Growth Hormone Deficiency in Adults

Growth Hormone Deficiency in Adults

Author: Jens O. L. Jørgensen

Publisher: Karger Medical and Scientific Publishers

Published: 2005-01-01

Total Pages: 241

ISBN-13: 3805579926

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It has been known for over 40 years that GH-deficient-children benefit from replacement with the hormone. But GH, essential for longitudinal growth, also plays a role after completion of final height. With the introduction of biosynthetic human GH 20 years ago, the use of GH was no longer restricted to severe growth retardation in hypopituitary children. This book will take the reader behind the myths of GH and into the real world of clinical endocrinology. The contributions stem from recognized clinicians and scientists who have been working in the field for decades. The contents encompass traditional end points of GH therapy such as body composition, bone biology and physical performance. Attention is also devoted to diagnostic aspects and side effects. Additional features range from clinical epidemiology to quality of life, and novel areas such as the impact of traumatic brain injury on pituitary function are also covered. The present volume of Frontiers of Hormone Research is essential reading for health care professionals interested in clinical endocrinology and GH.


Book Synopsis Growth Hormone Deficiency in Adults by : Jens O. L. Jørgensen

Download or read book Growth Hormone Deficiency in Adults written by Jens O. L. Jørgensen and published by Karger Medical and Scientific Publishers. This book was released on 2005-01-01 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has been known for over 40 years that GH-deficient-children benefit from replacement with the hormone. But GH, essential for longitudinal growth, also plays a role after completion of final height. With the introduction of biosynthetic human GH 20 years ago, the use of GH was no longer restricted to severe growth retardation in hypopituitary children. This book will take the reader behind the myths of GH and into the real world of clinical endocrinology. The contributions stem from recognized clinicians and scientists who have been working in the field for decades. The contents encompass traditional end points of GH therapy such as body composition, bone biology and physical performance. Attention is also devoted to diagnostic aspects and side effects. Additional features range from clinical epidemiology to quality of life, and novel areas such as the impact of traumatic brain injury on pituitary function are also covered. The present volume of Frontiers of Hormone Research is essential reading for health care professionals interested in clinical endocrinology and GH.

Gigantism and Acromegaly

Gigantism and Acromegaly

Author: Constantine A. Stratakis

Publisher: Academic Press

Published: 2021-06-01

Total Pages: 312

ISBN-13: 0128145382

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Gigantism and Acromegaly brings together pituitary experts, taking readers from bench research, to genetic analysis, clinical analysis, and new therapeutic approaches. This book serves as a reference for growth hormone over-secretion and its diagnosis and treatment for endocrinologists, pediatricians, internists, and neurosurgeons, and for geneticists. Pharmaceutical companies may use it as a reference for drug development and research. Students, residents and fellows in medicine and endocrinology and genetics will also find it valuable as it provides a single up-to-date review of the molecular biology of gigantism and acromegaly as well as recommended approaches to evaluation and management. Acromegaly is a rare pituitary disorder that slowly changes its adult victim’s appearance over time: larger hands and feet, bigger jaw, forehead, nose, and lips. Generally, a benign pituitary tumor is the cause and symptoms of acromegaly can vary from patient to patient, making a diagnosis difficult and prolonging suffering for years. Early detection is key in the management of acromegaly as the pathologic effects of increased growth hormone (GH) production are progressive and can be life-threatening as the result of associated cardiovascular, cerebrovascular, and respiratory disorders and malignancies. Accessible, up-to-date overview of the characteristics, state-of-the-art diagnostic procedures, and management of acromegaly and gigantism Provides a unique compendium of endocrinology, genetics, clinical diagnosis and therapeutics Contains contributions from internationally known experts who have treated patients with acromegaly and gigantism


Book Synopsis Gigantism and Acromegaly by : Constantine A. Stratakis

Download or read book Gigantism and Acromegaly written by Constantine A. Stratakis and published by Academic Press. This book was released on 2021-06-01 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gigantism and Acromegaly brings together pituitary experts, taking readers from bench research, to genetic analysis, clinical analysis, and new therapeutic approaches. This book serves as a reference for growth hormone over-secretion and its diagnosis and treatment for endocrinologists, pediatricians, internists, and neurosurgeons, and for geneticists. Pharmaceutical companies may use it as a reference for drug development and research. Students, residents and fellows in medicine and endocrinology and genetics will also find it valuable as it provides a single up-to-date review of the molecular biology of gigantism and acromegaly as well as recommended approaches to evaluation and management. Acromegaly is a rare pituitary disorder that slowly changes its adult victim’s appearance over time: larger hands and feet, bigger jaw, forehead, nose, and lips. Generally, a benign pituitary tumor is the cause and symptoms of acromegaly can vary from patient to patient, making a diagnosis difficult and prolonging suffering for years. Early detection is key in the management of acromegaly as the pathologic effects of increased growth hormone (GH) production are progressive and can be life-threatening as the result of associated cardiovascular, cerebrovascular, and respiratory disorders and malignancies. Accessible, up-to-date overview of the characteristics, state-of-the-art diagnostic procedures, and management of acromegaly and gigantism Provides a unique compendium of endocrinology, genetics, clinical diagnosis and therapeutics Contains contributions from internationally known experts who have treated patients with acromegaly and gigantism

Human Growth Hormone

Human Growth Hormone

Author: Adair Stuart Mason

Publisher:

Published: 1972

Total Pages: 218

ISBN-13:

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Human Growth Hormone is a compendium of papers that discusses all aspects of human growth hormone (HGH) relevant in the treatment of dwarfs who are HGH deficient. This book discusses the approach of growth hormone treatment including the preparation of the hormone, its effect and interactions with other hormones, the methods used to detect growth hormone in human plasma, as well as its clinical applications. One author discusses the preparation of human growth hormone, its storage, method of bioassay, and procedures for ampouling HGH for clinical use. A couple of authors review the metabolic a ...


Book Synopsis Human Growth Hormone by : Adair Stuart Mason

Download or read book Human Growth Hormone written by Adair Stuart Mason and published by . This book was released on 1972 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Growth Hormone is a compendium of papers that discusses all aspects of human growth hormone (HGH) relevant in the treatment of dwarfs who are HGH deficient. This book discusses the approach of growth hormone treatment including the preparation of the hormone, its effect and interactions with other hormones, the methods used to detect growth hormone in human plasma, as well as its clinical applications. One author discusses the preparation of human growth hormone, its storage, method of bioassay, and procedures for ampouling HGH for clinical use. A couple of authors review the metabolic a ...

Human Growth Hormone

Human Growth Hormone

Author: S. Raiti

Publisher: Springer Science & Business Media

Published: 2013-11-09

Total Pages: 642

ISBN-13: 1461572010

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It has been ten years since the National Hormone and Pituitary Program (then called the National Pituitary Agency) sponsored a symposium on human growth hormone (hGH). Numerous advances have occurred during this period. This book does not attempt to summarize past achievements. Rather, it deals with the contemporary issues in hGH research. A discussion of the present state of the art, of necessity, includes a review of the past. Some of the topics herein discussed include the following: 1. Growth hormone releasing factor (GRF). In 1973, the growth hormone inhibitory factor (somatostatin) had recently been discovered. The search for a releasing factor in humans led to its discovery not in the pituitary but in a pancreatic tumor that secreted growth hormone. The advances are discussed in this book. The current hope is that GRF will eventually become an effective therapeutic agent for idiopathic hypopituitarism in childhood and adolescence. 2. Biosynthesis of hGR by recombinant DNA technology. Current advances are discussed. Although hGH is not yet an approved drug, it will eventually become one. This will broaden our horizons in terms of hGH effectiveness in disorders other than hypopituitary dwarfism. The current experience with this type of hGH in both the Vnited States and Europe is reviewed by several authors.


Book Synopsis Human Growth Hormone by : S. Raiti

Download or read book Human Growth Hormone written by S. Raiti and published by Springer Science & Business Media. This book was released on 2013-11-09 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has been ten years since the National Hormone and Pituitary Program (then called the National Pituitary Agency) sponsored a symposium on human growth hormone (hGH). Numerous advances have occurred during this period. This book does not attempt to summarize past achievements. Rather, it deals with the contemporary issues in hGH research. A discussion of the present state of the art, of necessity, includes a review of the past. Some of the topics herein discussed include the following: 1. Growth hormone releasing factor (GRF). In 1973, the growth hormone inhibitory factor (somatostatin) had recently been discovered. The search for a releasing factor in humans led to its discovery not in the pituitary but in a pancreatic tumor that secreted growth hormone. The advances are discussed in this book. The current hope is that GRF will eventually become an effective therapeutic agent for idiopathic hypopituitarism in childhood and adolescence. 2. Biosynthesis of hGR by recombinant DNA technology. Current advances are discussed. Although hGH is not yet an approved drug, it will eventually become one. This will broaden our horizons in terms of hGH effectiveness in disorders other than hypopituitary dwarfism. The current experience with this type of hGH in both the Vnited States and Europe is reviewed by several authors.

Growth Hormone Therapy in Pediatrics

Growth Hormone Therapy in Pediatrics

Author: Michael B. Ranke

Publisher: Karger Medical and Scientific Publishers

Published: 2007-01-01

Total Pages: 534

ISBN-13: 3805582560

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For 20 years, KIGS (Pfizer International Growth Database) has provided an outstanding tool for monitoring the use, efficacy and safety of growth hormone (GH) treatment in children with short stature of varying origin. This volume offers a comprehensive update of the continuing experiences in KIGS and is based on data from more than 50 countries and more than 60,000 patients. International experts analyse in detail the basic auxological characteristics of patients and their response to GH treatment for a broad spectrum of growth disorders. These include idiopathic GH deficiency, organic GH deficiency due to a variety of causes such as congenital malformations and syndromes, genetic disorders or treatment for leukaemia or central nervous system tumours and short stature in children born small for gestational age, specific syndromes and systemic disorders. Each growth disorder is also covered by a review of relevant published data by international experts. KIGS has also established itself as a primary source of information about adverse events during long-term GH treatment in children. The recent analysis of KIGS data has revealed no new adverse drug reactions since the 10-year follow-up. Therefore, treatment with GH seems a low-risk intervention in children and adolescents with various growth disorders. The process of developing disease-specific growth response prediction models has been ongoing in KIGS for many years. The available models are accurate, precise and have a relatively high degree of predictive power, although further predictors of the growth response remain to be identified. The KIGS prediction models can be applied prospectively to new patients, enabling their GH therapy to be better tailored and monitored to achieve optimal growth, safety and cost outcomes. The future of KIGS within the era of evidence-based medicine will continue to depend upon the quality of the data reported. Therefore, the commitment of participating physicians will continue to be a decisive element. The ongoing recognition of the importance of valid safety and efficacy information in the practice of paediatric endocrinology is exemplified by this valuable international collaboration of clinicians and the pharmaceutical community.


Book Synopsis Growth Hormone Therapy in Pediatrics by : Michael B. Ranke

Download or read book Growth Hormone Therapy in Pediatrics written by Michael B. Ranke and published by Karger Medical and Scientific Publishers. This book was released on 2007-01-01 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: For 20 years, KIGS (Pfizer International Growth Database) has provided an outstanding tool for monitoring the use, efficacy and safety of growth hormone (GH) treatment in children with short stature of varying origin. This volume offers a comprehensive update of the continuing experiences in KIGS and is based on data from more than 50 countries and more than 60,000 patients. International experts analyse in detail the basic auxological characteristics of patients and their response to GH treatment for a broad spectrum of growth disorders. These include idiopathic GH deficiency, organic GH deficiency due to a variety of causes such as congenital malformations and syndromes, genetic disorders or treatment for leukaemia or central nervous system tumours and short stature in children born small for gestational age, specific syndromes and systemic disorders. Each growth disorder is also covered by a review of relevant published data by international experts. KIGS has also established itself as a primary source of information about adverse events during long-term GH treatment in children. The recent analysis of KIGS data has revealed no new adverse drug reactions since the 10-year follow-up. Therefore, treatment with GH seems a low-risk intervention in children and adolescents with various growth disorders. The process of developing disease-specific growth response prediction models has been ongoing in KIGS for many years. The available models are accurate, precise and have a relatively high degree of predictive power, although further predictors of the growth response remain to be identified. The KIGS prediction models can be applied prospectively to new patients, enabling their GH therapy to be better tailored and monitored to achieve optimal growth, safety and cost outcomes. The future of KIGS within the era of evidence-based medicine will continue to depend upon the quality of the data reported. Therefore, the commitment of participating physicians will continue to be a decisive element. The ongoing recognition of the importance of valid safety and efficacy information in the practice of paediatric endocrinology is exemplified by this valuable international collaboration of clinicians and the pharmaceutical community.

Clinical Neuroendocrinology

Clinical Neuroendocrinology

Author: Michael Wilkinson

Publisher: Cambridge University Press

Published: 2019-01-03

Total Pages: 207

ISBN-13: 1316645193

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A concise and innovative account of clinical neuroendocrine disorders and the key principles underlying their diagnosis and management.


Book Synopsis Clinical Neuroendocrinology by : Michael Wilkinson

Download or read book Clinical Neuroendocrinology written by Michael Wilkinson and published by Cambridge University Press. This book was released on 2019-01-03 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: A concise and innovative account of clinical neuroendocrine disorders and the key principles underlying their diagnosis and management.

Secrets About Growth Hormone To Build Muscle Mass, Increase Bone Density, And Burn Body Fat!

Secrets About Growth Hormone To Build Muscle Mass, Increase Bone Density, And Burn Body Fat!

Author: Y. L. Wright

Publisher: Lulu.com

Published: 2011-10

Total Pages: 38

ISBN-13: 1105092135

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GROWTH HORMONE (GH) IS A HOT TOPIC. It seems that all of the movie stars, celebrities, and body-builders are taking it, and they look fantastic. Baby boomers interested in anti-aging are taking it and saying that it keeps them young. But you may have heard that it is expensive... and dangerous. So what's the story? What are your options? Do you need it? Should you take it? How do you use it? Can you afford it? How can you raise GH naturally? We will see how GH levels drop as we get older, when to intervene, and what treatment options are available to optimize health. Carefully read this book before making any decisions about using GH supplements. This book could save you from an early death, either from using risky supplements or from not doing anything at all. You will learn how to determine if you need GH replacement. You will find out how to get tested and what tests you will need. You will learn what options you have for GH replacement, risks, side effects, and affordability.


Book Synopsis Secrets About Growth Hormone To Build Muscle Mass, Increase Bone Density, And Burn Body Fat! by : Y. L. Wright

Download or read book Secrets About Growth Hormone To Build Muscle Mass, Increase Bone Density, And Burn Body Fat! written by Y. L. Wright and published by Lulu.com. This book was released on 2011-10 with total page 38 pages. Available in PDF, EPUB and Kindle. Book excerpt: GROWTH HORMONE (GH) IS A HOT TOPIC. It seems that all of the movie stars, celebrities, and body-builders are taking it, and they look fantastic. Baby boomers interested in anti-aging are taking it and saying that it keeps them young. But you may have heard that it is expensive... and dangerous. So what's the story? What are your options? Do you need it? Should you take it? How do you use it? Can you afford it? How can you raise GH naturally? We will see how GH levels drop as we get older, when to intervene, and what treatment options are available to optimize health. Carefully read this book before making any decisions about using GH supplements. This book could save you from an early death, either from using risky supplements or from not doing anything at all. You will learn how to determine if you need GH replacement. You will find out how to get tested and what tests you will need. You will learn what options you have for GH replacement, risks, side effects, and affordability.

Human Growth Hormone

Human Growth Hormone

Author: A. Stuart Mason

Publisher: Butterworth-Heinemann

Published: 2013-10-22

Total Pages: 209

ISBN-13: 1483192962

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Human Growth Hormone is a compendium of papers that discusses all aspects of human growth hormone (HGH) relevant in the treatment of dwarfs who are HGH deficient. This book discusses the approach of growth hormone treatment including the preparation of the hormone, its effect and interactions with other hormones, the methods used to detect growth hormone in human plasma, as well as its clinical applications. One author discusses the preparation of human growth hormone, its storage, method of bioassay, and procedures for ampouling HGH for clinical use. A couple of authors review the metabolic actions of HGH, namely, on the anabolic and skeletal systems, on carbohydrate and fat metabolism, and miscellaneous effects (renotropic, aldosterone, haematopoietic). One paper evaluates the treatment of dwarfism with HGH, and reports that in cases of HGH deficiency, the use of such treatment can be effective as long as the growth potential of the patient remains, and antibodies do not interfere with the treatment. The compendium can prove helpful for endocrinologists, genetic scientists, cellular microbiologists, and scientists involved in pharmacology and developmental anatomy.


Book Synopsis Human Growth Hormone by : A. Stuart Mason

Download or read book Human Growth Hormone written by A. Stuart Mason and published by Butterworth-Heinemann. This book was released on 2013-10-22 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Growth Hormone is a compendium of papers that discusses all aspects of human growth hormone (HGH) relevant in the treatment of dwarfs who are HGH deficient. This book discusses the approach of growth hormone treatment including the preparation of the hormone, its effect and interactions with other hormones, the methods used to detect growth hormone in human plasma, as well as its clinical applications. One author discusses the preparation of human growth hormone, its storage, method of bioassay, and procedures for ampouling HGH for clinical use. A couple of authors review the metabolic actions of HGH, namely, on the anabolic and skeletal systems, on carbohydrate and fat metabolism, and miscellaneous effects (renotropic, aldosterone, haematopoietic). One paper evaluates the treatment of dwarfism with HGH, and reports that in cases of HGH deficiency, the use of such treatment can be effective as long as the growth potential of the patient remains, and antibodies do not interfere with the treatment. The compendium can prove helpful for endocrinologists, genetic scientists, cellular microbiologists, and scientists involved in pharmacology and developmental anatomy.

Growth Hormone And The Heart

Growth Hormone And The Heart

Author: Andrea Giustina

Publisher: Springer Science & Business Media

Published: 2000-11-30

Total Pages: 538

ISBN-13: 9780792372127

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Growth Hormone and the Heart endeavors to bring together knowledge that has been accumulated in the area of GH and the heart, from basic to clinical studies, by research groups working on this topic throughout the world. Lessons from different experimental models and from several human diseases (acromegaly, adult GH deficiency, heart failure) suggest to endocrinologists and cardiologists that GH may not only have a role in the physiology and pathophysiology of heart function, but that GH itself may have a place in the treatment of primary heart diseases (such as dilated cardiomyopathy) or of cardiac complications of hypopituitarism. Growth Hormone and the Heart will be a useful update of the research produced in the field of cardiovascular endocrinology. The Editors also hope that this book will serve as the primary step in the recognition of the wide physiological and clinical significance of GH and heart interactions.


Book Synopsis Growth Hormone And The Heart by : Andrea Giustina

Download or read book Growth Hormone And The Heart written by Andrea Giustina and published by Springer Science & Business Media. This book was released on 2000-11-30 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: Growth Hormone and the Heart endeavors to bring together knowledge that has been accumulated in the area of GH and the heart, from basic to clinical studies, by research groups working on this topic throughout the world. Lessons from different experimental models and from several human diseases (acromegaly, adult GH deficiency, heart failure) suggest to endocrinologists and cardiologists that GH may not only have a role in the physiology and pathophysiology of heart function, but that GH itself may have a place in the treatment of primary heart diseases (such as dilated cardiomyopathy) or of cardiac complications of hypopituitarism. Growth Hormone and the Heart will be a useful update of the research produced in the field of cardiovascular endocrinology. The Editors also hope that this book will serve as the primary step in the recognition of the wide physiological and clinical significance of GH and heart interactions.

Heightened Expectations

Heightened Expectations

Author: Aimee Medeiros

Publisher: University of Alabama Press

Published: 2016-03-15

Total Pages: 208

ISBN-13: 0817319107

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Includes research using the UCLA Library Baby Books Collection.


Book Synopsis Heightened Expectations by : Aimee Medeiros

Download or read book Heightened Expectations written by Aimee Medeiros and published by University of Alabama Press. This book was released on 2016-03-15 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Includes research using the UCLA Library Baby Books Collection.