Exercise Countermeasures for Bed Rest Deconditioning

Exercise Countermeasures for Bed Rest Deconditioning

Author: John Edward Greenleaf

Publisher:

Published: 1989

Total Pages: 68

ISBN-13:

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Book Synopsis Exercise Countermeasures for Bed Rest Deconditioning by : John Edward Greenleaf

Download or read book Exercise Countermeasures for Bed Rest Deconditioning written by John Edward Greenleaf and published by . This book was released on 1989 with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt:


Exercise Countermeasures for Bed-Rest Deconditioning

Exercise Countermeasures for Bed-Rest Deconditioning

Author: National Aeronautics and Space Administration (NASA)

Publisher: Createspace Independent Publishing Platform

Published: 2018-07-25

Total Pages: 232

ISBN-13: 9781723573774

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The purpose for this 30-day bed rest study was to investigate the effects of short-term, high intensity isotonic and isokinetic exercise training on maintenance of working capacity (peak oxygen uptake), muscular strength and endurance, and on orthostatic tolerance, posture and gait. Other data were collected on muscle atrophy, bone mineralization and density, endocrine analyses concerning vasoactivity and fluid-electrolyte balance, muscle intermediary metabolism, and on performance and mood of the subjects. It was concluded that: The subjects maintained a relatively stable mood, high morale, and high esprit de corps throughout the study. Performance improved in nearly all tests in almost all the subjects. Isotonic training, as opposed to isokinetic exercise training, was associated more with decreasing levels of psychological tension, concentration, and motivation; and improvement in the quality of sleep. Working capacity (peak oxygen uptake) was maintained during bed rest with isotonic exercise training; it was not maintained with isokinetic or no exercise training. In general, there was no significant decrease in strength or endurance of arm or leg muscles during bed rest, in spite of some reduction in muscle size (atrophy) of some leg muscles. There was no effect of isotonic exercise training on orthostasis, since tilt-table tolerance was reduced similarly in all three groups following bed rest. Bed rest resulted in significant decreases of postural stability and self-selected step length, stride length, and walking velocity, which were not influenced by either exercise training regimen. Most pre-bed rest responses were restored by the fourth day of recovery. Greenleaf, John (Editor) Ames Research Center NASA-TM-103987, A-93008, NAS 1.15:103987 RTOP 199-21-12-07...


Book Synopsis Exercise Countermeasures for Bed-Rest Deconditioning by : National Aeronautics and Space Administration (NASA)

Download or read book Exercise Countermeasures for Bed-Rest Deconditioning written by National Aeronautics and Space Administration (NASA) and published by Createspace Independent Publishing Platform. This book was released on 2018-07-25 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose for this 30-day bed rest study was to investigate the effects of short-term, high intensity isotonic and isokinetic exercise training on maintenance of working capacity (peak oxygen uptake), muscular strength and endurance, and on orthostatic tolerance, posture and gait. Other data were collected on muscle atrophy, bone mineralization and density, endocrine analyses concerning vasoactivity and fluid-electrolyte balance, muscle intermediary metabolism, and on performance and mood of the subjects. It was concluded that: The subjects maintained a relatively stable mood, high morale, and high esprit de corps throughout the study. Performance improved in nearly all tests in almost all the subjects. Isotonic training, as opposed to isokinetic exercise training, was associated more with decreasing levels of psychological tension, concentration, and motivation; and improvement in the quality of sleep. Working capacity (peak oxygen uptake) was maintained during bed rest with isotonic exercise training; it was not maintained with isokinetic or no exercise training. In general, there was no significant decrease in strength or endurance of arm or leg muscles during bed rest, in spite of some reduction in muscle size (atrophy) of some leg muscles. There was no effect of isotonic exercise training on orthostasis, since tilt-table tolerance was reduced similarly in all three groups following bed rest. Bed rest resulted in significant decreases of postural stability and self-selected step length, stride length, and walking velocity, which were not influenced by either exercise training regimen. Most pre-bed rest responses were restored by the fourth day of recovery. Greenleaf, John (Editor) Ames Research Center NASA-TM-103987, A-93008, NAS 1.15:103987 RTOP 199-21-12-07...


Exercise Countermeasures for Bed-rest Deconditioning

Exercise Countermeasures for Bed-rest Deconditioning

Author: John Edward Greenleaf

Publisher:

Published: 1993

Total Pages: 234

ISBN-13:

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The purpose for this 30-day bed-rest study was to investigate the effects of short-term, high-intensity isotonic and isokinetic exercise training on maintenance of aerobic work capacity (peak oxygen uptake); muscular strength and endurance; and orthostatic tolerance, equilibrium, and gait. Other data were collected on muscle atrophy, bone mineralization and density, endocrine analyses of vasoactivity and fluid-electrolyte balance, muscle intermediary metabolism, and performance and mood of the subjects. Nineteen men (32-42 yr) were allocated into three groups: no-exercise control (peak oxygen uptake and isokinetic tests once/wk, N = 5), isotonic exercise training (electronic Quinton ergometer, supine, N = 7), and isokinetic exercise training (electronic Lido ergometer, supine, N = 7). The exercise training regimens were conducted near peak levels for 30 min in the morning and 30 min in the afternoon 5 d/wk. The protocol consisted of a 7-d ambulatory control period during which the subjects equilibrated on the standardized diet, 30 d of 6 degrees head-down bed rest, and a final 4.5 d of ambulatory recovery. Their diet consisted of commonly available fresh and frozen foods; mean caloric consumption of 2,678 +/- SE 75 kcal/d (control), 2,833 +/- SE 82 kcal/day (isotonic), and 2,890 +/- SE 75 kcal/d (isokinetic) resulted in mean weight losses during bed rest of 1.01 kg, 0.85 kg, and 0.0 kg, respectively. The results indicated that: (1) The subjects maintained a relatively stable mood, high morale, and high esprit de corps throughout the study. Scores improved in nearly all performance and mood tests in almost all the subjects. Isotonic training, as opposed to isokinetic exercise training, was associated with decreasing levels of psychological tension, concentration, and motivation, and with improvement in the quality of sleep. (2) Peak oxygen uptake was maintained during bed rest with isotonic exercise training; it was not maintained as well with isokinetic ( -9.0%) or no-exercise ( -18.2%) training. If a 9% reduction in aerobic power is acceptable, isokinetic exercise training could be used for maintenance of strength, endurance, and the reduced aerobic capacity in astronauts during flight. (3) In general, there were few decreases in strength or endurance of arm or leg muscles during bed rest, in spite of reduction in size (atrophy) of some leg muscles. (4) There was no effect of isotonic or isokinetic exercise training on orthostasis, because tilt-table tolerances were reduced similarly from 42-53 min to 30-34 min in the three groups following bed rest. (5) Bed rest resulted in significant decreases of postural stability and self-selected step length, stride length, and walking velocity, which were not influenced by either exercise training regimen. Pre-bed-rest responses were restored by the fourth day of recovery.


Book Synopsis Exercise Countermeasures for Bed-rest Deconditioning by : John Edward Greenleaf

Download or read book Exercise Countermeasures for Bed-rest Deconditioning written by John Edward Greenleaf and published by . This book was released on 1993 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose for this 30-day bed-rest study was to investigate the effects of short-term, high-intensity isotonic and isokinetic exercise training on maintenance of aerobic work capacity (peak oxygen uptake); muscular strength and endurance; and orthostatic tolerance, equilibrium, and gait. Other data were collected on muscle atrophy, bone mineralization and density, endocrine analyses of vasoactivity and fluid-electrolyte balance, muscle intermediary metabolism, and performance and mood of the subjects. Nineteen men (32-42 yr) were allocated into three groups: no-exercise control (peak oxygen uptake and isokinetic tests once/wk, N = 5), isotonic exercise training (electronic Quinton ergometer, supine, N = 7), and isokinetic exercise training (electronic Lido ergometer, supine, N = 7). The exercise training regimens were conducted near peak levels for 30 min in the morning and 30 min in the afternoon 5 d/wk. The protocol consisted of a 7-d ambulatory control period during which the subjects equilibrated on the standardized diet, 30 d of 6 degrees head-down bed rest, and a final 4.5 d of ambulatory recovery. Their diet consisted of commonly available fresh and frozen foods; mean caloric consumption of 2,678 +/- SE 75 kcal/d (control), 2,833 +/- SE 82 kcal/day (isotonic), and 2,890 +/- SE 75 kcal/d (isokinetic) resulted in mean weight losses during bed rest of 1.01 kg, 0.85 kg, and 0.0 kg, respectively. The results indicated that: (1) The subjects maintained a relatively stable mood, high morale, and high esprit de corps throughout the study. Scores improved in nearly all performance and mood tests in almost all the subjects. Isotonic training, as opposed to isokinetic exercise training, was associated with decreasing levels of psychological tension, concentration, and motivation, and with improvement in the quality of sleep. (2) Peak oxygen uptake was maintained during bed rest with isotonic exercise training; it was not maintained as well with isokinetic ( -9.0%) or no-exercise ( -18.2%) training. If a 9% reduction in aerobic power is acceptable, isokinetic exercise training could be used for maintenance of strength, endurance, and the reduced aerobic capacity in astronauts during flight. (3) In general, there were few decreases in strength or endurance of arm or leg muscles during bed rest, in spite of reduction in size (atrophy) of some leg muscles. (4) There was no effect of isotonic or isokinetic exercise training on orthostasis, because tilt-table tolerances were reduced similarly from 42-53 min to 30-34 min in the three groups following bed rest. (5) Bed rest resulted in significant decreases of postural stability and self-selected step length, stride length, and walking velocity, which were not influenced by either exercise training regimen. Pre-bed-rest responses were restored by the fourth day of recovery.


Recovery After Prolonged Bed-Rest Deconditioning

Recovery After Prolonged Bed-Rest Deconditioning

Author:

Publisher:

Published: 2003

Total Pages: 90

ISBN-13:

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Book Synopsis Recovery After Prolonged Bed-Rest Deconditioning by :

Download or read book Recovery After Prolonged Bed-Rest Deconditioning written by and published by . This book was released on 2003 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt:


Bed Rest, Exercise Countermeasure and Reconditioning Effects on the Human Resting Muscle Tone System

Bed Rest, Exercise Countermeasure and Reconditioning Effects on the Human Resting Muscle Tone System

Author: Britt Schoenrock

Publisher:

Published: 2018

Total Pages:

ISBN-13:

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Book Synopsis Bed Rest, Exercise Countermeasure and Reconditioning Effects on the Human Resting Muscle Tone System by : Britt Schoenrock

Download or read book Bed Rest, Exercise Countermeasure and Reconditioning Effects on the Human Resting Muscle Tone System written by Britt Schoenrock and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:


Deconditioning and Reconditioning

Deconditioning and Reconditioning

Author: John Greenleaf

Publisher: CRC Press

Published: 2004-02-11

Total Pages: 200

ISBN-13: 1134401418

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Deconditioning is an integrated physiological response of the body to a reduction in metabolic rate, that is, to a reduction in energy use or in exercise level. Deconditioning and Reconditioning presents selected background information on the many aspects of ground-based and in-flight physiological research and applications. This multi-auth


Book Synopsis Deconditioning and Reconditioning by : John Greenleaf

Download or read book Deconditioning and Reconditioning written by John Greenleaf and published by CRC Press. This book was released on 2004-02-11 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Deconditioning is an integrated physiological response of the body to a reduction in metabolic rate, that is, to a reduction in energy use or in exercise level. Deconditioning and Reconditioning presents selected background information on the many aspects of ground-based and in-flight physiological research and applications. This multi-auth


Optimization of Exercise Countermeasures for Human Space Flight – Lessons from Terrestrial Physiology and Operational Implementation

Optimization of Exercise Countermeasures for Human Space Flight – Lessons from Terrestrial Physiology and Operational Implementation

Author: Tobias Weber

Publisher: Frontiers Media SA

Published: 2020-03-04

Total Pages: 148

ISBN-13: 2889634736

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Human spaceflight has required space agencies to study and develop exercise countermeasure (CM) strategies to manage the profound, multi-system adaptation of the human body to prolonged microgravity (μG). Future space exploration will present new challenges in terms of adaptation management that will require the attention of both exercise physiologists and operational experts. In the short to medium-term, all exploration missions will be realised using relatively small vehicles/habitats, with some exploration scenarios including surface operations in low (<1G) gravity conditions. The evolution of CM hardware has allowed modern-day astronauts to return to Earth with, on average, relatively moderate levels μG-induced adaptation of the musculoskeletal (MS) and cardiovascular (CV) systems. However, although the intense use of CM has attenuated many aspects of MS and CV adaptation, on an individual level, there remains wide variation in the magnitude of these changes. Innovations in CM programs have been largely engineering-driven, with new hardware providing capability for new modes of exercise and a wider range of exercise protocols, which, in turn, has facilitated the transfer of traditional, but effective, terrestrial concepts based around high frequency resistance (multiple-set, multiple repetition) and mediumintensity continuous aerobic training. As a result, International Space Station (ISS) CM specialists have focused their efforts in these domains, taking advantage of hardware innovations as and when they became available. However, terrestrial knowledge in human and exercise physiology has expanded rapidly during the lifetime of the ISS and, consequently, there is potential to optimize current approaches by re-examining terrestrial knowledge and identifying opportunities to implement this knowledge into operational practices. Current terrestrial knowledge in exercise physiology is the product of a large number of intervention studies in which the variables that contribute to the effects of physical activity (mode, frequency, duration, intensity, recovery) have been controlled and systematically manipulated. However, due to limited opportunities to perform intervention studies in both spaceflight analogues – head-down bed rest (HDBR) being considered the ‘gold standard’ – and spaceflight itself, it will not be possible to systematically investigate the contribution of these factors to the efficacy of in-flight CM. As such, it will be necessary to draw on terrestrial evidence to identify solutions/strategies that may be best suited to the constraints of exploration and prioritise specific solutions/strategies for evaluation in HDBR and in flight.


Book Synopsis Optimization of Exercise Countermeasures for Human Space Flight – Lessons from Terrestrial Physiology and Operational Implementation by : Tobias Weber

Download or read book Optimization of Exercise Countermeasures for Human Space Flight – Lessons from Terrestrial Physiology and Operational Implementation written by Tobias Weber and published by Frontiers Media SA. This book was released on 2020-03-04 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human spaceflight has required space agencies to study and develop exercise countermeasure (CM) strategies to manage the profound, multi-system adaptation of the human body to prolonged microgravity (μG). Future space exploration will present new challenges in terms of adaptation management that will require the attention of both exercise physiologists and operational experts. In the short to medium-term, all exploration missions will be realised using relatively small vehicles/habitats, with some exploration scenarios including surface operations in low (<1G) gravity conditions. The evolution of CM hardware has allowed modern-day astronauts to return to Earth with, on average, relatively moderate levels μG-induced adaptation of the musculoskeletal (MS) and cardiovascular (CV) systems. However, although the intense use of CM has attenuated many aspects of MS and CV adaptation, on an individual level, there remains wide variation in the magnitude of these changes. Innovations in CM programs have been largely engineering-driven, with new hardware providing capability for new modes of exercise and a wider range of exercise protocols, which, in turn, has facilitated the transfer of traditional, but effective, terrestrial concepts based around high frequency resistance (multiple-set, multiple repetition) and mediumintensity continuous aerobic training. As a result, International Space Station (ISS) CM specialists have focused their efforts in these domains, taking advantage of hardware innovations as and when they became available. However, terrestrial knowledge in human and exercise physiology has expanded rapidly during the lifetime of the ISS and, consequently, there is potential to optimize current approaches by re-examining terrestrial knowledge and identifying opportunities to implement this knowledge into operational practices. Current terrestrial knowledge in exercise physiology is the product of a large number of intervention studies in which the variables that contribute to the effects of physical activity (mode, frequency, duration, intensity, recovery) have been controlled and systematically manipulated. However, due to limited opportunities to perform intervention studies in both spaceflight analogues – head-down bed rest (HDBR) being considered the ‘gold standard’ – and spaceflight itself, it will not be possible to systematically investigate the contribution of these factors to the efficacy of in-flight CM. As such, it will be necessary to draw on terrestrial evidence to identify solutions/strategies that may be best suited to the constraints of exploration and prioritise specific solutions/strategies for evaluation in HDBR and in flight.


Spinal Control: The Rehabilitation of Back Pain

Spinal Control: The Rehabilitation of Back Pain

Author: Paul W. Hodges

Publisher: Elsevier Health Sciences

Published: 2013-08-19

Total Pages: 537

ISBN-13: 0702054542

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For the first time, international scientific and clinical leaders have collaborated to present this exclusive book which integrates state-of-the art engineering concepts of spine control into clinically relevant approaches for the rehabilitation of low back pain. Spinal Control identifies the scope of the problem around motor control of the spine and pelvis while defining key terminology and methods as well as placing experimental findings into context. Spinal Control also includes contributions that put forward different sides of critical arguments (e.g. whether or not to focus on training the deep muscles of the trunk) and then bring these arguments together to help both scientists and clinicians better understand the convergences and divergences within this field. On the one hand, this book seeks to resolve many of the issues that are debated in existing literature, while on the other, its contributing opinion leaders present current best practice on how to study the questions facing the field of spine control, and then go on to outline the key directions for future research. Spinal Control – the only expert resource which provides a trusted, consensus approach to low back pain rehabilitation for both clinicians and scientists alike! Covers the most important issues in spine control research Illustrates the clinical relevance of research and how this is or can be applied in clinical practice Edited and written by world leading experts, contributing first class content on different aspects of spine control Chapters that bring together the expertise of these world leaders on topics such as neuromotor mechanisms of spine control, proprioception, subgrouping in back pain and modelling spine stability An extensive and illustrated clinical consensus chapter that brings together the philosophies of clinical opinion leaders for the first time


Book Synopsis Spinal Control: The Rehabilitation of Back Pain by : Paul W. Hodges

Download or read book Spinal Control: The Rehabilitation of Back Pain written by Paul W. Hodges and published by Elsevier Health Sciences. This book was released on 2013-08-19 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the first time, international scientific and clinical leaders have collaborated to present this exclusive book which integrates state-of-the art engineering concepts of spine control into clinically relevant approaches for the rehabilitation of low back pain. Spinal Control identifies the scope of the problem around motor control of the spine and pelvis while defining key terminology and methods as well as placing experimental findings into context. Spinal Control also includes contributions that put forward different sides of critical arguments (e.g. whether or not to focus on training the deep muscles of the trunk) and then bring these arguments together to help both scientists and clinicians better understand the convergences and divergences within this field. On the one hand, this book seeks to resolve many of the issues that are debated in existing literature, while on the other, its contributing opinion leaders present current best practice on how to study the questions facing the field of spine control, and then go on to outline the key directions for future research. Spinal Control – the only expert resource which provides a trusted, consensus approach to low back pain rehabilitation for both clinicians and scientists alike! Covers the most important issues in spine control research Illustrates the clinical relevance of research and how this is or can be applied in clinical practice Edited and written by world leading experts, contributing first class content on different aspects of spine control Chapters that bring together the expertise of these world leaders on topics such as neuromotor mechanisms of spine control, proprioception, subgrouping in back pain and modelling spine stability An extensive and illustrated clinical consensus chapter that brings together the philosophies of clinical opinion leaders for the first time


Musculoskeletal Tissue Regeneration

Musculoskeletal Tissue Regeneration

Author: William S. Pietrzak

Publisher: Springer Science & Business Media

Published: 2008-04-11

Total Pages: 647

ISBN-13: 1597452394

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The repair of musculoskeletal tissue is a vital concern of all surgical specialties, orthopedics and related disciplines. Written by recognized experts, this book aims to provide both basic and advanced knowledge of the newer methodologies being developed and introduced to the clinical arena. A valuable resource for researchers, developers, and clinicians, the book presents a foundation to propel the technology and integration of the current state of knowledge into the 21st century.


Book Synopsis Musculoskeletal Tissue Regeneration by : William S. Pietrzak

Download or read book Musculoskeletal Tissue Regeneration written by William S. Pietrzak and published by Springer Science & Business Media. This book was released on 2008-04-11 with total page 647 pages. Available in PDF, EPUB and Kindle. Book excerpt: The repair of musculoskeletal tissue is a vital concern of all surgical specialties, orthopedics and related disciplines. Written by recognized experts, this book aims to provide both basic and advanced knowledge of the newer methodologies being developed and introduced to the clinical arena. A valuable resource for researchers, developers, and clinicians, the book presents a foundation to propel the technology and integration of the current state of knowledge into the 21st century.


Recapturing a Future for Space Exploration

Recapturing a Future for Space Exploration

Author: National Research Council

Publisher: National Academies Press

Published: 2012-01-30

Total Pages: 464

ISBN-13: 0309163846

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More than four decades have passed since a human first set foot on the Moon. Great strides have been made in our understanding of what is required to support an enduring human presence in space, as evidenced by progressively more advanced orbiting human outposts, culminating in the current International Space Station (ISS). However, of the more than 500 humans who have so far ventured into space, most have gone only as far as near-Earth orbit, and none have traveled beyond the orbit of the Moon. Achieving humans' further progress into the solar system had proved far more difficult than imagined in the heady days of the Apollo missions, but the potential rewards remain substantial. During its more than 50-year history, NASA's success in human space exploration has depended on the agency's ability to effectively address a wide range of biomedical, engineering, physical science, and related obstacles-an achievement made possible by NASA's strong and productive commitments to life and physical sciences research for human space exploration, and by its use of human space exploration infrastructures for scientific discovery. The Committee for the Decadal Survey of Biological and Physical Sciences acknowledges the many achievements of NASA, which are all the more remarkable given budgetary challenges and changing directions within the agency. In the past decade, however, a consequence of those challenges has been a life and physical sciences research program that was dramatically reduced in both scale and scope, with the result that the agency is poorly positioned to take full advantage of the scientific opportunities offered by the now fully equipped and staffed ISS laboratory, or to effectively pursue the scientific research needed to support the development of advanced human exploration capabilities. Although its review has left it deeply concerned about the current state of NASA's life and physical sciences research, the Committee for the Decadal Survey on Biological and Physical Sciences in Space is nevertheless convinced that a focused science and engineering program can achieve successes that will bring the space community, the U.S. public, and policymakers to an understanding that we are ready for the next significant phase of human space exploration. The goal of this report is to lay out steps and develop a forward-looking portfolio of research that will provide the basis for recapturing the excitement and value of human spaceflight-thereby enabling the U.S. space program to deliver on new exploration initiatives that serve the nation, excite the public, and place the United States again at the forefront of space exploration for the global good.


Book Synopsis Recapturing a Future for Space Exploration by : National Research Council

Download or read book Recapturing a Future for Space Exploration written by National Research Council and published by National Academies Press. This book was released on 2012-01-30 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than four decades have passed since a human first set foot on the Moon. Great strides have been made in our understanding of what is required to support an enduring human presence in space, as evidenced by progressively more advanced orbiting human outposts, culminating in the current International Space Station (ISS). However, of the more than 500 humans who have so far ventured into space, most have gone only as far as near-Earth orbit, and none have traveled beyond the orbit of the Moon. Achieving humans' further progress into the solar system had proved far more difficult than imagined in the heady days of the Apollo missions, but the potential rewards remain substantial. During its more than 50-year history, NASA's success in human space exploration has depended on the agency's ability to effectively address a wide range of biomedical, engineering, physical science, and related obstacles-an achievement made possible by NASA's strong and productive commitments to life and physical sciences research for human space exploration, and by its use of human space exploration infrastructures for scientific discovery. The Committee for the Decadal Survey of Biological and Physical Sciences acknowledges the many achievements of NASA, which are all the more remarkable given budgetary challenges and changing directions within the agency. In the past decade, however, a consequence of those challenges has been a life and physical sciences research program that was dramatically reduced in both scale and scope, with the result that the agency is poorly positioned to take full advantage of the scientific opportunities offered by the now fully equipped and staffed ISS laboratory, or to effectively pursue the scientific research needed to support the development of advanced human exploration capabilities. Although its review has left it deeply concerned about the current state of NASA's life and physical sciences research, the Committee for the Decadal Survey on Biological and Physical Sciences in Space is nevertheless convinced that a focused science and engineering program can achieve successes that will bring the space community, the U.S. public, and policymakers to an understanding that we are ready for the next significant phase of human space exploration. The goal of this report is to lay out steps and develop a forward-looking portfolio of research that will provide the basis for recapturing the excitement and value of human spaceflight-thereby enabling the U.S. space program to deliver on new exploration initiatives that serve the nation, excite the public, and place the United States again at the forefront of space exploration for the global good.