Membranes to Molecular Machines

Membranes to Molecular Machines

Author: Mathias Grote

Publisher: University of Chicago Press

Published: 2019-07-09

Total Pages: 307

ISBN-13: 022662515X

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Today's science tells us that our bodies are filled with molecular machinery that orchestrates all sorts of life processes. When we think, microscopic "channels" open and close in our brain cell membranes; when we run, tiny "motors" spin in our muscle cell membranes; and when we see, light operates "molecular switches" in our eyes and nerves. A molecular-mechanical vision of life has become commonplace in both the halls of philosophy and the offices of drug companies, where researchers are developing “proton pump inhibitors” or medicines similar to Prozac. Membranes to Molecular Machines explores just how late twentieth-century science came to think of our cells and bodies this way. This story is told through the lens of membrane research, an unwritten history at the crossroads of molecular biology, biochemistry, physiology, and the neurosciences, that directly feeds into today's synthetic biology as well as nano- and biotechnology. Mathias Grote shows how these sciences not only have made us think differently about life, they have, by reworking what membranes and proteins represent in laboratories, allowed us to manipulate life as "active matter" in new ways. Covering the science of biological membranes in the United States and Europe from the mid-1960s to the 1990s, this book connects that history to contemporary work with optogenetics, a method for stimulating individual neurons using light, and will enlighten and provoke anyone interested in the intersection of chemical research and the life sciences—from practitioner to historian to philosopher.


Book Synopsis Membranes to Molecular Machines by : Mathias Grote

Download or read book Membranes to Molecular Machines written by Mathias Grote and published by University of Chicago Press. This book was released on 2019-07-09 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Today's science tells us that our bodies are filled with molecular machinery that orchestrates all sorts of life processes. When we think, microscopic "channels" open and close in our brain cell membranes; when we run, tiny "motors" spin in our muscle cell membranes; and when we see, light operates "molecular switches" in our eyes and nerves. A molecular-mechanical vision of life has become commonplace in both the halls of philosophy and the offices of drug companies, where researchers are developing “proton pump inhibitors” or medicines similar to Prozac. Membranes to Molecular Machines explores just how late twentieth-century science came to think of our cells and bodies this way. This story is told through the lens of membrane research, an unwritten history at the crossroads of molecular biology, biochemistry, physiology, and the neurosciences, that directly feeds into today's synthetic biology as well as nano- and biotechnology. Mathias Grote shows how these sciences not only have made us think differently about life, they have, by reworking what membranes and proteins represent in laboratories, allowed us to manipulate life as "active matter" in new ways. Covering the science of biological membranes in the United States and Europe from the mid-1960s to the 1990s, this book connects that history to contemporary work with optogenetics, a method for stimulating individual neurons using light, and will enlighten and provoke anyone interested in the intersection of chemical research and the life sciences—from practitioner to historian to philosopher.


Molecular Machines

Molecular Machines

Author: Benoît Roux

Publisher: World Scientific

Published: 2011

Total Pages: 288

ISBN-13: 9814343463

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Ch. 1. Molecular behavior in biological cells : the bacterial cytoplasm as a model system / Adrian H. Elcock and Andrew S. Thomas -- ch. 2. The light-harvesting apparatus in purple photosynthetic bacteria : introduction to a quantum biological device / Johan Strumpfer [und weitere] -- ch. 3. DNA polymerases : structure, function, and modeling / Tamar Schlick -- ch. 4. Information processing by nanomachines : decoding by the ribosome / Karissa Y. Sanbonmatsu, Scott C. Blanchard and Paul C. Whitford -- ch. 5. Chaperonins : the machines which fold proteins / Del Lucent, Martin C Stumpe and Vijay S Pande -- ch. 6. Muscle and myosin / Ronald S. Rock -- ch. 7. Protein kinases : phosphorylation machines / Elaine E. Thompson, Susan S. Taylor and J. Andrew McCammon -- ch. 8. Computational studies of Na+/H+ antiporter : structure, dynamics and function / Assaf Ganoth, Raphael Alhadeff and Isaiah T. Arkin -- ch. 9. Membrane transporters : molecular machines coupling cellular energy to vectorial transport across the membrane / Zhijian Huang [und weitere] -- ch. 10. ABC transporters / E.P. Coll and D.P. Tieleman -- ch. 11. Sodium-coupled secondary transporters : insights from structure-based computations / Elia Zomot [und weitere] -- ch. 12. Voltage-gated ion channels : the machines responsible for the nerve impulse / Benoit Roux and Francisco Bezanilla -- ch. 13. Voltage-gated channels and the heart / Jonathan R. Silva and Yoram Rudy


Book Synopsis Molecular Machines by : Benoît Roux

Download or read book Molecular Machines written by Benoît Roux and published by World Scientific. This book was released on 2011 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ch. 1. Molecular behavior in biological cells : the bacterial cytoplasm as a model system / Adrian H. Elcock and Andrew S. Thomas -- ch. 2. The light-harvesting apparatus in purple photosynthetic bacteria : introduction to a quantum biological device / Johan Strumpfer [und weitere] -- ch. 3. DNA polymerases : structure, function, and modeling / Tamar Schlick -- ch. 4. Information processing by nanomachines : decoding by the ribosome / Karissa Y. Sanbonmatsu, Scott C. Blanchard and Paul C. Whitford -- ch. 5. Chaperonins : the machines which fold proteins / Del Lucent, Martin C Stumpe and Vijay S Pande -- ch. 6. Muscle and myosin / Ronald S. Rock -- ch. 7. Protein kinases : phosphorylation machines / Elaine E. Thompson, Susan S. Taylor and J. Andrew McCammon -- ch. 8. Computational studies of Na+/H+ antiporter : structure, dynamics and function / Assaf Ganoth, Raphael Alhadeff and Isaiah T. Arkin -- ch. 9. Membrane transporters : molecular machines coupling cellular energy to vectorial transport across the membrane / Zhijian Huang [und weitere] -- ch. 10. ABC transporters / E.P. Coll and D.P. Tieleman -- ch. 11. Sodium-coupled secondary transporters : insights from structure-based computations / Elia Zomot [und weitere] -- ch. 12. Voltage-gated ion channels : the machines responsible for the nerve impulse / Benoit Roux and Francisco Bezanilla -- ch. 13. Voltage-gated channels and the heart / Jonathan R. Silva and Yoram Rudy


Cell Biology by the Numbers

Cell Biology by the Numbers

Author: Ron Milo

Publisher: Garland Science

Published: 2015-12-07

Total Pages: 400

ISBN-13: 1317230698

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A Top 25 CHOICE 2016 Title, and recipient of the CHOICE Outstanding Academic Title (OAT) Award. How much energy is released in ATP hydrolysis? How many mRNAs are in a cell? How genetically similar are two random people? What is faster, transcription or translation?Cell Biology by the Numbers explores these questions and dozens of others provid


Book Synopsis Cell Biology by the Numbers by : Ron Milo

Download or read book Cell Biology by the Numbers written by Ron Milo and published by Garland Science. This book was released on 2015-12-07 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Top 25 CHOICE 2016 Title, and recipient of the CHOICE Outstanding Academic Title (OAT) Award. How much energy is released in ATP hydrolysis? How many mRNAs are in a cell? How genetically similar are two random people? What is faster, transcription or translation?Cell Biology by the Numbers explores these questions and dozens of others provid


Life's Ratchet

Life's Ratchet

Author: Peter M. Hoffmann

Publisher:

Published: 2012-10-30

Total Pages: 290

ISBN-13: 0465022537

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Life, Hoffman argues, emerges from the random motions of atoms filtered through the sophisticated structures of our evolved machinery. People are essentially giant assemblies of interacting nanoscale machines.


Book Synopsis Life's Ratchet by : Peter M. Hoffmann

Download or read book Life's Ratchet written by Peter M. Hoffmann and published by . This book was released on 2012-10-30 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Life, Hoffman argues, emerges from the random motions of atoms filtered through the sophisticated structures of our evolved machinery. People are essentially giant assemblies of interacting nanoscale machines.


Concepts for Molecular Machines

Concepts for Molecular Machines

Author: Jubaraj Bikash Baruah

Publisher: World Scientific Publishing Company

Published: 2017-08-11

Total Pages: 180

ISBN-13: 9813223723

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Actions of living beings at any stage of life are of general interest; molecular machines can be a replica of such activities. Stimuli guided movements and shape changes of molecules are one of the rapidly developing areas on which fundamental principles of molecular machine banks. Thus, the understanding of intriguing concepts of molecular machines is essential. Miniaturization, efficiency, stability and robustness in performing activities are some of the important points associated with molecular machines. Using molecular machines for practical purposes will further strengthen fundamentals of science and technology and also guide future market economy. Recent advent of techniques to handle materials at microscopic level has benefited the topic of molecular machines and is ready to be taken to a higher level as compared to other competing topics of science and technology. Molecular machines is a contemporary hot topic with future scope. The Nobel Prize in the year 2016 was shared by three scientists Prof. Ben Feringa, Prof. J Fraser Stoddart and Prof. Jean-Pierre Sauvage for their contribution to the topic. This book on molecular machines is aimed to cater to the need of graduate students and researchers by providing the fundamental aspects on molecular machines. Contents: Introduction to Molecular Machines:Preliminary Aspects of a Conventional MachineMiniaturization of MachinesMolecular MachineTerminology in Molecular MachinesBio-inspired Concepts in the Development of Molecular MachinesEnergetics and States of Molecular MachinesBiological Molecular MachinesOperational Aspects of Molecular Machines:BackgroundStructural EquilibrationMolecular Machine DesignInterlocked Systems as Molecular Machines:Principles for Formation of Interlocked MoleculesCatenanesRotaxanesThermodynamics of Interlocked SystemsShuttling Motion in RotaxanesSwitching in RotaxanesKnotsControllable Properties in Rotaxanes Relating to Molecular MachinesMolecular Machine for Peptide SynthesisA Molecular ElevatorLogic Gate Based on RotaxanePhotochemically and Electrochemically Guided Molecular Machines:Principles of Photochemical SwitchingElectrochemically Driven MachinesArtificial Molecular Machine Based on DNA:PrinciplesDNA TweezersDNA WalkerDNA Based Molecular GearpH Dependent DNA Nano-machineMolecular AssemblerTrends of Study Readership: Chemists, biochemists, glycobiologists, materials scientists, students in biochemistry and biology.


Book Synopsis Concepts for Molecular Machines by : Jubaraj Bikash Baruah

Download or read book Concepts for Molecular Machines written by Jubaraj Bikash Baruah and published by World Scientific Publishing Company. This book was released on 2017-08-11 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Actions of living beings at any stage of life are of general interest; molecular machines can be a replica of such activities. Stimuli guided movements and shape changes of molecules are one of the rapidly developing areas on which fundamental principles of molecular machine banks. Thus, the understanding of intriguing concepts of molecular machines is essential. Miniaturization, efficiency, stability and robustness in performing activities are some of the important points associated with molecular machines. Using molecular machines for practical purposes will further strengthen fundamentals of science and technology and also guide future market economy. Recent advent of techniques to handle materials at microscopic level has benefited the topic of molecular machines and is ready to be taken to a higher level as compared to other competing topics of science and technology. Molecular machines is a contemporary hot topic with future scope. The Nobel Prize in the year 2016 was shared by three scientists Prof. Ben Feringa, Prof. J Fraser Stoddart and Prof. Jean-Pierre Sauvage for their contribution to the topic. This book on molecular machines is aimed to cater to the need of graduate students and researchers by providing the fundamental aspects on molecular machines. Contents: Introduction to Molecular Machines:Preliminary Aspects of a Conventional MachineMiniaturization of MachinesMolecular MachineTerminology in Molecular MachinesBio-inspired Concepts in the Development of Molecular MachinesEnergetics and States of Molecular MachinesBiological Molecular MachinesOperational Aspects of Molecular Machines:BackgroundStructural EquilibrationMolecular Machine DesignInterlocked Systems as Molecular Machines:Principles for Formation of Interlocked MoleculesCatenanesRotaxanesThermodynamics of Interlocked SystemsShuttling Motion in RotaxanesSwitching in RotaxanesKnotsControllable Properties in Rotaxanes Relating to Molecular MachinesMolecular Machine for Peptide SynthesisA Molecular ElevatorLogic Gate Based on RotaxanePhotochemically and Electrochemically Guided Molecular Machines:Principles of Photochemical SwitchingElectrochemically Driven MachinesArtificial Molecular Machine Based on DNA:PrinciplesDNA TweezersDNA WalkerDNA Based Molecular GearpH Dependent DNA Nano-machineMolecular AssemblerTrends of Study Readership: Chemists, biochemists, glycobiologists, materials scientists, students in biochemistry and biology.


Molecular Machines

Molecular Machines

Author: Anthony Gordon Lee

Publisher:

Published: 1996

Total Pages: 30

ISBN-13: 9780854325771

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Book Synopsis Molecular Machines by : Anthony Gordon Lee

Download or read book Molecular Machines written by Anthony Gordon Lee and published by . This book was released on 1996 with total page 30 pages. Available in PDF, EPUB and Kindle. Book excerpt:


The Enzymes

The Enzymes

Author: Ross Dalbey

Publisher: Elsevier

Published: 2007-08-28

Total Pages: 651

ISBN-13: 0080552161

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This volume of The Enzymes features high-caliber thematic articles on the topic of molecular machines involved in protein transport across cellular membranes. The book consists of five parts which span the range of membranes including bacterial, endoplasmic reticulum, mitochondrial, chloroplast, and peroxismal.


Book Synopsis The Enzymes by : Ross Dalbey

Download or read book The Enzymes written by Ross Dalbey and published by Elsevier. This book was released on 2007-08-28 with total page 651 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of The Enzymes features high-caliber thematic articles on the topic of molecular machines involved in protein transport across cellular membranes. The book consists of five parts which span the range of membranes including bacterial, endoplasmic reticulum, mitochondrial, chloroplast, and peroxismal.


Mechanisms of Primary Energy Transduction in Biology

Mechanisms of Primary Energy Transduction in Biology

Author: Mårten Wikström

Publisher: Royal Society of Chemistry

Published: 2017-11-28

Total Pages: 396

ISBN-13: 1782628657

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This book describes the events of primary energy transduction in life processes. Life as we know it depends on pumping protons across membranes. New tools to study the protein complexes involved has led to recent intensified progress in the field. Primary Energy Transduction in Biology focusses on recent structural results and new biophysical insights. These have been made possible by recent advances in high-resolution protein structures, in physical techniques to study reactions in real time, and in computational methods to study and refine both structures and their dynamics. Written and edited by leading experts, chapters discuss the latest key questions in cell respiration, photosynthesis, bioenergetics, proton transfer, electron transfer and membrane transport. Biochemists, biophysicists and chemical biologists will find this book an essential resource for a complete understanding of the molecular machines of bioenergetics.


Book Synopsis Mechanisms of Primary Energy Transduction in Biology by : Mårten Wikström

Download or read book Mechanisms of Primary Energy Transduction in Biology written by Mårten Wikström and published by Royal Society of Chemistry. This book was released on 2017-11-28 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the events of primary energy transduction in life processes. Life as we know it depends on pumping protons across membranes. New tools to study the protein complexes involved has led to recent intensified progress in the field. Primary Energy Transduction in Biology focusses on recent structural results and new biophysical insights. These have been made possible by recent advances in high-resolution protein structures, in physical techniques to study reactions in real time, and in computational methods to study and refine both structures and their dynamics. Written and edited by leading experts, chapters discuss the latest key questions in cell respiration, photosynthesis, bioenergetics, proton transfer, electron transfer and membrane transport. Biochemists, biophysicists and chemical biologists will find this book an essential resource for a complete understanding of the molecular machines of bioenergetics.


Molecular Biology of The Cell

Molecular Biology of The Cell

Author: Bruce Alberts

Publisher:

Published: 2002

Total Pages: 0

ISBN-13: 9780815332183

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Book Synopsis Molecular Biology of The Cell by : Bruce Alberts

Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:


Computational Biophysics of Membrane Proteins

Computational Biophysics of Membrane Proteins

Author: Carmen Domene

Publisher: Royal Society of Chemistry

Published: 2016-11-30

Total Pages: 264

ISBN-13: 1782626697

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Exploring current themes in modern computational and membrane protein biophysics, this book presents a comprehensive account of the fundamental principles underlying different methods and techniques used to describe the intriguing mechanisms by which membrane proteins function. The book discusses the experimental approaches employed to study these proteins, with chapters reviewing recent crucial structural advances that have allowed computational biophysicists to discern how these molecular machines work. The book then explores what computational methods are available to researchers and what these have taught us about three key families of membrane proteins: ion channels, transporters and receptors. The book is ideal for researchers in computational chemistry and computational biophysics.


Book Synopsis Computational Biophysics of Membrane Proteins by : Carmen Domene

Download or read book Computational Biophysics of Membrane Proteins written by Carmen Domene and published by Royal Society of Chemistry. This book was released on 2016-11-30 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exploring current themes in modern computational and membrane protein biophysics, this book presents a comprehensive account of the fundamental principles underlying different methods and techniques used to describe the intriguing mechanisms by which membrane proteins function. The book discusses the experimental approaches employed to study these proteins, with chapters reviewing recent crucial structural advances that have allowed computational biophysicists to discern how these molecular machines work. The book then explores what computational methods are available to researchers and what these have taught us about three key families of membrane proteins: ion channels, transporters and receptors. The book is ideal for researchers in computational chemistry and computational biophysics.