Ivermectin and Abamectin

Ivermectin and Abamectin

Author: William C. Campbell

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 380

ISBN-13: 1461236266

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Ivermectin and abamectin, members of the avermectin family of compounds, were introduced to the market in the 1980's as a veterinary antiparasitic drug and agricultural pesticide, respectively. Their acceptance and commercial success have been remarkable; both are highly effective and in worldwide use. The efficacy of ivermectin in river blindness has expanded the interest in its use in human medicine. In response to the intense scientific and industrial interest in ivermectin and abamectin and the likelihood that they will be forerunners of an expanding family of drugs, this comprehensive monograph satisfies the need for a review and synthesis of current knowledge about the use of these substances in crop protection as well as in cattle, sheep, swine, horses, dogs, cats, birds, fish, reptiles, and in man. This overview presents chemical, biochemical, and microbiological data, as well as pharmacological, safety, and environmental aspects and covers practical use of the compounds as antiparasitic and pesticide agents, as well as the available safety data that have emerged from the clinical experience with human applications.


Book Synopsis Ivermectin and Abamectin by : William C. Campbell

Download or read book Ivermectin and Abamectin written by William C. Campbell and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ivermectin and abamectin, members of the avermectin family of compounds, were introduced to the market in the 1980's as a veterinary antiparasitic drug and agricultural pesticide, respectively. Their acceptance and commercial success have been remarkable; both are highly effective and in worldwide use. The efficacy of ivermectin in river blindness has expanded the interest in its use in human medicine. In response to the intense scientific and industrial interest in ivermectin and abamectin and the likelihood that they will be forerunners of an expanding family of drugs, this comprehensive monograph satisfies the need for a review and synthesis of current knowledge about the use of these substances in crop protection as well as in cattle, sheep, swine, horses, dogs, cats, birds, fish, reptiles, and in man. This overview presents chemical, biochemical, and microbiological data, as well as pharmacological, safety, and environmental aspects and covers practical use of the compounds as antiparasitic and pesticide agents, as well as the available safety data that have emerged from the clinical experience with human applications.

Insecticides with Novel Modes of Action

Insecticides with Novel Modes of Action

Author: Isaac Ishaaya

Publisher: Springer Science & Business Media

Published: 2013-06-29

Total Pages: 442

ISBN-13: 3662035650

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The future of insect control looked very bright in the 1950s and 1960s with new insecticides constantly coming onto the market. Today, however, whole classes of pesticide chemistry have fallen by the wayside due to misuse which generated resistance problems reaching crisis proportions, severe adverse effects on the environment, and public outcry that has led to increasingly stricter regulation and legislation. It is with this background, demanding the need for safer, environmentally friendly pesticides and new strategies to reduce resistance problems, that this book was written. The authors of the various chapters have a wealth of experience in pesticide chemistry, biochemical modes of action, mechanism of resistance and application, and have presented concise reviews. Each is actively involved in thedevelopment of new groups of pesticide chemistry which led to the development of novel insecticides with special impact in controlling agricultural pests. Emphasis has been given to insecticides with selective properties, such as insect growth regulators hormone mimics, ecdysone agonists), (chitin synthesis inhibitors, juvenile chloronicotinyl insecticides (imidacloprid, acetamiprid), botanical insecticides (neem, plant oils), pymetrozine, diafenthiuron, pyrrole insecticides, and others. The importance of these compounds, as components in integrated pest management programs and in insecticide resistance management strategies, is discussed. The data presented are essential in establishing new technologies and developing novel groups of compounds which will have impact on our future agricultural practices.


Book Synopsis Insecticides with Novel Modes of Action by : Isaac Ishaaya

Download or read book Insecticides with Novel Modes of Action written by Isaac Ishaaya and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: The future of insect control looked very bright in the 1950s and 1960s with new insecticides constantly coming onto the market. Today, however, whole classes of pesticide chemistry have fallen by the wayside due to misuse which generated resistance problems reaching crisis proportions, severe adverse effects on the environment, and public outcry that has led to increasingly stricter regulation and legislation. It is with this background, demanding the need for safer, environmentally friendly pesticides and new strategies to reduce resistance problems, that this book was written. The authors of the various chapters have a wealth of experience in pesticide chemistry, biochemical modes of action, mechanism of resistance and application, and have presented concise reviews. Each is actively involved in thedevelopment of new groups of pesticide chemistry which led to the development of novel insecticides with special impact in controlling agricultural pests. Emphasis has been given to insecticides with selective properties, such as insect growth regulators hormone mimics, ecdysone agonists), (chitin synthesis inhibitors, juvenile chloronicotinyl insecticides (imidacloprid, acetamiprid), botanical insecticides (neem, plant oils), pymetrozine, diafenthiuron, pyrrole insecticides, and others. The importance of these compounds, as components in integrated pest management programs and in insecticide resistance management strategies, is discussed. The data presented are essential in establishing new technologies and developing novel groups of compounds which will have impact on our future agricultural practices.

Approaches to Design and Synthesis of Antiparasitic Drugs

Approaches to Design and Synthesis of Antiparasitic Drugs

Author: N. Anand

Publisher: Elsevier

Published: 1997-07-10

Total Pages: 525

ISBN-13: 0080527523

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This book presents a comprehensive and up to date account of the chemotherapy of parasitic diseases, both human and veterinary. The book starts with an overview of parasitic diseases. The body of the book is divided into two parts: antihelminthic drugs, and antiprotozoal drugs. Both parts start with chapters highlighting the 'biochemical targets' available for chemotherapeutic interference. Individual chapters deal with one chemical class of compounds and describe their origin, structure-activity relationship, mode of action, and methods of synthesis and their status both in clinical and veterinary practice. The book will be useful to a wide spectrum of readers: students embarking on a research career in parasitic chemotherapy, clinicians (and veterinarians) and clinical pharmacologists desiring detailed information about the drugs currently in use, and pharmaceutical technologists wanting to update their knowledge of the methods of manufacture.


Book Synopsis Approaches to Design and Synthesis of Antiparasitic Drugs by : N. Anand

Download or read book Approaches to Design and Synthesis of Antiparasitic Drugs written by N. Anand and published by Elsevier. This book was released on 1997-07-10 with total page 525 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a comprehensive and up to date account of the chemotherapy of parasitic diseases, both human and veterinary. The book starts with an overview of parasitic diseases. The body of the book is divided into two parts: antihelminthic drugs, and antiprotozoal drugs. Both parts start with chapters highlighting the 'biochemical targets' available for chemotherapeutic interference. Individual chapters deal with one chemical class of compounds and describe their origin, structure-activity relationship, mode of action, and methods of synthesis and their status both in clinical and veterinary practice. The book will be useful to a wide spectrum of readers: students embarking on a research career in parasitic chemotherapy, clinicians (and veterinarians) and clinical pharmacologists desiring detailed information about the drugs currently in use, and pharmaceutical technologists wanting to update their knowledge of the methods of manufacture.

Hayes' Handbook of Pesticide Toxicology

Hayes' Handbook of Pesticide Toxicology

Author:

Publisher: Academic Press

Published: 2010-02-15

Total Pages: 2407

ISBN-13: 0080922015

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The Handbook of Pesticide Toxicology is a comprehensive, two-volume reference guide to the properties, effects, and regulation of pesticides that provides the latest and most complete information to researchers investigating the environmental, agricultural, veterinary, and human-health impacts of pesticide use. Written by international experts from academia, government, and the private sector, the Handbook of Pesticide Toxicology is an in-depth examination of critical issues related to the need for, use of, and nature of chemicals used in modern pest management. This updated 3e carries on the book’s tradition of serving as the definitive reference on pesticide toxicology and recognizes the seminal contribution of Wayland J. Hayes, Jr., co-Editor of the first edition. Feature: Presents a comprehensive look at all aspects of pesticide toxicology in one reference work. Benefit: Saves researchers time in quickly accessing the very latest definitive details on toxicity of specific pesticides as opposed to searching through thousands of journal articles. Feature: Clear exposition of hazard identification and dose response relationships in each chapter featuring pesticide agents and actions Benefit: Connects the experimental laboratory results to real-life applications in human health, animal health and the environment. Feature: All major classes of pesticide considered. Benefit: Provides relevance to a wider variety of researchers who are conducting comparative work in pesticides or their health impacts. Feature: Different routes of exposure critically evaluated. Benefit: Connects the loop between exposure and harmful affects to those who are researching the affects of pesticides on humans or wildlife.


Book Synopsis Hayes' Handbook of Pesticide Toxicology by :

Download or read book Hayes' Handbook of Pesticide Toxicology written by and published by Academic Press. This book was released on 2010-02-15 with total page 2407 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Pesticide Toxicology is a comprehensive, two-volume reference guide to the properties, effects, and regulation of pesticides that provides the latest and most complete information to researchers investigating the environmental, agricultural, veterinary, and human-health impacts of pesticide use. Written by international experts from academia, government, and the private sector, the Handbook of Pesticide Toxicology is an in-depth examination of critical issues related to the need for, use of, and nature of chemicals used in modern pest management. This updated 3e carries on the book’s tradition of serving as the definitive reference on pesticide toxicology and recognizes the seminal contribution of Wayland J. Hayes, Jr., co-Editor of the first edition. Feature: Presents a comprehensive look at all aspects of pesticide toxicology in one reference work. Benefit: Saves researchers time in quickly accessing the very latest definitive details on toxicity of specific pesticides as opposed to searching through thousands of journal articles. Feature: Clear exposition of hazard identification and dose response relationships in each chapter featuring pesticide agents and actions Benefit: Connects the experimental laboratory results to real-life applications in human health, animal health and the environment. Feature: All major classes of pesticide considered. Benefit: Provides relevance to a wider variety of researchers who are conducting comparative work in pesticides or their health impacts. Feature: Different routes of exposure critically evaluated. Benefit: Connects the loop between exposure and harmful affects to those who are researching the affects of pesticides on humans or wildlife.

Optimal Health with Multiple Sclerosis

Optimal Health with Multiple Sclerosis

Author: Allen C. Bowling, MD, PhD

Publisher: Demos Medical Publishing

Published: 2014-10-20

Total Pages: 600

ISBN-13: 1617052086

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The only source for reliable, evidence-based information on the relevance, safety, and effectiveness of alternative and lifestyle medicine approaches to MS treatment and the best ways to safely integrate them with conventional medicine. In addition to conventional medicine, many people with MS also use some form of alternative medicine, and there is growing evidence and interest in the effects of lifestyle factors, such as diet and exercise, on MS. Yet, until now, it has been difficult to obtain unbiased information about the MS-relevant aspects of these nonmedication approaches. Optimal Health with Multiple Sclerosis provides the accurate and unbiased information people with MS, their friends and family, health care professionals, and educators need to make responsible decisions and achieve the very best outcome. Find other options that may provide symptomatic relief when conventional therapies are limited Learn about potentially dangerous interactions between alternative therapies and medical treatments used in the management of MS Identify alternative and lifestyle therapies that are effective, low risk, and inexpensive Recognize ineffective, dangerous, or costly alternative therapies


Book Synopsis Optimal Health with Multiple Sclerosis by : Allen C. Bowling, MD, PhD

Download or read book Optimal Health with Multiple Sclerosis written by Allen C. Bowling, MD, PhD and published by Demos Medical Publishing. This book was released on 2014-10-20 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: The only source for reliable, evidence-based information on the relevance, safety, and effectiveness of alternative and lifestyle medicine approaches to MS treatment and the best ways to safely integrate them with conventional medicine. In addition to conventional medicine, many people with MS also use some form of alternative medicine, and there is growing evidence and interest in the effects of lifestyle factors, such as diet and exercise, on MS. Yet, until now, it has been difficult to obtain unbiased information about the MS-relevant aspects of these nonmedication approaches. Optimal Health with Multiple Sclerosis provides the accurate and unbiased information people with MS, their friends and family, health care professionals, and educators need to make responsible decisions and achieve the very best outcome. Find other options that may provide symptomatic relief when conventional therapies are limited Learn about potentially dangerous interactions between alternative therapies and medical treatments used in the management of MS Identify alternative and lifestyle therapies that are effective, low risk, and inexpensive Recognize ineffective, dangerous, or costly alternative therapies

Drug Transporters

Drug Transporters

Author: Martin F. Fromm

Publisher: Springer Science & Business Media

Published: 2010-11-19

Total Pages: 457

ISBN-13: 3642145418

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It is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects. This book will give an overview on the transporter families which are most important for drug therapy. Most chapters will focus on one transporter family highlighting tissue expression, substrates, inhibitors, knock-out mouse models and clinical studies.


Book Synopsis Drug Transporters by : Martin F. Fromm

Download or read book Drug Transporters written by Martin F. Fromm and published by Springer Science & Business Media. This book was released on 2010-11-19 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is increasingly recognized that various transporter proteins are expressed throughout the body and determine absorption, tissue distribution, biliary and renal elimination of endogenous compounds and drugs and drug effects. This book will give an overview on the transporter families which are most important for drug therapy. Most chapters will focus on one transporter family highlighting tissue expression, substrates, inhibitors, knock-out mouse models and clinical studies.

Clinical Veterinary Toxicology - E-Book

Clinical Veterinary Toxicology - E-Book

Author: Konnie Plumlee

Publisher: Elsevier Health Sciences

Published: 2003-12-10

Total Pages: 504

ISBN-13: 0323058345

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This book covers all aspects of toxicology, including toxic diseases of large animals, small animals, and exotic pets. It provides key information on how poisons affect the body, how the body responds to a foreign substance, how poisonings are diagnosed, and how poisonings are treated. Coverage includes every organ system of every species of animal with details on each body system's susceptibility to poison. Poisons affect animals differently depending on species, breed, age, gender, health status, and reproductive status. This resource addresses these differences, allowing the veterinarian to determine the class of toxicant, the mechanism of action, and the proper course of treatment. If confronted with an unknown poison, the information in this book will assist the veterinarian in formulating a list of potential poisons based on the clinical signs that the animal is exhibiting, and in choosing the appropriate tests to narrow the list to one or a few possible poisons. Most comprehensive toxicology book available Written in a user-friendly style that makes it easy to master the content Covers poisonings in both large and small domestic animals The Principles of Toxicology section provides comprehensive coverage of concepts & terminology, toxicokinetics, treatments, and regulatory information The Manifestations of Toxicoses section is devoted to differentiating between poisons based on lesions and clinical signs The Classes of Toxicants section offers detailed information on each poison, including sources, risk factors, pathophysiology, clinical signs and lesions, diagnostic testing, and treatment The author is board-certified in toxicology, and the contributors are all toxicologists and educators, ensuring authoritative, up-to-date clinical information


Book Synopsis Clinical Veterinary Toxicology - E-Book by : Konnie Plumlee

Download or read book Clinical Veterinary Toxicology - E-Book written by Konnie Plumlee and published by Elsevier Health Sciences. This book was released on 2003-12-10 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers all aspects of toxicology, including toxic diseases of large animals, small animals, and exotic pets. It provides key information on how poisons affect the body, how the body responds to a foreign substance, how poisonings are diagnosed, and how poisonings are treated. Coverage includes every organ system of every species of animal with details on each body system's susceptibility to poison. Poisons affect animals differently depending on species, breed, age, gender, health status, and reproductive status. This resource addresses these differences, allowing the veterinarian to determine the class of toxicant, the mechanism of action, and the proper course of treatment. If confronted with an unknown poison, the information in this book will assist the veterinarian in formulating a list of potential poisons based on the clinical signs that the animal is exhibiting, and in choosing the appropriate tests to narrow the list to one or a few possible poisons. Most comprehensive toxicology book available Written in a user-friendly style that makes it easy to master the content Covers poisonings in both large and small domestic animals The Principles of Toxicology section provides comprehensive coverage of concepts & terminology, toxicokinetics, treatments, and regulatory information The Manifestations of Toxicoses section is devoted to differentiating between poisons based on lesions and clinical signs The Classes of Toxicants section offers detailed information on each poison, including sources, risk factors, pathophysiology, clinical signs and lesions, diagnostic testing, and treatment The author is board-certified in toxicology, and the contributors are all toxicologists and educators, ensuring authoritative, up-to-date clinical information

Physical Medicine and Rehabilitation Pocketpedia

Physical Medicine and Rehabilitation Pocketpedia

Author: Matthew Shatzer, DO

Publisher: Springer Publishing Company

Published: 2017-12-28

Total Pages: 328

ISBN-13: 1617052930

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Pocketpedia is the essential quick reference for medical students, residents, and attending physicians in the field of physical medicine and rehabilitation. Designed for the busy clinician, this pocket-sized compendium is crammed with useful tables, charts, illustrations, and clinical tips and guidelines for effective patient care and restoration of function. Covering core topics in PM&R and field-tested in the clinic and at the bedside over two successful editions, this indispensable resource delivers the information practitioners need on a daily basis. The Third Edition has been reorganized and thoroughly updated to include the latest evidence-based treatment recommendations and protocols. Features PM&R in your pocket—perfect for rounding or concise review Distills the practical essentials with focused coverage of key topics New chapters on Ultrasound, Cancer Rehabilitation, Acupuncture, and Quality Improvement Expanded coverage of musculoskeletal rehabilitation, concussion, and interventional pain procedures Enhanced illustrations and charts Now includes downloadable ebook for anytime access on mobile devices or computer


Book Synopsis Physical Medicine and Rehabilitation Pocketpedia by : Matthew Shatzer, DO

Download or read book Physical Medicine and Rehabilitation Pocketpedia written by Matthew Shatzer, DO and published by Springer Publishing Company. This book was released on 2017-12-28 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pocketpedia is the essential quick reference for medical students, residents, and attending physicians in the field of physical medicine and rehabilitation. Designed for the busy clinician, this pocket-sized compendium is crammed with useful tables, charts, illustrations, and clinical tips and guidelines for effective patient care and restoration of function. Covering core topics in PM&R and field-tested in the clinic and at the bedside over two successful editions, this indispensable resource delivers the information practitioners need on a daily basis. The Third Edition has been reorganized and thoroughly updated to include the latest evidence-based treatment recommendations and protocols. Features PM&R in your pocket—perfect for rounding or concise review Distills the practical essentials with focused coverage of key topics New chapters on Ultrasound, Cancer Rehabilitation, Acupuncture, and Quality Improvement Expanded coverage of musculoskeletal rehabilitation, concussion, and interventional pain procedures Enhanced illustrations and charts Now includes downloadable ebook for anytime access on mobile devices or computer

Facing the Cognitive Challenges of Multiple Sclerosis

Facing the Cognitive Challenges of Multiple Sclerosis

Author: Jeffrey Gingold

Publisher: Demos Medical Publishing

Published: 2011-06-17

Total Pages: 234

ISBN-13: 1936303205

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"When attorney Jeffrey N. Gingold misplaced his wife on the living room couch and lost awareness of his children, little did he know that he was experiencing a hidden symptom of multiple sclerosis: cognitive difficulties. How do you handle getting lost, while driving just blocks from your home? Facing the Cognitive Challenges of Multiple Sclerosis is a courageous and compelling personal account of one man's anguishing struggle with this aspect of the disease. It is written for the silent majority of MS patients who are privately dealing with MS cognitive symptoms and potential disabilities. The National Multiple Sclerosis Society estimates that over 400,000 people in the U.S. have been diagnosed with multiple sclerosis, and there are millions more worldwide. Conservatively speaking, half of them will encounter varying degrees of cognitive difficulties. Facing the Cognitive Challenges of Multiple Sclerosis brings this hidden disability into the open. It is an essential resource that will educate individuals coping with multiple sclerosis, and inform their families, caregivers, doctors and therapists. This new edition has been revised with on-point cognitive strategies and updated MS resources. The book includes a new foreword written by Dr. Dawn Langdon of the UK MS Trust and four completely new chapters that follow Jeffrey's journey since 2006. He openly explores some MS physical symptoms, which may accompany the thinking impediments that strike at his cognitive awareness and functions. Jeffrey carves a path of finding physical and cognitive wellness, as well as weighing the need to accept beneficial MS medical therapies. Not only did he become more active in the movement to cure MS, the progression of his MS led to a more controversial MS treatment, in effort to make his disease manageable. Jeffrey also shares the benefits of introducing a œsafety person” into a life with MS and the strength gained from helping others, even while they may be assisting you. Whether or not a person is dealing with the cognitive issues associated with multiple sclerosis this book deserves to be on the bookshelf of every individual who is dealing with multiple sclerosis."


Book Synopsis Facing the Cognitive Challenges of Multiple Sclerosis by : Jeffrey Gingold

Download or read book Facing the Cognitive Challenges of Multiple Sclerosis written by Jeffrey Gingold and published by Demos Medical Publishing. This book was released on 2011-06-17 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: "When attorney Jeffrey N. Gingold misplaced his wife on the living room couch and lost awareness of his children, little did he know that he was experiencing a hidden symptom of multiple sclerosis: cognitive difficulties. How do you handle getting lost, while driving just blocks from your home? Facing the Cognitive Challenges of Multiple Sclerosis is a courageous and compelling personal account of one man's anguishing struggle with this aspect of the disease. It is written for the silent majority of MS patients who are privately dealing with MS cognitive symptoms and potential disabilities. The National Multiple Sclerosis Society estimates that over 400,000 people in the U.S. have been diagnosed with multiple sclerosis, and there are millions more worldwide. Conservatively speaking, half of them will encounter varying degrees of cognitive difficulties. Facing the Cognitive Challenges of Multiple Sclerosis brings this hidden disability into the open. It is an essential resource that will educate individuals coping with multiple sclerosis, and inform their families, caregivers, doctors and therapists. This new edition has been revised with on-point cognitive strategies and updated MS resources. The book includes a new foreword written by Dr. Dawn Langdon of the UK MS Trust and four completely new chapters that follow Jeffrey's journey since 2006. He openly explores some MS physical symptoms, which may accompany the thinking impediments that strike at his cognitive awareness and functions. Jeffrey carves a path of finding physical and cognitive wellness, as well as weighing the need to accept beneficial MS medical therapies. Not only did he become more active in the movement to cure MS, the progression of his MS led to a more controversial MS treatment, in effort to make his disease manageable. Jeffrey also shares the benefits of introducing a œsafety person” into a life with MS and the strength gained from helping others, even while they may be assisting you. Whether or not a person is dealing with the cognitive issues associated with multiple sclerosis this book deserves to be on the bookshelf of every individual who is dealing with multiple sclerosis."

Pyrantel Parasiticide Therapy in Humans and Domestic Animals

Pyrantel Parasiticide Therapy in Humans and Domestic Animals

Author: Alan A Marchiondo

Publisher: Academic Press

Published: 2016-06-03

Total Pages: 0

ISBN-13: 9780128014493

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Pyrantel Parasiticide Therapy in Humans and Domestic Animals presents a single source history and reference on the parasiticide activity and pharmacology of the tetrahydropyrimidines and their salts in humans and domestic animals, also collating evidence that resistance to pyrantel has developed in human and domestic animal nematodes. Other books of this nature have been compiled historically for specific anthelmintic compounds, but none has been written to date for the pyrantel family of drugs. Pyrantel, a nicotinic receptor agonist, has been used in domestic animal and human medicine since the 1970's to control two important nematode groups, the hookworms and the roundworms. Given the zoonotic potential of these parasites, pyrantel has served a dual role in helping to protect the health of both domestic animals and the public for more than 45 years.


Book Synopsis Pyrantel Parasiticide Therapy in Humans and Domestic Animals by : Alan A Marchiondo

Download or read book Pyrantel Parasiticide Therapy in Humans and Domestic Animals written by Alan A Marchiondo and published by Academic Press. This book was released on 2016-06-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pyrantel Parasiticide Therapy in Humans and Domestic Animals presents a single source history and reference on the parasiticide activity and pharmacology of the tetrahydropyrimidines and their salts in humans and domestic animals, also collating evidence that resistance to pyrantel has developed in human and domestic animal nematodes. Other books of this nature have been compiled historically for specific anthelmintic compounds, but none has been written to date for the pyrantel family of drugs. Pyrantel, a nicotinic receptor agonist, has been used in domestic animal and human medicine since the 1970's to control two important nematode groups, the hookworms and the roundworms. Given the zoonotic potential of these parasites, pyrantel has served a dual role in helping to protect the health of both domestic animals and the public for more than 45 years.