From Ion Channels to Cell-to-Cell Conversations

From Ion Channels to Cell-to-Cell Conversations

Author: Ramón Latorre

Publisher: Springer Science & Business Media

Published: 2013-11-21

Total Pages: 515

ISBN-13: 1489917950

DOWNLOAD EBOOK

Ion channels allow us to see nature in all its magnificence, to hear a Bach suite, to smell the aroma of grandmother's cooking, and, in this regard, they put us in contact with the external world. These ion channels are protein molecules located in the cell membrane. In complex organisms, cells need to communicate in order to know about their metabolic status and to act in a coordinate manner. The latter is also accomplished by a class of ion channels able to pierce the lipid bilayer membranes of two adjacent cells. These intercellular channels are the functional subunits of gap junctions. Accordingly, the book is divided in two parts: the first part is dedicated to ion channels that look to the external world, and the second part is dedicated to gap junctions found at cell interfaces. This book is based on a series of symposia for a meeting on ion channels and gap junctions held in Santiago, Chile, on November 28-30, 1995. The book should be useful to graduate students taking the first steps in this field as well as a reference for the aficionado. The aim of the meeting was mainly to show the impact of various modern techniques, including cell biology, molecular biology, biophysics, and molecular genetics techniques in the study of these ubiquitous intrinsic membrane proteins. Molecular-genetics techniques paved the road to the manipulation of the channel forming molecules.


Book Synopsis From Ion Channels to Cell-to-Cell Conversations by : Ramón Latorre

Download or read book From Ion Channels to Cell-to-Cell Conversations written by Ramón Latorre and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 515 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channels allow us to see nature in all its magnificence, to hear a Bach suite, to smell the aroma of grandmother's cooking, and, in this regard, they put us in contact with the external world. These ion channels are protein molecules located in the cell membrane. In complex organisms, cells need to communicate in order to know about their metabolic status and to act in a coordinate manner. The latter is also accomplished by a class of ion channels able to pierce the lipid bilayer membranes of two adjacent cells. These intercellular channels are the functional subunits of gap junctions. Accordingly, the book is divided in two parts: the first part is dedicated to ion channels that look to the external world, and the second part is dedicated to gap junctions found at cell interfaces. This book is based on a series of symposia for a meeting on ion channels and gap junctions held in Santiago, Chile, on November 28-30, 1995. The book should be useful to graduate students taking the first steps in this field as well as a reference for the aficionado. The aim of the meeting was mainly to show the impact of various modern techniques, including cell biology, molecular biology, biophysics, and molecular genetics techniques in the study of these ubiquitous intrinsic membrane proteins. Molecular-genetics techniques paved the road to the manipulation of the channel forming molecules.

Pumps, Transporters, and Ion Channels

Pumps, Transporters, and Ion Channels

Author: Francisco Sepulveda

Publisher: Springer Science & Business Media

Published: 2006-03-30

Total Pages: 175

ISBN-13: 0387274243

DOWNLOAD EBOOK

This book is a compilation of articles based on some of the talks given at the Centro de Estudios Cientificos (CECS) in Valdivia during the course of a celebration to th mark the 60 birthdays of Ramon Latorre and Enrico Stefani. Ramon Latorre is one of the most outstanding figures in channel Biophysics today. The first surprise is that he trained as a Biochemist! He soon, however, became a biophysicist through his work with Guayo (Eduardo) Rojas who guided him during his Ph. D thesis in the Laboratorio de Fisiologia Celular in Montemar. His work at N.I.H with Gerald Eherenstein and Harold Lecar constitutes one of the milestones of single ion channel Biophysics. This classical work, done in planar bilayers, set the basis for understanding voltage-dependent conductances with single channel studies and predates, by many years, later studies using patch clamping techniques. Ramon was one of the firsts to find and recognize the importance of calci- activated potassium channels and to begin a detailed study of channel properties. He pioneered the ideas of voltage and calcium modulation of the open probability and he added detailed studies of gating and its modulation by other ions. Ramon is also interested in permeation and selectivity and he produced classical studies on the number of water molecules in the channel and sites occupied by barium. Results and concepts that have recently taken front page as the structure of KcSa has been described.


Book Synopsis Pumps, Transporters, and Ion Channels by : Francisco Sepulveda

Download or read book Pumps, Transporters, and Ion Channels written by Francisco Sepulveda and published by Springer Science & Business Media. This book was released on 2006-03-30 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a compilation of articles based on some of the talks given at the Centro de Estudios Cientificos (CECS) in Valdivia during the course of a celebration to th mark the 60 birthdays of Ramon Latorre and Enrico Stefani. Ramon Latorre is one of the most outstanding figures in channel Biophysics today. The first surprise is that he trained as a Biochemist! He soon, however, became a biophysicist through his work with Guayo (Eduardo) Rojas who guided him during his Ph. D thesis in the Laboratorio de Fisiologia Celular in Montemar. His work at N.I.H with Gerald Eherenstein and Harold Lecar constitutes one of the milestones of single ion channel Biophysics. This classical work, done in planar bilayers, set the basis for understanding voltage-dependent conductances with single channel studies and predates, by many years, later studies using patch clamping techniques. Ramon was one of the firsts to find and recognize the importance of calci- activated potassium channels and to begin a detailed study of channel properties. He pioneered the ideas of voltage and calcium modulation of the open probability and he added detailed studies of gating and its modulation by other ions. Ramon is also interested in permeation and selectivity and he produced classical studies on the number of water molecules in the channel and sites occupied by barium. Results and concepts that have recently taken front page as the structure of KcSa has been described.

Cell Volume Regulation

Cell Volume Regulation

Author:

Publisher: Academic Press

Published: 2018-09-20

Total Pages: 514

ISBN-13: 0128154578

DOWNLOAD EBOOK

Cell Volume Regulation and Fluid Secretion, Volume 81, the latest release in the Current Topics in Membranes series highlights new advances in the field, with this new volume presenting interesting chapters on General principles of cell volume regulation, Cell volume maintenance: water and salt homeostasis, The search for ubiquitous cell volume sensor: the role of plasma membrane and cytoplasmic hydrogel, More than membranes, Cellular and membrane biomechanics of CVR response, Molecular identities of volume-regulatory anion channels, Molecular biology and physiology of volume-regulated anion channel (VRAC), the Role of WNKs in the modulation of intracellular chloride, amongst other topics. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Membranes series Includes the latest information on Cell Volume Regulation


Book Synopsis Cell Volume Regulation by :

Download or read book Cell Volume Regulation written by and published by Academic Press. This book was released on 2018-09-20 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell Volume Regulation and Fluid Secretion, Volume 81, the latest release in the Current Topics in Membranes series highlights new advances in the field, with this new volume presenting interesting chapters on General principles of cell volume regulation, Cell volume maintenance: water and salt homeostasis, The search for ubiquitous cell volume sensor: the role of plasma membrane and cytoplasmic hydrogel, More than membranes, Cellular and membrane biomechanics of CVR response, Molecular identities of volume-regulatory anion channels, Molecular biology and physiology of volume-regulated anion channel (VRAC), the Role of WNKs in the modulation of intracellular chloride, amongst other topics. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Membranes series Includes the latest information on Cell Volume Regulation

Gap Junctions: Molecular Basis of Cell Communication in Health and Disease

Gap Junctions: Molecular Basis of Cell Communication in Health and Disease

Author:

Publisher: Academic Press

Published: 1999-12-22

Total Pages: 648

ISBN-13: 9780080585208

DOWNLOAD EBOOK

Since the first gap junction protein (connexin) was cloned over a decade ago, more than a dozen connexin genes have been cloned. Consequently, a wealth of information on the molecular basis of gap junctional communication has been accumulated. This book pays tribute to this exciting era in the history of cell communication research by documenting the great strides made in this field as a result of the merging of biophysics and molecular biology, two of the most powerful approaches to studying the molecular basis of membrane channel behavior. Twenty-eight comprehensive chapters, authored by internationally recognized leaders in the field, discuss the biophysical, physiological, and molecular characteristics of cell-to-cell communication via gap junctions. Key aspects of molecular structure, formation, gating, conductance, and permeability of vertebrate and invertebrate gap junction channels are highlighted. In addition, a number of chapters focus on recent discoveries that implicate connexin mutations and alterations of gap junctional communication in the pathogenesis of several diseases, including the X-linked Charcot Marie Tooth demyelinating disease, some forms of inherited sensorineural deafness, malignant transformation, cardiac malformations and arrhythmia, eye lens cataract, and Chagas' disease.


Book Synopsis Gap Junctions: Molecular Basis of Cell Communication in Health and Disease by :

Download or read book Gap Junctions: Molecular Basis of Cell Communication in Health and Disease written by and published by Academic Press. This book was released on 1999-12-22 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first gap junction protein (connexin) was cloned over a decade ago, more than a dozen connexin genes have been cloned. Consequently, a wealth of information on the molecular basis of gap junctional communication has been accumulated. This book pays tribute to this exciting era in the history of cell communication research by documenting the great strides made in this field as a result of the merging of biophysics and molecular biology, two of the most powerful approaches to studying the molecular basis of membrane channel behavior. Twenty-eight comprehensive chapters, authored by internationally recognized leaders in the field, discuss the biophysical, physiological, and molecular characteristics of cell-to-cell communication via gap junctions. Key aspects of molecular structure, formation, gating, conductance, and permeability of vertebrate and invertebrate gap junction channels are highlighted. In addition, a number of chapters focus on recent discoveries that implicate connexin mutations and alterations of gap junctional communication in the pathogenesis of several diseases, including the X-linked Charcot Marie Tooth demyelinating disease, some forms of inherited sensorineural deafness, malignant transformation, cardiac malformations and arrhythmia, eye lens cataract, and Chagas' disease.

Introduction to Nanoscience and Nanotechnology

Introduction to Nanoscience and Nanotechnology

Author: Gabor L. Hornyak

Publisher: CRC Press

Published: 2008-12-22

Total Pages: 1791

ISBN-13: 1439889953

DOWNLOAD EBOOK

The maturation of nanotechnology has revealed it to be a unique and distinct discipline rather than a specialization within a larger field. Its textbook cannot afford to be a chemistry, physics, or engineering text focused on nano. It must be an integrated, multidisciplinary, and specifically nano textbook. The archetype of the modern nano textbook


Book Synopsis Introduction to Nanoscience and Nanotechnology by : Gabor L. Hornyak

Download or read book Introduction to Nanoscience and Nanotechnology written by Gabor L. Hornyak and published by CRC Press. This book was released on 2008-12-22 with total page 1791 pages. Available in PDF, EPUB and Kindle. Book excerpt: The maturation of nanotechnology has revealed it to be a unique and distinct discipline rather than a specialization within a larger field. Its textbook cannot afford to be a chemistry, physics, or engineering text focused on nano. It must be an integrated, multidisciplinary, and specifically nano textbook. The archetype of the modern nano textbook

Voltage-Sensitive Ion Channels

Voltage-Sensitive Ion Channels

Author: H. Richard Leuchtag

Publisher: Springer Science & Business Media

Published: 2008-12-21

Total Pages: 545

ISBN-13: 1402055250

DOWNLOAD EBOOK

Voltage-sensitive ion channels are macromolecules embedded in the membranes of nerve and muscle fibers of animals. Despite decades of intensive research under the traditional approach of gated structural pores, the relation between the structure of these molecules and their function remains enigmatic. This book examines physically oriented approaches not covered in other ion-channel books, and it develops a new physics-based approach to the problem of molecular excitability.


Book Synopsis Voltage-Sensitive Ion Channels by : H. Richard Leuchtag

Download or read book Voltage-Sensitive Ion Channels written by H. Richard Leuchtag and published by Springer Science & Business Media. This book was released on 2008-12-21 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: Voltage-sensitive ion channels are macromolecules embedded in the membranes of nerve and muscle fibers of animals. Despite decades of intensive research under the traditional approach of gated structural pores, the relation between the structure of these molecules and their function remains enigmatic. This book examines physically oriented approaches not covered in other ion-channel books, and it develops a new physics-based approach to the problem of molecular excitability.

Introduction to Nanoscience

Introduction to Nanoscience

Author: Gabor L. Hornyak

Publisher: CRC Press

Published: 2008-05-15

Total Pages: 852

ISBN-13: 1420048066

DOWNLOAD EBOOK

Tomorrow's nanoscientist will have a truly interdisciplinary and nano-centric education, rather than, for example, a degree in chemistry with a specialization in nanoscience. For this to happen, the field needs a truly focused and dedicated textbook. This full-color masterwork is such a textbook. It introduces the nanoscale along with the societal


Book Synopsis Introduction to Nanoscience by : Gabor L. Hornyak

Download or read book Introduction to Nanoscience written by Gabor L. Hornyak and published by CRC Press. This book was released on 2008-05-15 with total page 852 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tomorrow's nanoscientist will have a truly interdisciplinary and nano-centric education, rather than, for example, a degree in chemistry with a specialization in nanoscience. For this to happen, the field needs a truly focused and dedicated textbook. This full-color masterwork is such a textbook. It introduces the nanoscale along with the societal

Lectures on Quantum Gravity

Lectures on Quantum Gravity

Author: Andres Gomberoff

Publisher: Springer Science & Business Media

Published: 2006-05-30

Total Pages: 357

ISBN-13: 0387249923

DOWNLOAD EBOOK

The 2002 Pan-American Advanced Studies Institute School on Quantum Gravity was held at the Centro de Estudios Cientificos (CECS),Valdivia, Chile, January 4-14, 2002. The school featured lectures by ten speakers, and was attended by nearly 70 students from over 14 countries. A primary goal was to foster interaction and communication between participants from different cultures, both in the layman’s sense of the term and in terms of approaches to quantum gravity. We hope that the links formed by students and the school will persist throughout their professional lives, continuing to promote interaction and the essential exchange of ideas that drives research forward. This volume contains improved and updated versions of the lectures given at the School. It has been prepared both as a reminder for the participants, and so that these pedagogical introductions can be made available to others who were unable to attend. We expect them to serve students of all ages well.


Book Synopsis Lectures on Quantum Gravity by : Andres Gomberoff

Download or read book Lectures on Quantum Gravity written by Andres Gomberoff and published by Springer Science & Business Media. This book was released on 2006-05-30 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 2002 Pan-American Advanced Studies Institute School on Quantum Gravity was held at the Centro de Estudios Cientificos (CECS),Valdivia, Chile, January 4-14, 2002. The school featured lectures by ten speakers, and was attended by nearly 70 students from over 14 countries. A primary goal was to foster interaction and communication between participants from different cultures, both in the layman’s sense of the term and in terms of approaches to quantum gravity. We hope that the links formed by students and the school will persist throughout their professional lives, continuing to promote interaction and the essential exchange of ideas that drives research forward. This volume contains improved and updated versions of the lectures given at the School. It has been prepared both as a reminder for the participants, and so that these pedagogical introductions can be made available to others who were unable to attend. We expect them to serve students of all ages well.

Cell Physiology Source Book

Cell Physiology Source Book

Author: Nicholas Sperelakis

Publisher: Elsevier

Published: 2012-12-02

Total Pages: 1262

ISBN-13: 0080574556

DOWNLOAD EBOOK

This authoritative book gathers together a broad range of ideas and topics that define the field. It provides clear, concise, and comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics. The Third Edition contains substantial new material. Most chapters have been thoroughly reworked. The book includes chapters on important topics such as sensory transduction, the physiology of protozoa and bacteria, the regulation of cell division, and programmed cell death. Completely revised and updated - includes 8 new chapters on such topics as membrane structure, intracellular chloride regulation, transport, sensory receptors, pressure, and olfactory/taste receptors Includes broad coverage of both animal and plant cells Appendixes review basics of the propagation of action potentials, electricity, and cable properties Authored by leading experts in the field Clear, concise, comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics


Book Synopsis Cell Physiology Source Book by : Nicholas Sperelakis

Download or read book Cell Physiology Source Book written by Nicholas Sperelakis and published by Elsevier. This book was released on 2012-12-02 with total page 1262 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative book gathers together a broad range of ideas and topics that define the field. It provides clear, concise, and comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics. The Third Edition contains substantial new material. Most chapters have been thoroughly reworked. The book includes chapters on important topics such as sensory transduction, the physiology of protozoa and bacteria, the regulation of cell division, and programmed cell death. Completely revised and updated - includes 8 new chapters on such topics as membrane structure, intracellular chloride regulation, transport, sensory receptors, pressure, and olfactory/taste receptors Includes broad coverage of both animal and plant cells Appendixes review basics of the propagation of action potentials, electricity, and cable properties Authored by leading experts in the field Clear, concise, comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics

Membrane Transporters in the Pathogenesis of Cardiovascular and Lung Disorders

Membrane Transporters in the Pathogenesis of Cardiovascular and Lung Disorders

Author:

Publisher: Academic Press

Published: 2019-06-05

Total Pages: 414

ISBN-13: 0128177659

DOWNLOAD EBOOK

Membrane Transporters in the Pathogenesis of Cardiovascular and Lung Disorders, Volume 83, the latest release in the Current Topics in Membranes series, highlights new advances in the field, with this volume presenting chapters from recognized experts on topics such as cardiotonic steroids, Na+, K+ pumps and vascular fibrosis, purinergic signaling in the lung, structural models of a2-subunit N-termini and binding interfaces, ubiquitous and cell type-specific transcriptomic changes triggered by dissipation of monovalent cation gradients, the Na, K-ATPase alpha2 isoform in cardiovascular pathologies, the role of cell swelling and volume-sensitive ion channels in stroke pathology, structure-function relationships in the renal NaCl cotransporter, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Membranes series Includes the latest information on membrane ion transporters


Book Synopsis Membrane Transporters in the Pathogenesis of Cardiovascular and Lung Disorders by :

Download or read book Membrane Transporters in the Pathogenesis of Cardiovascular and Lung Disorders written by and published by Academic Press. This book was released on 2019-06-05 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: Membrane Transporters in the Pathogenesis of Cardiovascular and Lung Disorders, Volume 83, the latest release in the Current Topics in Membranes series, highlights new advances in the field, with this volume presenting chapters from recognized experts on topics such as cardiotonic steroids, Na+, K+ pumps and vascular fibrosis, purinergic signaling in the lung, structural models of a2-subunit N-termini and binding interfaces, ubiquitous and cell type-specific transcriptomic changes triggered by dissipation of monovalent cation gradients, the Na, K-ATPase alpha2 isoform in cardiovascular pathologies, the role of cell swelling and volume-sensitive ion channels in stroke pathology, structure-function relationships in the renal NaCl cotransporter, and more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Membranes series Includes the latest information on membrane ion transporters