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Handbook of Oxidative Stress in Cancer: Therapeutic Aspects

Author: Sajal Chakraborti

Publisher: Springer Nature

Published: 2022-09-28

Total Pages: 4078

ISBN-13: 9811654220

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This reference book, which is the second volume of Targeting Oxidative Stress in Cancer, explores oxidative stress as the potential therapeutic target for cancer therapy. The initial chapters discuss the molecular mechanisms of oxidative stress and its effects on different signaling pathways. Subsequently, the sections examine the impact of redox signaling on tumor cell proliferation and consider the therapeutic potential of dietary phytochemicals and nutraceuticals in reactive oxygen species (ROS)-induced cancer. In turn, it examines the evidence supporting the use of Vitamin C in cancer management, before presenting various synthetic and natural compounds that have therapeutic implications for oxidative stress-induced cancer. It also explores the correlation between non-coding RNA and oxidative stress. Furthermore, the book summarizes the role of stem cells in ROS-induced cancer therapy and reviews the therapeutic applications of nanoparticles to alter redox haemostasis in cancer cells. Lastly, it explores heat-shock proteins, ubiquitin ligases, and probiotics as potential therapeutic agents in ROS-mediated cancer. This book is a useful resource for basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy.

Book Synopsis Handbook of Oxidative Stress in Cancer: Therapeutic Aspects by : Sajal Chakraborti

Download or read book Handbook of Oxidative Stress in Cancer: Therapeutic Aspects written by Sajal Chakraborti and published by Springer Nature. This book was released on 2022-09-28 with total page 4078 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference book, which is the second volume of Targeting Oxidative Stress in Cancer, explores oxidative stress as the potential therapeutic target for cancer therapy. The initial chapters discuss the molecular mechanisms of oxidative stress and its effects on different signaling pathways. Subsequently, the sections examine the impact of redox signaling on tumor cell proliferation and consider the therapeutic potential of dietary phytochemicals and nutraceuticals in reactive oxygen species (ROS)-induced cancer. In turn, it examines the evidence supporting the use of Vitamin C in cancer management, before presenting various synthetic and natural compounds that have therapeutic implications for oxidative stress-induced cancer. It also explores the correlation between non-coding RNA and oxidative stress. Furthermore, the book summarizes the role of stem cells in ROS-induced cancer therapy and reviews the therapeutic applications of nanoparticles to alter redox haemostasis in cancer cells. Lastly, it explores heat-shock proteins, ubiquitin ligases, and probiotics as potential therapeutic agents in ROS-mediated cancer. This book is a useful resource for basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy.

Handbook of Oxidative Stress in Cancer: Mechanistic Aspects

Author: Sajal Chakraborti

Publisher: Springer

Published: 2022-02-01

Total Pages: 2675

ISBN-13: 9789811594106

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This comprehensive, up-to-date reference work compiles the scientific research on the relationship between various forms of cancer and reactive oxygen species (ROS). It is well known that ROS play a key role in the various steps leading to malignancy, this includes increase in DNA mutation rates. The book brings together exciting reviews, written by leading experts all over the world. The book is divided into four broad sections. Each section describes the role of oxidative stress and underlying mechanisms and pathways, at various stages of cancer, including its role in carcinogenesis, cancer progression and metastasis. Further, the book describes how the reactive oxygen species (ROS) modulate gene expression and signal transduction pathways in cancer. The book discusses the ways to interfere with the cancer progression, and design of anti-cancer drugs. The book provides an integrated approach for better understanding of the development phases of oxidative stress-induced cancers, and mainly the current perspectives about mechanistic aspects of cancer initiation, progression and metastasis. It is a highly resourceful book and would be extremely important to clinicians, students and researchers in the field of cancer genetics, therapeutics and oncology.

Book Synopsis Handbook of Oxidative Stress in Cancer: Mechanistic Aspects by : Sajal Chakraborti

Download or read book Handbook of Oxidative Stress in Cancer: Mechanistic Aspects written by Sajal Chakraborti and published by Springer. This book was released on 2022-02-01 with total page 2675 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive, up-to-date reference work compiles the scientific research on the relationship between various forms of cancer and reactive oxygen species (ROS). It is well known that ROS play a key role in the various steps leading to malignancy, this includes increase in DNA mutation rates. The book brings together exciting reviews, written by leading experts all over the world. The book is divided into four broad sections. Each section describes the role of oxidative stress and underlying mechanisms and pathways, at various stages of cancer, including its role in carcinogenesis, cancer progression and metastasis. Further, the book describes how the reactive oxygen species (ROS) modulate gene expression and signal transduction pathways in cancer. The book discusses the ways to interfere with the cancer progression, and design of anti-cancer drugs. The book provides an integrated approach for better understanding of the development phases of oxidative stress-induced cancers, and mainly the current perspectives about mechanistic aspects of cancer initiation, progression and metastasis. It is a highly resourceful book and would be extremely important to clinicians, students and researchers in the field of cancer genetics, therapeutics and oncology.

Oxidative Stress in Cancer, AIDS, and Neurodegenerative Diseases

Author: Luc Montagnier

Publisher: CRC Press

Published: 1997-10-06

Total Pages: 578

ISBN-13: 9781420002928

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Based on a conference on Oxidative Stress and Redox Regulation, held at the Pasteur Institute, Paris, this work examines fundamental, chemical, biological and medical studies of free radicals on different targets and the consequences of their reactivity. It covers the chemistry and biochemistry of free radicals, free radicals as second messengers that group the activation of transcription factors and enzymes, the importance of the antioxidant system in cell metabolism regulation, and the role of free radicals and antioxidants in disease management. The editors of this work are three of the most respected pioneers in the field. Dr. Montagnier is credited as the discoverer of HIV.

Book Synopsis Oxidative Stress in Cancer, AIDS, and Neurodegenerative Diseases by : Luc Montagnier

Download or read book Oxidative Stress in Cancer, AIDS, and Neurodegenerative Diseases written by Luc Montagnier and published by CRC Press. This book was released on 1997-10-06 with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on a conference on Oxidative Stress and Redox Regulation, held at the Pasteur Institute, Paris, this work examines fundamental, chemical, biological and medical studies of free radicals on different targets and the consequences of their reactivity. It covers the chemistry and biochemistry of free radicals, free radicals as second messengers that group the activation of transcription factors and enzymes, the importance of the antioxidant system in cell metabolism regulation, and the role of free radicals and antioxidants in disease management. The editors of this work are three of the most respected pioneers in the field. Dr. Montagnier is credited as the discoverer of HIV.

Oxidative Stress in Cancer Biology and Therapy

Author: Douglas R. Spitz

Publisher: Springer Science & Business Media

Published: 2011-11-25

Total Pages: 465

ISBN-13: 1617793973

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During the last 30 years it has become clearly evident that oxidative stress and free radical biology play key roles in carcinogenesis, cancer progression, cancer therapy, and normal tissue damage that limits treatment efficacy during cancer therapy. These mechanistic observations have led to the realization that free radical biology and cancer biology are two integrally related fields of investigation that can greatly benefit from cross fertilization of theoretical constructs. The current volume of scientific papers was assembled under the heading of Oxidative Stress in Cancer Biology and Therapy in order to stimulate the discussion of how the knowledge gained in the emerging field of oxidative stress in cancer biology can be utilized to more effectively design interventions to enhance therapeutic responses while causing fewer treatment limiting complications. The chapters contained in this volume provide highly informative emerging perspectives on how that selective enhancement of oxidative stress in cancerous tissues can be used as a target for enhancing therapeutic outcomes as well as how selective inhibition of oxidative stress could spare normal tissue damage and inhibit carcinogenesis. In this regard, the book represents an outstanding resource for both basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy.

Book Synopsis Oxidative Stress in Cancer Biology and Therapy by : Douglas R. Spitz

Download or read book Oxidative Stress in Cancer Biology and Therapy written by Douglas R. Spitz and published by Springer Science & Business Media. This book was released on 2011-11-25 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last 30 years it has become clearly evident that oxidative stress and free radical biology play key roles in carcinogenesis, cancer progression, cancer therapy, and normal tissue damage that limits treatment efficacy during cancer therapy. These mechanistic observations have led to the realization that free radical biology and cancer biology are two integrally related fields of investigation that can greatly benefit from cross fertilization of theoretical constructs. The current volume of scientific papers was assembled under the heading of Oxidative Stress in Cancer Biology and Therapy in order to stimulate the discussion of how the knowledge gained in the emerging field of oxidative stress in cancer biology can be utilized to more effectively design interventions to enhance therapeutic responses while causing fewer treatment limiting complications. The chapters contained in this volume provide highly informative emerging perspectives on how that selective enhancement of oxidative stress in cancerous tissues can be used as a target for enhancing therapeutic outcomes as well as how selective inhibition of oxidative stress could spare normal tissue damage and inhibit carcinogenesis. In this regard, the book represents an outstanding resource for both basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy.

Handbook of Oxidative Stress and Cancer

Author: Sajal Chakraborti

Publisher:

Published: 2020

Total Pages:

ISBN-13: 9789811545016

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Book Synopsis Handbook of Oxidative Stress and Cancer by : Sajal Chakraborti

Download or read book Handbook of Oxidative Stress and Cancer written by Sajal Chakraborti and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Fundamentals of Inhomogeneous Fluids

Author: Douglas Henderson

Publisher: CRC Press

Published: 2021-12-17

Total Pages: 616

ISBN-13: 1000104834

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A monograph examining recent progress in the field of inhomogeneous fluids, focusing on the theoretical - as well as experimental - techniques used. It presents the comprehensive theory of first-order phase transitions, including melting, and contains numerous figures, tables and display equations.;The contributors treat such subjects as: exact sum rules for inhomogenous fluids, explaining density functional and integral equation methods; exact solutions for two-dimensional homogeneous and inhomogeneous plasmas; current advances in the theory of interfacial electrochemistry; wetting experiments and the theory of wetting; freezing, with an emphasis on quantum systems and homogeneous nucleation in liquid-vapour and solid-liquid transitions; self-organizing liquids as well as kinetic phenomena in inhomogeneous fluids, using a modified Enskog theory.;Featuring over 1000 bibliographic citations, this volume is aimed at physical, surface, colloid and surfactant chemists; also physicists, electrochemists and graduate-level students in these disciplines.

Book Synopsis Fundamentals of Inhomogeneous Fluids by : Douglas Henderson

Download or read book Fundamentals of Inhomogeneous Fluids written by Douglas Henderson and published by CRC Press. This book was released on 2021-12-17 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: A monograph examining recent progress in the field of inhomogeneous fluids, focusing on the theoretical - as well as experimental - techniques used. It presents the comprehensive theory of first-order phase transitions, including melting, and contains numerous figures, tables and display equations.;The contributors treat such subjects as: exact sum rules for inhomogenous fluids, explaining density functional and integral equation methods; exact solutions for two-dimensional homogeneous and inhomogeneous plasmas; current advances in the theory of interfacial electrochemistry; wetting experiments and the theory of wetting; freezing, with an emphasis on quantum systems and homogeneous nucleation in liquid-vapour and solid-liquid transitions; self-organizing liquids as well as kinetic phenomena in inhomogeneous fluids, using a modified Enskog theory.;Featuring over 1000 bibliographic citations, this volume is aimed at physical, surface, colloid and surfactant chemists; also physicists, electrochemists and graduate-level students in these disciplines.

Fatigue Life Analyses of Welded Structures

Author: Tom Lassen

Publisher: John Wiley & Sons

Published: 2013-03-01

Total Pages: 442

ISBN-13: 1118614704

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Avoiding or controlling fatigue damage is a major issue in the design and inspection of welded structures subjected to dynamic loading. Life predictions are usually used for safe life analysis, i.e. for verifying that it is very unlikely that fatigue damage will occur during the target service life of a structure. Damage tolerance analysis is used for predicting the behavior of a fatigue crack and for planning of in-service scheduled inspections. It should be a high probability that any cracks appearing are detected and repaired before they become critical. In both safe life analysis and the damage tolerance analysis there may be large uncertainties involved that have to be treated in a logical and consistent manner by stochastic modeling. This book focuses on fatigue life predictions and damage tolerance analysis of welded joints and is divided into three parts. The first part outlines the common practice used for safe life and damage tolerance analysis with reference to rules and regulations. The second part emphasises stochastic modeling and decision-making under uncertainty, while the final part is devoted to recent advances within fatigue research on welded joints. Industrial examples that are included are mainly dealing with offshore steel structures. Spreadsheets which accompany the book give the reader the possibility for hands-on experience of fatigue life predictions, crack growth analysis and inspection planning. As such, these different areas will be of use to engineers and researchers.

Book Synopsis Fatigue Life Analyses of Welded Structures by : Tom Lassen

Download or read book Fatigue Life Analyses of Welded Structures written by Tom Lassen and published by John Wiley & Sons. This book was released on 2013-03-01 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: Avoiding or controlling fatigue damage is a major issue in the design and inspection of welded structures subjected to dynamic loading. Life predictions are usually used for safe life analysis, i.e. for verifying that it is very unlikely that fatigue damage will occur during the target service life of a structure. Damage tolerance analysis is used for predicting the behavior of a fatigue crack and for planning of in-service scheduled inspections. It should be a high probability that any cracks appearing are detected and repaired before they become critical. In both safe life analysis and the damage tolerance analysis there may be large uncertainties involved that have to be treated in a logical and consistent manner by stochastic modeling. This book focuses on fatigue life predictions and damage tolerance analysis of welded joints and is divided into three parts. The first part outlines the common practice used for safe life and damage tolerance analysis with reference to rules and regulations. The second part emphasises stochastic modeling and decision-making under uncertainty, while the final part is devoted to recent advances within fatigue research on welded joints. Industrial examples that are included are mainly dealing with offshore steel structures. Spreadsheets which accompany the book give the reader the possibility for hands-on experience of fatigue life predictions, crack growth analysis and inspection planning. As such, these different areas will be of use to engineers and researchers.

Essential Classical Mechanics

Author: Choonkyu Lee

Publisher: World Scientific Publishing Company

Published: 2018-04-17

Total Pages: 764

ISBN-13: 9813234660

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Book Synopsis Essential Classical Mechanics by : Choonkyu Lee

Download or read book Essential Classical Mechanics written by Choonkyu Lee and published by World Scientific Publishing Company. This book was released on 2018-04-17 with total page 764 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Fundamentals of Inorganic Glasses

Author: Arun K. Varshneya

Publisher: Elsevier

Published: 2019-05-09

Total Pages: 753

ISBN-13: 0128162260

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Fundamentals of Inorganic Glasses, Third Edition, is a comprehensive reference on the field of glass science and engineering that covers numerous, significant advances. This new edition includes the most recent advances in glass physics and chemistry, also discussing groundbreaking applications of glassy materials. It is suitable for upper level glass science courses and professional glass scientists and engineers at industrial and government labs. Fundamental concepts, chapter-ending problem sets, an emphasis on key ideas, and timely notes on suggested readings are all included. The book provides the breadth required of a comprehensive reference, offering coverage of the composition, structure and properties of inorganic glasses. Clearly develops fundamental concepts and the basics of glass science and glass chemistry Provides a comprehensive discussion of the composition, structure and properties of inorganic glasses Features a discussion of the emerging applications of glass, including applications in energy, environment, pharmaceuticals, and more Concludes chapters with problem sets and suggested readings to facilitate self-study

Book Synopsis Fundamentals of Inorganic Glasses by : Arun K. Varshneya

Download or read book Fundamentals of Inorganic Glasses written by Arun K. Varshneya and published by Elsevier. This book was released on 2019-05-09 with total page 753 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamentals of Inorganic Glasses, Third Edition, is a comprehensive reference on the field of glass science and engineering that covers numerous, significant advances. This new edition includes the most recent advances in glass physics and chemistry, also discussing groundbreaking applications of glassy materials. It is suitable for upper level glass science courses and professional glass scientists and engineers at industrial and government labs. Fundamental concepts, chapter-ending problem sets, an emphasis on key ideas, and timely notes on suggested readings are all included. The book provides the breadth required of a comprehensive reference, offering coverage of the composition, structure and properties of inorganic glasses. Clearly develops fundamental concepts and the basics of glass science and glass chemistry Provides a comprehensive discussion of the composition, structure and properties of inorganic glasses Features a discussion of the emerging applications of glass, including applications in energy, environment, pharmaceuticals, and more Concludes chapters with problem sets and suggested readings to facilitate self-study

Handbook of Bond Dissociation Energies in Organic Compounds

Author: Yu-Ran Luo

Publisher: CRC Press

Published: 2002-12-26

Total Pages: 395

ISBN-13: 1420039865

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So many compounds, so many experiments reported by so many researchers using so many methods Finding reliable data on bond dissociation energies (BDEs) can be like looking for a needle in a haystack. But these data are crucial to work in chemical kinetics, free radical chemistry, organic thermochemistry, and physical organic chemistry-so where does

Book Synopsis Handbook of Bond Dissociation Energies in Organic Compounds by : Yu-Ran Luo

Download or read book Handbook of Bond Dissociation Energies in Organic Compounds written by Yu-Ran Luo and published by CRC Press. This book was released on 2002-12-26 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: So many compounds, so many experiments reported by so many researchers using so many methods Finding reliable data on bond dissociation energies (BDEs) can be like looking for a needle in a haystack. But these data are crucial to work in chemical kinetics, free radical chemistry, organic thermochemistry, and physical organic chemistry-so where does