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Will update existing publications on carbohydrate-based drug design and further shape the emerging data and thinking in this new area.
Book Synopsis Glycobiology and Drug Design by : Anatole A. Klyosov
Download or read book Glycobiology and Drug Design written by Anatole A. Klyosov and published by OUP USA. This book was released on 2013-03-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Will update existing publications on carbohydrate-based drug design and further shape the emerging data and thinking in this new area.
In recent years there has been increasing evidence of the importance of carbohydrates and glycoconjugates in biomedical applications, and the use of synthetic ligands based on carbohydrates as drugs has received much attention. Focussing on drug discovery from key targets and placing an emphasis on the multi-disciplinary approaches necessary to challenge these issues, this book comprehensively covers the new and recent discoveries in the area of carbohydrate drug discovery. Carbohydrates in Drug Design and Discovery is split into five sections, beginning with a introduction and perspective on the current market. The book then goes on to discuss new synthetic methods in glycobiology, the use of glycobiology in chemical biology and glycobiology in drug discovery. Providing a worldwide perspective on this broad area, and providing examples of therapeutics already developed using these methods, this book provides a comprehensive introduction, discussion and update on this fast developing field for medicinal chemists and biochemists working in industry and academia.
Book Synopsis Carbohydrates in Drug Design and Discovery by : Jesús Jímenez-Barbero
Download or read book Carbohydrates in Drug Design and Discovery written by Jesús Jímenez-Barbero and published by Royal Society of Chemistry. This book was released on 2015-04-10 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years there has been increasing evidence of the importance of carbohydrates and glycoconjugates in biomedical applications, and the use of synthetic ligands based on carbohydrates as drugs has received much attention. Focussing on drug discovery from key targets and placing an emphasis on the multi-disciplinary approaches necessary to challenge these issues, this book comprehensively covers the new and recent discoveries in the area of carbohydrate drug discovery. Carbohydrates in Drug Design and Discovery is split into five sections, beginning with a introduction and perspective on the current market. The book then goes on to discuss new synthetic methods in glycobiology, the use of glycobiology in chemical biology and glycobiology in drug discovery. Providing a worldwide perspective on this broad area, and providing examples of therapeutics already developed using these methods, this book provides a comprehensive introduction, discussion and update on this fast developing field for medicinal chemists and biochemists working in industry and academia.
Along with nucleic acids, proteins, and lipids, carbohydrates stand as one of four main components of cellular architecture. However, glycobiology (or carbohydrate bioscience) is little understood by non-experts, partly because carbohydrates are a complex, diverse class of molecules structurally and functionally. In recent years, advances in computational analytics (glycomics) have allowed us to better interpret and realize the importance of glycobiology in human health and disease, and glycans and their associated processes have been shown to play a significant role across a variety of disease types. As the biomedical sciences continue to adopt multi-omic and precision medicine approaches, a greater understanding of glycobiology is essential for maintaining healthy physiology and advancing disease treatment.Translational Glycobiology in Human Health and Disease offers a deep examination of glycobiology for experts and non-experts alike in areas ranging from the role of glycobiology in chronic and infectious diseases to advances in technologies for higher throughput analysis and diagnosis. While keeping human health in the forefront, this book integrates a thorough discussion of glycobiology fundamentals with its growing areas of application and societal impact. With emphasis throughout on the interdisciplinary nature of glycosciences, this book also features perspectives from the health, computational (glycoanalytics), materials, biopharmaceutical, and diagnostic sciences.Disease and speciality areas addressed include gycoimmunology, neuroglycobiology, commensal glycobiology, gut health, regenerative medicine and glycobiology, glycobiology and cancer, congenital disorders of glycosylation, infectious disease glycobiology, and parasite glycobiology. Computational approaches discussed, supporting the advance of new research, include advanced glycoanalytics, glycomics microarrays, glycoengineering, and glycol systems biology. Additionally, authors consider impact areas for society and public health, such as glycobiology and entrepreneurship, policy and regulatory requirements for glycosylation, future research, and translation to new diagnostics and drug discovery. Provides a deep, foundational overview of glycoscience and its translational potential, highlighting glycobiology’s growing role in human health and disease study Examines a broad range of relevant disease areas and applications of glycobiology in policy and public health Features chapter contributions from leading, international experts in the field, fully integrating perspectives from the health, computational, materials, biopharmaceutical, and diagnostic sciences
Book Synopsis Translational Glycobiology in Human Health and Disease by : Michelle Kilcoyne
Download or read book Translational Glycobiology in Human Health and Disease written by Michelle Kilcoyne and published by Academic Press. This book was released on 2023-11-29 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Along with nucleic acids, proteins, and lipids, carbohydrates stand as one of four main components of cellular architecture. However, glycobiology (or carbohydrate bioscience) is little understood by non-experts, partly because carbohydrates are a complex, diverse class of molecules structurally and functionally. In recent years, advances in computational analytics (glycomics) have allowed us to better interpret and realize the importance of glycobiology in human health and disease, and glycans and their associated processes have been shown to play a significant role across a variety of disease types. As the biomedical sciences continue to adopt multi-omic and precision medicine approaches, a greater understanding of glycobiology is essential for maintaining healthy physiology and advancing disease treatment.Translational Glycobiology in Human Health and Disease offers a deep examination of glycobiology for experts and non-experts alike in areas ranging from the role of glycobiology in chronic and infectious diseases to advances in technologies for higher throughput analysis and diagnosis. While keeping human health in the forefront, this book integrates a thorough discussion of glycobiology fundamentals with its growing areas of application and societal impact. With emphasis throughout on the interdisciplinary nature of glycosciences, this book also features perspectives from the health, computational (glycoanalytics), materials, biopharmaceutical, and diagnostic sciences.Disease and speciality areas addressed include gycoimmunology, neuroglycobiology, commensal glycobiology, gut health, regenerative medicine and glycobiology, glycobiology and cancer, congenital disorders of glycosylation, infectious disease glycobiology, and parasite glycobiology. Computational approaches discussed, supporting the advance of new research, include advanced glycoanalytics, glycomics microarrays, glycoengineering, and glycol systems biology. Additionally, authors consider impact areas for society and public health, such as glycobiology and entrepreneurship, policy and regulatory requirements for glycosylation, future research, and translation to new diagnostics and drug discovery. Provides a deep, foundational overview of glycoscience and its translational potential, highlighting glycobiology’s growing role in human health and disease study Examines a broad range of relevant disease areas and applications of glycobiology in policy and public health Features chapter contributions from leading, international experts in the field, fully integrating perspectives from the health, computational, materials, biopharmaceutical, and diagnostic sciences
The structural complexity and the synthetic challenges facing glycans have historically hampered efforts to study their multifaceted roles and the application of carbohydrates in drug development. However, in very recent years, new synthetic techniques flanked by the growing knowledge about carbohydrate involvement in physiological and pathological states has spurred renewed interest in the chemistry, biology and therapeutic potentialities of carbohydrates. This book offers an overview of key aspects of carbohydrate biology and chemistry that are fundamental for the design of novel therapeutics. The four-part structure of this book introduces these essential components to life, starting from their structure and biological roles and covering analytical methods and synthesis which pave the way for the development of a wide range of therapeutic applications.Leading experts from around the world are brought together to offer their recent research with the ultimate aim of enlightening the reader on the complex yet exciting field of carbohydrate chemistry. Academic and industrial researchers in structural biology, drug discovery and carbohydrate chemistry will find this book an essential guide to the latest research and future potential of medicinal chemistry.
Book Synopsis Carbohydrate Chemistry: State Of The Art And Challenges For Drug Development - An Overview On Structure, Biological Roles, Synthetic Methods And Application As Therapeutics by : Laura Cipolla
Download or read book Carbohydrate Chemistry: State Of The Art And Challenges For Drug Development - An Overview On Structure, Biological Roles, Synthetic Methods And Application As Therapeutics written by Laura Cipolla and published by World Scientific. This book was released on 2015-07-23 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: The structural complexity and the synthetic challenges facing glycans have historically hampered efforts to study their multifaceted roles and the application of carbohydrates in drug development. However, in very recent years, new synthetic techniques flanked by the growing knowledge about carbohydrate involvement in physiological and pathological states has spurred renewed interest in the chemistry, biology and therapeutic potentialities of carbohydrates. This book offers an overview of key aspects of carbohydrate biology and chemistry that are fundamental for the design of novel therapeutics. The four-part structure of this book introduces these essential components to life, starting from their structure and biological roles and covering analytical methods and synthesis which pave the way for the development of a wide range of therapeutic applications.Leading experts from around the world are brought together to offer their recent research with the ultimate aim of enlightening the reader on the complex yet exciting field of carbohydrate chemistry. Academic and industrial researchers in structural biology, drug discovery and carbohydrate chemistry will find this book an essential guide to the latest research and future potential of medicinal chemistry.
To exploit the full potential of this diverse compound class for the development of novel active substances, this handbook presents the latest knowledge on carbohydrate chemistry and biochemistry. While it is unique in covering the entire field, particular emphasis is placed on carbohydrates with pharmaceutical potential. Topics include the following: > Chemical Synthesis of Carbohydrates > Carbohydrate Biosynthesis and Metabolism > Carbohydrate Analysis > Cellular Functions of Carbohydrates > Development of Carbohydrate-based Drugs A premier resource for carbohydrate chemists and drug developers, this comprehensive two-volume work contains contributions by more than 50 of the world's leading carbohydrate chemists.
Book Synopsis Carbohydrate-based Drug Discovery by : Chi-Huey Wong
Download or read book Carbohydrate-based Drug Discovery written by Chi-Huey Wong and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 980 pages. Available in PDF, EPUB and Kindle. Book excerpt: To exploit the full potential of this diverse compound class for the development of novel active substances, this handbook presents the latest knowledge on carbohydrate chemistry and biochemistry. While it is unique in covering the entire field, particular emphasis is placed on carbohydrates with pharmaceutical potential. Topics include the following: > Chemical Synthesis of Carbohydrates > Carbohydrate Biosynthesis and Metabolism > Carbohydrate Analysis > Cellular Functions of Carbohydrates > Development of Carbohydrate-based Drugs A premier resource for carbohydrate chemists and drug developers, this comprehensive two-volume work contains contributions by more than 50 of the world's leading carbohydrate chemists.
In this 3 volume collection focusing on glycomics, readers will appreciate how such discoveries were made and how such methods can be applied for readers' own research efforts Each chapter has been designed so that enough scientific background will be given in each chapter for further development of methods by readers themselves Useful for all levels of scientists starting from the last years of colleges, graduate students, postdoctoral fellows to professors and to all levels of scientists in research institutes including industry
Book Synopsis Glycobiology by :
Download or read book Glycobiology written by and published by Academic Press. This book was released on 2010-09-29 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this 3 volume collection focusing on glycomics, readers will appreciate how such discoveries were made and how such methods can be applied for readers' own research efforts Each chapter has been designed so that enough scientific background will be given in each chapter for further development of methods by readers themselves Useful for all levels of scientists starting from the last years of colleges, graduate students, postdoctoral fellows to professors and to all levels of scientists in research institutes including industry
Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Book Synopsis Essentials of Glycobiology by : Ajit Varki
Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Glycobiology is the study of the structure, biosynthesis and biology of saccharides that are widely distributed in nature and are essential components of all living things. This field combines expertise in both carbohydrate biochemistry and molecular biology. The ABC drug transporter, P glycoprotein or MDR1 is one such example discussed in this book. The relationship of glycosphingolipid (GSL) biosynthesis to the Pgp-mediated multiple drug resistance phenotype, and the role of MDR1 in lipid biosynthesis in particular is evaluated. The structure and activities of natural complex polysaccharides are also analysed. Specifically, heparin (Hep) as an anticoagulant and antithrombotic (macro)molecule and CS in the treatment of osteoarthritis is reviewed, and the GAG structure-function relationship, which has led to the discovery of novel drugs for the possible treatment of some serious diseases. The gene targeting analyses of certain enzymes, which revealed that the HNK-1 carbohydrate plays important roles in synaptic plasticity and memory function, is described as well. Recent work on the topic "protein-specific glycosylation" is highlighted also, focusing on the primary structure of a protein which directly exerts a cis-control of the glycosylation event.
Book Synopsis Glycobiology Research Trends by : Olivier McCabe
Download or read book Glycobiology Research Trends written by Olivier McCabe and published by . This book was released on 2009 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glycobiology is the study of the structure, biosynthesis and biology of saccharides that are widely distributed in nature and are essential components of all living things. This field combines expertise in both carbohydrate biochemistry and molecular biology. The ABC drug transporter, P glycoprotein or MDR1 is one such example discussed in this book. The relationship of glycosphingolipid (GSL) biosynthesis to the Pgp-mediated multiple drug resistance phenotype, and the role of MDR1 in lipid biosynthesis in particular is evaluated. The structure and activities of natural complex polysaccharides are also analysed. Specifically, heparin (Hep) as an anticoagulant and antithrombotic (macro)molecule and CS in the treatment of osteoarthritis is reviewed, and the GAG structure-function relationship, which has led to the discovery of novel drugs for the possible treatment of some serious diseases. The gene targeting analyses of certain enzymes, which revealed that the HNK-1 carbohydrate plays important roles in synaptic plasticity and memory function, is described as well. Recent work on the topic "protein-specific glycosylation" is highlighted also, focusing on the primary structure of a protein which directly exerts a cis-control of the glycosylation event.
Comprehensive Glycoscience, Second Edition covers the most elementary of topics and progresses to the most current and advanced research in the field. This allows for readers to quickly and easily find the appropriate glycoscience information for their research. It assembles the top minds in this area and provide an update to the renowned 2007 first edition, including new discoveries and latest advances in glycoscience-related research areas such as glycan microarrays, carbohydrate materials, glycoengineering and microbiome research. The result is an up-to-date work which will impress readers with the many new advances that are outlined and taught in this second edition. Most areas of the original edition have been majorly updated, some overlapping topics have been consolidated, and several topics have been rearranged into more appropriate sections. Combines multiple aspects of glycoscience in one comprehensive and reliable reference work Includes all major developments since 2007 (e.g. nanotechnology) This new edition places glycoscience at the crossroads of several disciplines such as biology, biochemistry, glycobiology and synthetic chemistry offering a truly interdisciplinary perspective
Book Synopsis Comprehensive Glycoscience by :
Download or read book Comprehensive Glycoscience written by and published by Elsevier. This book was released on 2021-08-09 with total page 3458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Glycoscience, Second Edition covers the most elementary of topics and progresses to the most current and advanced research in the field. This allows for readers to quickly and easily find the appropriate glycoscience information for their research. It assembles the top minds in this area and provide an update to the renowned 2007 first edition, including new discoveries and latest advances in glycoscience-related research areas such as glycan microarrays, carbohydrate materials, glycoengineering and microbiome research. The result is an up-to-date work which will impress readers with the many new advances that are outlined and taught in this second edition. Most areas of the original edition have been majorly updated, some overlapping topics have been consolidated, and several topics have been rearranged into more appropriate sections. Combines multiple aspects of glycoscience in one comprehensive and reliable reference work Includes all major developments since 2007 (e.g. nanotechnology) This new edition places glycoscience at the crossroads of several disciplines such as biology, biochemistry, glycobiology and synthetic chemistry offering a truly interdisciplinary perspective
This book contains contributions from interdisciplinary scientists to collectively address the issue of targeting carbohydrate recognition for the development of novel therapeutic and diagnostic agents. The book covers (1) biological problems involving carbohydrate recognition, (2) structural factors mediating carbohydrate recognition, (3) design and synthesis of lectin mimics that recognize carbohydrate ligands with high specificity and affinity, and (4) modulation of biological and pathological processes through carbohydrate recognition.
Book Synopsis Carbohydrate Recognition by : Binghe Wang
Download or read book Carbohydrate Recognition written by Binghe Wang and published by John Wiley & Sons. This book was released on 2011-09-09 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains contributions from interdisciplinary scientists to collectively address the issue of targeting carbohydrate recognition for the development of novel therapeutic and diagnostic agents. The book covers (1) biological problems involving carbohydrate recognition, (2) structural factors mediating carbohydrate recognition, (3) design and synthesis of lectin mimics that recognize carbohydrate ligands with high specificity and affinity, and (4) modulation of biological and pathological processes through carbohydrate recognition.
