modelling. Models stand for and represent technical objects in physics, chemistry, engineering, social events and behaviours in sociology, financial matters, investments and stock markets in economy, strategy and tactics, defence, security and safety in military fields. There is one common point for all models. We expect them to fulfil the validity of prediction. It means that through the analysis of models it is possible to predict phenomena, which may occur in a fragment of the real world represented by a given model. We also expect to be able to predict future reactions to signals from the outside world.

Modeling Dynamic Biological Systems

Modeling Dynamic Biological Systems

Author: Bruce Hannon

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 399

ISBN-13: 1461206510

DOWNLOAD EBOOK

Models help us understand the dynamics of real-world processes by using the computer to mimic the actual forces that are known or assumed to result in a system's behavior. This book does not require a substantial background in mathematics or computer science.


Book Synopsis Modeling Dynamic Biological Systems by : Bruce Hannon

Download or read book Modeling Dynamic Biological Systems written by Bruce Hannon and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Models help us understand the dynamics of real-world processes by using the computer to mimic the actual forces that are known or assumed to result in a system's behavior. This book does not require a substantial background in mathematics or computer science.

Modeling of Dynamic Systems

Modeling of Dynamic Systems

Author: Lennart Ljung

Publisher: Prentice Hall

Published: 1994

Total Pages: 0

ISBN-13: 9780135970973

DOWNLOAD EBOOK

Written by a recognized authority in the field of identification and control, this book draws together into a single volume the important aspects of system identification AND physical modelling. KEY TOPICS: Explores techniques used to construct mathematical models of systems based on knowledge from physics, chemistry, biology, etc. (e.g., techniques with so called bond-graphs, as well those which use computer algebra for the modeling work). Explains system identification techniques used to infer knowledge about the behavior of dynamic systems based on observations of the various input and output signals that are available for measurement. Shows how both types of techniques need to be applied in any given practical modeling situation. Considers applications, primarily simulation. MARKET: For practicing engineers who are faced with problems of modeling.


Book Synopsis Modeling of Dynamic Systems by : Lennart Ljung

Download or read book Modeling of Dynamic Systems written by Lennart Ljung and published by Prentice Hall. This book was released on 1994 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by a recognized authority in the field of identification and control, this book draws together into a single volume the important aspects of system identification AND physical modelling. KEY TOPICS: Explores techniques used to construct mathematical models of systems based on knowledge from physics, chemistry, biology, etc. (e.g., techniques with so called bond-graphs, as well those which use computer algebra for the modeling work). Explains system identification techniques used to infer knowledge about the behavior of dynamic systems based on observations of the various input and output signals that are available for measurement. Shows how both types of techniques need to be applied in any given practical modeling situation. Considers applications, primarily simulation. MARKET: For practicing engineers who are faced with problems of modeling.

Dynamic Biosystem Modeling & Simulation Methodology - Integrated & Accessible

Dynamic Biosystem Modeling & Simulation Methodology - Integrated & Accessible

Author: Joseph Distefano, 3rd

Publisher: Biomodeling

Published: 2019-09-16

Total Pages: 354

ISBN-13: 9781733495028

DOWNLOAD EBOOK

This textbook is uniquely crafted for use in teaching undergraduate students in the life, math, computer and other sciences and engineering. It is INTRODUCTORY LEVEL, for students who have taken or are currently completing their undergraduate math requirements, and are acquiring analytical-thinking and doing skills, along with introductory biology, chemistry and physics subject matter. It's about learning HOW to model and simulate dynamic biological systems, which also makes it useful for graduate students and professional researchers who want a more rigorous treatment of introductory life science math modeling, integrated with the biology. It brings together the multidisciplinary pedagogy of these subjects into a SINGLE INTRODUCTORY MODELING METHODOLOGY COURSE, crystalizing the experience of an author who has been teaching dynamic biosystems modeling and simulation methodology for the life sciences for more than 50 years. DiStefano maximizes accessibility and "systems-math-biology" integration - without diminishing conceptual rigor. Minimally essential applied math and SYSTEMS ENGINEERING METHODS are included, along with a synopsis of the biology and physiology underlying dynamic biosystem modeling, all in a modeling pedagogy context. This textbook fills a major need in the training of contemporary biology students.Dynamic biosystems modeling methodology is presented over 12 distinctive chapters, primarily with systems diagrams and simple differential equations and algebra for expressing them quantitatively, integrated with the biology. Solving and analyzing (quantifying) the biomodels are then accomplished by simulation, using a facile control system simulation language Simulink, a GUI/Matlab toolbox that emulates control systems diagramming, rather than by "coding" the model in a standard computer programming language. Students see and work with the system model - not the code - a big plus. Higher math and complex analytical solutions are avoided.Each chapter begins with a list of LEARNING GOALS, to help with both perspective for the chapter material, and retrospective, to measure learning. EXERCISES for the student at the end of each chapter are designed to test and reinforce learning. A SOLUTIONS MANUAL for chapter exercises is available to qualified instructors from the author, as are LECTURE SLIDES and LAB ASSIGNMENTS AND SOLUTIONS, for courses that adopt the textbook for student use.


Book Synopsis Dynamic Biosystem Modeling & Simulation Methodology - Integrated & Accessible by : Joseph Distefano, 3rd

Download or read book Dynamic Biosystem Modeling & Simulation Methodology - Integrated & Accessible written by Joseph Distefano, 3rd and published by Biomodeling. This book was released on 2019-09-16 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook is uniquely crafted for use in teaching undergraduate students in the life, math, computer and other sciences and engineering. It is INTRODUCTORY LEVEL, for students who have taken or are currently completing their undergraduate math requirements, and are acquiring analytical-thinking and doing skills, along with introductory biology, chemistry and physics subject matter. It's about learning HOW to model and simulate dynamic biological systems, which also makes it useful for graduate students and professional researchers who want a more rigorous treatment of introductory life science math modeling, integrated with the biology. It brings together the multidisciplinary pedagogy of these subjects into a SINGLE INTRODUCTORY MODELING METHODOLOGY COURSE, crystalizing the experience of an author who has been teaching dynamic biosystems modeling and simulation methodology for the life sciences for more than 50 years. DiStefano maximizes accessibility and "systems-math-biology" integration - without diminishing conceptual rigor. Minimally essential applied math and SYSTEMS ENGINEERING METHODS are included, along with a synopsis of the biology and physiology underlying dynamic biosystem modeling, all in a modeling pedagogy context. This textbook fills a major need in the training of contemporary biology students.Dynamic biosystems modeling methodology is presented over 12 distinctive chapters, primarily with systems diagrams and simple differential equations and algebra for expressing them quantitatively, integrated with the biology. Solving and analyzing (quantifying) the biomodels are then accomplished by simulation, using a facile control system simulation language Simulink, a GUI/Matlab toolbox that emulates control systems diagramming, rather than by "coding" the model in a standard computer programming language. Students see and work with the system model - not the code - a big plus. Higher math and complex analytical solutions are avoided.Each chapter begins with a list of LEARNING GOALS, to help with both perspective for the chapter material, and retrospective, to measure learning. EXERCISES for the student at the end of each chapter are designed to test and reinforce learning. A SOLUTIONS MANUAL for chapter exercises is available to qualified instructors from the author, as are LECTURE SLIDES and LAB ASSIGNMENTS AND SOLUTIONS, for courses that adopt the textbook for student use.