Interferon: The Dawn of Recombinant Protein Drugs

Interferon: The Dawn of Recombinant Protein Drugs

Author: J. Lindenmann

Publisher: Springer Science & Business Media

Published: 2013-06-29

Total Pages: 149

ISBN-13: 3662037874

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Forty years of Interferon I wish to dedicate this short introduction to the memory of Alick Isaacs (1921-1967), and to that of Sir Christopher Andrewes (1896-1988). Let us go back more than 40 years. In 1956 Isaacs was in charge of the Wodd Influenza Centre. Andrewes was head of the division of bac teriology and virology, and deputy director of the National Institute for Medical Research in London. When researchers are faced with a seemingly new phenomenon, ex planations are easy to come by. These explanations fall into two broad categories: the phenomenon in question is either due to something or to the lack of something. I apologize for the primitive way in which I ex press this, but I am going to give three examples, scattered over 100 years, of what I mean. First example: in 1880 the great French microbiologist Louis Pas teur was involved in work on chicken cholera. He was struck by the following observation: if a suitable chicken broth was inoculated with the bacterium, the organism grew profusely and the liquid became tur bid. If he now freed the fluid, by sedimentation or filtration, from the bulk of the organisms and re-inoculated it with the same bacterium, no growth occurred.


Book Synopsis Interferon: The Dawn of Recombinant Protein Drugs by : J. Lindenmann

Download or read book Interferon: The Dawn of Recombinant Protein Drugs written by J. Lindenmann and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: Forty years of Interferon I wish to dedicate this short introduction to the memory of Alick Isaacs (1921-1967), and to that of Sir Christopher Andrewes (1896-1988). Let us go back more than 40 years. In 1956 Isaacs was in charge of the Wodd Influenza Centre. Andrewes was head of the division of bac teriology and virology, and deputy director of the National Institute for Medical Research in London. When researchers are faced with a seemingly new phenomenon, ex planations are easy to come by. These explanations fall into two broad categories: the phenomenon in question is either due to something or to the lack of something. I apologize for the primitive way in which I ex press this, but I am going to give three examples, scattered over 100 years, of what I mean. First example: in 1880 the great French microbiologist Louis Pas teur was involved in work on chicken cholera. He was struck by the following observation: if a suitable chicken broth was inoculated with the bacterium, the organism grew profusely and the liquid became tur bid. If he now freed the fluid, by sedimentation or filtration, from the bulk of the organisms and re-inoculated it with the same bacterium, no growth occurred.


Recombinant Protein Drugs

Recombinant Protein Drugs

Author: P. Buckel

Publisher: Springer Science & Business Media

Published: 2001-08-01

Total Pages: 226

ISBN-13: 9783764359041

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Recombinant protein drugs are intimately associated with the impressive success story of the Biotech Industry during the past thirty years, some of them belonging to the most successful pharmaceutical products. More than thirty different proteins are available for a variety of clinical applications, over 300 proteins are presently being evaluated in clinical trials. In this new volume of the MDT series, historical, technical and clinical aspects of recombinant protein drug discovery and development are presented, covering past, present and future highlights. Leading scientists and co-founders of early Biotech companies describe technical breakthroughs and the fascinating story of pioneering discoveries, as well as the long way of translating them into products and business. Therefore, this book represents an exciting documentation of the beginning of a new era in the pharmaceutical industry. In addition, scientists from basic research, clinic and industry actively involved in new developments discuss...


Book Synopsis Recombinant Protein Drugs by : P. Buckel

Download or read book Recombinant Protein Drugs written by P. Buckel and published by Springer Science & Business Media. This book was released on 2001-08-01 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recombinant protein drugs are intimately associated with the impressive success story of the Biotech Industry during the past thirty years, some of them belonging to the most successful pharmaceutical products. More than thirty different proteins are available for a variety of clinical applications, over 300 proteins are presently being evaluated in clinical trials. In this new volume of the MDT series, historical, technical and clinical aspects of recombinant protein drug discovery and development are presented, covering past, present and future highlights. Leading scientists and co-founders of early Biotech companies describe technical breakthroughs and the fascinating story of pioneering discoveries, as well as the long way of translating them into products and business. Therefore, this book represents an exciting documentation of the beginning of a new era in the pharmaceutical industry. In addition, scientists from basic research, clinic and industry actively involved in new developments discuss...


Interferon

Interferon

Author: Toine Pieters

Publisher: Routledge

Published: 2005

Total Pages: 285

ISBN-13: 1134293062

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This book charts the history and development of one of the most important medical substances of the twentieth century, Interferon, as a drug.


Book Synopsis Interferon by : Toine Pieters

Download or read book Interferon written by Toine Pieters and published by Routledge. This book was released on 2005 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book charts the history and development of one of the most important medical substances of the twentieth century, Interferon, as a drug.


A History of Biochemistry

A History of Biochemistry

Author: Marcel Florkin

Publisher: Gulf Professional Publishing

Published: 1972

Total Pages: 450

ISBN-13: 9780444518668

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Book Synopsis A History of Biochemistry by : Marcel Florkin

Download or read book A History of Biochemistry written by Marcel Florkin and published by Gulf Professional Publishing. This book was released on 1972 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt:


The Western Medical Tradition

The Western Medical Tradition

Author: W. F. Bynum

Publisher: Cambridge University Press

Published: 2006-03-20

Total Pages: 648

ISBN-13: 9780521475655

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This book, first published in 2006, is an authoritative description of the important changes in Western medicine over the past two centuries.


Book Synopsis The Western Medical Tradition by : W. F. Bynum

Download or read book The Western Medical Tradition written by W. F. Bynum and published by Cambridge University Press. This book was released on 2006-03-20 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, first published in 2006, is an authoritative description of the important changes in Western medicine over the past two centuries.


Appropriate Dose Selection - How to Optimize Clinical Drug Development

Appropriate Dose Selection - How to Optimize Clinical Drug Development

Author: J. Venitz

Publisher: Springer Science & Business Media

Published: 2007-03-06

Total Pages: 224

ISBN-13: 3540495290

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Optimal dose individualization has become more important in improving clinical efficacy and safety. This is due in part to the variability in drug response. Therefore, the role of optimal dose finding in early clinical drug development so as to maximize successful clinical use is emphasized. This book reviews innovative methods, tools and examples of rational drug development strategies, particularly for novel oncological agents.


Book Synopsis Appropriate Dose Selection - How to Optimize Clinical Drug Development by : J. Venitz

Download or read book Appropriate Dose Selection - How to Optimize Clinical Drug Development written by J. Venitz and published by Springer Science & Business Media. This book was released on 2007-03-06 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optimal dose individualization has become more important in improving clinical efficacy and safety. This is due in part to the variability in drug response. Therefore, the role of optimal dose finding in early clinical drug development so as to maximize successful clinical use is emphasized. This book reviews innovative methods, tools and examples of rational drug development strategies, particularly for novel oncological agents.


The Role of Natural Products in Drug Discovery

The Role of Natural Products in Drug Discovery

Author: J. Mulzer

Publisher: Springer Science & Business Media

Published: 2013-04-17

Total Pages: 363

ISBN-13: 3662040425

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Natural Products have been important sources of useful drugs from prehistoric times to the present. This book gives an overview about this field and provides important recent contributions to the discovery of new drugs generated by research on natural products. Total synthesis of natural products with interesting biological activities is paving the way for the preparation of new and improved analogs. The methods of combinatorial chemistry permit the selection of the best drug from a large number of candidates. Beyond synthesis and evaluation of organic molecules a number of new bioorganic methods are coming to the fore and will be discucced in this isue of the ERnst schering Research Foundation workshop proceedings.


Book Synopsis The Role of Natural Products in Drug Discovery by : J. Mulzer

Download or read book The Role of Natural Products in Drug Discovery written by J. Mulzer and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural Products have been important sources of useful drugs from prehistoric times to the present. This book gives an overview about this field and provides important recent contributions to the discovery of new drugs generated by research on natural products. Total synthesis of natural products with interesting biological activities is paving the way for the preparation of new and improved analogs. The methods of combinatorial chemistry permit the selection of the best drug from a large number of candidates. Beyond synthesis and evaluation of organic molecules a number of new bioorganic methods are coming to the fore and will be discucced in this isue of the ERnst schering Research Foundation workshop proceedings.


Small Molecule — Protein Interactions

Small Molecule — Protein Interactions

Author: Herbert Waldmann

Publisher: Springer Science & Business Media

Published: 2013-03-09

Total Pages: 248

ISBN-13: 3662053144

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Based on the international workshop on 'Small Molecule - Protein Interactions' held in Berlin, April 24-26, 2002, researchers from industry and academic laboratories describe novel and efficient ways selecting promising new drug targets and developing small molecule inhibitors against them. The structure of the book corresponds to the different aspects of the drug discovery process. All chapters are written by leading experts in the field, who present and discuss the most recent state-of-the-art tools and techniques for the development of novel drugs. The value of the book lies in surveying and summarizing the approaches taken by different companies and institutions giving the reader a balanced view on the use of the latest techniques on the one hand and experience-based assistance in selecting appropriate tools for their own work on the other hand.


Book Synopsis Small Molecule — Protein Interactions by : Herbert Waldmann

Download or read book Small Molecule — Protein Interactions written by Herbert Waldmann and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on the international workshop on 'Small Molecule - Protein Interactions' held in Berlin, April 24-26, 2002, researchers from industry and academic laboratories describe novel and efficient ways selecting promising new drug targets and developing small molecule inhibitors against them. The structure of the book corresponds to the different aspects of the drug discovery process. All chapters are written by leading experts in the field, who present and discuss the most recent state-of-the-art tools and techniques for the development of novel drugs. The value of the book lies in surveying and summarizing the approaches taken by different companies and institutions giving the reader a balanced view on the use of the latest techniques on the one hand and experience-based assistance in selecting appropriate tools for their own work on the other hand.


The Promises and Challenges of Regenerative Medicine

The Promises and Challenges of Regenerative Medicine

Author: John Morser

Publisher: Springer Science & Business Media

Published: 2007-01-19

Total Pages: 142

ISBN-13: 3540376445

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Presents the advances in stem cell research. This book discusses the analysis and use of stem cells in basic biology, and their application in clinical practice.


Book Synopsis The Promises and Challenges of Regenerative Medicine by : John Morser

Download or read book The Promises and Challenges of Regenerative Medicine written by John Morser and published by Springer Science & Business Media. This book was released on 2007-01-19 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents the advances in stem cell research. This book discusses the analysis and use of stem cells in basic biology, and their application in clinical practice.


Basic and Applied Aspects of Biotechnology

Basic and Applied Aspects of Biotechnology

Author: Varsha Gupta

Publisher: Springer

Published: 2016-10-22

Total Pages: 527

ISBN-13: 9811008752

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This book explores the journey of biotechnology, searching for new avenues and noting the impressive accomplishments to date. It has harmonious blend of facts, applications and new ideas. Fast-paced biotechnologies are broadly applied and are being continuously explored in areas like the environmental, industrial, agricultural and medical sciences. The sequencing of the human genome has opened new therapeutic opportunities and enriched the field of medical biotechnology while analysis of biomolecules using proteomics and microarray technologies along with the simultaneous discovery and development of new modes of detection are paving the way for ever-faster and more reliable diagnostic methods. Life-saving bio-pharmaceuticals are being churned out at an amazing rate, and the unraveling of biological processes has facilitated drug designing and discovery processes. Advances in regenerative medical technologies (stem cell therapy, tissue engineering, and gene therapy) look extremely promising, transcending the limitations of all existing fields and opening new dimensions for characterizing and combating diseases.


Book Synopsis Basic and Applied Aspects of Biotechnology by : Varsha Gupta

Download or read book Basic and Applied Aspects of Biotechnology written by Varsha Gupta and published by Springer. This book was released on 2016-10-22 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the journey of biotechnology, searching for new avenues and noting the impressive accomplishments to date. It has harmonious blend of facts, applications and new ideas. Fast-paced biotechnologies are broadly applied and are being continuously explored in areas like the environmental, industrial, agricultural and medical sciences. The sequencing of the human genome has opened new therapeutic opportunities and enriched the field of medical biotechnology while analysis of biomolecules using proteomics and microarray technologies along with the simultaneous discovery and development of new modes of detection are paving the way for ever-faster and more reliable diagnostic methods. Life-saving bio-pharmaceuticals are being churned out at an amazing rate, and the unraveling of biological processes has facilitated drug designing and discovery processes. Advances in regenerative medical technologies (stem cell therapy, tissue engineering, and gene therapy) look extremely promising, transcending the limitations of all existing fields and opening new dimensions for characterizing and combating diseases.