Irreversible Electroporation in Clinical Practice

Irreversible Electroporation in Clinical Practice

Author: Martijn R. Meijerink

Publisher: Springer

Published: 2017-12-27

Total Pages: 281

ISBN-13: 3319551132

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This book provides a comprehensive overview of the clinical use of irreversible electroporation (IRE) – better known by its commercial name, NanoKnife – which is one of the most exciting new needle-guided cancer treatments. The coverage includes the history of IRE, general technique, preclinical research, applications in clinical practice and early clinical results, and future perspectives. Contraindications, treatment planning, potential complications, follow-up imaging, and other practical aspects are fully discussed, with highlighting of useful tips and tricks. Through the delivery of short but highly intense electrical pulses, IRE results in tumor cell membrane permeabilization, causing cells to go into apoptosis. The minimally invasive nature of IRE, combined with the prospect of completely eradicating tumors while preserving delicate structures in the ablation zone, makes IRE the object of worldwide clinical research. This book will be of value for practitioners and trainees in interventional and diagnostic radiology, surgery, medical oncology, HPB and gastroenterology, urology, and radiation oncology.


Book Synopsis Irreversible Electroporation in Clinical Practice by : Martijn R. Meijerink

Download or read book Irreversible Electroporation in Clinical Practice written by Martijn R. Meijerink and published by Springer. This book was released on 2017-12-27 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the clinical use of irreversible electroporation (IRE) – better known by its commercial name, NanoKnife – which is one of the most exciting new needle-guided cancer treatments. The coverage includes the history of IRE, general technique, preclinical research, applications in clinical practice and early clinical results, and future perspectives. Contraindications, treatment planning, potential complications, follow-up imaging, and other practical aspects are fully discussed, with highlighting of useful tips and tricks. Through the delivery of short but highly intense electrical pulses, IRE results in tumor cell membrane permeabilization, causing cells to go into apoptosis. The minimally invasive nature of IRE, combined with the prospect of completely eradicating tumors while preserving delicate structures in the ablation zone, makes IRE the object of worldwide clinical research. This book will be of value for practitioners and trainees in interventional and diagnostic radiology, surgery, medical oncology, HPB and gastroenterology, urology, and radiation oncology.

Irreversible Electroporation

Irreversible Electroporation

Author: Boris Rubinsky

Publisher: Springer Science & Business Media

Published: 2009-11-25

Total Pages: 320

ISBN-13: 364205420X

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Non-thermal irreversible electroporation is a new minimally invasive surgical p- cedure with unique molecular selectivity attributes – in fact it may be considered the first clinical molecular surgery procedure. Non-thermal irreversible electro- ration is a molecular selective mode of cell ablation that employs brief electrical fields to produce nanoscale defects in the cell membrane, which can lead to cell death, without an effect on any of the other tissue molecules. The electrical fields can be produced through contact by insertion of electrode needles around the undesirable tissue and non-invasively by electromagnetic induction. This new - dition to the medical armamentarium requires the active involvement and is of interest to clinical physicians, medical researchers, mechanical engineers, che- cal engineers, electrical engineers, instrumentation designers, medical companies and many other fields and disciplines that were never exposed in their training to irreversible electroporation or to a similar concept. This edited book is designed to be a comprehensive introduction to the field of irreversible electroporation to those that were not exposed or trained in the field before and can also serve as a reference manual. Irreversible electroporation is broad and interdisciplinary. Therefore, we have made an attempt to cover every one of the various aspects of the field from an introductory basic level to state of the art.


Book Synopsis Irreversible Electroporation by : Boris Rubinsky

Download or read book Irreversible Electroporation written by Boris Rubinsky and published by Springer Science & Business Media. This book was released on 2009-11-25 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Non-thermal irreversible electroporation is a new minimally invasive surgical p- cedure with unique molecular selectivity attributes – in fact it may be considered the first clinical molecular surgery procedure. Non-thermal irreversible electro- ration is a molecular selective mode of cell ablation that employs brief electrical fields to produce nanoscale defects in the cell membrane, which can lead to cell death, without an effect on any of the other tissue molecules. The electrical fields can be produced through contact by insertion of electrode needles around the undesirable tissue and non-invasively by electromagnetic induction. This new - dition to the medical armamentarium requires the active involvement and is of interest to clinical physicians, medical researchers, mechanical engineers, che- cal engineers, electrical engineers, instrumentation designers, medical companies and many other fields and disciplines that were never exposed in their training to irreversible electroporation or to a similar concept. This edited book is designed to be a comprehensive introduction to the field of irreversible electroporation to those that were not exposed or trained in the field before and can also serve as a reference manual. Irreversible electroporation is broad and interdisciplinary. Therefore, we have made an attempt to cover every one of the various aspects of the field from an introductory basic level to state of the art.

Clinical Aspects of Electroporation

Clinical Aspects of Electroporation

Author: Stephen T. Kee

Publisher: Springer Science & Business Media

Published: 2011-04-06

Total Pages: 251

ISBN-13: 1441983635

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Electroporation is the forefront in tumor ablation. This book presents the basic principles and clinical applications of electroporation, including the latest research results and patient data. A comprehensive approach to the basic science behind the development of this ground-breaking technique and its introduction into clinical practice, the book discusses the entire spectrum of currently available reversible treatments, the emerging irreversible applications, and their impact on patient care. Clinical Aspects of Electroporation is the first book intended for clinicians on this extremely important and rapidly developing field.


Book Synopsis Clinical Aspects of Electroporation by : Stephen T. Kee

Download or read book Clinical Aspects of Electroporation written by Stephen T. Kee and published by Springer Science & Business Media. This book was released on 2011-04-06 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: Electroporation is the forefront in tumor ablation. This book presents the basic principles and clinical applications of electroporation, including the latest research results and patient data. A comprehensive approach to the basic science behind the development of this ground-breaking technique and its introduction into clinical practice, the book discusses the entire spectrum of currently available reversible treatments, the emerging irreversible applications, and their impact on patient care. Clinical Aspects of Electroporation is the first book intended for clinicians on this extremely important and rapidly developing field.

Electroporation in Veterinary Oncology Practice

Electroporation in Veterinary Oncology Practice

Author: Joseph A. Impellizeri

Publisher: Springer Nature

Published: 2021-11-20

Total Pages: 354

ISBN-13: 3030806685

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This is the first edited collection on veterinary applications of electroporation. Written by an international team of experts, this book presents worldwide emerging therapy options for cancer treatments in veterinary oncology practice. Electroporation offers a precision tool to target cancer cells without destroying surrounding tissue structures. The opening of tumor cell membranes facilitates local control of solid tumors either through the delivery of chemotherapeutics or by direct ablation of tissues using electric fields. In addition, transfer of gene-based products into the cancer cells can be used for genetic vaccination to achieve systemic responses and cancer control. Readers will discover valuable reference texts for practitioner education, including chapters on electrodes for unique anatomical access and treatment planning for deep-seated tumors, different immunotherapy applications with gene electrotransfer, calcium electroporation, irreversible electroporation applications and combinations with other common treatments such as surgery, radiation therapy and chemotherapy. Therapy options with electroporation are gaining interest around the world in both human and veterinary oncology, making this book valuable for oncologists, surgeons, primary care veterinarians, residents, interns and students at veterinary schools, where teaching of Electrochemotherapy will become part of the curriculum. Featuring cross-disciplinary authorship, this work further contributes to advances in comparative medicine and translation research in support of the One Health concept.


Book Synopsis Electroporation in Veterinary Oncology Practice by : Joseph A. Impellizeri

Download or read book Electroporation in Veterinary Oncology Practice written by Joseph A. Impellizeri and published by Springer Nature. This book was released on 2021-11-20 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first edited collection on veterinary applications of electroporation. Written by an international team of experts, this book presents worldwide emerging therapy options for cancer treatments in veterinary oncology practice. Electroporation offers a precision tool to target cancer cells without destroying surrounding tissue structures. The opening of tumor cell membranes facilitates local control of solid tumors either through the delivery of chemotherapeutics or by direct ablation of tissues using electric fields. In addition, transfer of gene-based products into the cancer cells can be used for genetic vaccination to achieve systemic responses and cancer control. Readers will discover valuable reference texts for practitioner education, including chapters on electrodes for unique anatomical access and treatment planning for deep-seated tumors, different immunotherapy applications with gene electrotransfer, calcium electroporation, irreversible electroporation applications and combinations with other common treatments such as surgery, radiation therapy and chemotherapy. Therapy options with electroporation are gaining interest around the world in both human and veterinary oncology, making this book valuable for oncologists, surgeons, primary care veterinarians, residents, interns and students at veterinary schools, where teaching of Electrochemotherapy will become part of the curriculum. Featuring cross-disciplinary authorship, this work further contributes to advances in comparative medicine and translation research in support of the One Health concept.

Interventional Urology

Interventional Urology

Author: Ardeshir R. Rastinehad

Publisher: Springer Nature

Published: 2021-11-17

Total Pages: 567

ISBN-13: 3030735656

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This updated text provides a concise yet comprehensive and state-of-the-art review of evolving techniques in the new and exciting subspecialty of interventional urology. Significant advances in imaging technologies, diagnostic tools, fusion navigation, and minimally invasive image-guided therapies such as focal ablative therapies have expanded the interventional urologists’ clinical toolkit over the past decade. Organized by organ system with subtopics covering imaging technologies, interventional techniques, recipes for successful practice, pitfalls to shorten the learning curves for new technologies, and clinical outcomes for the vast variety of interventional urologic procedures, this second edition includes many more medical images as well as helpful graphics and reference illustrations. The second edition of Interventional Urology serves as a valuable resource for clinicians, interventional urologists, interventional radiologists, interventional oncologists, urologic oncologists, as well as scientists, researchers, students, and residents with an interest in interventional urology.


Book Synopsis Interventional Urology by : Ardeshir R. Rastinehad

Download or read book Interventional Urology written by Ardeshir R. Rastinehad and published by Springer Nature. This book was released on 2021-11-17 with total page 567 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated text provides a concise yet comprehensive and state-of-the-art review of evolving techniques in the new and exciting subspecialty of interventional urology. Significant advances in imaging technologies, diagnostic tools, fusion navigation, and minimally invasive image-guided therapies such as focal ablative therapies have expanded the interventional urologists’ clinical toolkit over the past decade. Organized by organ system with subtopics covering imaging technologies, interventional techniques, recipes for successful practice, pitfalls to shorten the learning curves for new technologies, and clinical outcomes for the vast variety of interventional urologic procedures, this second edition includes many more medical images as well as helpful graphics and reference illustrations. The second edition of Interventional Urology serves as a valuable resource for clinicians, interventional urologists, interventional radiologists, interventional oncologists, urologic oncologists, as well as scientists, researchers, students, and residents with an interest in interventional urology.

Advanced Electroporation Techniques in Biology and Medicine

Advanced Electroporation Techniques in Biology and Medicine

Author: Andrei G. Pakhomov

Publisher: CRC Press

Published: 2010-06-02

Total Pages: 542

ISBN-13: 1439819076

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A reflection of the intense study of the effects of electromagnetic fields on living tissues that has taken place during the last decades, Advanced Electroporation Techniques in Biology and Medicine summarizes most recent experimental findings and theories related to permeabilization of biomembranes by pulsed electric fields. Edited by experts and


Book Synopsis Advanced Electroporation Techniques in Biology and Medicine by : Andrei G. Pakhomov

Download or read book Advanced Electroporation Techniques in Biology and Medicine written by Andrei G. Pakhomov and published by CRC Press. This book was released on 2010-06-02 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: A reflection of the intense study of the effects of electromagnetic fields on living tissues that has taken place during the last decades, Advanced Electroporation Techniques in Biology and Medicine summarizes most recent experimental findings and theories related to permeabilization of biomembranes by pulsed electric fields. Edited by experts and

Hepatocellular Carcinoma

Hepatocellular Carcinoma

Author: Yujin Hoshida

Publisher: Springer

Published: 2019-08-05

Total Pages: 366

ISBN-13: 3030215407

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This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment options including rapidly evolving molecular targeted therapies and immune therapies, multi-omics molecular characterization, and clinically relevant experimental models. The book is intended to assist collaboration between the diverse disciplines and facilitate forward and reverse translation between basic and clinical research by providing a comprehensive overview of relevant areas, covering epidemiological trend and population-level patient management strategies, new diagnostic and prognostic tools, recent advances in the standard care and novel therapeutic approaches, and new concepts in pathogenesis and experimental approaches and tools, by experts and opinion leaders in their respective fields. By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC.


Book Synopsis Hepatocellular Carcinoma by : Yujin Hoshida

Download or read book Hepatocellular Carcinoma written by Yujin Hoshida and published by Springer. This book was released on 2019-08-05 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment options including rapidly evolving molecular targeted therapies and immune therapies, multi-omics molecular characterization, and clinically relevant experimental models. The book is intended to assist collaboration between the diverse disciplines and facilitate forward and reverse translation between basic and clinical research by providing a comprehensive overview of relevant areas, covering epidemiological trend and population-level patient management strategies, new diagnostic and prognostic tools, recent advances in the standard care and novel therapeutic approaches, and new concepts in pathogenesis and experimental approaches and tools, by experts and opinion leaders in their respective fields. By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC.

Tumor Ablation

Tumor Ablation

Author: Eric van Sonnenberg

Publisher: Springer Science & Business Media

Published: 2008-09-08

Total Pages: 554

ISBN-13: 0387286748

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There is an enormous sense of excitement in the communities of cancer research and cancer care as we move into the middle third of the ?rst decade of the 21st century. For the ?rst time,there is a true sense of c- ?dence that the tools provided by the human genome project will enable cancer researchers to crack the code of genomic abnormalities that allow tumor cells to live within the body and provide highly speci?c, virtually non-toxic therapies for the eradication,or at least ?rm control of human cancers. There is also good reason to hope that these same lines of inquiry will yield better tests for screening, early detection, and prev- tion of progression beyond curability. While these developments provide a legitimate basis for much op- mism, many patients will continue to develop cancers and suffer from their debilitating effects, even as research moves ahead. For these in- viduals, it is imperative that the cancer ?eld make the best possible use of the tools available to provide present day cancer patients with the best chances for cure, effective palliation, or, at the very least, relief from symptoms caused by acute intercurrent complications of cancer. A modality that has emerged as a very useful approach to at least some of these goals is tumor ablation by the use of physical or physiochemical approaches.


Book Synopsis Tumor Ablation by : Eric van Sonnenberg

Download or read book Tumor Ablation written by Eric van Sonnenberg and published by Springer Science & Business Media. This book was released on 2008-09-08 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is an enormous sense of excitement in the communities of cancer research and cancer care as we move into the middle third of the ?rst decade of the 21st century. For the ?rst time,there is a true sense of c- ?dence that the tools provided by the human genome project will enable cancer researchers to crack the code of genomic abnormalities that allow tumor cells to live within the body and provide highly speci?c, virtually non-toxic therapies for the eradication,or at least ?rm control of human cancers. There is also good reason to hope that these same lines of inquiry will yield better tests for screening, early detection, and prev- tion of progression beyond curability. While these developments provide a legitimate basis for much op- mism, many patients will continue to develop cancers and suffer from their debilitating effects, even as research moves ahead. For these in- viduals, it is imperative that the cancer ?eld make the best possible use of the tools available to provide present day cancer patients with the best chances for cure, effective palliation, or, at the very least, relief from symptoms caused by acute intercurrent complications of cancer. A modality that has emerged as a very useful approach to at least some of these goals is tumor ablation by the use of physical or physiochemical approaches.

Clinical Pancreatology for Practising Gastroenterologists and Surgeons

Clinical Pancreatology for Practising Gastroenterologists and Surgeons

Author: Juan Enrique Dominguez-Munoz

Publisher: John Wiley & Sons

Published: 2021-03-17

Total Pages: 752

ISBN-13: 111957014X

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Clinical Pancreatology Since the book Clinical Pancreatology for Practising Gastroenterologists and Surgeons was first published sixteen years ago, the knowledge and clinical management of pancreatic diseases have developed markedly. Thanks to the development of the translational research and the from bench to bedside concept, much progress from the lab has been applied to clinical practice. In addition, several highly relevant clinical trials published over the last years have resulted in the update and optimisation of clinical guidelines. A new and validated classification of severity and complications of acute pancreatitis is firmly rooted in clinical practice and has been the basis for the development of minimally invasive approaches to pancreatic necrosis. The etiopathogenic knowledge of chronic pancreatitis and other pancreatopaties, like that associated with diabetes mellitus, has developed significantly. Especially important has been the development of the field of cystic pancreatic tumours, which has been reflected in the publication of several guidelines and consensus reports over the last few years. Most research efforts have focused on pancreatic cancer, which have led and will further lead to a significant increase in the therapeutic armamentarium against this devastating disease. Finally, many newly published studies have changed the concept, causes, clinical relevance, diagnosis and treatment of exocrine pancreatic insufficiency. This new edition of Clinical Pancreatology for Practising Gastroenterologists and Surgeons has enjoyed the collaboration of the world’s leading experts in each of the areas of clinical pancreatology with the aim of facilitating gastroenterologists, surgeons, oncologists, internists, nutritionists, diabetologists, paediatricians, radiologists, pathologists and other specialists in their decision making when facing patients with pancreatic diseases in their daily clinical practice. All in all, this book supplies an indispensable update of the relevant aspects of clinical pancreatology.


Book Synopsis Clinical Pancreatology for Practising Gastroenterologists and Surgeons by : Juan Enrique Dominguez-Munoz

Download or read book Clinical Pancreatology for Practising Gastroenterologists and Surgeons written by Juan Enrique Dominguez-Munoz and published by John Wiley & Sons. This book was released on 2021-03-17 with total page 752 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Pancreatology Since the book Clinical Pancreatology for Practising Gastroenterologists and Surgeons was first published sixteen years ago, the knowledge and clinical management of pancreatic diseases have developed markedly. Thanks to the development of the translational research and the from bench to bedside concept, much progress from the lab has been applied to clinical practice. In addition, several highly relevant clinical trials published over the last years have resulted in the update and optimisation of clinical guidelines. A new and validated classification of severity and complications of acute pancreatitis is firmly rooted in clinical practice and has been the basis for the development of minimally invasive approaches to pancreatic necrosis. The etiopathogenic knowledge of chronic pancreatitis and other pancreatopaties, like that associated with diabetes mellitus, has developed significantly. Especially important has been the development of the field of cystic pancreatic tumours, which has been reflected in the publication of several guidelines and consensus reports over the last few years. Most research efforts have focused on pancreatic cancer, which have led and will further lead to a significant increase in the therapeutic armamentarium against this devastating disease. Finally, many newly published studies have changed the concept, causes, clinical relevance, diagnosis and treatment of exocrine pancreatic insufficiency. This new edition of Clinical Pancreatology for Practising Gastroenterologists and Surgeons has enjoyed the collaboration of the world’s leading experts in each of the areas of clinical pancreatology with the aim of facilitating gastroenterologists, surgeons, oncologists, internists, nutritionists, diabetologists, paediatricians, radiologists, pathologists and other specialists in their decision making when facing patients with pancreatic diseases in their daily clinical practice. All in all, this book supplies an indispensable update of the relevant aspects of clinical pancreatology.

Percutaneous Tumor Ablation

Percutaneous Tumor Ablation

Author: Kelvin Hong

Publisher: Thieme

Published: 2011-01-01

Total Pages: 457

ISBN-13: 1638532184

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Learn from the experts with this hands-on guide to the latest tumor ablation modalities and techniques Leading authorities on percutaneous tumor ablation come together in this volume to provide a complete overview of everything physicians and other health professionals need to know to successfully implement and administer an image-guided ablation service. After an introduction to the protocols and attendant physics of ablation technology, concise organ-based chapters focus on a wide range of both straightforward and atypical cases to teach readers how to handle the unique clinical and technical challenges associated with percutaneous tumor ablation in different areas of the body. Succinct, step-by-step descriptions complement high-resolution images throughout to illustrate the nuances of each procedure. Features: In-depth guidance on the advantages and drawbacks of various cutting-edge ablation modalities, including radiofrequency ablation, microwave ablation, cryoablation, and irreversible electroporation Numerous examples of difficult cases and advice on how to mitigate complications More than 500 high-quality images document the cases and showcase all currently available ablation systems and probes Practical chapters address practice building, patient selection, the pre- and post-operative care of high-risk patients, and more Narrated videos on an accompanying DVD demonstrate state-of-the art tumor ablation equipment and procedures This must-have clinical reference will develop the technical and clinical tumor ablation skills of every fellow and practicing physician in interventional radiology, oncology, and surgical oncology.


Book Synopsis Percutaneous Tumor Ablation by : Kelvin Hong

Download or read book Percutaneous Tumor Ablation written by Kelvin Hong and published by Thieme. This book was released on 2011-01-01 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn from the experts with this hands-on guide to the latest tumor ablation modalities and techniques Leading authorities on percutaneous tumor ablation come together in this volume to provide a complete overview of everything physicians and other health professionals need to know to successfully implement and administer an image-guided ablation service. After an introduction to the protocols and attendant physics of ablation technology, concise organ-based chapters focus on a wide range of both straightforward and atypical cases to teach readers how to handle the unique clinical and technical challenges associated with percutaneous tumor ablation in different areas of the body. Succinct, step-by-step descriptions complement high-resolution images throughout to illustrate the nuances of each procedure. Features: In-depth guidance on the advantages and drawbacks of various cutting-edge ablation modalities, including radiofrequency ablation, microwave ablation, cryoablation, and irreversible electroporation Numerous examples of difficult cases and advice on how to mitigate complications More than 500 high-quality images document the cases and showcase all currently available ablation systems and probes Practical chapters address practice building, patient selection, the pre- and post-operative care of high-risk patients, and more Narrated videos on an accompanying DVD demonstrate state-of-the art tumor ablation equipment and procedures This must-have clinical reference will develop the technical and clinical tumor ablation skills of every fellow and practicing physician in interventional radiology, oncology, and surgical oncology.