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Download or read book Current Topics in Microbiology and Immunology written by Robert L. Coffman and published by . This book was released on 1967 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author: Ann Cook
Publisher: Barron's Educational Series, Incorporated
Published: 2000
Total Pages: 162
ISBN-13: 9780764173691
DOWNLOAD EBOOKDirected to speakers of English as a second language, a multi-media guide to pronouncing American English uses a "pure-sound" approach to speaking to help imitate the fluid ways of American speech.
Download or read book American Accent Training written by Ann Cook and published by Barron's Educational Series, Incorporated. This book was released on 2000 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: Directed to speakers of English as a second language, a multi-media guide to pronouncing American English uses a "pure-sound" approach to speaking to help imitate the fluid ways of American speech.
Download or read book Market Leader written by and published by . This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author: S.M. Mansour Haeryfar
Publisher: Frontiers Media SA
Published: 2016-01-21
Total Pages: 191
ISBN-13: 2889197506
DOWNLOAD EBOOKCell-mediated immunity to extracellular and intracellular microbes has been traditionally linked to CD4+ and CD8+ T cells that recognize pathogen-derived peptides in the context of major histocompatibility complex (MHC) class II and class I molecules, respectively. Recent progress in our understanding of early host defense mechanisms has brought ‘unconventional’, innate-like T cells into the spotlight. These are a heterogeneous population of non-MHC-restricted T cells that exhibit ‘memory-like’ properties and mount emergency responses to infection. They may directly detect and destroy infected cells, but are best known for their ability to regulate downstream effector cells including but not limited to conventional T cells. Innate-like T cells include among others CD1-restricted natural killer T (NKT) cells and MR1-restricted mucosa-associated invariant T (MAIT) cells. NKT cells recognize lipid antigens, and MAIT cells were recently demonstrated to respond to microbe-derived vitamin B metabolites. However, much remains to be learned about the antigen specificity range of these cells, their activation mode and their true potentials in immunotherapeutic applications. Like in many other areas of biology, uncertainties and controversies surrounding these cells and some of the experimental models, techniques and reagents employed to study them have brought about excitement and sometimes hot debates. This Special Topic was launched to provide updated reviews on protective and/or pathogenic roles of NKT and MAIT cells during infection. Leading experts discuss current controversies, pressing questions and the challenges that lie ahead for the advancement of this intriguing and rapidly evolving area of immunology. Unlike MHC, CD1 and MR1 display very limited polymorphism. Therefore, NKT and MAIT cells may be considered attractive targets for various diseases in diverse human populations. The potential benefits of NKT cell- and MAIT cell-based vaccination and treatment strategies in infectious diseases is an important subject that is also covered in this Topic.
Download or read book CD1- and MR1-restricted T Cells in Antimicrobial Immunity written by S.M. Mansour Haeryfar and published by Frontiers Media SA. This book was released on 2016-01-21 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell-mediated immunity to extracellular and intracellular microbes has been traditionally linked to CD4+ and CD8+ T cells that recognize pathogen-derived peptides in the context of major histocompatibility complex (MHC) class II and class I molecules, respectively. Recent progress in our understanding of early host defense mechanisms has brought ‘unconventional’, innate-like T cells into the spotlight. These are a heterogeneous population of non-MHC-restricted T cells that exhibit ‘memory-like’ properties and mount emergency responses to infection. They may directly detect and destroy infected cells, but are best known for their ability to regulate downstream effector cells including but not limited to conventional T cells. Innate-like T cells include among others CD1-restricted natural killer T (NKT) cells and MR1-restricted mucosa-associated invariant T (MAIT) cells. NKT cells recognize lipid antigens, and MAIT cells were recently demonstrated to respond to microbe-derived vitamin B metabolites. However, much remains to be learned about the antigen specificity range of these cells, their activation mode and their true potentials in immunotherapeutic applications. Like in many other areas of biology, uncertainties and controversies surrounding these cells and some of the experimental models, techniques and reagents employed to study them have brought about excitement and sometimes hot debates. This Special Topic was launched to provide updated reviews on protective and/or pathogenic roles of NKT and MAIT cells during infection. Leading experts discuss current controversies, pressing questions and the challenges that lie ahead for the advancement of this intriguing and rapidly evolving area of immunology. Unlike MHC, CD1 and MR1 display very limited polymorphism. Therefore, NKT and MAIT cells may be considered attractive targets for various diseases in diverse human populations. The potential benefits of NKT cell- and MAIT cell-based vaccination and treatment strategies in infectious diseases is an important subject that is also covered in this Topic.
Author: Kazuya Iwabuchi
Publisher: Frontiers Media SA
Published: 2019-10-18
Total Pages: 429
ISBN-13: 2889631222
DOWNLOAD EBOOKCD1 and MR1 are major histocompatibility complex (MHC) class I-related proteins that bind and present non-peptide antigens to subsets of T cells with specialized functions. CD1 proteins typically present lipid antigens to CD1-restricted T cells, whereas MR1 presents vitamin B-based ligands and a variety of drugs and drug-like molecules to MR1-restricted T cells. The CD1 family of antigen presenting molecules has been divided into two groups: Group 1 contains CD1a, CD1b and CD1c, and Group 2 contains CD1d. Additionally, CD1e is expressed intracellularly and is involved in the loading of lipid antigens onto Group 1 CD1 proteins. Humans express both Groups 1 and 2 CD1 proteins, whereas mice only express CD1d. Group 1 CD1 proteins present lipid antigens to T cells that generally express diverse T cell receptors (TCRs) and exhibit adaptive-like functions, whereas CD1d presents lipid antigens to subsets of T cells that express either diverse or highly restricted TCRs and exhibit innate-like functions. CD1d-restricted T cells are called natural killer T (NKT) cells, which includes Type I or invariant NKT (iNKT) cells expressing semi-invariant TCRs, and Type II NKT cells expressing more diverse TCRs. CD1-restricted T cells have been implicated in a wide variety of diseases, including cancer, infections, and autoimmune, inflammatory and metabolic diseases. Additionally, NKT cells have been targeted for immunotherapy of disease with ligands such as α-galactosylceramide for iNKT cells, or sulfatide for Type II NKT cells. Like iNKT cells, MR1-restricted T cells express semi-invariant TCRs and display innate-like functions. MR1-restricted T cells, also called mucosal-associated invariant T (MAIT) cells, have been implicated in immune responses against a variety of pathogens such as Mycobacterium tuberculosis, Pseudomonas aeruginosa, Helicobacter pylori, hepatitis C virus and influenza virus. Moreover, these cells contribute to autoimmune and inflammatory diseases, including colitis, rheumatoid arthritis, psoriasis, lupus, and diabetes.
Download or read book Role of CD1- and MR1-restricted T cells in Immunity and Disease written by Kazuya Iwabuchi and published by Frontiers Media SA. This book was released on 2019-10-18 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: CD1 and MR1 are major histocompatibility complex (MHC) class I-related proteins that bind and present non-peptide antigens to subsets of T cells with specialized functions. CD1 proteins typically present lipid antigens to CD1-restricted T cells, whereas MR1 presents vitamin B-based ligands and a variety of drugs and drug-like molecules to MR1-restricted T cells. The CD1 family of antigen presenting molecules has been divided into two groups: Group 1 contains CD1a, CD1b and CD1c, and Group 2 contains CD1d. Additionally, CD1e is expressed intracellularly and is involved in the loading of lipid antigens onto Group 1 CD1 proteins. Humans express both Groups 1 and 2 CD1 proteins, whereas mice only express CD1d. Group 1 CD1 proteins present lipid antigens to T cells that generally express diverse T cell receptors (TCRs) and exhibit adaptive-like functions, whereas CD1d presents lipid antigens to subsets of T cells that express either diverse or highly restricted TCRs and exhibit innate-like functions. CD1d-restricted T cells are called natural killer T (NKT) cells, which includes Type I or invariant NKT (iNKT) cells expressing semi-invariant TCRs, and Type II NKT cells expressing more diverse TCRs. CD1-restricted T cells have been implicated in a wide variety of diseases, including cancer, infections, and autoimmune, inflammatory and metabolic diseases. Additionally, NKT cells have been targeted for immunotherapy of disease with ligands such as α-galactosylceramide for iNKT cells, or sulfatide for Type II NKT cells. Like iNKT cells, MR1-restricted T cells express semi-invariant TCRs and display innate-like functions. MR1-restricted T cells, also called mucosal-associated invariant T (MAIT) cells, have been implicated in immune responses against a variety of pathogens such as Mycobacterium tuberculosis, Pseudomonas aeruginosa, Helicobacter pylori, hepatitis C virus and influenza virus. Moreover, these cells contribute to autoimmune and inflammatory diseases, including colitis, rheumatoid arthritis, psoriasis, lupus, and diabetes.
Author: Chris Redston
Publisher: Cambridge University Press
Published: 2012-02-23
Total Pages: 169
ISBN-13: 1107422043
DOWNLOAD EBOOKface2face is the flexible, easy-to-teach General English course that helps adults and young adults to speak and listen with confidence. face2face is informed by Cambridge English Corpus and its vocabulary syllabus has been mapped to the English Vocabulary Profile, meaning students learn the language they really need at each CEFR level. The course improves students' listening skills by drawing their attention to the elements of spoken English that are difficult to understand. The free DVD-ROM in the Student's Book includes consolidation activities and electronic portfolio for learners to track their progress with customisable tests and grammar and vocabulary reference sections.
Download or read book Face2face Elementary Student's Book with DVD-ROM written by Chris Redston and published by Cambridge University Press. This book was released on 2012-02-23 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: face2face is the flexible, easy-to-teach General English course that helps adults and young adults to speak and listen with confidence. face2face is informed by Cambridge English Corpus and its vocabulary syllabus has been mapped to the English Vocabulary Profile, meaning students learn the language they really need at each CEFR level. The course improves students' listening skills by drawing their attention to the elements of spoken English that are difficult to understand. The free DVD-ROM in the Student's Book includes consolidation activities and electronic portfolio for learners to track their progress with customisable tests and grammar and vocabulary reference sections.
Author: Omar Santos
Publisher: Pearson IT Certification
Published: 2018-11-15
Total Pages: 1011
ISBN-13: 013522618X
DOWNLOAD EBOOKThis is the eBook version of the print title. Note that the eBook does not provide access to the practice test software that accompanies the print book. Learn, prepare, and practice for CompTIA Pentest+ PT0-001 exam success with this CompTIA Cert Guide from Pearson IT Certification, a leader in IT Certification. Master CompTIA Pentest+ PT0-001 exam topics Assess your knowledge with chapter-ending quizzes Review key concepts with exam preparation tasks Practice with realistic exam questions Get practical guidance for next steps and more advanced certifications CompTIA Pentest+ Cert Guide is a best-of-breed exam study guide. Leading IT security experts Omar Santos and Ron Taylor share preparation hints and test-taking tips, helping you identify areas of weakness and improve both your conceptual knowledge and hands-on skills. Material is presented in a concise manner, focusing on increasing your understanding and retention of exam topics. The book presents you with an organized test preparation routine through the use of proven series elements and techniques. Exam topic lists make referencing easy. Chapter-ending Exam Preparation Tasks help you drill on key concepts you must know thoroughly. Review questions help you assess your knowledge, and a final preparation chapter guides you through tools and resources to help you craft your final study plan. Well regarded for its level of detail, assessment features, and challenging review questions and exercises, this study guide helps you master the concepts and techniques that will allow you to succeed on the exam the first time. The CompTIA study guide helps you master all the topics on the Pentest+ exam, including: Planning and scoping: Explain the importance of proper planning and scoping, understand key legal concepts, explore key aspects of compliance-based assessments Information gathering and vulnerability identification: Understand passive and active reconnaissance, conduct appropriate information gathering and use open source intelligence (OSINT); perform vulnerability scans; analyze results; explain how to leverage gathered information in exploitation; understand weaknesses of specialized systems Attacks and exploits: Compare and contrast social engineering attacks; exploit network-based, wireless, RF-based, application-based, and local host vulnerabilities; summarize physical security attacks; perform post-exploitation techniques Penetration testing tools: Use numerous tools to perform reconnaissance, exploit vulnerabilities and perform post-exploitation activities; leverage the Bash shell, Python, Ruby, and PowerShell for basic scripting Reporting and communication: Write reports containing effective findings and recommendations for mitigation; master best practices for reporting and communication; perform post-engagement activities such as cleanup of tools or shells
Download or read book CompTIA PenTest+ PT0-001 Cert Guide written by Omar Santos and published by Pearson IT Certification. This book was released on 2018-11-15 with total page 1011 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the eBook version of the print title. Note that the eBook does not provide access to the practice test software that accompanies the print book. Learn, prepare, and practice for CompTIA Pentest+ PT0-001 exam success with this CompTIA Cert Guide from Pearson IT Certification, a leader in IT Certification. Master CompTIA Pentest+ PT0-001 exam topics Assess your knowledge with chapter-ending quizzes Review key concepts with exam preparation tasks Practice with realistic exam questions Get practical guidance for next steps and more advanced certifications CompTIA Pentest+ Cert Guide is a best-of-breed exam study guide. Leading IT security experts Omar Santos and Ron Taylor share preparation hints and test-taking tips, helping you identify areas of weakness and improve both your conceptual knowledge and hands-on skills. Material is presented in a concise manner, focusing on increasing your understanding and retention of exam topics. The book presents you with an organized test preparation routine through the use of proven series elements and techniques. Exam topic lists make referencing easy. Chapter-ending Exam Preparation Tasks help you drill on key concepts you must know thoroughly. Review questions help you assess your knowledge, and a final preparation chapter guides you through tools and resources to help you craft your final study plan. Well regarded for its level of detail, assessment features, and challenging review questions and exercises, this study guide helps you master the concepts and techniques that will allow you to succeed on the exam the first time. The CompTIA study guide helps you master all the topics on the Pentest+ exam, including: Planning and scoping: Explain the importance of proper planning and scoping, understand key legal concepts, explore key aspects of compliance-based assessments Information gathering and vulnerability identification: Understand passive and active reconnaissance, conduct appropriate information gathering and use open source intelligence (OSINT); perform vulnerability scans; analyze results; explain how to leverage gathered information in exploitation; understand weaknesses of specialized systems Attacks and exploits: Compare and contrast social engineering attacks; exploit network-based, wireless, RF-based, application-based, and local host vulnerabilities; summarize physical security attacks; perform post-exploitation techniques Penetration testing tools: Use numerous tools to perform reconnaissance, exploit vulnerabilities and perform post-exploitation activities; leverage the Bash shell, Python, Ruby, and PowerShell for basic scripting Reporting and communication: Write reports containing effective findings and recommendations for mitigation; master best practices for reporting and communication; perform post-engagement activities such as cleanup of tools or shells
Author: Angela Carter
Publisher: Penguin
Published: 1986-03-04
Total Pages: 225
ISBN-13: 0140235191
DOWNLOAD EBOOKThe transformation of Desiderio's city into a mysterious kingdom is instantaneous: Hallucination flows with magical speed in every brain; avenues and plazas are suddenly as fertile as fairy-book forests. And the evil comes, too, as imaginary massacres fill the streets with blood, the dead return to question the living, and profound anxiety drives hundreds to suicide. Behind it all stands Doctor Hoffman, whose gigantic generators crack the immutable surfaces of time and space and plunge civilization into a world without the chains – or structures – of reason. Only Desiderio, immune to mirages and fantasy, can defeat him. But Desiderio's battle will take him to the very brink of undeniable, irresistible desire.
Download or read book The Infernal Desire Machines of Doctor Hoffman written by Angela Carter and published by Penguin. This book was released on 1986-03-04 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: The transformation of Desiderio's city into a mysterious kingdom is instantaneous: Hallucination flows with magical speed in every brain; avenues and plazas are suddenly as fertile as fairy-book forests. And the evil comes, too, as imaginary massacres fill the streets with blood, the dead return to question the living, and profound anxiety drives hundreds to suicide. Behind it all stands Doctor Hoffman, whose gigantic generators crack the immutable surfaces of time and space and plunge civilization into a world without the chains – or structures – of reason. Only Desiderio, immune to mirages and fantasy, can defeat him. But Desiderio's battle will take him to the very brink of undeniable, irresistible desire.
Author: Rebecca Robb Benne
Publisher:
Published: 2006-05-01
Total Pages:
ISBN-13: 9781905248094
DOWNLOAD EBOOKDownload or read book QSE Quick Smart English Pre-Intermediate Workbook written by Rebecca Robb Benne and published by . This book was released on 2006-05-01 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author: Ichiro Katayama
Publisher: Springer
Published: 2017-12-06
Total Pages: 381
ISBN-13: 9811055416
DOWNLOAD EBOOKThis comprehensive guide offers a state-of-the-art overview of basic and clinical aspects of atopic dermatitis (AD). The name "atopic dermatitis" was first used in 1933, and Drs. Lewis Webb Hill and Marion B. Sulzberger presented their report "Evolution of atopic dermatitis" in 1935. Their observations accurately forecasted the contemporary issues in the management of the condition, such as the conclusions that should be drawn from our understanding of the pathogenesis of AD, and the use of steroids as the main treatment. Several aggravating factors have recently been identified, and these also need to be addressed. In this context, the expert contributors to this book describe and discuss the evolution of atopic dermatology from Sulzberger’s era to the present day, including clinical manifestations, etiopathology and treatment. In addition, it explores skin care intervention, the role of microbiom and GWAS studies, and presents unique, previously unpublished cohort studies. It provides insights into the dynamic changes in AD since Sulzberger introduced topical steroids for its treatment. It is a valuable resource for dermatologists, medical practitioners and researchers who are interested in atopic dermatology.
Download or read book Evolution of Atopic Dermatitis in the 21st Century written by Ichiro Katayama and published by Springer. This book was released on 2017-12-06 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive guide offers a state-of-the-art overview of basic and clinical aspects of atopic dermatitis (AD). The name "atopic dermatitis" was first used in 1933, and Drs. Lewis Webb Hill and Marion B. Sulzberger presented their report "Evolution of atopic dermatitis" in 1935. Their observations accurately forecasted the contemporary issues in the management of the condition, such as the conclusions that should be drawn from our understanding of the pathogenesis of AD, and the use of steroids as the main treatment. Several aggravating factors have recently been identified, and these also need to be addressed. In this context, the expert contributors to this book describe and discuss the evolution of atopic dermatology from Sulzberger’s era to the present day, including clinical manifestations, etiopathology and treatment. In addition, it explores skin care intervention, the role of microbiom and GWAS studies, and presents unique, previously unpublished cohort studies. It provides insights into the dynamic changes in AD since Sulzberger introduced topical steroids for its treatment. It is a valuable resource for dermatologists, medical practitioners and researchers who are interested in atopic dermatology.
