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The principle of magnetic resonance elastography (MRE) is the focus of this book. The functional and structural properties of the skeletal muscle (in passive and active conditions), the liver and the kidney are characterized in particular. Viscoelatic properties are calculated with multifrequency MRE tests and rheological models and results are compared between MR and ultrasound elastography techniques. MRE is applied to pathological muscles and fibrotic livers to follow the effects of the treatment. The authors also analyze MRE post-processing, a key stage in diagnosis. In later chapters a phantom mimicking the soft tissues is created and a FE model is developed in order to simulate wave displacement.
Book Synopsis Mechanical Properties of Soft Tissues with MR Elastography Technique by : Sabine Bensamoun
Download or read book Mechanical Properties of Soft Tissues with MR Elastography Technique written by Sabine Bensamoun and published by John Wiley & Sons. This book was released on 2020-12-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The principle of magnetic resonance elastography (MRE) is the focus of this book. The functional and structural properties of the skeletal muscle (in passive and active conditions), the liver and the kidney are characterized in particular. Viscoelatic properties are calculated with multifrequency MRE tests and rheological models and results are compared between MR and ultrasound elastography techniques. MRE is applied to pathological muscles and fibrotic livers to follow the effects of the treatment. The authors also analyze MRE post-processing, a key stage in diagnosis. In later chapters a phantom mimicking the soft tissues is created and a FE model is developed in order to simulate wave displacement.
The first book to cover the groundbreaking development and clinical applications of Magnetic Resonance Elastography, this book is essential for all practitioners interested in this revolutionary diagnostic modality. The book is divided into three sections. The first covers the history of MRE. The second covers technique and clinical applications of MRE in the liver with respect to fibrosis, liver masses, and other diseases. Case descriptions are presented to give the reader a hands-on approach. The final section presents the techniques, sequence and preliminary results of applications in other areas of the body including muscle, brain, lung, heart, and breast.
Book Synopsis Magnetic Resonance Elastography by : Sudhakar K. Venkatesh
Download or read book Magnetic Resonance Elastography written by Sudhakar K. Venkatesh and published by Springer. This book was released on 2014-10-01 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first book to cover the groundbreaking development and clinical applications of Magnetic Resonance Elastography, this book is essential for all practitioners interested in this revolutionary diagnostic modality. The book is divided into three sections. The first covers the history of MRE. The second covers technique and clinical applications of MRE in the liver with respect to fibrosis, liver masses, and other diseases. Case descriptions are presented to give the reader a hands-on approach. The final section presents the techniques, sequence and preliminary results of applications in other areas of the body including muscle, brain, lung, heart, and breast.
This Open Access volume provides readers with an open access protocol collection and wide-ranging recommendations for preclinical renal MRI used in translational research. The chapters in this book are interdisciplinary in nature and bridge the gaps between physics, physiology, and medicine. They are designed to enhance training in renal MRI sciences and improve the reproducibility of renal imaging research. Chapters provide guidance for exploring, using and developing small animal renal MRI in your laboratory as a unique tool for advanced in vivo phenotyping, diagnostic imaging, and research into potential new therapies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Preclinical MRI of the Kidney: Methods and Protocols is a valuable resource and will be of importance to anyone interested in the preclinical aspect of renal and cardiorenal diseases in the fields of physiology, nephrology, radiology, and cardiology. This publication is based upon work from COST Action PARENCHIMA, supported by European Cooperation in Science and Technology (COST). COST (www.cost.eu) is a funding agency for research and innovation networks. COST Actions help connect research initiatives across Europe and enable scientists to grow their ideas by sharing them with their peers. This boosts their research, career and innovation. PARENCHIMA (renalmri.org) is a community-driven Action in the COST program of the European Union, which unites more than 200 experts in renal MRI from 30 countries with the aim to improve the reproducibility and standardization of renal MRI biomarkers.
Book Synopsis Preclinical MRI of the Kidney by : Andreas Pohlmann
Download or read book Preclinical MRI of the Kidney written by Andreas Pohlmann and published by Humana. This book was released on 2021-01-22 with total page 725 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Open Access volume provides readers with an open access protocol collection and wide-ranging recommendations for preclinical renal MRI used in translational research. The chapters in this book are interdisciplinary in nature and bridge the gaps between physics, physiology, and medicine. They are designed to enhance training in renal MRI sciences and improve the reproducibility of renal imaging research. Chapters provide guidance for exploring, using and developing small animal renal MRI in your laboratory as a unique tool for advanced in vivo phenotyping, diagnostic imaging, and research into potential new therapies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Preclinical MRI of the Kidney: Methods and Protocols is a valuable resource and will be of importance to anyone interested in the preclinical aspect of renal and cardiorenal diseases in the fields of physiology, nephrology, radiology, and cardiology. This publication is based upon work from COST Action PARENCHIMA, supported by European Cooperation in Science and Technology (COST). COST (www.cost.eu) is a funding agency for research and innovation networks. COST Actions help connect research initiatives across Europe and enable scientists to grow their ideas by sharing them with their peers. This boosts their research, career and innovation. PARENCHIMA (renalmri.org) is a community-driven Action in the COST program of the European Union, which unites more than 200 experts in renal MRI from 30 countries with the aim to improve the reproducibility and standardization of renal MRI biomarkers.
The emerging paradigm of incorporating images and biomechanical properties of soft tissues has proven to be an integral part of the advancement of several medical applications, including image guided radiotherapy and surgery, brachytherapy, and diagnostics. This expansion has resulted in a growing community of medical, science, and engineering professionals applying mechanical principles to address medical concerns. This book is tailored to cover a range of mechanical principles, properties, and applications of soft tissues that have previously been addressed in various journals and "anatomical site-specific" books. Biomechanics of Soft Tissues follows a different approach by offering a simplified overview of widely used mechanical models and measuring techniques of soft tissue parameters. This is followed by an investigation of different medical applications, including: biomechanical aspects of cancerous tumor progressions, radiotherapy treatment, and image guided ultrasound guided interventions. Written by leading scholars and professionals in the field, Biomechanics of Soft Tissues combines engineering and medical expertise, thereby producing an excellent source of information for professionals interested in the theoretical and technological advancements related to soft tissues. The book provides medical professionals with an insight on various modeling approaches, testing techniques, and mechanical characteristics that are frequently used by engineers. Conversely, the presented medical applications provide engineers with a glimpse of amazing medical practices and encourage them to expand their roles in the medical field. Provides a simplified overview of mechanics of soft tissues. Highlights different techniques to measure tissues properties for engineering and medical applications. Contains novel ideas to address roles of mechanics in disease progression and treatment. Presents innovative applications of biomechanics in medical procedures.
Book Synopsis Biomechanics of Soft Tissues by : Adil Al Mayah
Download or read book Biomechanics of Soft Tissues written by Adil Al Mayah and published by CRC Press. This book was released on 2018-02-21 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: The emerging paradigm of incorporating images and biomechanical properties of soft tissues has proven to be an integral part of the advancement of several medical applications, including image guided radiotherapy and surgery, brachytherapy, and diagnostics. This expansion has resulted in a growing community of medical, science, and engineering professionals applying mechanical principles to address medical concerns. This book is tailored to cover a range of mechanical principles, properties, and applications of soft tissues that have previously been addressed in various journals and "anatomical site-specific" books. Biomechanics of Soft Tissues follows a different approach by offering a simplified overview of widely used mechanical models and measuring techniques of soft tissue parameters. This is followed by an investigation of different medical applications, including: biomechanical aspects of cancerous tumor progressions, radiotherapy treatment, and image guided ultrasound guided interventions. Written by leading scholars and professionals in the field, Biomechanics of Soft Tissues combines engineering and medical expertise, thereby producing an excellent source of information for professionals interested in the theoretical and technological advancements related to soft tissues. The book provides medical professionals with an insight on various modeling approaches, testing techniques, and mechanical characteristics that are frequently used by engineers. Conversely, the presented medical applications provide engineers with a glimpse of amazing medical practices and encourage them to expand their roles in the medical field. Provides a simplified overview of mechanics of soft tissues. Highlights different techniques to measure tissues properties for engineering and medical applications. Contains novel ideas to address roles of mechanics in disease progression and treatment. Presents innovative applications of biomechanics in medical procedures.
Ultrasound Elastography for Biomedical Applications and Medicine Ivan Z. Nenadic, Matthew W. Urban, James F. Greenleaf, Mayo Clinic Ultrasound Research Laboratory, Mayo Clinic College of Medicine, USA Jean-Luc Gennisson, Miguel Bernal, Mickael Tanter, Institut Langevin – Ondes et Images, ESPCI ParisTech CNRS, France Covers all major developments and techniques of Ultrasound Elastography and biomedical applications The field of ultrasound elastography has developed various techniques with the potential to diagnose and track the progression of diseases such as breast and thyroid cancer, liver and kidney fibrosis, congestive heart failure, and atherosclerosis. Having emerged in the last decade, ultrasound elastography is a medical imaging modality that can noninvasively measure and map the elastic and viscous properties of soft tissues. Ultrasound Elastography for Biomedical Applications and Medicine covers the basic physics of ultrasound wave propagation and the interaction of ultrasound with various media. The book introduces tissue elastography, covers the history of the field, details the various methods that have been developed by research groups across the world, and describes its novel applications, particularly in shear wave elastography. Key features: Covers all major developments and techniques of ultrasound elastography and biomedical applications. Contributions from the pioneers of the field secure the most complete coverage of ultrasound elastography available. The book is essential reading for researchers and engineers working in ultrasound and elastography, as well as biomedical engineering students and those working in the field of biomechanics.
Book Synopsis Ultrasound Elastography for Biomedical Applications and Medicine by : Ivan Z. Nenadic
Download or read book Ultrasound Elastography for Biomedical Applications and Medicine written by Ivan Z. Nenadic and published by John Wiley & Sons. This book was released on 2018-10-25 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ultrasound Elastography for Biomedical Applications and Medicine Ivan Z. Nenadic, Matthew W. Urban, James F. Greenleaf, Mayo Clinic Ultrasound Research Laboratory, Mayo Clinic College of Medicine, USA Jean-Luc Gennisson, Miguel Bernal, Mickael Tanter, Institut Langevin – Ondes et Images, ESPCI ParisTech CNRS, France Covers all major developments and techniques of Ultrasound Elastography and biomedical applications The field of ultrasound elastography has developed various techniques with the potential to diagnose and track the progression of diseases such as breast and thyroid cancer, liver and kidney fibrosis, congestive heart failure, and atherosclerosis. Having emerged in the last decade, ultrasound elastography is a medical imaging modality that can noninvasively measure and map the elastic and viscous properties of soft tissues. Ultrasound Elastography for Biomedical Applications and Medicine covers the basic physics of ultrasound wave propagation and the interaction of ultrasound with various media. The book introduces tissue elastography, covers the history of the field, details the various methods that have been developed by research groups across the world, and describes its novel applications, particularly in shear wave elastography. Key features: Covers all major developments and techniques of ultrasound elastography and biomedical applications. Contributions from the pioneers of the field secure the most complete coverage of ultrasound elastography available. The book is essential reading for researchers and engineers working in ultrasound and elastography, as well as biomedical engineering students and those working in the field of biomechanics.
Magnetic resonance elastography (MRE) is a medical imaging technique that combines magnetic resonance imaging (MRI) with mechanical vibrations to generate maps of viscoelastic properties of biological tissue. It serves as a non-invasive tool to detect and quantify mechanical changes in tissue structure, which can be symptoms or causes of various diseases. Clinical and research applications of MRE include staging of liver fibrosis, assessment of tumor stiffness and investigation of neurodegenerative diseases. The first part of this book is dedicated to the physical and technological principles underlying MRE, with an introduction to MRI physics, viscoelasticity theory and classical waves, as well as vibration generation, image acquisition and viscoelastic parameter reconstruction. The second part of the book focuses on clinical applications of MRE to various organs. Each section starts with a discussion of the specific properties of the organ, followed by an extensive overview of clinical and preclinical studies that have been performed, tabulating reference values from published literature. The book is completed by a chapter discussing technical aspects of elastography methods based on ultrasound.
Book Synopsis Magnetic Resonance Elastography by : Sebastian Hirsch
Download or read book Magnetic Resonance Elastography written by Sebastian Hirsch and published by John Wiley & Sons. This book was released on 2017-03-20 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Magnetic resonance elastography (MRE) is a medical imaging technique that combines magnetic resonance imaging (MRI) with mechanical vibrations to generate maps of viscoelastic properties of biological tissue. It serves as a non-invasive tool to detect and quantify mechanical changes in tissue structure, which can be symptoms or causes of various diseases. Clinical and research applications of MRE include staging of liver fibrosis, assessment of tumor stiffness and investigation of neurodegenerative diseases. The first part of this book is dedicated to the physical and technological principles underlying MRE, with an introduction to MRI physics, viscoelasticity theory and classical waves, as well as vibration generation, image acquisition and viscoelastic parameter reconstruction. The second part of the book focuses on clinical applications of MRE to various organs. Each section starts with a discussion of the specific properties of the organ, followed by an extensive overview of clinical and preclinical studies that have been performed, tabulating reference values from published literature. The book is completed by a chapter discussing technical aspects of elastography methods based on ultrasound.
Human soft tissues are highly complex networks comprised of a variety of components that contribute to the overall functionality of the tissue, but these structures can be disrupted through injury or pathology, leading to tissue dysfunction. Magnetic resonance elastography (MRE) is a developing imaging technique that has shown promise in evaluating human soft tissues in-vivo by providing mechanical property estimates that are sensitive to structural changes in these tissues, including sensitivity to pathological changes. While MRE has proved to be an effective technique in much of human soft tissue, fibrous soft tissues, such as brain white matter and skeletal muscle, cause standard assumptions of mechanical isotropy to fail, resulting in data-model mismatches and inaccurate evaluations of tissue integrity and health. In this thesis, we propose to develop and test an MRE method to evaluate the health of fibrous soft tissues by evaluating structural and functional changes from pathology or injury.
Book Synopsis Mechanical Evaluation of Structure and Function in Fibrous Soft Tissue Using MR Elastography by : Daniel R. Smith
Download or read book Mechanical Evaluation of Structure and Function in Fibrous Soft Tissue Using MR Elastography written by Daniel R. Smith and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human soft tissues are highly complex networks comprised of a variety of components that contribute to the overall functionality of the tissue, but these structures can be disrupted through injury or pathology, leading to tissue dysfunction. Magnetic resonance elastography (MRE) is a developing imaging technique that has shown promise in evaluating human soft tissues in-vivo by providing mechanical property estimates that are sensitive to structural changes in these tissues, including sensitivity to pathological changes. While MRE has proved to be an effective technique in much of human soft tissue, fibrous soft tissues, such as brain white matter and skeletal muscle, cause standard assumptions of mechanical isotropy to fail, resulting in data-model mismatches and inaccurate evaluations of tissue integrity and health. In this thesis, we propose to develop and test an MRE method to evaluate the health of fibrous soft tissues by evaluating structural and functional changes from pathology or injury.
Elastography, the science of creating noninvasive images of mechanical characteristics of tissues, has been rapidly evolving in recent years. The advantage of this technique resides in the ability to rapidly detect and quantify the changes in the stiffness of soft tissues resulting from specific pathological or physiological processes. Ultrasound elastography is nowadays applied especially on the liver and breast, but the technique has been increasingly used for other tissues including the thyroid, lymph nodes, spleen, pancreas, gastrointestinal tract, kidney, prostate, and the musculoskeletal and vascular systems. This book presents some of the applications of strain and shear-wave ultrasound elastography in hepatic, pancreatic, breast, and musculoskeletal conditions.
Book Synopsis Ultrasound Elastography by : Monica Lupsor-Platon
Download or read book Ultrasound Elastography written by Monica Lupsor-Platon and published by BoD – Books on Demand. This book was released on 2020-03-04 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: Elastography, the science of creating noninvasive images of mechanical characteristics of tissues, has been rapidly evolving in recent years. The advantage of this technique resides in the ability to rapidly detect and quantify the changes in the stiffness of soft tissues resulting from specific pathological or physiological processes. Ultrasound elastography is nowadays applied especially on the liver and breast, but the technique has been increasingly used for other tissues including the thyroid, lymph nodes, spleen, pancreas, gastrointestinal tract, kidney, prostate, and the musculoskeletal and vascular systems. This book presents some of the applications of strain and shear-wave ultrasound elastography in hepatic, pancreatic, breast, and musculoskeletal conditions.
The diagnosis of various pathologies, including some cancers, has long been based on palpation, since a tumor is significantly stiffer than healthy tissue. More advanced and quantitative methods have been developed over the last decades, especially the Magnetic Resonance Elastography (MRE). This method uses magnetic resonance imaging (MRI) on mechanically stressed tissue to estimate the mechanical properties of soft tissue. The reconstruction of the elasticity modulus of the tissue in MRE is often based on a model with simple behavior laws of the imaged tissue (linear elasticity, isotropy, homogeneity), which could be extended to more complex cases thanks to modeling by the Finite Element Method (FEM) in particular. FEM has been used in MRE to simulate the propagation of mechanical waves in a tissue, to better understand the effects of different parameters on MRE measurements, to reconstruct stiffness, to evaluate novel MRE inversion methods, etc. However, in inhomogeneous cases with complex interfaces, FEM modeling can be particularly costly as it requires an explicit mesh of these interfaces. In this work, we explored, using an explicit dynamic FE solver developed in this thesis, the behavior of mechanical waves propagating in a linear, isotropic, viscoelastic and inhomogeneous medium, in order to better control the parameters of a MRE experiment. In the solver, the eXtended Finite Element Method (XFEM) has been implemented; this formulation of FEM originates from fracture mechanics and has been widely used over the last two decades to model discontinuities such as cracks and inclusions. Using the developed numerical tool, we studied the behavior of waves in the vicinity of an interface (oblique or complex), in particular the phenomena of wave reflection and wave conversion. It has been shown that the use of the XFEM method significantly reduces the computation time while ensuring an equivalent accuracy, in terms of displacement fields and reconstructed stiffness. Furthermore, we have addressed, by simulation, the criterion of establishing the steady state of the waves which must be reached to ensure correct recording by MRI. Today, this criterion is still empirical and can influence the quality of MRE data. We have thus proposed a metric to quantify the achievement of the steady state of wave propagation in a tissue with or without inclusion. Finally, these methods were implemented on a practical case of breast MRE. Based on breast models, we evaluated the influence of experimental parameters (size and position of the inclusion, polarization of the excitation, boundary conditions, etc.) on the achievement of steady state.
Book Synopsis Numerical Modeling of MR Elastography Experiment by : Quanshangze Du
Download or read book Numerical Modeling of MR Elastography Experiment written by Quanshangze Du and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The diagnosis of various pathologies, including some cancers, has long been based on palpation, since a tumor is significantly stiffer than healthy tissue. More advanced and quantitative methods have been developed over the last decades, especially the Magnetic Resonance Elastography (MRE). This method uses magnetic resonance imaging (MRI) on mechanically stressed tissue to estimate the mechanical properties of soft tissue. The reconstruction of the elasticity modulus of the tissue in MRE is often based on a model with simple behavior laws of the imaged tissue (linear elasticity, isotropy, homogeneity), which could be extended to more complex cases thanks to modeling by the Finite Element Method (FEM) in particular. FEM has been used in MRE to simulate the propagation of mechanical waves in a tissue, to better understand the effects of different parameters on MRE measurements, to reconstruct stiffness, to evaluate novel MRE inversion methods, etc. However, in inhomogeneous cases with complex interfaces, FEM modeling can be particularly costly as it requires an explicit mesh of these interfaces. In this work, we explored, using an explicit dynamic FE solver developed in this thesis, the behavior of mechanical waves propagating in a linear, isotropic, viscoelastic and inhomogeneous medium, in order to better control the parameters of a MRE experiment. In the solver, the eXtended Finite Element Method (XFEM) has been implemented; this formulation of FEM originates from fracture mechanics and has been widely used over the last two decades to model discontinuities such as cracks and inclusions. Using the developed numerical tool, we studied the behavior of waves in the vicinity of an interface (oblique or complex), in particular the phenomena of wave reflection and wave conversion. It has been shown that the use of the XFEM method significantly reduces the computation time while ensuring an equivalent accuracy, in terms of displacement fields and reconstructed stiffness. Furthermore, we have addressed, by simulation, the criterion of establishing the steady state of the waves which must be reached to ensure correct recording by MRI. Today, this criterion is still empirical and can influence the quality of MRE data. We have thus proposed a metric to quantify the achievement of the steady state of wave propagation in a tissue with or without inclusion. Finally, these methods were implemented on a practical case of breast MRE. Based on breast models, we evaluated the influence of experimental parameters (size and position of the inclusion, polarization of the excitation, boundary conditions, etc.) on the achievement of steady state.
A practical how-to manual on breast elastography This comprehensive reference covers the principles and techniques used in performing breast elastography, an innovative imaging technology that can dramatically reduce the need for biopsies. The book begins with an introduction of the techniques, followed by sections on how to perform each technique and methods of interpretation, and concludes with more than 60 detailed case studies. Key Features: Includes case studies covering a wide range of breast pathologies and illustrating the use of all available elastography techniques to help radiologists obtain the best images for each pathology Covers all methods of breast elastography, including sheer wave and strain wave Contains more than 200 high-quality color images that demonstrate how to perform each technique Breast Elastography is an essential reference for all radiologists, residents and fellows, and sonographers involved in breast imaging and evaluation.
Book Synopsis Breast Elastography by : Richard G. Barr
Download or read book Breast Elastography written by Richard G. Barr and published by Thieme. This book was released on 2015-01-28 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practical how-to manual on breast elastography This comprehensive reference covers the principles and techniques used in performing breast elastography, an innovative imaging technology that can dramatically reduce the need for biopsies. The book begins with an introduction of the techniques, followed by sections on how to perform each technique and methods of interpretation, and concludes with more than 60 detailed case studies. Key Features: Includes case studies covering a wide range of breast pathologies and illustrating the use of all available elastography techniques to help radiologists obtain the best images for each pathology Covers all methods of breast elastography, including sheer wave and strain wave Contains more than 200 high-quality color images that demonstrate how to perform each technique Breast Elastography is an essential reference for all radiologists, residents and fellows, and sonographers involved in breast imaging and evaluation.
