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All the latest tools needed to plan and perform the synthesis of complex bioactive molecules Focusing on organic, organometallic, and bio-oriented processes, this book explores the impact and use of the latest synthetic tools for the synthesis of complex biologically active compounds. Readers will discover step by step how these synthetic tools have provided new, elegant solutions to many synthetic puzzles. Moreover, they will discover innovative methods that make it possible to control the exact connectivity of atoms within a molecule in order to set precise three-dimensional arrangements. Modern Tools for the Synthesis of Complex Bioactive Molecules features sixteen chapters, each one written by one or more leading experts in organic synthesis from around the world. It covers a broad range of topics that enable readers to take advantage of the latest methods for synthesizing complex molecules, including: Modern catalysis, emphasizing key transformations such as C-H functionalizations, cross-couplings, gold-catalyzed reactions, metathesis-based syntheses, and asymmetric organocatalysis Eco-compatible transformations, including rearrangements and domino reactions Tools for the synthesis of carbohydrates and alkaloids New techniques, including the use of fluorous tags and engineered biosynthesis The last two chapters explore target- and diversity-oriented organic synthesis as well as the use of DNA-based asymmetric catalysis, which are all promising tools for the successful synthesis of complex bioactive molecules. Modern Tools for the Synthesis of Complex Bioactive Molecules is ideal for students and researchers who need to plan and perform the synthesis of complex molecules as efficiently as possible. The book's expert advice will help these readers quickly resolve a broad range of problems that can arise in organic syntheses.
Book Synopsis Modern Tools for the Synthesis of Complex Bioactive Molecules by : Janine Cossy
Download or read book Modern Tools for the Synthesis of Complex Bioactive Molecules written by Janine Cossy and published by John Wiley & Sons. This book was released on 2012-10-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: All the latest tools needed to plan and perform the synthesis of complex bioactive molecules Focusing on organic, organometallic, and bio-oriented processes, this book explores the impact and use of the latest synthetic tools for the synthesis of complex biologically active compounds. Readers will discover step by step how these synthetic tools have provided new, elegant solutions to many synthetic puzzles. Moreover, they will discover innovative methods that make it possible to control the exact connectivity of atoms within a molecule in order to set precise three-dimensional arrangements. Modern Tools for the Synthesis of Complex Bioactive Molecules features sixteen chapters, each one written by one or more leading experts in organic synthesis from around the world. It covers a broad range of topics that enable readers to take advantage of the latest methods for synthesizing complex molecules, including: Modern catalysis, emphasizing key transformations such as C-H functionalizations, cross-couplings, gold-catalyzed reactions, metathesis-based syntheses, and asymmetric organocatalysis Eco-compatible transformations, including rearrangements and domino reactions Tools for the synthesis of carbohydrates and alkaloids New techniques, including the use of fluorous tags and engineered biosynthesis The last two chapters explore target- and diversity-oriented organic synthesis as well as the use of DNA-based asymmetric catalysis, which are all promising tools for the successful synthesis of complex bioactive molecules. Modern Tools for the Synthesis of Complex Bioactive Molecules is ideal for students and researchers who need to plan and perform the synthesis of complex molecules as efficiently as possible. The book's expert advice will help these readers quickly resolve a broad range of problems that can arise in organic syntheses.
Modern Sustainable Techniques in Total Synthesis of Bioactive Natural Products comprises five parts for green tools, such as ultrasonic waves, microwave heating, visible-light photochemistry, organic electrochemistry, and flow chemistry, along with 72 chapters for each bioactive molecule of natural origin. Each chapter explores the natural source, structure, systematic name, structural features, compound class, biological activity, conventional approaches for their chemical synthesis, and demerit(s) of conventional approaches (where applicable). Finally, critical features of total synthesis using modern sustainable techniques, including reaction types, synthetic strategy, and synthetic route utilizing modern sustainable tools for each bioactive natural product and secondary metabolites, are discussed brilliantly. The spectrum of application of total synthesis of bioactive natural products using modern sustainable techniques may promote the development of more eco-friendly synthetic processes so that the next generations can live on this planet with a minimum energy requirement for chemical reactions with the least pollution.
Book Synopsis Modern Sustainable Techniques In Total Synthesis Of Bioactive Natural Products by : Sasadhar Majhi
Download or read book Modern Sustainable Techniques In Total Synthesis Of Bioactive Natural Products written by Sasadhar Majhi and published by World Scientific. This book was released on 2023-04-25 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern Sustainable Techniques in Total Synthesis of Bioactive Natural Products comprises five parts for green tools, such as ultrasonic waves, microwave heating, visible-light photochemistry, organic electrochemistry, and flow chemistry, along with 72 chapters for each bioactive molecule of natural origin. Each chapter explores the natural source, structure, systematic name, structural features, compound class, biological activity, conventional approaches for their chemical synthesis, and demerit(s) of conventional approaches (where applicable). Finally, critical features of total synthesis using modern sustainable techniques, including reaction types, synthetic strategy, and synthetic route utilizing modern sustainable tools for each bioactive natural product and secondary metabolites, are discussed brilliantly. The spectrum of application of total synthesis of bioactive natural products using modern sustainable techniques may promote the development of more eco-friendly synthetic processes so that the next generations can live on this planet with a minimum energy requirement for chemical reactions with the least pollution.
Drug design is a complex, challenging and innovative research area. Structure-based molecular design has transformed the drug discovery approach in modern medicine. Traditionally, focus has been placed on computational, structural or synthetic methods only in isolation. This one-of-akind guide integrates all three skill sets for a complete picture of contemporary structure-based design. This practical approach provides the tools to develop a high-affinity ligand with drug-like properties for a given drug target for which a high-resolution structure exists. The authors use numerous examples of recently developed drugs to present "best practice" methods in structurebased drug design with both newcomers and practicing researchers in mind. By way of a carefully balanced mix of theoretical background and case studies from medicinal chemistry applications, readers will quickly and efficiently master the basic skills of successful drug design. This book is aimed at new and active medicinal chemists, biochemists, pharmacologists, natural product chemists and those working in drug discovery in the pharmaceutical industry. It is highly recommended as a desk reference to guide students in medicinal and chemical sciences as well as to aid researchers engaged in drug design today.
Book Synopsis Structure-based Design of Drugs and Other Bioactive Molecules by : Arun K. Ghosh
Download or read book Structure-based Design of Drugs and Other Bioactive Molecules written by Arun K. Ghosh and published by John Wiley & Sons. This book was released on 2014-07-16 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug design is a complex, challenging and innovative research area. Structure-based molecular design has transformed the drug discovery approach in modern medicine. Traditionally, focus has been placed on computational, structural or synthetic methods only in isolation. This one-of-akind guide integrates all three skill sets for a complete picture of contemporary structure-based design. This practical approach provides the tools to develop a high-affinity ligand with drug-like properties for a given drug target for which a high-resolution structure exists. The authors use numerous examples of recently developed drugs to present "best practice" methods in structurebased drug design with both newcomers and practicing researchers in mind. By way of a carefully balanced mix of theoretical background and case studies from medicinal chemistry applications, readers will quickly and efficiently master the basic skills of successful drug design. This book is aimed at new and active medicinal chemists, biochemists, pharmacologists, natural product chemists and those working in drug discovery in the pharmaceutical industry. It is highly recommended as a desk reference to guide students in medicinal and chemical sciences as well as to aid researchers engaged in drug design today.
Bioactive compounds play a central role in high-value product development in the chemical industry. Bioactive compounds have been identified from diverse sources and their therapeutic benefits, nutritional value and protective effects in human and animal healthcare have underpinned their application as pharmaceuticals and functional food ingredients. The orderly study of biologically active products and the exploration of potential biological activities of these secondary metabolites, including their clinical applications, standardization, quality control, mode of action and potential biomolecular interactions, has emerged as one of the most exciting developments in modern natural medicine. Biotechnology of Bioactive Compounds describes the current stage of knowledge on the production of bioactive compounds from microbial, algal and vegetable sources. In addition, the molecular approach for screening bioactive compounds is also discussed, as well as examples of applications of these compounds on human health. The first half of the book comprises information on diverse sources of bioactive compounds, ranging from microorganisms and algae to plants and dietary foods. The second half of the book reviews synthetic approaches, as well as selected bioactivities and biotechnological and biomedical potential. The bioactive compounds profiled include compounds such as C-phycocyanins, glycosides, phytosterols and natural steroids. An overview of the usage of bioactive compounds as antioxidants and anti-inflammatory agents, anti-allergic compounds and in stem cell research is also presented, along with an overview of the medicinal applications of plant-derived compounds. Biotechnology of Bioactive Compounds will be an informative text for undergraduate and graduate students of bio-medicinal chemistry who are keen to explore the potential of bioactive natural products. It also provides useful information for scientists working in various research fields where natural products have a primary role.
Book Synopsis Biotechnology of Bioactive Compounds by : Vijai Kumar Gupta
Download or read book Biotechnology of Bioactive Compounds written by Vijai Kumar Gupta and published by John Wiley & Sons. This book was released on 2015-04-20 with total page 742 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioactive compounds play a central role in high-value product development in the chemical industry. Bioactive compounds have been identified from diverse sources and their therapeutic benefits, nutritional value and protective effects in human and animal healthcare have underpinned their application as pharmaceuticals and functional food ingredients. The orderly study of biologically active products and the exploration of potential biological activities of these secondary metabolites, including their clinical applications, standardization, quality control, mode of action and potential biomolecular interactions, has emerged as one of the most exciting developments in modern natural medicine. Biotechnology of Bioactive Compounds describes the current stage of knowledge on the production of bioactive compounds from microbial, algal and vegetable sources. In addition, the molecular approach for screening bioactive compounds is also discussed, as well as examples of applications of these compounds on human health. The first half of the book comprises information on diverse sources of bioactive compounds, ranging from microorganisms and algae to plants and dietary foods. The second half of the book reviews synthetic approaches, as well as selected bioactivities and biotechnological and biomedical potential. The bioactive compounds profiled include compounds such as C-phycocyanins, glycosides, phytosterols and natural steroids. An overview of the usage of bioactive compounds as antioxidants and anti-inflammatory agents, anti-allergic compounds and in stem cell research is also presented, along with an overview of the medicinal applications of plant-derived compounds. Biotechnology of Bioactive Compounds will be an informative text for undergraduate and graduate students of bio-medicinal chemistry who are keen to explore the potential of bioactive natural products. It also provides useful information for scientists working in various research fields where natural products have a primary role.
This dissertation describes the development of synthetic methodologies and approaches that leverage strain-driven reactivity to access complex molecules, as well as enzymatic studies and advances in the field of chemical education. The high potential energy stored within strained bonds offers a powerful tool in organic synthesis for the construction of new covalent bonds. Controlling the reactivity of strained molecules, while challenging in many cases, offers a means to form multiple bonds in a single step, under mild reaction conditions, and generate products that may be inaccessible by other means. Herein, several synthetic endeavors are described that seek to leverage strain release to push our understanding of chemical reactivity and gain new entryways into important classes of organic and organometallic compounds. Moreover, two studies in the area of biosynthesis and are described, which take advantage of synergy between chemical synthesis and enzymatic chemistry to access bioactive compounds with high selectivity. Finally, studies in the area of chemical education are described. These efforts seek to make organic chemistry accessible to wider audiences through the development of interactive, globally available educational tools and the creation of a new undergraduate lecture course that highlights the role of organic chemistry in the world around us. Chapter one describes a perspective on the field of complex molecule synthesis (i.e., total synthesis), with a focus on the power of collaborations across research groups. Although historically competitive, there is a growing spirit of teamwork and collaboration in the field of total synthesis. This chapter discusses recent breakthroughs in both academic and industrial laboratories that have succeeded as a direct result of alliances between research groups. Chapter two describes progress toward the total synthesis of dodecahedrane, a complex and highly symmetrical hydrocarbon that bears twelve fused rings arranged in a cage-like architecture. Central to our approach is an ambitious [2+2+2+2+2] poly-ene cyclization cascade which would serve to provide new insights into chemical reactivity. Current efforts center around constructing key linkages found in the target by harnessing the strain release of norbornene ring systems to form new carbon-carbon bonds. Chapter three describes a concise and scalable synthetic approach to precursors to strained intermediates. Although historically avoided due to their high reactivity, strained cyclic alkynes and allenes have demonstrated value in the synthesis of medicinally privileged, polycyclic compounds. These efforts, which provide efficient access to silyl triflate precursors to cyclohexyne and 1,2-cyclohexadiene, serve to enable further studies involving strained alkynes and allenes. Chapters four and five describe the development of new methodologies that exploit strained aryne intermediates in the synthesis of complex organic and organometallic materials. Both chapters investigate the controlled generation and reactivity of aryne intermediates, as well as engagement of these intermediates in Pd-catalysis to build new ring systems. Chapter four specifically details the development of aryne chemistry "on-the-complex," wherein fleeting aryne intermediates are reacted with pre-coordinated metal-ligand complexes to form new carbon-carbon bonds. These studies, performed in the context of privileged, photoactive polypyridyl metal complexes, provide an effective strategy to annulate organometallic complexes and access complex metal-ligand scaffolds, while furthering the synthetic utility of strained intermediates in chemical synthesis. Chapter five details the development of Pd-catalyzed reactions of indole and carbazole-based arynes (i.e., hetarynes) to access [pi]-extended heterocyclic materials. The products obtained were applied as ligands in two-coordinate metal complexes to access new OLED emitters. Chapters six and seven are concerned with uncovering and investigating highly selective reactions catalyzed by fungal enzymes. In particular, chapter six describes the discovery of two groups of enzymes that catalyze distinct reactions, an Alder-ene reaction (previously unknown in biology) and a stereoselective hetero-Diels-Alder reaction. Chapter seven presents studies pertaining to the aminoacylation and thiolation of polyketides in fungi, with a focus on elucidating mechanistic pathways. Both chapters showcase important synergy between chemical synthesis and enzymatic chemistry, and elucidate new enzymatic pathways that ultimately give rise to molecular complexity. Chapters eight and nine illustrate advances in chemical education. Chapter eight specifically details the development and execution of a new undergraduate course taught by graduate students. The course, entitled Catalysis in Modern Drug Discovery, served to highlight the central role of organic chemistry in drug discovery, while also conveying key concepts in catalysis. Moreover, the course spotlighted the various careers that organic chemists play in the development of new medicines. Chapter nine presents a perspective that highlights our recent efforts to develop interactive resources in chemical education for worldwide usage. In particular, these efforts seek to promote a spirit of innovation in chemical education and spur the development of widely accessible resources that improve learning outcomes and promote positive perception of chemistry in the broader community
Book Synopsis Harnessing Strain-Driven Reactivity for Complex Molecule Synthesis and Advances in Chemical Education by : Jason Chari
Download or read book Harnessing Strain-Driven Reactivity for Complex Molecule Synthesis and Advances in Chemical Education written by Jason Chari and published by . This book was released on 2022 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation describes the development of synthetic methodologies and approaches that leverage strain-driven reactivity to access complex molecules, as well as enzymatic studies and advances in the field of chemical education. The high potential energy stored within strained bonds offers a powerful tool in organic synthesis for the construction of new covalent bonds. Controlling the reactivity of strained molecules, while challenging in many cases, offers a means to form multiple bonds in a single step, under mild reaction conditions, and generate products that may be inaccessible by other means. Herein, several synthetic endeavors are described that seek to leverage strain release to push our understanding of chemical reactivity and gain new entryways into important classes of organic and organometallic compounds. Moreover, two studies in the area of biosynthesis and are described, which take advantage of synergy between chemical synthesis and enzymatic chemistry to access bioactive compounds with high selectivity. Finally, studies in the area of chemical education are described. These efforts seek to make organic chemistry accessible to wider audiences through the development of interactive, globally available educational tools and the creation of a new undergraduate lecture course that highlights the role of organic chemistry in the world around us. Chapter one describes a perspective on the field of complex molecule synthesis (i.e., total synthesis), with a focus on the power of collaborations across research groups. Although historically competitive, there is a growing spirit of teamwork and collaboration in the field of total synthesis. This chapter discusses recent breakthroughs in both academic and industrial laboratories that have succeeded as a direct result of alliances between research groups. Chapter two describes progress toward the total synthesis of dodecahedrane, a complex and highly symmetrical hydrocarbon that bears twelve fused rings arranged in a cage-like architecture. Central to our approach is an ambitious [2+2+2+2+2] poly-ene cyclization cascade which would serve to provide new insights into chemical reactivity. Current efforts center around constructing key linkages found in the target by harnessing the strain release of norbornene ring systems to form new carbon-carbon bonds. Chapter three describes a concise and scalable synthetic approach to precursors to strained intermediates. Although historically avoided due to their high reactivity, strained cyclic alkynes and allenes have demonstrated value in the synthesis of medicinally privileged, polycyclic compounds. These efforts, which provide efficient access to silyl triflate precursors to cyclohexyne and 1,2-cyclohexadiene, serve to enable further studies involving strained alkynes and allenes. Chapters four and five describe the development of new methodologies that exploit strained aryne intermediates in the synthesis of complex organic and organometallic materials. Both chapters investigate the controlled generation and reactivity of aryne intermediates, as well as engagement of these intermediates in Pd-catalysis to build new ring systems. Chapter four specifically details the development of aryne chemistry "on-the-complex," wherein fleeting aryne intermediates are reacted with pre-coordinated metal-ligand complexes to form new carbon-carbon bonds. These studies, performed in the context of privileged, photoactive polypyridyl metal complexes, provide an effective strategy to annulate organometallic complexes and access complex metal-ligand scaffolds, while furthering the synthetic utility of strained intermediates in chemical synthesis. Chapter five details the development of Pd-catalyzed reactions of indole and carbazole-based arynes (i.e., hetarynes) to access [pi]-extended heterocyclic materials. The products obtained were applied as ligands in two-coordinate metal complexes to access new OLED emitters. Chapters six and seven are concerned with uncovering and investigating highly selective reactions catalyzed by fungal enzymes. In particular, chapter six describes the discovery of two groups of enzymes that catalyze distinct reactions, an Alder-ene reaction (previously unknown in biology) and a stereoselective hetero-Diels-Alder reaction. Chapter seven presents studies pertaining to the aminoacylation and thiolation of polyketides in fungi, with a focus on elucidating mechanistic pathways. Both chapters showcase important synergy between chemical synthesis and enzymatic chemistry, and elucidate new enzymatic pathways that ultimately give rise to molecular complexity. Chapters eight and nine illustrate advances in chemical education. Chapter eight specifically details the development and execution of a new undergraduate course taught by graduate students. The course, entitled Catalysis in Modern Drug Discovery, served to highlight the central role of organic chemistry in drug discovery, while also conveying key concepts in catalysis. Moreover, the course spotlighted the various careers that organic chemists play in the development of new medicines. Chapter nine presents a perspective that highlights our recent efforts to develop interactive resources in chemical education for worldwide usage. In particular, these efforts seek to promote a spirit of innovation in chemical education and spur the development of widely accessible resources that improve learning outcomes and promote positive perception of chemistry in the broader community
Book Synopsis Development and Application of Chemical Tools for the Design and Synthesis of Bioactive Molecules by : Janice Lawandi
Download or read book Development and Application of Chemical Tools for the Design and Synthesis of Bioactive Molecules written by Janice Lawandi and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
This useful reference focuses on the currently available toolbox of bio-catalysed reductions of C=O, C=C and formal C=N bonds to show which transformations can be reliably used in manufacturing processes and which still require improvements. Following an introductory chapter, chapters 2-4 present the synthetic strategies that are currently available for the reduction of C=C and C=O bonds and for reductive amination, by means of whole-cell catalysts and isolated enzymes. Chapters 5-7 go on to describe the improvements achieved thus far, illustrating the current versatility of enzymes in organic synthesis. Chapters 8-12 present the improvements brought about by the optimization of reaction conditions, and the use of particular synthetic sequences. The final chapter describes practical applications of bio-reductions for the synthesis of active pharmaceutical ingredients. With its excellent and comprehensive overview, this book will be of great interest to those working in academia and industry. From the contents: * Development of Sustainable Biocatalyzed Reduction Processes for Organic Chemists * Reductases: From Natural Diversity to Biocatalysis and Emerging Enzymatic Activities. * Synthetic Strategies Based on C=C Bioreductions * Synthetic Strategies Based on C=O Bioreductions * Development of Novel Enzymes for the Improved Reduction of C=C Double Bonds * Development of Novel Enzymes for the Improved Reduction of C=O Double Bonds * Synthetic Applications of Aminotransferases * Strategies for Cofactor Regeneration in Biocatalyzed Reductions * Effects of Solvent System and Substrate Loading in Bioreduction * Perspectives in the Use of In-Situ Product Removal (ISPR) Techniques in Bioreductions * Multi-Enzymatic Cascade Reactions Based on Reduction Processes * Relevant Practical Applications of Bioreduction Processes in the Synthesis of Active Pharmaceutical Ingredients
Book Synopsis Synthetic Methods for Biologically Active Molecules by : Elisabetta Brenna
Download or read book Synthetic Methods for Biologically Active Molecules written by Elisabetta Brenna and published by John Wiley & Sons. This book was released on 2013-08-29 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: This useful reference focuses on the currently available toolbox of bio-catalysed reductions of C=O, C=C and formal C=N bonds to show which transformations can be reliably used in manufacturing processes and which still require improvements. Following an introductory chapter, chapters 2-4 present the synthetic strategies that are currently available for the reduction of C=C and C=O bonds and for reductive amination, by means of whole-cell catalysts and isolated enzymes. Chapters 5-7 go on to describe the improvements achieved thus far, illustrating the current versatility of enzymes in organic synthesis. Chapters 8-12 present the improvements brought about by the optimization of reaction conditions, and the use of particular synthetic sequences. The final chapter describes practical applications of bio-reductions for the synthesis of active pharmaceutical ingredients. With its excellent and comprehensive overview, this book will be of great interest to those working in academia and industry. From the contents: * Development of Sustainable Biocatalyzed Reduction Processes for Organic Chemists * Reductases: From Natural Diversity to Biocatalysis and Emerging Enzymatic Activities. * Synthetic Strategies Based on C=C Bioreductions * Synthetic Strategies Based on C=O Bioreductions * Development of Novel Enzymes for the Improved Reduction of C=C Double Bonds * Development of Novel Enzymes for the Improved Reduction of C=O Double Bonds * Synthetic Applications of Aminotransferases * Strategies for Cofactor Regeneration in Biocatalyzed Reductions * Effects of Solvent System and Substrate Loading in Bioreduction * Perspectives in the Use of In-Situ Product Removal (ISPR) Techniques in Bioreductions * Multi-Enzymatic Cascade Reactions Based on Reduction Processes * Relevant Practical Applications of Bioreduction Processes in the Synthesis of Active Pharmaceutical Ingredients
Focusing on biosynthesis, this book provides readers with approaches and methodologies for modern organic synthesis. By discussing major biosynthetic pathways and their chemical reactions, transformations, and natural products applications; it links biosynthetic mechanisms and more efficient total synthesis. • Describes four major biosynthetic pathways (acetate, mevalonate, shikimic acid, and mixed pathways and alkaloids) and their related mechanisms • Covers reactions, tactics, and strategies for chemical transformations, linking biosynthetic processes and total synthesis • Includes strategies for optimal synthetic plans and introduces a modern molecular approach to natural product synthesis and applications • Acts as a key reference for industry and academic readers looking to advance knowledge in classical total synthesis, organic synthesis, and future directions in the field
Book Synopsis From Biosynthesis to Total Synthesis by : Alexandros L. Zografos
Download or read book From Biosynthesis to Total Synthesis written by Alexandros L. Zografos and published by John Wiley & Sons. This book was released on 2016-03-17 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on biosynthesis, this book provides readers with approaches and methodologies for modern organic synthesis. By discussing major biosynthetic pathways and their chemical reactions, transformations, and natural products applications; it links biosynthetic mechanisms and more efficient total synthesis. • Describes four major biosynthetic pathways (acetate, mevalonate, shikimic acid, and mixed pathways and alkaloids) and their related mechanisms • Covers reactions, tactics, and strategies for chemical transformations, linking biosynthetic processes and total synthesis • Includes strategies for optimal synthetic plans and introduces a modern molecular approach to natural product synthesis and applications • Acts as a key reference for industry and academic readers looking to advance knowledge in classical total synthesis, organic synthesis, and future directions in the field
Heteroarenes are among the most prevalent structural units in natural products, pharmaceuticals, agrochemicals, and other compounds of scientific or commercial interest. In the last decade, a broad range of novel synthetic methods has been developed to not only facilitate construction of the heteroarene motif, but to enable its modification through direct C–H functionalization. This Handbook describes 117 key reagents for selective heteroarene functionalization reactions, including both traditional and transition metal-catalyzed C–H functionalization. Since these reactions typically involve one heteroarene, a coupling partner and a catalyst, the handbook not only focuses on the catalyst itself but also contains other key reaction species. All the information compiled in this volume is also available in electronic format on Wiley Online Library. The 117 reagents represented here are but a small fraction of the ca. 5,000 reagents available in the electronic Encyclopedia of Reagents for Organic Synthesis (e-EROS). e-EROS offers various search interfaces to locate reagents of interest, including chemical structure, substructure and reactions search modes. e-EROS is updated regularly with new and updated entries.
Book Synopsis Handbook of Reagents for Organic Synthesis by : André B. Charette
Download or read book Handbook of Reagents for Organic Synthesis written by André B. Charette and published by John Wiley & Sons. This book was released on 2015-07-15 with total page 824 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heteroarenes are among the most prevalent structural units in natural products, pharmaceuticals, agrochemicals, and other compounds of scientific or commercial interest. In the last decade, a broad range of novel synthetic methods has been developed to not only facilitate construction of the heteroarene motif, but to enable its modification through direct C–H functionalization. This Handbook describes 117 key reagents for selective heteroarene functionalization reactions, including both traditional and transition metal-catalyzed C–H functionalization. Since these reactions typically involve one heteroarene, a coupling partner and a catalyst, the handbook not only focuses on the catalyst itself but also contains other key reaction species. All the information compiled in this volume is also available in electronic format on Wiley Online Library. The 117 reagents represented here are but a small fraction of the ca. 5,000 reagents available in the electronic Encyclopedia of Reagents for Organic Synthesis (e-EROS). e-EROS offers various search interfaces to locate reagents of interest, including chemical structure, substructure and reactions search modes. e-EROS is updated regularly with new and updated entries.
Mechanochemistry has been recently ackwnoledged by IUPAC as one of the top ten emerging technologies in chemistry, answering to the increased demand for clean processes and sustainable reaction conditions. This book focuses on the rediscovery of mechanochemistry for inorganic, organic and organo-metallic materials. Focus on experimental techniques and equipment will show how to implement mechanochemistry as an innovative way to sustainability in academic laboratories. The contents are ideal for researchers starting off in industry and academia, as well as advanced students.
Book Synopsis Mechanochemistry by : Evelina Colacino
Download or read book Mechanochemistry written by Evelina Colacino and published by Walter de Gruyter GmbH & Co KG. This book was released on 2020-12-07 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanochemistry has been recently ackwnoledged by IUPAC as one of the top ten emerging technologies in chemistry, answering to the increased demand for clean processes and sustainable reaction conditions. This book focuses on the rediscovery of mechanochemistry for inorganic, organic and organo-metallic materials. Focus on experimental techniques and equipment will show how to implement mechanochemistry as an innovative way to sustainability in academic laboratories. The contents are ideal for researchers starting off in industry and academia, as well as advanced students.
