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In this book the current knowledge on human cytomegalovirus (HCMV) as a human pathogen is lucidly summarized, bringing the reader fully up to date with current knowledge concerning HCMV and all the known clincial and medical aspects of diseases caused by, and associated with, HCMV. The book is divided into four parts: (I) Human cytomegalovirus and human diseases; (II) human cytomegalovirus infections and the immunocompromised host; (III) diagnosis, treatment, and prevention of human cytomegalovirus and human diseases; and (IV) molecular aspects of human cytomegalovirus. Each part is put together from chapters written by experts in the respective fields, providing basic medical and molecular knowledge in addition to more specific understanding of HCMV infections.
Book Synopsis Molecular Aspects of Human Cytomegalovirus Diseases by : Yechiel Becker
Download or read book Molecular Aspects of Human Cytomegalovirus Diseases written by Yechiel Becker and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book the current knowledge on human cytomegalovirus (HCMV) as a human pathogen is lucidly summarized, bringing the reader fully up to date with current knowledge concerning HCMV and all the known clincial and medical aspects of diseases caused by, and associated with, HCMV. The book is divided into four parts: (I) Human cytomegalovirus and human diseases; (II) human cytomegalovirus infections and the immunocompromised host; (III) diagnosis, treatment, and prevention of human cytomegalovirus and human diseases; and (IV) molecular aspects of human cytomegalovirus. Each part is put together from chapters written by experts in the respective fields, providing basic medical and molecular knowledge in addition to more specific understanding of HCMV infections.
In this book the current knowledge on human cytomegalovirus (HCMV) as a human pathogen is lucidly summarized, bringing the reader fully up to date with current knowledge concerning HCMV and all the known clincial and medical aspects of diseases caused by, and associated with, HCMV. The book is divided into four parts: (I) Human cytomegalovirus and human diseases; (II) human cytomegalovirus infections and the immunocompromised host; (III) diagnosis, treatment, and prevention of human cytomegalovirus and human diseases; and (IV) molecular aspects of human cytomegalovirus. Each part is put together from chapters written by experts in the respective fields, providing basic medical and molecular knowledge in addition to more specific understanding of HCMV infections.
Book Synopsis Molecular Aspects of Human Cytomegalovirus Diseases by : Yechiel Becker
Download or read book Molecular Aspects of Human Cytomegalovirus Diseases written by Yechiel Becker and published by Springer. This book was released on 1993-04-29 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book the current knowledge on human cytomegalovirus (HCMV) as a human pathogen is lucidly summarized, bringing the reader fully up to date with current knowledge concerning HCMV and all the known clincial and medical aspects of diseases caused by, and associated with, HCMV. The book is divided into four parts: (I) Human cytomegalovirus and human diseases; (II) human cytomegalovirus infections and the immunocompromised host; (III) diagnosis, treatment, and prevention of human cytomegalovirus and human diseases; and (IV) molecular aspects of human cytomegalovirus. Each part is put together from chapters written by experts in the respective fields, providing basic medical and molecular knowledge in addition to more specific understanding of HCMV infections.
This volume has gathered some of the experts in the field to review aspects of our understanding of CMV and to offer perspectives of the current problems associated with CMV. The editors and authors hope that the chapters will lead to a better understanding of the virus that will assist in the development of new and unique antivirals, a protective vaccine, and a full understanding of CMV's involvement in human disease.
Book Synopsis Human Cytomegalovirus by : Thomas E. Shenk
Download or read book Human Cytomegalovirus written by Thomas E. Shenk and published by Springer Science & Business Media. This book was released on 2008-05-09 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume has gathered some of the experts in the field to review aspects of our understanding of CMV and to offer perspectives of the current problems associated with CMV. The editors and authors hope that the chapters will lead to a better understanding of the virus that will assist in the development of new and unique antivirals, a protective vaccine, and a full understanding of CMV's involvement in human disease.
This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Book Synopsis Human Herpesviruses by : Ann Arvin
Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
This new edition explores and provides an update on the biology and pathogenesis of human cytomegalovirus infection. Modern techniques that are currently being utilized to investigate the molecular aspects of viral infection, as well as how these new research studies are leading to new approaches to mitigate disease, are also provided. Given the key role the virus plays in significant acute and chronic human disease in all stages of life, from newborns to seniors, the need for clear methodologies to further explore the biology of HCMV infection and mitigation strategies is readily apparent. Written in the highly successful Methods in Molecular Biology format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Human Cytomegaloviruses: Methods and Protocols, Second Edition serves as an ideal scientific reference for basic and clinical scientists and medical personnel on the modern understanding of the pathobiology of the virus, and the approaches, techniques, and models to study human cytomegalovirus infection and disease.
Book Synopsis Human Cytomegaloviruses by : Andrew D. Yurochko
Download or read book Human Cytomegaloviruses written by Andrew D. Yurochko and published by Humana. This book was released on 2022-02-23 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new edition explores and provides an update on the biology and pathogenesis of human cytomegalovirus infection. Modern techniques that are currently being utilized to investigate the molecular aspects of viral infection, as well as how these new research studies are leading to new approaches to mitigate disease, are also provided. Given the key role the virus plays in significant acute and chronic human disease in all stages of life, from newborns to seniors, the need for clear methodologies to further explore the biology of HCMV infection and mitigation strategies is readily apparent. Written in the highly successful Methods in Molecular Biology format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Human Cytomegaloviruses: Methods and Protocols, Second Edition serves as an ideal scientific reference for basic and clinical scientists and medical personnel on the modern understanding of the pathobiology of the virus, and the approaches, techniques, and models to study human cytomegalovirus infection and disease.
John Sinclair and a panel of expert investigators present a comprehensive collection of cellular and molecular techniques for the analysis of cytomegalovirus (CMV) biology and its pathogenetic mechanisms. The methods-all described in step-by-step detail with ready reproducibility in mind-range from basic virus culture to complex molecular analysis of CMV structure and function. Included are methods for CMV detection using both immunological and biological techniques, methods for analyzing fundamental aspects of the CMV infection cycle, and methods for analyzing T cell response to cytomegalovirus infection in the human host. Comprehensive and state-of-the-art, Cytomegalovirus Protocols provides investigators with a collection of the key methods that are illuminating not only the basic biology of this complex and intriguing human herpesvirus, but also its significant role in human infectious diseases and their emergent therapies.
Book Synopsis Cytomegalovirus Protocols by : John Sinclair
Download or read book Cytomegalovirus Protocols written by John Sinclair and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: John Sinclair and a panel of expert investigators present a comprehensive collection of cellular and molecular techniques for the analysis of cytomegalovirus (CMV) biology and its pathogenetic mechanisms. The methods-all described in step-by-step detail with ready reproducibility in mind-range from basic virus culture to complex molecular analysis of CMV structure and function. Included are methods for CMV detection using both immunological and biological techniques, methods for analyzing fundamental aspects of the CMV infection cycle, and methods for analyzing T cell response to cytomegalovirus infection in the human host. Comprehensive and state-of-the-art, Cytomegalovirus Protocols provides investigators with a collection of the key methods that are illuminating not only the basic biology of this complex and intriguing human herpesvirus, but also its significant role in human infectious diseases and their emergent therapies.
Cytomegalovirus (CMV) infection causes severe diseases in immunocompromised patients. CMV-related morbidity is frequently linked to aberrant immune responses occurring locally within the respective tissues including immune-privileged sites such as the retina. There is growing evidence that CMV-related pathomechanisms differ profoundly as a function of cell type and differentiation state of the host cell. This book provides important new insights into CMV-related immunopathology, discusses molecular mechanisms involved in HCMV-mediated tissue injury, CMV latency and reactivation, and presents novel ideas and concepts to develop alternative antiviral drugs. As an important focus, the role of CMV-reactive T cells in protection, pathogenesis, diagnosis and therapy of HCMV infection is discussed. The contributions to this book are written by leading scientists and clinicians in the field of CMV who participated in the fourth international meeting on CMV-related immunopathology, held in Berlin, September 2002. Comprehensive and up-to-date, this volume is a vital reference for clinicians involved in the diagnosis and treatment of CMV infections, as well as for researchers working in the field of herpesvirus biology and the development of antiviral drugs.
Book Synopsis New Aspects of CMV-related Immunopathology by : Susanna Prösch
Download or read book New Aspects of CMV-related Immunopathology written by Susanna Prösch and published by Karger Medical and Scientific Publishers. This book was released on 2003-01-01 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytomegalovirus (CMV) infection causes severe diseases in immunocompromised patients. CMV-related morbidity is frequently linked to aberrant immune responses occurring locally within the respective tissues including immune-privileged sites such as the retina. There is growing evidence that CMV-related pathomechanisms differ profoundly as a function of cell type and differentiation state of the host cell. This book provides important new insights into CMV-related immunopathology, discusses molecular mechanisms involved in HCMV-mediated tissue injury, CMV latency and reactivation, and presents novel ideas and concepts to develop alternative antiviral drugs. As an important focus, the role of CMV-reactive T cells in protection, pathogenesis, diagnosis and therapy of HCMV infection is discussed. The contributions to this book are written by leading scientists and clinicians in the field of CMV who participated in the fourth international meeting on CMV-related immunopathology, held in Berlin, September 2002. Comprehensive and up-to-date, this volume is a vital reference for clinicians involved in the diagnosis and treatment of CMV infections, as well as for researchers working in the field of herpesvirus biology and the development of antiviral drugs.
Human Cytomegalovirus (CMV) - a member of the herpesvirus family - is an underrated health risk. A low public awareness results from the relatively mild symptoms it causes in otherwise healthy people whose immune systems are intact, with primary infection usually going unnoticed. During pregnancy, however, transmission from the mother to the fetus is currently the most frequent viral cause of birth defects with lifelong neurological sequelae, sensorineural hearing loss in particular. People at risk also include the growing number of immune compromised patients requiring either a solid organ graft or receiving a hematopoietic cell graft for the treatment of hematopoietic malignancies that are refractory to standard therapies. Under the condition of weakened immune surveillance in these patients, latent CMV hidden in transplanted donor cells or in the recipients' own tissues can awake to cause a destructive infection resulting in graft loss and multiple end-organ disease, of which viral pneumonia is the most feared. This two volume work is an updated and upgraded second edition of Cytomegaloviruses: Molecular Biology and Immunology (2006). The second edition's title - Cytomegaloviruses: From Molecular Pathogenesis to Intervention - reflects its expanded commitment not only to cover cutting edge basic science, but also to include the translation of this to clinical science. In an interdisciplinary approach to understanding CMV disease and outlining options for prevention and treatment, leading international experts provide comprehensive and authoritative reviews on literally every aspect of current research with an unprecedented completeness, integrating research on human CMV and insights gained from experimental animal models. With contributions from over 100 authors, the topics covered in the 46 chapters range from the most contemporary systems biology 'omics' views on virus-host interaction to considerations of the health and economic impact of CMV disease for evaluating the hoped-for benefit from a vaccine. Volume 1 (as an individual volume: ISBN 978 1 908230 19 5) focuses on basic science laying the foundations of clinical research, starting with the comparative genomics of primate CMVs and ending with the emerging field of humanized mouse models. This Volume 2 (as an individual volume: ISBN 978 1 908230 20 1; as a two volume set: ISBN 978 1 908230 18 8) is more clinically oriented, covering the immune response to CMV, the most pressing medical problems in the newborn and in transplantation patients, as well as diagnostics, the management of antiviral drug resistance, the state and future of a CMV vaccine, and the potential of using CMV as a vaccine vector to fight unrelated diseases. The book closes with a critical survey of disputed associations between CMV and atherosclerotic cardiovascular disease, certain tumors such as Glioblastoma Multiforme, and the phenomenon of 'immune senescence' in the elderly. The two volume set (ISBN 978 1 908230 18 8) is liberally illustrated with more than 200 figures, most of which are in full color. There are over 60 tables and several thousand references which enhance the set even further, making it an invaluable source of information. This will be essential reading for all virologists with an interest in cytomegaloviruses, for all clinicians in pediatric intensive care medicine and at transplantation centers, for scientists working on antiviral drug and vaccine development, as well as for public health service and science funding system authorities.
Book Synopsis Cytomegaloviruses by : Matthias Johannes Reddehase
Download or read book Cytomegaloviruses written by Matthias Johannes Reddehase and published by Caister Academic Press Limited. This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Cytomegalovirus (CMV) - a member of the herpesvirus family - is an underrated health risk. A low public awareness results from the relatively mild symptoms it causes in otherwise healthy people whose immune systems are intact, with primary infection usually going unnoticed. During pregnancy, however, transmission from the mother to the fetus is currently the most frequent viral cause of birth defects with lifelong neurological sequelae, sensorineural hearing loss in particular. People at risk also include the growing number of immune compromised patients requiring either a solid organ graft or receiving a hematopoietic cell graft for the treatment of hematopoietic malignancies that are refractory to standard therapies. Under the condition of weakened immune surveillance in these patients, latent CMV hidden in transplanted donor cells or in the recipients' own tissues can awake to cause a destructive infection resulting in graft loss and multiple end-organ disease, of which viral pneumonia is the most feared. This two volume work is an updated and upgraded second edition of Cytomegaloviruses: Molecular Biology and Immunology (2006). The second edition's title - Cytomegaloviruses: From Molecular Pathogenesis to Intervention - reflects its expanded commitment not only to cover cutting edge basic science, but also to include the translation of this to clinical science. In an interdisciplinary approach to understanding CMV disease and outlining options for prevention and treatment, leading international experts provide comprehensive and authoritative reviews on literally every aspect of current research with an unprecedented completeness, integrating research on human CMV and insights gained from experimental animal models. With contributions from over 100 authors, the topics covered in the 46 chapters range from the most contemporary systems biology 'omics' views on virus-host interaction to considerations of the health and economic impact of CMV disease for evaluating the hoped-for benefit from a vaccine. Volume 1 (as an individual volume: ISBN 978 1 908230 19 5) focuses on basic science laying the foundations of clinical research, starting with the comparative genomics of primate CMVs and ending with the emerging field of humanized mouse models. This Volume 2 (as an individual volume: ISBN 978 1 908230 20 1; as a two volume set: ISBN 978 1 908230 18 8) is more clinically oriented, covering the immune response to CMV, the most pressing medical problems in the newborn and in transplantation patients, as well as diagnostics, the management of antiviral drug resistance, the state and future of a CMV vaccine, and the potential of using CMV as a vaccine vector to fight unrelated diseases. The book closes with a critical survey of disputed associations between CMV and atherosclerotic cardiovascular disease, certain tumors such as Glioblastoma Multiforme, and the phenomenon of 'immune senescence' in the elderly. The two volume set (ISBN 978 1 908230 18 8) is liberally illustrated with more than 200 figures, most of which are in full color. There are over 60 tables and several thousand references which enhance the set even further, making it an invaluable source of information. This will be essential reading for all virologists with an interest in cytomegaloviruses, for all clinicians in pediatric intensive care medicine and at transplantation centers, for scientists working on antiviral drug and vaccine development, as well as for public health service and science funding system authorities.
Book Synopsis Cytomegalovirus Pathogenesis and Host Interactions by : Emma Poole
Download or read book Cytomegalovirus Pathogenesis and Host Interactions written by Emma Poole and published by Frontiers Media SA. This book was released on 2021-04-21 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Cytomegaloviruses are members of the herpesvirus group and can infect humans and other primates. Between 50-80% of adults in developed countries and up to 100% in developing countries are infected with human cytomegalovirus. Infection causes problems in immunocompromised hosts including AIDS victims or patients undergoing organ and stem cell transplantation and congenital infection can cause birth defects in the child. Development of an effective vaccine has high priority. In this book leading international experts provide comprehensive and authoritative reviews on every aspect of current research. By integrating viral genomics, proteomics, immunology and molecular biology with the emerging knowledge of the genomics of the host organism, penetrating new insights into the virus-host interaction are provided. The focus of the book is on the molecular and genomic aspects and the authors provide an insight into the current understanding of the subject and the future direction of research. Topics covered include disease mechanisms, genomics, proteomics, BAC mutagenesis, virus entry and activation of innate immunity, regulation of viral gene expression, regulation of viral mRNA export, animal models of infection, novel therapeutics, vaccine development, antivirals, and much more. The book is liberally illustrated with many figures in full colour and is set is a clear, easy-to-follow layout. Essential reading for all virologists with an interest in cytomegaloviruses and a recommended text for scientists working on antiviral drug and vaccine development.
Book Synopsis Cytomegaloviruses by : Matthias J. Reddehase
Download or read book Cytomegaloviruses written by Matthias J. Reddehase and published by Caister Academic Press Limited. This book was released on 2006 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytomegaloviruses are members of the herpesvirus group and can infect humans and other primates. Between 50-80% of adults in developed countries and up to 100% in developing countries are infected with human cytomegalovirus. Infection causes problems in immunocompromised hosts including AIDS victims or patients undergoing organ and stem cell transplantation and congenital infection can cause birth defects in the child. Development of an effective vaccine has high priority. In this book leading international experts provide comprehensive and authoritative reviews on every aspect of current research. By integrating viral genomics, proteomics, immunology and molecular biology with the emerging knowledge of the genomics of the host organism, penetrating new insights into the virus-host interaction are provided. The focus of the book is on the molecular and genomic aspects and the authors provide an insight into the current understanding of the subject and the future direction of research. Topics covered include disease mechanisms, genomics, proteomics, BAC mutagenesis, virus entry and activation of innate immunity, regulation of viral gene expression, regulation of viral mRNA export, animal models of infection, novel therapeutics, vaccine development, antivirals, and much more. The book is liberally illustrated with many figures in full colour and is set is a clear, easy-to-follow layout. Essential reading for all virologists with an interest in cytomegaloviruses and a recommended text for scientists working on antiviral drug and vaccine development.