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Evidence Synthesis for Decision Making in Healthcare

Author: Nicky J. Welton

Publisher: John Wiley & Sons

Published: 2012-05-29

Total Pages: 296

ISBN-13: 047006109X

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In the evaluation of healthcare, rigorous methods of quantitative assessment are necessary to establish interventions that are both effective and cost-effective. Usually a single study will not fully address these issues and it is desirable to synthesize evidence from multiple sources. This book aims to provide a practical guide to evidence synthesis for the purpose of decision making, starting with a simple single parameter model, where all studies estimate the same quantity (pairwise meta-analysis) and progressing to more complex multi-parameter structures (including meta-regression, mixed treatment comparisons, Markov models of disease progression, and epidemiology models). A comprehensive, coherent framework is adopted and estimated using Bayesian methods. Key features: A coherent approach to evidence synthesis from multiple sources. Focus is given to Bayesian methods for evidence synthesis that can be integrated within cost-effectiveness analyses in a probabilistic framework using Markov Chain Monte Carlo simulation. Provides methods to statistically combine evidence from a range of evidence structures. Emphasizes the importance of model critique and checking for evidence consistency. Presents numerous worked examples, exercises and solutions drawn from a variety of medical disciplines throughout the book. WinBUGS code is provided for all examples. Evidence Synthesis for Decision Making in Healthcare is intended for health economists, decision modelers, statisticians and others involved in evidence synthesis, health technology assessment, and economic evaluation of health technologies.

Book Synopsis Evidence Synthesis for Decision Making in Healthcare by : Nicky J. Welton

Download or read book Evidence Synthesis for Decision Making in Healthcare written by Nicky J. Welton and published by John Wiley & Sons. This book was released on 2012-05-29 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the evaluation of healthcare, rigorous methods of quantitative assessment are necessary to establish interventions that are both effective and cost-effective. Usually a single study will not fully address these issues and it is desirable to synthesize evidence from multiple sources. This book aims to provide a practical guide to evidence synthesis for the purpose of decision making, starting with a simple single parameter model, where all studies estimate the same quantity (pairwise meta-analysis) and progressing to more complex multi-parameter structures (including meta-regression, mixed treatment comparisons, Markov models of disease progression, and epidemiology models). A comprehensive, coherent framework is adopted and estimated using Bayesian methods. Key features: A coherent approach to evidence synthesis from multiple sources. Focus is given to Bayesian methods for evidence synthesis that can be integrated within cost-effectiveness analyses in a probabilistic framework using Markov Chain Monte Carlo simulation. Provides methods to statistically combine evidence from a range of evidence structures. Emphasizes the importance of model critique and checking for evidence consistency. Presents numerous worked examples, exercises and solutions drawn from a variety of medical disciplines throughout the book. WinBUGS code is provided for all examples. Evidence Synthesis for Decision Making in Healthcare is intended for health economists, decision modelers, statisticians and others involved in evidence synthesis, health technology assessment, and economic evaluation of health technologies.

Evidence Synthesis in Healthcare

Author: Thanos Athanasiou

Publisher: Springer Science & Business Media

Published: 2011-02-14

Total Pages: 337

ISBN-13: 0857292064

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Evidence Synthesis in Healthcare – a Practical Handbook for Clinicians is the first book to reveal the field of Evidence Synthesis, by combining multiple sources of quantitative/qualitative data to derive the best evidence for use in healthcare. Through the use of clearly explained examples and practical explanations, Evidence Synthesis in Healthcare – a Practical Handbook for Clinicians describes the practical tools, techniques, uses and policy considerations of evidence synthesis techniques in modern healthcare practice.

Book Synopsis Evidence Synthesis in Healthcare by : Thanos Athanasiou

Download or read book Evidence Synthesis in Healthcare written by Thanos Athanasiou and published by Springer Science & Business Media. This book was released on 2011-02-14 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evidence Synthesis in Healthcare – a Practical Handbook for Clinicians is the first book to reveal the field of Evidence Synthesis, by combining multiple sources of quantitative/qualitative data to derive the best evidence for use in healthcare. Through the use of clearly explained examples and practical explanations, Evidence Synthesis in Healthcare – a Practical Handbook for Clinicians describes the practical tools, techniques, uses and policy considerations of evidence synthesis techniques in modern healthcare practice.

Systematic Reviews

Author: Cynthia Diane Mulrow

Publisher: ACP Press

Published: 1998

Total Pages: 134

ISBN-13: 9780943126661

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The use and creation of systematic reviews, with a discussion on their value, and information on how to locate, appraise and use them, and on state-of-the-art methods for conducting them.

Book Synopsis Systematic Reviews by : Cynthia Diane Mulrow

Download or read book Systematic Reviews written by Cynthia Diane Mulrow and published by ACP Press. This book was released on 1998 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use and creation of systematic reviews, with a discussion on their value, and information on how to locate, appraise and use them, and on state-of-the-art methods for conducting them.

Shared Decision Making in Health Care

Author: Glyn Elwyn

Publisher: Oxford University Press

Published: 2016

Total Pages: 337

ISBN-13: 019872344X

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First edition published as: Evidence-based patient choice.. Oxford: Oxford University Press, 2001.

Book Synopsis Shared Decision Making in Health Care by : Glyn Elwyn

Download or read book Shared Decision Making in Health Care written by Glyn Elwyn and published by Oxford University Press. This book was released on 2016 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: First edition published as: Evidence-based patient choice.. Oxford: Oxford University Press, 2001.

Evidence on Mechanisms and Tools for Use of Health Information for Decision-making

Author: Victoria Blessing

Publisher: World Health Organization

Published: 2017-12-06

Total Pages: 67

ISBN-13: 9289052759

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The World Health Assembly in 2005 urged Member States to establish or strengthen knowledge transfer mechanisms to support evidence-informed health policies and health care delivery. The European Health Information Initiative was set up to strengthen the use of evidence information and research for policy-making in the WHO European Region. While good-quality health information is a key component for decision-making it needs to be packaged and communicated in an effective way to policy-makers the end-users. This report describes tools and mechanisms that can help to increase the use of health information in policy development. Packaging tools include synthesis methods such as policy briefs and visualization methods. Application tools include surveillance data and modelling/simulation to explore the behaviour and performance of processes and interventions. Dissemination and communication tools include health information-sharing platforms newsletters and person-to-person communications. Finally linkage and exchange tools such as knowledge networks facilitate the dissemination and refining of health information thus increasing the chance of its translation into policy.

Book Synopsis Evidence on Mechanisms and Tools for Use of Health Information for Decision-making by : Victoria Blessing

Download or read book Evidence on Mechanisms and Tools for Use of Health Information for Decision-making written by Victoria Blessing and published by World Health Organization. This book was released on 2017-12-06 with total page 67 pages. Available in PDF, EPUB and Kindle. Book excerpt: The World Health Assembly in 2005 urged Member States to establish or strengthen knowledge transfer mechanisms to support evidence-informed health policies and health care delivery. The European Health Information Initiative was set up to strengthen the use of evidence information and research for policy-making in the WHO European Region. While good-quality health information is a key component for decision-making it needs to be packaged and communicated in an effective way to policy-makers the end-users. This report describes tools and mechanisms that can help to increase the use of health information in policy development. Packaging tools include synthesis methods such as policy briefs and visualization methods. Application tools include surveillance data and modelling/simulation to explore the behaviour and performance of processes and interventions. Dissemination and communication tools include health information-sharing platforms newsletters and person-to-person communications. Finally linkage and exchange tools such as knowledge networks facilitate the dissemination and refining of health information thus increasing the chance of its translation into policy.

Evidence-based Decisions and Economics

Author: Ian Shemilt

Publisher: John Wiley & Sons

Published: 2011-09-22

Total Pages: 216

ISBN-13: 1444320408

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The need for evidence-based decisions that take account of botheffectiveness and economics is greater now than ever. Using casestudies and illustrative examples throughout the authors describehow the activities and outputs of evidence synthesis, systematicreview, economic analysis and decision-making interact within andacross different spheres of health and social policy and practice. Expanding on the first edition the book now covers approaches toevidence synthesis that combine economics and systematic reviewmethods in the applied fields of social welfare, education andcriminal justice, as well as health care. Written by economists andhealth services researchers closely involved in developingevidence-based policy and practice it showcases currentstate-of-the-art methodology and will be an invaluable read for allpolicy-makers and practitioners using evidence to inform decisions,analysts conducting research to support decisions and studentsdiscovering the need for evidence-based decisions to incorporateeconomic perspectives and evidence.

Book Synopsis Evidence-based Decisions and Economics by : Ian Shemilt

Download or read book Evidence-based Decisions and Economics written by Ian Shemilt and published by John Wiley & Sons. This book was released on 2011-09-22 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: The need for evidence-based decisions that take account of botheffectiveness and economics is greater now than ever. Using casestudies and illustrative examples throughout the authors describehow the activities and outputs of evidence synthesis, systematicreview, economic analysis and decision-making interact within andacross different spheres of health and social policy and practice. Expanding on the first edition the book now covers approaches toevidence synthesis that combine economics and systematic reviewmethods in the applied fields of social welfare, education andcriminal justice, as well as health care. Written by economists andhealth services researchers closely involved in developingevidence-based policy and practice it showcases currentstate-of-the-art methodology and will be an invaluable read for allpolicy-makers and practitioners using evidence to inform decisions,analysts conducting research to support decisions and studentsdiscovering the need for evidence-based decisions to incorporateeconomic perspectives and evidence.

Finding What Works in Health Care

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2011-07-20

Total Pages: 267

ISBN-13: 0309164257

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Healthcare decision makers in search of reliable information that compares health interventions increasingly turn to systematic reviews for the best summary of the evidence. Systematic reviews identify, select, assess, and synthesize the findings of similar but separate studies, and can help clarify what is known and not known about the potential benefits and harms of drugs, devices, and other healthcare services. Systematic reviews can be helpful for clinicians who want to integrate research findings into their daily practices, for patients to make well-informed choices about their own care, for professional medical societies and other organizations that develop clinical practice guidelines. Too often systematic reviews are of uncertain or poor quality. There are no universally accepted standards for developing systematic reviews leading to variability in how conflicts of interest and biases are handled, how evidence is appraised, and the overall scientific rigor of the process. In Finding What Works in Health Care the Institute of Medicine (IOM) recommends 21 standards for developing high-quality systematic reviews of comparative effectiveness research. The standards address the entire systematic review process from the initial steps of formulating the topic and building the review team to producing a detailed final report that synthesizes what the evidence shows and where knowledge gaps remain. Finding What Works in Health Care also proposes a framework for improving the quality of the science underpinning systematic reviews. This book will serve as a vital resource for both sponsors and producers of systematic reviews of comparative effectiveness research.

Book Synopsis Finding What Works in Health Care by : Institute of Medicine

Download or read book Finding What Works in Health Care written by Institute of Medicine and published by National Academies Press. This book was released on 2011-07-20 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: Healthcare decision makers in search of reliable information that compares health interventions increasingly turn to systematic reviews for the best summary of the evidence. Systematic reviews identify, select, assess, and synthesize the findings of similar but separate studies, and can help clarify what is known and not known about the potential benefits and harms of drugs, devices, and other healthcare services. Systematic reviews can be helpful for clinicians who want to integrate research findings into their daily practices, for patients to make well-informed choices about their own care, for professional medical societies and other organizations that develop clinical practice guidelines. Too often systematic reviews are of uncertain or poor quality. There are no universally accepted standards for developing systematic reviews leading to variability in how conflicts of interest and biases are handled, how evidence is appraised, and the overall scientific rigor of the process. In Finding What Works in Health Care the Institute of Medicine (IOM) recommends 21 standards for developing high-quality systematic reviews of comparative effectiveness research. The standards address the entire systematic review process from the initial steps of formulating the topic and building the review team to producing a detailed final report that synthesizes what the evidence shows and where knowledge gaps remain. Finding What Works in Health Care also proposes a framework for improving the quality of the science underpinning systematic reviews. This book will serve as a vital resource for both sponsors and producers of systematic reviews of comparative effectiveness research.

Network Meta-Analysis for Decision-Making

Author: Sofia Dias

Publisher: John Wiley & Sons

Published: 2018-03-19

Total Pages: 484

ISBN-13: 1118647505

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A practical guide to network meta-analysis with examples and code In the evaluation of healthcare, rigorous methods of quantitative assessment are necessary to establish which interventions are effective and cost-effective. Often a single study will not provide the answers and it is desirable to synthesise evidence from multiple sources, usually randomised controlled trials. This book takes an approach to evidence synthesis that is specifically intended for decision making when there are two or more treatment alternatives being evaluated, and assumes that the purpose of every synthesis is to answer the question "for this pre-identified population of patients, which treatment is 'best'?" A comprehensive, coherent framework for network meta-analysis (mixed treatment comparisons) is adopted and estimated using Bayesian Markov Chain Monte Carlo methods implemented in the freely available software WinBUGS. Each chapter contains worked examples, exercises, solutions and code that may be adapted by readers to apply to their own analyses. This book can be used as an introduction to evidence synthesis and network meta-analysis, its key properties and policy implications. Examples and advanced methods are also presented for the more experienced reader. Methods used throughout this book can be applied consistently: model critique and checking for evidence consistency are emphasised. Methods are based on technical support documents produced for NICE Decision Support Unit, which support the NICE Methods of Technology Appraisal. Code presented is also the basis for the code used by the ISPOR Task Force on Indirect Comparisons. Includes extensive carefully worked examples, with thorough explanations of how to set out data for use in WinBUGS and how to interpret the output. Network Meta-Analysis for Decision Making will be of interest to decision makers, medical statisticians, health economists, and anyone involved in Health Technology Assessment including the pharmaceutical industry.

Book Synopsis Network Meta-Analysis for Decision-Making by : Sofia Dias

Download or read book Network Meta-Analysis for Decision-Making written by Sofia Dias and published by John Wiley & Sons. This book was released on 2018-03-19 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practical guide to network meta-analysis with examples and code In the evaluation of healthcare, rigorous methods of quantitative assessment are necessary to establish which interventions are effective and cost-effective. Often a single study will not provide the answers and it is desirable to synthesise evidence from multiple sources, usually randomised controlled trials. This book takes an approach to evidence synthesis that is specifically intended for decision making when there are two or more treatment alternatives being evaluated, and assumes that the purpose of every synthesis is to answer the question "for this pre-identified population of patients, which treatment is 'best'?" A comprehensive, coherent framework for network meta-analysis (mixed treatment comparisons) is adopted and estimated using Bayesian Markov Chain Monte Carlo methods implemented in the freely available software WinBUGS. Each chapter contains worked examples, exercises, solutions and code that may be adapted by readers to apply to their own analyses. This book can be used as an introduction to evidence synthesis and network meta-analysis, its key properties and policy implications. Examples and advanced methods are also presented for the more experienced reader. Methods used throughout this book can be applied consistently: model critique and checking for evidence consistency are emphasised. Methods are based on technical support documents produced for NICE Decision Support Unit, which support the NICE Methods of Technology Appraisal. Code presented is also the basis for the code used by the ISPOR Task Force on Indirect Comparisons. Includes extensive carefully worked examples, with thorough explanations of how to set out data for use in WinBUGS and how to interpret the output. Network Meta-Analysis for Decision Making will be of interest to decision makers, medical statisticians, health economists, and anyone involved in Health Technology Assessment including the pharmaceutical industry.

Ethical and Scientific Issues in Studying the Safety of Approved Drugs

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2012-07-30

Total Pages: 292

ISBN-13: 0309218160

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An estimated 48 percent of the population takes at least one prescription drug in a given month. Drugs provide great benefits to society by saving or improving lives. Many drugs are also associated with side effects or adverse events, some serious and some discovered only after the drug is on the market. The discovery of new adverse events in the postmarketing setting is part of the normal natural history of approved drugs, and timely identification and warning about drug risks are central to the mission of the Food and Drug Administration (FDA). Not all risks associated with a drug are known at the time of approval, because safety data are collected from studies that involve a relatively small number of human subjects during a relatively short period. Written in response to a request by the FDA, Ethical and Scientific Issues in Studying the Safety of Approved Drugs discusses ethical and informed consent issues in conducting studies in the postmarketing setting. It evaluates the strengths and weaknesses of various approaches to generate evidence about safety questions, and makes recommendations for appropriate followup studies and randomized clinical trials. The book provides guidance to the FDA on how it should factor in different kinds of evidence in its regulatory decisions. Ethical and Scientific Issues in Studying the Safety of Approved Drugs will be of interest to the pharmaceutical industry, patient advocates, researchers, and consumer groups.

Book Synopsis Ethical and Scientific Issues in Studying the Safety of Approved Drugs by : Institute of Medicine

Download or read book Ethical and Scientific Issues in Studying the Safety of Approved Drugs written by Institute of Medicine and published by National Academies Press. This book was released on 2012-07-30 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: An estimated 48 percent of the population takes at least one prescription drug in a given month. Drugs provide great benefits to society by saving or improving lives. Many drugs are also associated with side effects or adverse events, some serious and some discovered only after the drug is on the market. The discovery of new adverse events in the postmarketing setting is part of the normal natural history of approved drugs, and timely identification and warning about drug risks are central to the mission of the Food and Drug Administration (FDA). Not all risks associated with a drug are known at the time of approval, because safety data are collected from studies that involve a relatively small number of human subjects during a relatively short period. Written in response to a request by the FDA, Ethical and Scientific Issues in Studying the Safety of Approved Drugs discusses ethical and informed consent issues in conducting studies in the postmarketing setting. It evaluates the strengths and weaknesses of various approaches to generate evidence about safety questions, and makes recommendations for appropriate followup studies and randomized clinical trials. The book provides guidance to the FDA on how it should factor in different kinds of evidence in its regulatory decisions. Ethical and Scientific Issues in Studying the Safety of Approved Drugs will be of interest to the pharmaceutical industry, patient advocates, researchers, and consumer groups.

Network Meta-Analysis for Decision-Making

Author: Sofia Dias

Publisher: John Wiley & Sons

Published: 2018-01-08

Total Pages: 488

ISBN-13: 1118951727

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Book Synopsis Network Meta-Analysis for Decision-Making by : Sofia Dias

Download or read book Network Meta-Analysis for Decision-Making written by Sofia Dias and published by John Wiley & Sons. This book was released on 2018-01-08 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practical guide to network meta-analysis with examples and code In the evaluation of healthcare, rigorous methods of quantitative assessment are necessary to establish which interventions are effective and cost-effective. Often a single study will not provide the answers and it is desirable to synthesise evidence from multiple sources, usually randomised controlled trials. This book takes an approach to evidence synthesis that is specifically intended for decision making when there are two or more treatment alternatives being evaluated, and assumes that the purpose of every synthesis is to answer the question "for this pre-identified population of patients, which treatment is 'best'?" A comprehensive, coherent framework for network meta-analysis (mixed treatment comparisons) is adopted and estimated using Bayesian Markov Chain Monte Carlo methods implemented in the freely available software WinBUGS. Each chapter contains worked examples, exercises, solutions and code that may be adapted by readers to apply to their own analyses. This book can be used as an introduction to evidence synthesis and network meta-analysis, its key properties and policy implications. Examples and advanced methods are also presented for the more experienced reader. Methods used throughout this book can be applied consistently: model critique and checking for evidence consistency are emphasised. Methods are based on technical support documents produced for NICE Decision Support Unit, which support the NICE Methods of Technology Appraisal. Code presented is also the basis for the code used by the ISPOR Task Force on Indirect Comparisons. Includes extensive carefully worked examples, with thorough explanations of how to set out data for use in WinBUGS and how to interpret the output. Network Meta-Analysis for Decision Making will be of interest to decision makers, medical statisticians, health economists, and anyone involved in Health Technology Assessment including the pharmaceutical industry.