Glycochemical Synthesis

Glycochemical Synthesis

Author: Shang-Cheng Hung

Publisher: John Wiley & Sons

Published: 2016-09-12

Total Pages: 576

ISBN-13: 1119006279

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This book is a comprehensive and concise review on principles, strategies, and crucial advances in glycochemistry. It focuses on synthesis and practical applications and emphasizes state-of-the-art approaches to the assembly and design of sugars. • Provides detailed discussion on specific topics like oligosaccharide assembly and design of sugars, techniques in glycoconjugate preparation, multivalency, and carbohydrate-based drug design • Uses notable examples, like solution-based one-pot methods and automated methods for sugar assembly, to illustrate important concepts and advances in a rapidly emerging field • Discusses practical applications of carbohydrates, like medicine, therapeutics, drug and vaccine development


Book Synopsis Glycochemical Synthesis by : Shang-Cheng Hung

Download or read book Glycochemical Synthesis written by Shang-Cheng Hung and published by John Wiley & Sons. This book was released on 2016-09-12 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive and concise review on principles, strategies, and crucial advances in glycochemistry. It focuses on synthesis and practical applications and emphasizes state-of-the-art approaches to the assembly and design of sugars. • Provides detailed discussion on specific topics like oligosaccharide assembly and design of sugars, techniques in glycoconjugate preparation, multivalency, and carbohydrate-based drug design • Uses notable examples, like solution-based one-pot methods and automated methods for sugar assembly, to illustrate important concepts and advances in a rapidly emerging field • Discusses practical applications of carbohydrates, like medicine, therapeutics, drug and vaccine development

Glycochemical Synthesis

Glycochemical Synthesis

Author: Shang-Cheng Hung

Publisher: John Wiley & Sons

Published: 2016-10-10

Total Pages: 574

ISBN-13: 1118299841

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This book is a comprehensive and concise review on principles, strategies, and crucial advances in glycochemistry. It focuses on synthesis and practical applications and emphasizes state-of-the-art approaches to the assembly and design of sugars. • Provides detailed discussion on specific topics like oligosaccharide assembly and design of sugars, techniques in glycoconjugate preparation, multivalency, and carbohydrate-based drug design • Uses notable examples, like solution-based one-pot methods and automated methods for sugar assembly, to illustrate important concepts and advances in a rapidly emerging field • Discusses practical applications of carbohydrates, like medicine, therapeutics, drug and vaccine development


Book Synopsis Glycochemical Synthesis by : Shang-Cheng Hung

Download or read book Glycochemical Synthesis written by Shang-Cheng Hung and published by John Wiley & Sons. This book was released on 2016-10-10 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive and concise review on principles, strategies, and crucial advances in glycochemistry. It focuses on synthesis and practical applications and emphasizes state-of-the-art approaches to the assembly and design of sugars. • Provides detailed discussion on specific topics like oligosaccharide assembly and design of sugars, techniques in glycoconjugate preparation, multivalency, and carbohydrate-based drug design • Uses notable examples, like solution-based one-pot methods and automated methods for sugar assembly, to illustrate important concepts and advances in a rapidly emerging field • Discusses practical applications of carbohydrates, like medicine, therapeutics, drug and vaccine development

Glycochemistry

Glycochemistry

Author: Peng George Wang

Publisher: CRC Press

Published: 2001-06-15

Total Pages: 696

ISBN-13: 9780824705381

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US, Canadian, and Chinese chemists summarize recent research into the synthesis, principles, and applications of carbohydrates for graduate students and researchers in carbohydrate chemistry, biochemistry, medicinal chemistry, and glycobiology. The topics include solid phase oligosaccharide synthesis, the chemical synthesis of bioactive steroidal saponins, the chemistry and biology of multi-valent saccharide displays, structures and mechanisms of action of aminoglycoside antibiotics, synthesizing glycosaminoglycans, glycosyltransferases in oligosaccharide synthesis, and metabolic substrate engineering as a tool for glycobiology Glycochemistry: Principles, Synthesis, and Applications presents methods used in the development of carbohydrate-based therapeutics. It highlights applications in chemical and enzymatic synthesis of complex carbohydrates, carbohydrate function, and carbohydrate-mediated biological recognition processes. There are practical examples on the development of carbohydrate-based pharmaceuticals and polymers for commercial use. The text also emphasizes the role of carbohydrates as key elements in modern molecular recognition processes.


Book Synopsis Glycochemistry by : Peng George Wang

Download or read book Glycochemistry written by Peng George Wang and published by CRC Press. This book was released on 2001-06-15 with total page 696 pages. Available in PDF, EPUB and Kindle. Book excerpt: US, Canadian, and Chinese chemists summarize recent research into the synthesis, principles, and applications of carbohydrates for graduate students and researchers in carbohydrate chemistry, biochemistry, medicinal chemistry, and glycobiology. The topics include solid phase oligosaccharide synthesis, the chemical synthesis of bioactive steroidal saponins, the chemistry and biology of multi-valent saccharide displays, structures and mechanisms of action of aminoglycoside antibiotics, synthesizing glycosaminoglycans, glycosyltransferases in oligosaccharide synthesis, and metabolic substrate engineering as a tool for glycobiology Glycochemistry: Principles, Synthesis, and Applications presents methods used in the development of carbohydrate-based therapeutics. It highlights applications in chemical and enzymatic synthesis of complex carbohydrates, carbohydrate function, and carbohydrate-mediated biological recognition processes. There are practical examples on the development of carbohydrate-based pharmaceuticals and polymers for commercial use. The text also emphasizes the role of carbohydrates as key elements in modern molecular recognition processes.

Glycosphingolipids in the Central Nervous System

Glycosphingolipids in the Central Nervous System

Author: Zhongwu Guo

Publisher: Elsevier

Published: 2024-03-15

Total Pages: 455

ISBN-13: 0443161577

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Glycosphingolipids in the Central Nervous System: Diversity in Structure, Metabolism, Distribution, and Function comprehensively covers progress made in the discovery, profiling and understanding of the metabolism, function and functional mechanism of GSLs in the CNS –as well as their synthesis, relationships with and therapeutic applications to neurodegenerative disorders, and related CNS diseases. Due to the important roles of GSLs in the CNS and various CNS-related diseases, the interest in these biomolecules is growing. GSLs are the principal glycolipids on the cell surface and an essential constituent of the cell membrane. They are widespread, but especially enriched in the central nervous system (CNS) in vertebrates. The diversity of GSL structures forges the molecular foundation for their broad spectrum of activity. Presents a systematic review of literature and potential future developments in Glycosphingolipid research Highlights interdisciplinary interplay between various aspects of the neuronal system and its structural and functional properties Provides an overview, general trends, cases studies, summaries and future implications


Book Synopsis Glycosphingolipids in the Central Nervous System by : Zhongwu Guo

Download or read book Glycosphingolipids in the Central Nervous System written by Zhongwu Guo and published by Elsevier. This book was released on 2024-03-15 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glycosphingolipids in the Central Nervous System: Diversity in Structure, Metabolism, Distribution, and Function comprehensively covers progress made in the discovery, profiling and understanding of the metabolism, function and functional mechanism of GSLs in the CNS –as well as their synthesis, relationships with and therapeutic applications to neurodegenerative disorders, and related CNS diseases. Due to the important roles of GSLs in the CNS and various CNS-related diseases, the interest in these biomolecules is growing. GSLs are the principal glycolipids on the cell surface and an essential constituent of the cell membrane. They are widespread, but especially enriched in the central nervous system (CNS) in vertebrates. The diversity of GSL structures forges the molecular foundation for their broad spectrum of activity. Presents a systematic review of literature and potential future developments in Glycosphingolipid research Highlights interdisciplinary interplay between various aspects of the neuronal system and its structural and functional properties Provides an overview, general trends, cases studies, summaries and future implications

Glycoscience

Glycoscience

Author: Joachim Thiem

Publisher: Springer Science & Business Media

Published: 1997

Total Pages: 264

ISBN-13: 9783540620334

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Annotation This book presents the state of the art in the synthesis very complex saccharide structures, written by leading scientists at the forefront of this rapidly growing field. Reflecting the particular significance in recent years of efficient and selective procedures employing enzymes for preparative purposes in the carbohydrate field, a major proportion of the articles focus on these biocatalytic methods. In addition, recent strategies for the construction of unusual carbohydrates structures employing novel and creative methodologies are highlighted. Further, particular emphasis is placed on very complex saccharide structures as well as on special solutions to problems that are particularly challenging.


Book Synopsis Glycoscience by : Joachim Thiem

Download or read book Glycoscience written by Joachim Thiem and published by Springer Science & Business Media. This book was released on 1997 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annotation This book presents the state of the art in the synthesis very complex saccharide structures, written by leading scientists at the forefront of this rapidly growing field. Reflecting the particular significance in recent years of efficient and selective procedures employing enzymes for preparative purposes in the carbohydrate field, a major proportion of the articles focus on these biocatalytic methods. In addition, recent strategies for the construction of unusual carbohydrates structures employing novel and creative methodologies are highlighted. Further, particular emphasis is placed on very complex saccharide structures as well as on special solutions to problems that are particularly challenging.

Protecting Groups: Strategies and Applications in Carbohydrate Chemistry

Protecting Groups: Strategies and Applications in Carbohydrate Chemistry

Author: Sebastien Vidal

Publisher: John Wiley & Sons

Published: 2019-04-29

Total Pages: 522

ISBN-13: 3527340106

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A unique overview of the most important protecting group strategies in carbohydrate chemistry Protecting Groups: Strategies and Applications in Carbohydrate Chemistry provides a detailed account of key strategies and methodologies for the protection of carbohydrates. Divided into two parts, the first focuses on groups that are used best to protect a specific position on a carbohydrate. In the second part, specific carbohydrate residues or compounds are discussed in the context of a specific protecting group strategy used to reach the desired regioisomer. This important book: -Features chapters on protecting groups at the primary and secondary positions of carbohydrates -Describes protecting group strategies towards sialic acid derivatives, glycofuranoses, sulfated glycosaminoglycans, and cyclodextrins -Provides information on automated glycan assembly -Includes a chapter on the industrial scale synthesis of heparin analogs Written by a team of leaders in the field, Protecting Groups: Strategies and Applications in Carbohydrate Chemistry is an indispensable guide for academics and industrial researchers interested in carbohydrate and natural product synthesis, pharmaceutical chemistry, and biochemistry.


Book Synopsis Protecting Groups: Strategies and Applications in Carbohydrate Chemistry by : Sebastien Vidal

Download or read book Protecting Groups: Strategies and Applications in Carbohydrate Chemistry written by Sebastien Vidal and published by John Wiley & Sons. This book was released on 2019-04-29 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: A unique overview of the most important protecting group strategies in carbohydrate chemistry Protecting Groups: Strategies and Applications in Carbohydrate Chemistry provides a detailed account of key strategies and methodologies for the protection of carbohydrates. Divided into two parts, the first focuses on groups that are used best to protect a specific position on a carbohydrate. In the second part, specific carbohydrate residues or compounds are discussed in the context of a specific protecting group strategy used to reach the desired regioisomer. This important book: -Features chapters on protecting groups at the primary and secondary positions of carbohydrates -Describes protecting group strategies towards sialic acid derivatives, glycofuranoses, sulfated glycosaminoglycans, and cyclodextrins -Provides information on automated glycan assembly -Includes a chapter on the industrial scale synthesis of heparin analogs Written by a team of leaders in the field, Protecting Groups: Strategies and Applications in Carbohydrate Chemistry is an indispensable guide for academics and industrial researchers interested in carbohydrate and natural product synthesis, pharmaceutical chemistry, and biochemistry.

Synthetic Strategies in Carbohydrate Chemistry

Synthetic Strategies in Carbohydrate Chemistry

Author: Vinod Kumar Tiwari

Publisher: Elsevier

Published: 2023-11-01

Total Pages: 775

ISBN-13: 0323986498

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Synthetic Strategies in Carbohydrate Chemistry covers carbohydrate synthesis and its widespread application in various disciplines including catalysis. Basic and advanced aspects of carbohydrates are covered, starting with a brief introduction and then followed by protection-deprotection strategies in carbohydrate chemistry, glycosidic bond formation methodology, and their impact in oligosaccharide synthesis. Recent synthetic approaches for O-glycosides, N-glycosides, thioglycosides and C-glycosides, Intramolecular Aglycon Delivery (IAD), and carbohydrate modification are discussed, as well as stereoelectronic factors that control the chemical and biochemical behavior of carbohydrates in living cells. In addition, diverse applications of synthetic carbohydrate chemistry are covered, including sugar-based chiral catalyst in stereoselective synthesis, sugar-based ionic liquids, one-pot tandem reactions in carbohydrates, total synthesis of glycoconjugated natural products, impact of sugar in drug discovery and development, vaccine development, and glycoengineering. This reference is essential reading for researchers working in synthetic carbohydrate chemistry and biochemistry, and will be useful to those working in total synthesis, novel synthetic methodology, catalysis, polymer science, glycobiology, medicinal chemistry, and process development chemistry. Presents a practical and detailed overview on glycosylation methodology Covers automated glycosylation strategies in glycan synthesis Includes recent progress in the synthesis and significance of diverse thio-glycosides, C-glycosides, imino sugars and carbasugars Highlights the impact of enzymes in glycan synthesis Discusses the recent approaches for the synthesis of neoglycoconjugates


Book Synopsis Synthetic Strategies in Carbohydrate Chemistry by : Vinod Kumar Tiwari

Download or read book Synthetic Strategies in Carbohydrate Chemistry written by Vinod Kumar Tiwari and published by Elsevier. This book was released on 2023-11-01 with total page 775 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthetic Strategies in Carbohydrate Chemistry covers carbohydrate synthesis and its widespread application in various disciplines including catalysis. Basic and advanced aspects of carbohydrates are covered, starting with a brief introduction and then followed by protection-deprotection strategies in carbohydrate chemistry, glycosidic bond formation methodology, and their impact in oligosaccharide synthesis. Recent synthetic approaches for O-glycosides, N-glycosides, thioglycosides and C-glycosides, Intramolecular Aglycon Delivery (IAD), and carbohydrate modification are discussed, as well as stereoelectronic factors that control the chemical and biochemical behavior of carbohydrates in living cells. In addition, diverse applications of synthetic carbohydrate chemistry are covered, including sugar-based chiral catalyst in stereoselective synthesis, sugar-based ionic liquids, one-pot tandem reactions in carbohydrates, total synthesis of glycoconjugated natural products, impact of sugar in drug discovery and development, vaccine development, and glycoengineering. This reference is essential reading for researchers working in synthetic carbohydrate chemistry and biochemistry, and will be useful to those working in total synthesis, novel synthetic methodology, catalysis, polymer science, glycobiology, medicinal chemistry, and process development chemistry. Presents a practical and detailed overview on glycosylation methodology Covers automated glycosylation strategies in glycan synthesis Includes recent progress in the synthesis and significance of diverse thio-glycosides, C-glycosides, imino sugars and carbasugars Highlights the impact of enzymes in glycan synthesis Discusses the recent approaches for the synthesis of neoglycoconjugates

Modern Synthetic Methods in Carbohydrate Chemistry

Modern Synthetic Methods in Carbohydrate Chemistry

Author: Daniel B. Werz

Publisher: John Wiley & Sons

Published: 2013-12-23

Total Pages: 419

ISBN-13: 3527332847

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The fields of glycochemistry and glycoscience are rich and varied and where much can be learned from Nature. As Nature is not always able to produce carbohydrates in quantities useful for not only in research but also as therapeutic agents, new ways need to be found to optimize the yield. This book presents an overview of the latest developments in the field of carbohydrates, ranging from de-novo approaches via cyclodextrin chemistry to the synthesis of such highly complex glycoconjugates as glycosphingolipids and GPI anchors. The main emphasis remains on the synthetic aspects making the book an excellent source of information for those already involved in carbohydrate chemistry, as well as for those organic chemists who are beginners in this field. Equally of interest to synthetic chemists, as well as medicinal chemists and biochemists.


Book Synopsis Modern Synthetic Methods in Carbohydrate Chemistry by : Daniel B. Werz

Download or read book Modern Synthetic Methods in Carbohydrate Chemistry written by Daniel B. Werz and published by John Wiley & Sons. This book was released on 2013-12-23 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fields of glycochemistry and glycoscience are rich and varied and where much can be learned from Nature. As Nature is not always able to produce carbohydrates in quantities useful for not only in research but also as therapeutic agents, new ways need to be found to optimize the yield. This book presents an overview of the latest developments in the field of carbohydrates, ranging from de-novo approaches via cyclodextrin chemistry to the synthesis of such highly complex glycoconjugates as glycosphingolipids and GPI anchors. The main emphasis remains on the synthetic aspects making the book an excellent source of information for those already involved in carbohydrate chemistry, as well as for those organic chemists who are beginners in this field. Equally of interest to synthetic chemists, as well as medicinal chemists and biochemists.

Carbohydrates 2018

Carbohydrates 2018

Author: Amélia Pilar Rauter

Publisher: MDPI

Published: 2020-03-25

Total Pages: 172

ISBN-13: 3039283162

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This book contains original papers and reviews on carbohydrate research in medicine, authored by participants of the 29th International Carbohydrate Symposium, where this topic had a special emphasis. The focus on biological events involving carbohydrates and glycoconjugates has delivered reliable approaches for disease treatment and diagnosis. Research on carbohydrate-based compounds for therapeutic applications is illustrated in various contributions, namely those covering the development of novel agents against Alzheimer’s disease, e.g. the neuroprotective C-glucosylated flavones and the isonucleoside-based cholinesterase inhibitors. New imino sugar glucosidase inhibitors are also disclosed, a class of compounds with potential for diabetes, Gaucher disease or cancer treatment. Also the development of a useful synthetic method towards multivalent glycoclusters of biomedical interest is here highlighted. The relevance of glycomimetics in drug discovery and the progress on carbohydrates in early diagnosis and cancer treatment are reviewed. Noteworthy is the chitosan-based delivery system for drug oral administration, a new biomaterial-based approach to improve bioavailability. Another study on the conformation of Streptococcus capsular polysaccharide backbones by molecular modelling provides useful information for bacterial immunotherapeutic approaches. All original contributions and reviews clearly demonstrate the potential of glycosciences for innovation in medicinal (glyco)chemistry and pharmaceutical research.


Book Synopsis Carbohydrates 2018 by : Amélia Pilar Rauter

Download or read book Carbohydrates 2018 written by Amélia Pilar Rauter and published by MDPI. This book was released on 2020-03-25 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains original papers and reviews on carbohydrate research in medicine, authored by participants of the 29th International Carbohydrate Symposium, where this topic had a special emphasis. The focus on biological events involving carbohydrates and glycoconjugates has delivered reliable approaches for disease treatment and diagnosis. Research on carbohydrate-based compounds for therapeutic applications is illustrated in various contributions, namely those covering the development of novel agents against Alzheimer’s disease, e.g. the neuroprotective C-glucosylated flavones and the isonucleoside-based cholinesterase inhibitors. New imino sugar glucosidase inhibitors are also disclosed, a class of compounds with potential for diabetes, Gaucher disease or cancer treatment. Also the development of a useful synthetic method towards multivalent glycoclusters of biomedical interest is here highlighted. The relevance of glycomimetics in drug discovery and the progress on carbohydrates in early diagnosis and cancer treatment are reviewed. Noteworthy is the chitosan-based delivery system for drug oral administration, a new biomaterial-based approach to improve bioavailability. Another study on the conformation of Streptococcus capsular polysaccharide backbones by molecular modelling provides useful information for bacterial immunotherapeutic approaches. All original contributions and reviews clearly demonstrate the potential of glycosciences for innovation in medicinal (glyco)chemistry and pharmaceutical research.

Marine Glycosides

Marine Glycosides

Author: Thomas E Adrian

Publisher: MDPI

Published: 2019-05-03

Total Pages: 264

ISBN-13: 3038979023

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In recent years, there has been a steady increase in the publication of papers on the chemistry, biology, and potential clinical uses of marine glycosides. Indeed, more than half of the papers published in this field are less than a decade old. Glycosides have been isolated from species as diverse as algae, fungi, anthozoans, and echinoderms. Even fish of the genus Pardachirus produce glycosides, which they use as shark repellents.The major interest in these compounds as potential drugs stems from their broad spectrum of biological effects. They have been shown to have antimicrobial, antifungal, anti-inflammatory, immune modulatory, and anticancer effects. The anticancer effects of marine glycosides include cell cycle suppression, the induction of apoptosis, and the inhibition of migration, invasion, and metastasis, as well as antiangiogenesis. Marine glycosides influence membrane permeability and have been shown to influence membrane transport at the molecular level through effects on transport carriers and pumps, as well as effects on ligand-gated and voltage-gated channels. Various marine glycosides have been shown to activate sphingomyelinase and ceramide synthesis, to inhibit topoisomerase activity, receptor tyrosine kinase activity, and multidrug resistance protein activity, and to antagonize eicosanoid receptors.This Special Issue covers the entire scope of marine organism-derived glycosides that are of potential value as pharmaceutical agents or leads. These include, but are not limited to, tetracyclic triterpene glycosides, other triterpene glycosides, steroid glycosides, and glycosides of non-isoprenoid aglycones.


Book Synopsis Marine Glycosides by : Thomas E Adrian

Download or read book Marine Glycosides written by Thomas E Adrian and published by MDPI. This book was released on 2019-05-03 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, there has been a steady increase in the publication of papers on the chemistry, biology, and potential clinical uses of marine glycosides. Indeed, more than half of the papers published in this field are less than a decade old. Glycosides have been isolated from species as diverse as algae, fungi, anthozoans, and echinoderms. Even fish of the genus Pardachirus produce glycosides, which they use as shark repellents.The major interest in these compounds as potential drugs stems from their broad spectrum of biological effects. They have been shown to have antimicrobial, antifungal, anti-inflammatory, immune modulatory, and anticancer effects. The anticancer effects of marine glycosides include cell cycle suppression, the induction of apoptosis, and the inhibition of migration, invasion, and metastasis, as well as antiangiogenesis. Marine glycosides influence membrane permeability and have been shown to influence membrane transport at the molecular level through effects on transport carriers and pumps, as well as effects on ligand-gated and voltage-gated channels. Various marine glycosides have been shown to activate sphingomyelinase and ceramide synthesis, to inhibit topoisomerase activity, receptor tyrosine kinase activity, and multidrug resistance protein activity, and to antagonize eicosanoid receptors.This Special Issue covers the entire scope of marine organism-derived glycosides that are of potential value as pharmaceutical agents or leads. These include, but are not limited to, tetracyclic triterpene glycosides, other triterpene glycosides, steroid glycosides, and glycosides of non-isoprenoid aglycones.