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Gene Machine

Author: Venki Ramakrishnan

Publisher: Basic Books

Published: 2018-11-06

Total Pages: 290

ISBN-13: 046509337X

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A Nobel Prize-winning biologist tells the riveting story of his race to discover the inner workings of biology's most important molecule "Ramakrishnan's writing is so honest, lucid and engaging that I could not put this book down until I had read to the very end." -- Siddhartha Mukherjee, author of The Emperor of All Maladies and The Gene Everyone has heard of DNA. But by itself, DNA is just an inert blueprint for life. It is the ribosome -- an enormous molecular machine made up of a million atoms -- that makes DNA come to life, turning our genetic code into proteins and therefore into us. Gene Machine is an insider account of the race for the structure of the ribosome, a fundamental discovery that both advances our knowledge of all life and could lead to the development of better antibiotics against life-threatening diseases. But this is also a human story of Ramakrishnan's unlikely journey, from his first fumbling experiments in a biology lab to being the dark horse in a fierce competition with some of the world's best scientists. In the end, Gene Machine is a frank insider's account of the pursuit of high-stakes science.

Book Synopsis Gene Machine by : Venki Ramakrishnan

Download or read book Gene Machine written by Venki Ramakrishnan and published by Basic Books. This book was released on 2018-11-06 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Nobel Prize-winning biologist tells the riveting story of his race to discover the inner workings of biology's most important molecule "Ramakrishnan's writing is so honest, lucid and engaging that I could not put this book down until I had read to the very end." -- Siddhartha Mukherjee, author of The Emperor of All Maladies and The Gene Everyone has heard of DNA. But by itself, DNA is just an inert blueprint for life. It is the ribosome -- an enormous molecular machine made up of a million atoms -- that makes DNA come to life, turning our genetic code into proteins and therefore into us. Gene Machine is an insider account of the race for the structure of the ribosome, a fundamental discovery that both advances our knowledge of all life and could lead to the development of better antibiotics against life-threatening diseases. But this is also a human story of Ramakrishnan's unlikely journey, from his first fumbling experiments in a biology lab to being the dark horse in a fierce competition with some of the world's best scientists. In the end, Gene Machine is a frank insider's account of the pursuit of high-stakes science.

Gene Machines

Author: Fran Balkwill

Publisher: CSHL Press

Published: 2002

Total Pages: 36

ISBN-13: 9780879696115

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Summary: An introduction to how genes work, including basic information about cloning and gene therapy.

Book Synopsis Gene Machines by : Fran Balkwill

Download or read book Gene Machines written by Fran Balkwill and published by CSHL Press. This book was released on 2002 with total page 36 pages. Available in PDF, EPUB and Kindle. Book excerpt: Summary: An introduction to how genes work, including basic information about cloning and gene therapy.

The Selfish Gene

Author: Richard Dawkins

Publisher: Oxford University Press, USA

Published: 1989

Total Pages: 372

ISBN-13: 9780192860927

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Science need not be dull and bogged down by jargon, as Richard Dawkins proves in this entertaining look at evolution. The themes he takes up are the concepts of altruistic and selfish behaviour; the genetical definition of selfish interest; the evolution of aggressive behaviour; kinshiptheory; sex ratio theory; reciprocal altruism; deceit; and the natural selection of sex differences. 'Should be read, can be read by almost anyone. It describes with great skill a new face of the theory of evolution.' W.D. Hamilton, Science

Book Synopsis The Selfish Gene by : Richard Dawkins

Download or read book The Selfish Gene written by Richard Dawkins and published by Oxford University Press, USA. This book was released on 1989 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Science need not be dull and bogged down by jargon, as Richard Dawkins proves in this entertaining look at evolution. The themes he takes up are the concepts of altruistic and selfish behaviour; the genetical definition of selfish interest; the evolution of aggressive behaviour; kinshiptheory; sex ratio theory; reciprocal altruism; deceit; and the natural selection of sex differences. 'Should be read, can be read by almost anyone. It describes with great skill a new face of the theory of evolution.' W.D. Hamilton, Science

The Gene Machine

Author: Bonnie Rochman

Publisher: Scientific American / Farrar, Straus and Giroux

Published: 2017-02-28

Total Pages: 288

ISBN-13: 0374713960

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A sharp-eyed exploration of the promise and peril of having children in an age of genetic tests and interventions Is screening for disease in an embryo a humane form of family planning or a slippery slope toward eugenics? Should doctors tell you that your infant daughter is genetically predisposed to breast cancer? If tests revealed that your toddler has a genetic mutation whose significance isn’t clear, would you want to know? In The Gene Machine, the award-winning journalist Bonnie Rochman deftly explores these hot-button questions, guiding us through the new frontier of gene technology and how it is transforming medicine, bioethics, health care, and the factors that shape a family. Rochman tells the stories of scientists working to unlock the secrets of the human genome; genetic counselors and spiritual advisers guiding mothers and fathers through life-changing choices; and, of course, parents (including Rochman herself) grappling with revelations that are sometimes joyous, sometimes heartbreaking, but always profound. She navigates the dizzying and constantly expanding array of prenatal and postnatal tests, from carrier screening to genome sequencing, while considering how access to more tests is altering perceptions of disability and changing the conversation about what sort of life is worth living and who draws the line. Along the way, she highlights the most urgent ethical quandary: Is this technology a triumph of modern medicine or a Pandora’s box of possibilities? Propelled by human narratives and meticulously reported, The Gene Machine is both a scientific road map and a meditation on our power to shape the future. It is a book that gets to the very core of what it means to be human.

Book Synopsis The Gene Machine by : Bonnie Rochman

Download or read book The Gene Machine written by Bonnie Rochman and published by Scientific American / Farrar, Straus and Giroux. This book was released on 2017-02-28 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: A sharp-eyed exploration of the promise and peril of having children in an age of genetic tests and interventions Is screening for disease in an embryo a humane form of family planning or a slippery slope toward eugenics? Should doctors tell you that your infant daughter is genetically predisposed to breast cancer? If tests revealed that your toddler has a genetic mutation whose significance isn’t clear, would you want to know? In The Gene Machine, the award-winning journalist Bonnie Rochman deftly explores these hot-button questions, guiding us through the new frontier of gene technology and how it is transforming medicine, bioethics, health care, and the factors that shape a family. Rochman tells the stories of scientists working to unlock the secrets of the human genome; genetic counselors and spiritual advisers guiding mothers and fathers through life-changing choices; and, of course, parents (including Rochman herself) grappling with revelations that are sometimes joyous, sometimes heartbreaking, but always profound. She navigates the dizzying and constantly expanding array of prenatal and postnatal tests, from carrier screening to genome sequencing, while considering how access to more tests is altering perceptions of disability and changing the conversation about what sort of life is worth living and who draws the line. Along the way, she highlights the most urgent ethical quandary: Is this technology a triumph of modern medicine or a Pandora’s box of possibilities? Propelled by human narratives and meticulously reported, The Gene Machine is both a scientific road map and a meditation on our power to shape the future. It is a book that gets to the very core of what it means to be human.

Mother Earth and the Gene Machines

Author: A. Carlson Whalen

Publisher: A. Carlson Whalen

Published: 2006-08

Total Pages: 308

ISBN-13: 9780533153398

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Book Synopsis Mother Earth and the Gene Machines by : A. Carlson Whalen

Download or read book Mother Earth and the Gene Machines written by A. Carlson Whalen and published by A. Carlson Whalen. This book was released on 2006-08 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Enjoy Your Cells

Author: Frances R. Balkwill

Publisher: CSHL Press

Published: 2001-10

Total Pages: 36

ISBN-13: 9780879695842

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Enjoy Your Cells is a new series of children's books from the acclaimed creative partnership of scientist/author Fran Balkwill and illustrator Mic Rolph. The titles in the series include: Enjoy Your Cells Germ Zappers Have a Nice DNA! Gene Machines Once again, they use their unique brand of simple but scientifically accurate commentary and exuberantly colorful graphics to take young readers on an entertaining exploration of the amazing, hidden world of cells, proteins, and DNA. It's over ten years since Fran and Mic invented a new way of getting science across to children. Think what extraordinary advances have been made in biology in that time - and how often those discoveries made headlines. Stem cells, cloning, embryo transfer, emerging infections, vaccine development...here in these books are the basic facts behind the public debates. With these books, children will learn to enjoy their cells and current affairs at the same time. And they're getting information that has been written and reviewed by working scientists, so it's completely correct and up-to-date. Readers aged 7 and up will appreciate the stories' lively language and with help, even younger children will enjoy and learn from the jokes and illustrations - no expert required! This series is a must for all elementary school students and those who care about educating them to be well-informed in a world of increasingly complex health-related and environmental issues. Fran Balkwill is Professor of Cancer Biology at St. Bartholomew's Hospital and the London Queen Mary School of Medicine. Mic Rolph is a graphic designer with much television and publishing experience. Together, they have created many books for children, and have won several awards, including the prestigious COPUS Junior Science Book Prize.

Book Synopsis Enjoy Your Cells by : Frances R. Balkwill

Download or read book Enjoy Your Cells written by Frances R. Balkwill and published by CSHL Press. This book was released on 2001-10 with total page 36 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enjoy Your Cells is a new series of children's books from the acclaimed creative partnership of scientist/author Fran Balkwill and illustrator Mic Rolph. The titles in the series include: Enjoy Your Cells Germ Zappers Have a Nice DNA! Gene Machines Once again, they use their unique brand of simple but scientifically accurate commentary and exuberantly colorful graphics to take young readers on an entertaining exploration of the amazing, hidden world of cells, proteins, and DNA. It's over ten years since Fran and Mic invented a new way of getting science across to children. Think what extraordinary advances have been made in biology in that time - and how often those discoveries made headlines. Stem cells, cloning, embryo transfer, emerging infections, vaccine development...here in these books are the basic facts behind the public debates. With these books, children will learn to enjoy their cells and current affairs at the same time. And they're getting information that has been written and reviewed by working scientists, so it's completely correct and up-to-date. Readers aged 7 and up will appreciate the stories' lively language and with help, even younger children will enjoy and learn from the jokes and illustrations - no expert required! This series is a must for all elementary school students and those who care about educating them to be well-informed in a world of increasingly complex health-related and environmental issues. Fran Balkwill is Professor of Cancer Biology at St. Bartholomew's Hospital and the London Queen Mary School of Medicine. Mic Rolph is a graphic designer with much television and publishing experience. Together, they have created many books for children, and have won several awards, including the prestigious COPUS Junior Science Book Prize.

Darwin Machines and the Nature of Knowledge

Author: Henry Plotkin

Publisher: Harvard University Press

Published: 1997

Total Pages: 292

ISBN-13: 9780674192812

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Learn and survive. Behind this simple equation lies a revolution in the study of knowledge, which has left the halls of philosophy for the labs of science. This book offers a cogent account of what such a move does to our understanding of the nature of learning, rationality, and intelligence. Bringing together evolutionary biology, psychology, and philosophy, Henry Plotkin presents a new science of knowledge, one that traces an unbreakable link between instinct and our ability to know. Contrary to the modern liberal idea that knowledge is something derived from experience, this science shows us that what we know is what our nature allows us to know, what our instincts tell us we must know. Since our ability to know our world depends primarily on what we call intelligence, intelligence must be understood as an extension of instinct. Drawing on contemporary evolutionary theory, especially notions of hierarchical structure and universal Darwinism, Plotkin tells us that the capacity for knowledge, which is what makes us human, is deeply rooted in our biology and, in a special sense, is shared by all living things. This leads to a discussion of animal and human intelligence as well as an appraisal of what an instinct-based capacity for knowledge might mean to our understanding of language, reasoning, emotion, and culture. The result is nothing less than a three-dimensional theory of our nature, in which all knowledge is adaptation and all adaptation is a specific form of knowledge.

Book Synopsis Darwin Machines and the Nature of Knowledge by : Henry Plotkin

Download or read book Darwin Machines and the Nature of Knowledge written by Henry Plotkin and published by Harvard University Press. This book was released on 1997 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn and survive. Behind this simple equation lies a revolution in the study of knowledge, which has left the halls of philosophy for the labs of science. This book offers a cogent account of what such a move does to our understanding of the nature of learning, rationality, and intelligence. Bringing together evolutionary biology, psychology, and philosophy, Henry Plotkin presents a new science of knowledge, one that traces an unbreakable link between instinct and our ability to know. Contrary to the modern liberal idea that knowledge is something derived from experience, this science shows us that what we know is what our nature allows us to know, what our instincts tell us we must know. Since our ability to know our world depends primarily on what we call intelligence, intelligence must be understood as an extension of instinct. Drawing on contemporary evolutionary theory, especially notions of hierarchical structure and universal Darwinism, Plotkin tells us that the capacity for knowledge, which is what makes us human, is deeply rooted in our biology and, in a special sense, is shared by all living things. This leads to a discussion of animal and human intelligence as well as an appraisal of what an instinct-based capacity for knowledge might mean to our understanding of language, reasoning, emotion, and culture. The result is nothing less than a three-dimensional theory of our nature, in which all knowledge is adaptation and all adaptation is a specific form of knowledge.

The Ascent of Information

Author: Caleb Scharf

Publisher: Penguin

Published: 2022-06-14

Total Pages: 353

ISBN-13: 0593087259

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“Full of fascinating insights drawn from an impressive range of disciplines, The Ascent of Information casts the familiar and the foreign in a dramatic new light.” —Brian Greene, author of The Elegant Universe Your information has a life of its own, and it’s using you to get what it wants. One of the most peculiar and possibly unique features of humans is the vast amount of information we carry outside our biological selves. But in our rush to build the infrastructure for the 20 quintillion bits we create every day, we’ve failed to ask exactly why we’re expending ever-increasing amounts of energy, resources, and human effort to maintain all this data. Drawing on deep ideas and frontier thinking in evolutionary biology, computer science, information theory, and astrobiology, Caleb Scharf argues that information is, in a very real sense, alive. All the data we create—all of our emails, tweets, selfies, A.I.-generated text and funny cat videos—amounts to an aggregate lifeform. It has goals and needs. It can control our behavior and influence our well-being. And it’s an organism that has evolved right alongside us. This symbiotic relationship with information offers a startling new lens for looking at the world. Data isn’t just something we produce; it’s the reason we exist. This powerful idea has the potential to upend the way we think about our technology, our role as humans, and the fundamental nature of life. The Ascent of Information offers a humbling vision of a universe built of and for information. Scharf explores how our relationship with data will affect our ongoing evolution as a species. Understanding this relationship will be crucial to preventing our data from becoming more of a burden than an asset, and to preserving the possibility of a human future.

Book Synopsis The Ascent of Information by : Caleb Scharf

Download or read book The Ascent of Information written by Caleb Scharf and published by Penguin. This book was released on 2022-06-14 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Full of fascinating insights drawn from an impressive range of disciplines, The Ascent of Information casts the familiar and the foreign in a dramatic new light.” —Brian Greene, author of The Elegant Universe Your information has a life of its own, and it’s using you to get what it wants. One of the most peculiar and possibly unique features of humans is the vast amount of information we carry outside our biological selves. But in our rush to build the infrastructure for the 20 quintillion bits we create every day, we’ve failed to ask exactly why we’re expending ever-increasing amounts of energy, resources, and human effort to maintain all this data. Drawing on deep ideas and frontier thinking in evolutionary biology, computer science, information theory, and astrobiology, Caleb Scharf argues that information is, in a very real sense, alive. All the data we create—all of our emails, tweets, selfies, A.I.-generated text and funny cat videos—amounts to an aggregate lifeform. It has goals and needs. It can control our behavior and influence our well-being. And it’s an organism that has evolved right alongside us. This symbiotic relationship with information offers a startling new lens for looking at the world. Data isn’t just something we produce; it’s the reason we exist. This powerful idea has the potential to upend the way we think about our technology, our role as humans, and the fundamental nature of life. The Ascent of Information offers a humbling vision of a universe built of and for information. Scharf explores how our relationship with data will affect our ongoing evolution as a species. Understanding this relationship will be crucial to preventing our data from becoming more of a burden than an asset, and to preserving the possibility of a human future.

Smarter Than Their Machines

Author: John Cullinane

Publisher: Morgan & Claypool Publishers

Published: 2014-11-01

Total Pages: 216

ISBN-13: 1627055525

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Smarter Than Their Machines: Oral Histories of the Pioneers of Interactive Computing is based on oral histories archived at the Charles Babbage Institute, University of Minnesota. Included are the oral histories of some key pioneers of the computer industry selected by John that led to interactive computing, such as Richard Bloch, Gene Amdahl, Herbert W. Robinson, Sam Wyly, J.C.R. Licklider, Ivan Sutherland, Larry Roberts, Robert Kahn, Marvin Minsky, Michael Dertouzos, and Joseph Traub, as well as his own. John has woven them together via introductions that is, in essence, a personal walk down the computer industry road. John had the unique advantage of having been part of, or witness to, much of the history contained in these oral histories beginning as a co-op student at Arthur D. Little, Inc., in the 1950’s. Eventually, he would become a pioneer in his own right by creating the computer industry's first successful software products company (Cullinane Corporation). However, an added benefit of reading these oral histories is that they contain important messages for our leaders of today, at all levels, including that government, industry, and academia can accomplish great things when working together in an effective way. This is how the computer industry was created, which then led to the Internet, both totally unanticipated just 75 years ago.

Book Synopsis Smarter Than Their Machines by : John Cullinane

Download or read book Smarter Than Their Machines written by John Cullinane and published by Morgan & Claypool Publishers. This book was released on 2014-11-01 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Smarter Than Their Machines: Oral Histories of the Pioneers of Interactive Computing is based on oral histories archived at the Charles Babbage Institute, University of Minnesota. Included are the oral histories of some key pioneers of the computer industry selected by John that led to interactive computing, such as Richard Bloch, Gene Amdahl, Herbert W. Robinson, Sam Wyly, J.C.R. Licklider, Ivan Sutherland, Larry Roberts, Robert Kahn, Marvin Minsky, Michael Dertouzos, and Joseph Traub, as well as his own. John has woven them together via introductions that is, in essence, a personal walk down the computer industry road. John had the unique advantage of having been part of, or witness to, much of the history contained in these oral histories beginning as a co-op student at Arthur D. Little, Inc., in the 1950’s. Eventually, he would become a pioneer in his own right by creating the computer industry's first successful software products company (Cullinane Corporation). However, an added benefit of reading these oral histories is that they contain important messages for our leaders of today, at all levels, including that government, industry, and academia can accomplish great things when working together in an effective way. This is how the computer industry was created, which then led to the Internet, both totally unanticipated just 75 years ago.

Evolutionary Approach to Machine Learning and Deep Neural Networks

Author: Hitoshi Iba

Publisher: Springer

Published: 2018-06-15

Total Pages: 245

ISBN-13: 9811302006

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This book provides theoretical and practical knowledge about a methodology for evolutionary algorithm-based search strategy with the integration of several machine learning and deep learning techniques. These include convolutional neural networks, Gröbner bases, relevance vector machines, transfer learning, bagging and boosting methods, clustering techniques (affinity propagation), and belief networks, among others. The development of such tools contributes to better optimizing methodologies. Beginning with the essentials of evolutionary algorithms and covering interdisciplinary research topics, the contents of this book are valuable for different classes of readers: novice, intermediate, and also expert readers from related fields. Following the chapters on introduction and basic methods, Chapter 3 details a new research direction, i.e., neuro-evolution, an evolutionary method for the generation of deep neural networks, and also describes how evolutionary methods are extended in combination with machine learning techniques. Chapter 4 includes novel methods such as particle swarm optimization based on affinity propagation (PSOAP), and transfer learning for differential evolution (TRADE), another machine learning approach for extending differential evolution. The last chapter is dedicated to the state of the art in gene regulatory network (GRN) research as one of the most interesting and active research fields. The author describes an evolving reaction network, which expands the neuro-evolution methodology to produce a type of genetic network suitable for biochemical systems and has succeeded in designing genetic circuits in synthetic biology. The author also presents real-world GRN application to several artificial intelligent tasks, proposing a framework of motion generation by GRNs (MONGERN), which evolves GRNs to operate a real humanoid robot.

Book Synopsis Evolutionary Approach to Machine Learning and Deep Neural Networks by : Hitoshi Iba

Download or read book Evolutionary Approach to Machine Learning and Deep Neural Networks written by Hitoshi Iba and published by Springer. This book was released on 2018-06-15 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides theoretical and practical knowledge about a methodology for evolutionary algorithm-based search strategy with the integration of several machine learning and deep learning techniques. These include convolutional neural networks, Gröbner bases, relevance vector machines, transfer learning, bagging and boosting methods, clustering techniques (affinity propagation), and belief networks, among others. The development of such tools contributes to better optimizing methodologies. Beginning with the essentials of evolutionary algorithms and covering interdisciplinary research topics, the contents of this book are valuable for different classes of readers: novice, intermediate, and also expert readers from related fields. Following the chapters on introduction and basic methods, Chapter 3 details a new research direction, i.e., neuro-evolution, an evolutionary method for the generation of deep neural networks, and also describes how evolutionary methods are extended in combination with machine learning techniques. Chapter 4 includes novel methods such as particle swarm optimization based on affinity propagation (PSOAP), and transfer learning for differential evolution (TRADE), another machine learning approach for extending differential evolution. The last chapter is dedicated to the state of the art in gene regulatory network (GRN) research as one of the most interesting and active research fields. The author describes an evolving reaction network, which expands the neuro-evolution methodology to produce a type of genetic network suitable for biochemical systems and has succeeded in designing genetic circuits in synthetic biology. The author also presents real-world GRN application to several artificial intelligent tasks, proposing a framework of motion generation by GRNs (MONGERN), which evolves GRNs to operate a real humanoid robot.