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Hematopoietic stem cells (HSCs) continuously give rise to all lasses of blood cells, which belong to either the lymphoid or myeloid cell lineages, through multiple steps of lineage restriction. It remains unclear how HSCs commit to either the lymphoid or myeloid lineage during early hematopoietic differentiation. My thesis project focused on characterizing multipotent progenitors (MPPs), which are progenies of HSCs that have lost self-renewing ability but retain multi-lineage differentiation potential, in order to understand the developmental events that occur prior to lymphoid lineage commitment.
Book Synopsis Mechanisms of Lymphoid Lineage Commitment from Hematopoietic Stem Cell by : Anne Lai
Download or read book Mechanisms of Lymphoid Lineage Commitment from Hematopoietic Stem Cell written by Anne Lai and published by ProQuest. This book was released on 2007 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hematopoietic stem cells (HSCs) continuously give rise to all lasses of blood cells, which belong to either the lymphoid or myeloid cell lineages, through multiple steps of lineage restriction. It remains unclear how HSCs commit to either the lymphoid or myeloid lineage during early hematopoietic differentiation. My thesis project focused on characterizing multipotent progenitors (MPPs), which are progenies of HSCs that have lost self-renewing ability but retain multi-lineage differentiation potential, in order to understand the developmental events that occur prior to lymphoid lineage commitment.
Handbook of Benign Hematology is a practical guide to the diagnosis and management of benign hematologic conditions. The book begins with a chapter on normal hematopoiesis and follows with chapters devoted to groups of blood disorders and syndromes including neutrophil disorders, nonmalignant myeloid disorders, bone marrow failure syndromes, myeloproliferative disorders, anemias, iron metabolism disorders, platelet disorders, hemostasis and coagulation defects, and thrombosis. Each disorder subtype covered features a clinical case, an introduction to the condition, details on diagnosis including applicable criteria and lab work needed, key diagnostic dilemmas, prognosis, treatment options, details on clinical trials and emerging clinical strategies, and bulleted key points to highlight clinical pearls and common pitfalls. The final chapters provide best practices for transfusion medicine and a guide to pharmacologic agents and their uses in clinical practice for adult and pediatric patients. The handbook is filled with tables and illustrations which highlight FDA-approved drug information, clinical trials data, hematopathologic characteristics of different disorders, important management criteria and more, making it the ideal handbook for those in practice or for review. The Editors and chapter authors are experienced academic practitioners in the fields of adult and pediatric hematology, pathology, blood banking, and pharmacology. Emphasizing best practices for patient management, this handbook is essential for oncologists, hematologists, trainees, and other practitioners who regularly or increasingly receive referrals to diagnose and treat adults or children with nonmalignant hematologic conditions. Key Features: Includes dozens of clinical cases covering all nonmalignant blood disorders Emphasizes patient management and best practices for disorders seen in adults and children Contains over 30 color images and numerous tables for quick reference Presents important details of all pharmacologic agents used to treat or manage hematologic disorders and their complications Purchase includes access to the ebook for use on most mobile devices or computers
Book Synopsis Handbook of Benign Hematology by : Martha Pritchett Mims, MD, PhD
Download or read book Handbook of Benign Hematology written by Martha Pritchett Mims, MD, PhD and published by Springer Publishing Company. This book was released on 2019-12-11 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Benign Hematology is a practical guide to the diagnosis and management of benign hematologic conditions. The book begins with a chapter on normal hematopoiesis and follows with chapters devoted to groups of blood disorders and syndromes including neutrophil disorders, nonmalignant myeloid disorders, bone marrow failure syndromes, myeloproliferative disorders, anemias, iron metabolism disorders, platelet disorders, hemostasis and coagulation defects, and thrombosis. Each disorder subtype covered features a clinical case, an introduction to the condition, details on diagnosis including applicable criteria and lab work needed, key diagnostic dilemmas, prognosis, treatment options, details on clinical trials and emerging clinical strategies, and bulleted key points to highlight clinical pearls and common pitfalls. The final chapters provide best practices for transfusion medicine and a guide to pharmacologic agents and their uses in clinical practice for adult and pediatric patients. The handbook is filled with tables and illustrations which highlight FDA-approved drug information, clinical trials data, hematopathologic characteristics of different disorders, important management criteria and more, making it the ideal handbook for those in practice or for review. The Editors and chapter authors are experienced academic practitioners in the fields of adult and pediatric hematology, pathology, blood banking, and pharmacology. Emphasizing best practices for patient management, this handbook is essential for oncologists, hematologists, trainees, and other practitioners who regularly or increasingly receive referrals to diagnose and treat adults or children with nonmalignant hematologic conditions. Key Features: Includes dozens of clinical cases covering all nonmalignant blood disorders Emphasizes patient management and best practices for disorders seen in adults and children Contains over 30 color images and numerous tables for quick reference Presents important details of all pharmacologic agents used to treat or manage hematologic disorders and their complications Purchase includes access to the ebook for use on most mobile devices or computers
Although much is known with respect to blood cell formation and function, many new concepts in the areas of the regulation of hematopoietic stem cell commitment and the subsequent survival, proliferation, and differentiation of progenitors have been elucidated in the last five years. Our understanding of the microenvironment where stem cells reside and commit to distinct blood types (the niche) has grown significantly in recent years. Furthermore, blood cells have been used as the key model system to study microRNA function and the role of microRNAs in the transformation of normal cells into cancer cells. The current volume Molecular Basis of Hematopoiesis, edited by Amittha Wickrema & Barbara Kee, provides the most recent developments in the area in addition to a chapter on the utilization of basic science knowledge for the treatment of blood diseases. Each chapter in this book has been written and edited by faculty in major academic and research institutions around the world, who are pushing the frontiers of research in this important area.
Book Synopsis Molecular Basis of Hematopoiesis by : Amittha Wickrema
Download or read book Molecular Basis of Hematopoiesis written by Amittha Wickrema and published by Springer Science & Business Media. This book was released on 2008-12-26 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although much is known with respect to blood cell formation and function, many new concepts in the areas of the regulation of hematopoietic stem cell commitment and the subsequent survival, proliferation, and differentiation of progenitors have been elucidated in the last five years. Our understanding of the microenvironment where stem cells reside and commit to distinct blood types (the niche) has grown significantly in recent years. Furthermore, blood cells have been used as the key model system to study microRNA function and the role of microRNAs in the transformation of normal cells into cancer cells. The current volume Molecular Basis of Hematopoiesis, edited by Amittha Wickrema & Barbara Kee, provides the most recent developments in the area in addition to a chapter on the utilization of basic science knowledge for the treatment of blood diseases. Each chapter in this book has been written and edited by faculty in major academic and research institutions around the world, who are pushing the frontiers of research in this important area.
Mast Cells and Basophils will be essential reading for immunologists, biochemists and medical researchers. Detailed chapters cover all aspects of mast cell and basophil research, from cell development, proteases, histamine, cysteinyl leukotrienes, physiology and pathology to the role of these cells in health and disease. Chapters also discuss the clinical implications of histamine receptor antagonists.
Book Synopsis Mast Cells and Basophils by : Gianni Marone
Download or read book Mast Cells and Basophils written by Gianni Marone and published by Academic Press. This book was released on 2000-05-25 with total page 738 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mast Cells and Basophils will be essential reading for immunologists, biochemists and medical researchers. Detailed chapters cover all aspects of mast cell and basophil research, from cell development, proteases, histamine, cysteinyl leukotrienes, physiology and pathology to the role of these cells in health and disease. Chapters also discuss the clinical implications of histamine receptor antagonists.
Understanding the molecular mechanisms that govern human hematopoiesis remains a major goal of both developmental and clinical biology. My thesis projects focus on identifying and characterizing regulatory factors involved in myeloid commitment steps for human hematopoietic stem and progenitor cells (HSPCs), so as to expand them in vitro or direct them into desired lineages. I first studied the histone methyltransferases G9a and GLP, which play key roles during mammalian development through mono- and di-methylation of histone H3 lysine 9 (H3K9me1/2), modifications associated with transcriptional repression. I found that G9a/GLP activity drives progressive, genome-wide H3K9me2 patterning in euchromatin during HSPC lineage specification. Remarkably, HSPCs continuously treated with UNC0638, a G9a/GLP small molecular inhibitor, better retain stem cell-like phenotypes and function during in vitro expansion. This expansion effect was further enhanced by co-treatment of SR1, an aryl hydrocarbon receptor (AHR) inhibitor. Moreover, UNC0638 treated HSPCs preferentially gave rise to megakaryocytes over other myeloid lineages when differentiating. These results suggest that G9a/GLP activity facilitates human HSPC lineage commitment and inform clinical manipulation of donor-derived HSPCs in vitro. I also applied a high-throughput shRNA screening approach to identify genes controlling early myeloid differentiation of human HSPC. To aid in identification of candidate screen hits, data from the shRNA screen were compared to known hematopoietic/hematopoietic malignancy functions and mouse HSC eQTLs. Potential self-renewal and differentiation genes were validated by a secondary screen. Further functional validations will involve gene knockdown experiments followed by flow analysis, colony-forming unit assays, and in vivo experiments in a canine transplantation model. Ultimately our results will facilitate in vitro and in vivo manipulations of human HSPC to control lineage commitment.
Book Synopsis Regulation of Human Hematopoietic Stem Cell Lineage Commitment by : Xiaoji Chen
Download or read book Regulation of Human Hematopoietic Stem Cell Lineage Commitment written by Xiaoji Chen and published by . This book was released on 2013 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding the molecular mechanisms that govern human hematopoiesis remains a major goal of both developmental and clinical biology. My thesis projects focus on identifying and characterizing regulatory factors involved in myeloid commitment steps for human hematopoietic stem and progenitor cells (HSPCs), so as to expand them in vitro or direct them into desired lineages. I first studied the histone methyltransferases G9a and GLP, which play key roles during mammalian development through mono- and di-methylation of histone H3 lysine 9 (H3K9me1/2), modifications associated with transcriptional repression. I found that G9a/GLP activity drives progressive, genome-wide H3K9me2 patterning in euchromatin during HSPC lineage specification. Remarkably, HSPCs continuously treated with UNC0638, a G9a/GLP small molecular inhibitor, better retain stem cell-like phenotypes and function during in vitro expansion. This expansion effect was further enhanced by co-treatment of SR1, an aryl hydrocarbon receptor (AHR) inhibitor. Moreover, UNC0638 treated HSPCs preferentially gave rise to megakaryocytes over other myeloid lineages when differentiating. These results suggest that G9a/GLP activity facilitates human HSPC lineage commitment and inform clinical manipulation of donor-derived HSPCs in vitro. I also applied a high-throughput shRNA screening approach to identify genes controlling early myeloid differentiation of human HSPC. To aid in identification of candidate screen hits, data from the shRNA screen were compared to known hematopoietic/hematopoietic malignancy functions and mouse HSC eQTLs. Potential self-renewal and differentiation genes were validated by a secondary screen. Further functional validations will involve gene knockdown experiments followed by flow analysis, colony-forming unit assays, and in vivo experiments in a canine transplantation model. Ultimately our results will facilitate in vitro and in vivo manipulations of human HSPC to control lineage commitment.
Book Synopsis Progress in Hematology by : Elmer B. Brown
Download or read book Progress in Hematology written by Elmer B. Brown and published by . This book was released on 1964 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
This book represents a synergic effort of an international team of specialists in immunology to expand the scientific achievements in the field of lymphocytes. It offers important and specific updated information to researchers, students, teachers, and medical professionals. Moreover, considering the remarkable dynamics of immunology and immunotherapy, this book "Lymphocyte Updates - Cancer, Autoimmunity, and Infection" aims to represent a significant source of concise scientific data and advancement of knowledge in this field. The chapters offer new insights into the latest scientific progress on lymphocyte roles in protective immunity, as well as their involvement in pathogenesis of various disorders.
Book Synopsis Lymphocyte Updates by : Gheorghita Isvoranu
Download or read book Lymphocyte Updates written by Gheorghita Isvoranu and published by BoD – Books on Demand. This book was released on 2017-07-12 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book represents a synergic effort of an international team of specialists in immunology to expand the scientific achievements in the field of lymphocytes. It offers important and specific updated information to researchers, students, teachers, and medical professionals. Moreover, considering the remarkable dynamics of immunology and immunotherapy, this book "Lymphocyte Updates - Cancer, Autoimmunity, and Infection" aims to represent a significant source of concise scientific data and advancement of knowledge in this field. The chapters offer new insights into the latest scientific progress on lymphocyte roles in protective immunity, as well as their involvement in pathogenesis of various disorders.
This book is open access under a CC BY 4.0 license. This textbook, endorsed by the European Society for Blood and Marrow Transplantation (EBMT), provides adult and paediatric nurses with a full and informative guide covering all aspects of transplant nursing, from basic principles to advanced concepts. It takes the reader on a journey through the history of transplant nursing, including essential and progressive elements to help nurses improve their knowledge and benefit the patient experience, as well as a comprehensive introduction to research and auditing methods. This new volume specifically intended for nurses, complements the ESH-EBMT reference title, a popular educational resource originally developed in 2003 for physicians to accompany an annual training course also serving as an educational tool in its own right. This title is designed to develop the knowledge of nurses in transplantation. It is the first book of its kind specifically targeted at nurses in this specialist field and acknowledges the valuable contribution that nursing makes in this area. This volume presents information that is essential for the education of nurses new to transplantation, while also offering a valuable resource for more experienced nurses who wish to update their knowledge.
Book Synopsis The European Blood and Marrow Transplantation Textbook for Nurses by : Michelle Kenyon
Download or read book The European Blood and Marrow Transplantation Textbook for Nurses written by Michelle Kenyon and published by Springer. This book was released on 2018-03-14 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is open access under a CC BY 4.0 license. This textbook, endorsed by the European Society for Blood and Marrow Transplantation (EBMT), provides adult and paediatric nurses with a full and informative guide covering all aspects of transplant nursing, from basic principles to advanced concepts. It takes the reader on a journey through the history of transplant nursing, including essential and progressive elements to help nurses improve their knowledge and benefit the patient experience, as well as a comprehensive introduction to research and auditing methods. This new volume specifically intended for nurses, complements the ESH-EBMT reference title, a popular educational resource originally developed in 2003 for physicians to accompany an annual training course also serving as an educational tool in its own right. This title is designed to develop the knowledge of nurses in transplantation. It is the first book of its kind specifically targeted at nurses in this specialist field and acknowledges the valuable contribution that nursing makes in this area. This volume presents information that is essential for the education of nurses new to transplantation, while also offering a valuable resource for more experienced nurses who wish to update their knowledge.
Book Synopsis Molecular Biology of The Cell by : Bruce Alberts
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Tissue-specific stem cells have the capacity to self-renew and differentiate into several types of functional cells that replenish lost cells throughout an organism?s lifetime. Studies on stem cells from diverse systems have shown that stem cell function is controlled by extracellular cues from the niche and by intrinsic genetic programs within the stem cell. The objectives of this book would be to review the molecular mechanisms that mediate the balanced response of stem cells to the needs of the organisms. Likewise, niches have also been linked to pathologies, by imposing aberrant function on stem cells or other targets. Therefore, the second objective of this book would be to highligh the molecular dysregulation of niche biology leading to the disease. The third objective would be to review the therapeutical targets described within stem cell niches.
Book Synopsis Adult Stem Cell Niches by : Sabine Wislet
Download or read book Adult Stem Cell Niches written by Sabine Wislet and published by BoD – Books on Demand. This book was released on 2014-08-01 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tissue-specific stem cells have the capacity to self-renew and differentiate into several types of functional cells that replenish lost cells throughout an organism?s lifetime. Studies on stem cells from diverse systems have shown that stem cell function is controlled by extracellular cues from the niche and by intrinsic genetic programs within the stem cell. The objectives of this book would be to review the molecular mechanisms that mediate the balanced response of stem cells to the needs of the organisms. Likewise, niches have also been linked to pathologies, by imposing aberrant function on stem cells or other targets. Therefore, the second objective of this book would be to highligh the molecular dysregulation of niche biology leading to the disease. The third objective would be to review the therapeutical targets described within stem cell niches.
