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A dramatic increase in knowledge regarding the molecular biology of brain tumors has been established over the past few years. In particular, recent new avenues regarding the role of microRNAs along with further understanding of the importance of angiogenesis, immunotherapy and explanations for the resistance of the tumors to radiation therapy have been developed. A discussion of certain surgical management issues including improvements in imaging along with issues concerning tumor induced epilepsy is included. It is hopeful that this new information will lead to efficacious treatment strategies for these tumors which remain a challenge. In this book, a review of the latest information on these topics along with a variety of new therapeutic treatment strategies with an emphasis on molecular targeted therapies is provided.
Book Synopsis Molecular Considerations and Evolving Surgical Management Issues in the Treatment of Patients with a Brain Tumor by : Terry Lichtor
Download or read book Molecular Considerations and Evolving Surgical Management Issues in the Treatment of Patients with a Brain Tumor written by Terry Lichtor and published by BoD – Books on Demand. This book was released on 2015-03-25 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: A dramatic increase in knowledge regarding the molecular biology of brain tumors has been established over the past few years. In particular, recent new avenues regarding the role of microRNAs along with further understanding of the importance of angiogenesis, immunotherapy and explanations for the resistance of the tumors to radiation therapy have been developed. A discussion of certain surgical management issues including improvements in imaging along with issues concerning tumor induced epilepsy is included. It is hopeful that this new information will lead to efficacious treatment strategies for these tumors which remain a challenge. In this book, a review of the latest information on these topics along with a variety of new therapeutic treatment strategies with an emphasis on molecular targeted therapies is provided.
A dramatic increase in knowledge regarding the molecular biology of brain tumors has been established over the past few years, and this has lead to the development of novel therapeutic strategies for these patients. In this book a review of the options available for the clinical management of patients with these tumors are outlined. In addition advances in radiology both for pre-operative diagnostic purposes along with surgical planning are described. Furthermore a review of newer developments in chemotherapy along with the evolving field of photodynamic therapy both for intra-operative management and subsequent therapy is provided. A discussion of certain surgical management issues along with tumor induced epilepsy is included. Finally a discussion of the management of certain unique problems including brain metastases, brainstem glioma, central nervous system lymphoma along with issues involving patients with a brain tumor and pregnancy is provided.
Book Synopsis Clinical Management and Evolving Novel Therapeutic Strategies for Patients with Brain Tumors by : Terry Lichtor
Download or read book Clinical Management and Evolving Novel Therapeutic Strategies for Patients with Brain Tumors written by Terry Lichtor and published by BoD – Books on Demand. This book was released on 2013-04-10 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt: A dramatic increase in knowledge regarding the molecular biology of brain tumors has been established over the past few years, and this has lead to the development of novel therapeutic strategies for these patients. In this book a review of the options available for the clinical management of patients with these tumors are outlined. In addition advances in radiology both for pre-operative diagnostic purposes along with surgical planning are described. Furthermore a review of newer developments in chemotherapy along with the evolving field of photodynamic therapy both for intra-operative management and subsequent therapy is provided. A discussion of certain surgical management issues along with tumor induced epilepsy is included. Finally a discussion of the management of certain unique problems including brain metastases, brainstem glioma, central nervous system lymphoma along with issues involving patients with a brain tumor and pregnancy is provided.
A dramatic increase in knowledge regarding the molecular biology of brain tumors has been established over the past few years. In particular recent new avenues regarding the role of stem cells and microRNAs along with further understanding of the importance of angiogenesis, immunotherapy and explanations for the resistance of the tumors to chemotherapeutic agents and radiation therapy has been developed. It is hopeful that this new information will lead to efficacious treatment strategies for these tumors which remain a challenge. In this book a review of the latest information on these topics along with a variety of new therapeutic treatment strategies with an emphasis on molecular targeted therapies is provided.
Book Synopsis Evolution of the Molecular Biology of Brain Tumors and the Therapeutic Implications by : Terry Lichtor
Download or read book Evolution of the Molecular Biology of Brain Tumors and the Therapeutic Implications written by Terry Lichtor and published by BoD – Books on Demand. This book was released on 2013-02-27 with total page 652 pages. Available in PDF, EPUB and Kindle. Book excerpt: A dramatic increase in knowledge regarding the molecular biology of brain tumors has been established over the past few years. In particular recent new avenues regarding the role of stem cells and microRNAs along with further understanding of the importance of angiogenesis, immunotherapy and explanations for the resistance of the tumors to chemotherapeutic agents and radiation therapy has been developed. It is hopeful that this new information will lead to efficacious treatment strategies for these tumors which remain a challenge. In this book a review of the latest information on these topics along with a variety of new therapeutic treatment strategies with an emphasis on molecular targeted therapies is provided.
A dramatic increase in knowledge regarding the molecular biology of brain tumors has been established over the past few years, and this has lead to the development of novel therapeutic strategies for these patients. In this book a review of the options available for the clinical management of patients with these tumors are outlined. In addition advances in radiology both for pre-operative diagnostic purposes along with surgical planning are described. Furthermore a review of newer developments in chemotherapy along with the evolving field of photodynamic therapy both for intra-operative management and subsequent therapy is provided. A discussion of certain surgical management issues along with tumor induced epilepsy is included. Finally a discussion of the management of certain unique problems including brain metastases, brainstem glioma, central nervous system lymphoma along with issues involving patients with a brain tumor and pregnancy is provided.
Book Synopsis Clinical Management and Evolving Novel Therapeutic Strategies for Patients with Brain Tumors by : Terry Lichtor
Download or read book Clinical Management and Evolving Novel Therapeutic Strategies for Patients with Brain Tumors written by Terry Lichtor and published by IntechOpen. This book was released on 2013-04-10 with total page 654 pages. Available in PDF, EPUB and Kindle. Book excerpt: A dramatic increase in knowledge regarding the molecular biology of brain tumors has been established over the past few years, and this has lead to the development of novel therapeutic strategies for these patients. In this book a review of the options available for the clinical management of patients with these tumors are outlined. In addition advances in radiology both for pre-operative diagnostic purposes along with surgical planning are described. Furthermore a review of newer developments in chemotherapy along with the evolving field of photodynamic therapy both for intra-operative management and subsequent therapy is provided. A discussion of certain surgical management issues along with tumor induced epilepsy is included. Finally a discussion of the management of certain unique problems including brain metastases, brainstem glioma, central nervous system lymphoma along with issues involving patients with a brain tumor and pregnancy is provided.
Brain Tumor Invasion Biological, Clinical, and Therapeutic Considerations Edited by Tom Mikkelsen Rolf Bjerkvig Ole Didrik Laerum Mark L. Rosenblum Recent advances in molecular biology have given us profound new insights into the behavior of primary brain tumors. Not only are such tumors more diffuse in their infiltration of brain tissue and therefore less amenable to surgery than brain tumors originating elsewhere in the body—it now appears that the central nervous system and the normal brain itself constitute a biological environment conducive to the uncontrolled spread of primary tumors. Brain Tumor Invasion is the first comprehensive reference devoted to the invasive behavior of primary brain tumors. It examines the biological mechanisms responsible for the increased ability of gliomas to metastasize in the central nervous system, and discusses the role of chemical carcinogens, growth factors, oncogenes, and tumor suppressors in the progression of such metastases. This book surveys the latest research in the field, reviews present and future prospects of anti-invasive brain tumor therapy, and even translates preclinical trials and other research results into potential new therapies. The material is divided into five main categories: Developmental biology and molecular neuro-oncology Pathological and clinical features of malignant brain tumors Models for the study of brain tumor invasion in vivo and in vitro Mechanisms of invasion New therapeutic strategies Brain Tumor Invasion offers dozens of maps and photographs that illustrate topics under discussion. This in-depth introduction to one of the most difficult problems in the management of brain tumors is indispensable to neuro-oncologists involved in brain tumor research and therapy. It is also useful to researchers in cancer biology, neuroscience, cell biology, and molecular genetics.
Book Synopsis Brain Tumor Invasion by : Tom Mikkelsen
Download or read book Brain Tumor Invasion written by Tom Mikkelsen and published by Wiley-Liss. This book was released on 1998-05-05 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain Tumor Invasion Biological, Clinical, and Therapeutic Considerations Edited by Tom Mikkelsen Rolf Bjerkvig Ole Didrik Laerum Mark L. Rosenblum Recent advances in molecular biology have given us profound new insights into the behavior of primary brain tumors. Not only are such tumors more diffuse in their infiltration of brain tissue and therefore less amenable to surgery than brain tumors originating elsewhere in the body—it now appears that the central nervous system and the normal brain itself constitute a biological environment conducive to the uncontrolled spread of primary tumors. Brain Tumor Invasion is the first comprehensive reference devoted to the invasive behavior of primary brain tumors. It examines the biological mechanisms responsible for the increased ability of gliomas to metastasize in the central nervous system, and discusses the role of chemical carcinogens, growth factors, oncogenes, and tumor suppressors in the progression of such metastases. This book surveys the latest research in the field, reviews present and future prospects of anti-invasive brain tumor therapy, and even translates preclinical trials and other research results into potential new therapies. The material is divided into five main categories: Developmental biology and molecular neuro-oncology Pathological and clinical features of malignant brain tumors Models for the study of brain tumor invasion in vivo and in vitro Mechanisms of invasion New therapeutic strategies Brain Tumor Invasion offers dozens of maps and photographs that illustrate topics under discussion. This in-depth introduction to one of the most difficult problems in the management of brain tumors is indispensable to neuro-oncologists involved in brain tumor research and therapy. It is also useful to researchers in cancer biology, neuroscience, cell biology, and molecular genetics.
A dramatic increase in knowledge regarding the molecular biology of brain tumors has been established over the past few years, and this has lead to the development of novel therapeutic strategies for these patients. In this book a review of the options available for the clinical management of patients with these tumors are outlined. In addition advances in radiology both for pre-operative diagnostic purposes along with surgical planning are described. Furthermore a review of newer developments in chemotherapy along with the evolving field of photodynamic therapy both for intra-operative management and subsequent therapy is provided. A discussion of certain surgical management issues along with tumor induced epilepsy is included. Finally a discussion of the management of certain unique problems including brain metastases, brainstem glioma, central nervous system lymphoma along with issues involving patients with a brain tumor and pregnancy is provided.
Book Synopsis Clinical Management and Evolving Novel Therapeutic Strategies for Patients with Brain Tumors by : Terry Lichtor
Download or read book Clinical Management and Evolving Novel Therapeutic Strategies for Patients with Brain Tumors written by Terry Lichtor and published by IntechOpen. This book was released on 2013-04-10 with total page 654 pages. Available in PDF, EPUB and Kindle. Book excerpt: A dramatic increase in knowledge regarding the molecular biology of brain tumors has been established over the past few years, and this has lead to the development of novel therapeutic strategies for these patients. In this book a review of the options available for the clinical management of patients with these tumors are outlined. In addition advances in radiology both for pre-operative diagnostic purposes along with surgical planning are described. Furthermore a review of newer developments in chemotherapy along with the evolving field of photodynamic therapy both for intra-operative management and subsequent therapy is provided. A discussion of certain surgical management issues along with tumor induced epilepsy is included. Finally a discussion of the management of certain unique problems including brain metastases, brainstem glioma, central nervous system lymphoma along with issues involving patients with a brain tumor and pregnancy is provided.
This volume will bring together a review of research being carried out by international experts in this field, detailing treatment and research approaches in several forms of malignant brain tumors. These include glioblastoma (GBM), a highly aggressive and fatal form of astrocytoma which accounts for 80% of newly diagnosed brain tumor patients per year, and meningioma, of which 10% are malignant and extremely resistant to targeted therapies. The volume will also include a discussion of methods to overcome blood-brain barrier exclusion for more efficient targeted drug delivery in all forms of brain cancer treatment. The volume will include information on the repurposing of drugs in an attempt to circumvent drug resistance, use of small molecule inhibitors in GBM treatment, mechanisms of secondary brain metastasis, drug resistance, and state-of-the-art imaging of targeted therapies.
Book Synopsis Resistance to Targeted Therapies Against Adult Brain Cancers by : Amanda Tivnan
Download or read book Resistance to Targeted Therapies Against Adult Brain Cancers written by Amanda Tivnan and published by Springer. This book was released on 2016-11-26 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume will bring together a review of research being carried out by international experts in this field, detailing treatment and research approaches in several forms of malignant brain tumors. These include glioblastoma (GBM), a highly aggressive and fatal form of astrocytoma which accounts for 80% of newly diagnosed brain tumor patients per year, and meningioma, of which 10% are malignant and extremely resistant to targeted therapies. The volume will also include a discussion of methods to overcome blood-brain barrier exclusion for more efficient targeted drug delivery in all forms of brain cancer treatment. The volume will include information on the repurposing of drugs in an attempt to circumvent drug resistance, use of small molecule inhibitors in GBM treatment, mechanisms of secondary brain metastasis, drug resistance, and state-of-the-art imaging of targeted therapies.
Cannabis sativa is best known as the source of marijuana, the world’s most widely consumed illicit recreational drug. However, the plant is also extremely useful as a source of stem fiber, edible seed oil, and medicinal compounds, all of which are undergoing extremely promising research, technological applications, and business investment. Indeed, despite its capacity for harm as a recreational drug, cannabis has phenomenal potential for providing new products to benefit society and for generating extensive employment and huge profits. Misguided policies, until recently, have prevented legitimate research on the beneficial properties of cannabis, but there is now an explosion of societal, scientific, and political support to reappraise and remove some of the barriers to usage. Unfortunately, there is also a corresponding dearth of objective analysis. Towards redressing the limitation of information, Cannabis: A Complete Guide is a comprehensive reference summarizing botanical, business, chemical, ecological, genetic, historical, horticultural, legal, and medical considerations that are critical for the wise advancement and management of cannabis in its various forms. This book documents both the risks and benefits of what is indisputably one of the world’s most important species. The conflicting claims for medicinal virtues and toxicological vices are examined, based mainly on the most recent authoritative scientific reviews. The attempt is made consistently to reflect majority scientific opinion, although many aspects of cannabis are controversial. Aside from the relevance to specialists, the general public should find the presentation attractive because of the huge interest today in marijuana. Unfortunately, society has become so specialized and compartmentalized that most people have limited appreciation of the importance of science to their lives, except when a topic like marijuana becomes sensationalized. This review of cannabis can serve as a vehicle for public education in the realm of science and technology. Indeed, towards the goal of disseminating the important information in this book to a wide audience, the presentation is user-friendly, concise, and well-illustrated in the hope that non-specialists will find the topics both informative and entertaining.
Book Synopsis Cannabis by : Ernest Small
Download or read book Cannabis written by Ernest Small and published by CRC Press. This book was released on 2016-10-14 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cannabis sativa is best known as the source of marijuana, the world’s most widely consumed illicit recreational drug. However, the plant is also extremely useful as a source of stem fiber, edible seed oil, and medicinal compounds, all of which are undergoing extremely promising research, technological applications, and business investment. Indeed, despite its capacity for harm as a recreational drug, cannabis has phenomenal potential for providing new products to benefit society and for generating extensive employment and huge profits. Misguided policies, until recently, have prevented legitimate research on the beneficial properties of cannabis, but there is now an explosion of societal, scientific, and political support to reappraise and remove some of the barriers to usage. Unfortunately, there is also a corresponding dearth of objective analysis. Towards redressing the limitation of information, Cannabis: A Complete Guide is a comprehensive reference summarizing botanical, business, chemical, ecological, genetic, historical, horticultural, legal, and medical considerations that are critical for the wise advancement and management of cannabis in its various forms. This book documents both the risks and benefits of what is indisputably one of the world’s most important species. The conflicting claims for medicinal virtues and toxicological vices are examined, based mainly on the most recent authoritative scientific reviews. The attempt is made consistently to reflect majority scientific opinion, although many aspects of cannabis are controversial. Aside from the relevance to specialists, the general public should find the presentation attractive because of the huge interest today in marijuana. Unfortunately, society has become so specialized and compartmentalized that most people have limited appreciation of the importance of science to their lives, except when a topic like marijuana becomes sensationalized. This review of cannabis can serve as a vehicle for public education in the realm of science and technology. Indeed, towards the goal of disseminating the important information in this book to a wide audience, the presentation is user-friendly, concise, and well-illustrated in the hope that non-specialists will find the topics both informative and entertaining.
This volume gathers papers presented at the Workshop on Computational Diffusion MRI (CDMRI 2019), held under the auspices of the International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI), which took place in Shenzhen, China on October 17, 2019. This book presents the latest advances in the rapidly expanding field of diffusion MRI. It shares new perspectives on the latest research challenges for those currently working in the field, but also offers a valuable starting point for anyone interested in learning about computational techniques in diffusion MRI. The book includes rigorous mathematical derivations, a wealth of rich, full-colour visualisations and extensive clinically relevant results. As such, it will be of interest to researchers and practitioners in the fields of computer science, MRI physics and applied mathematics. Readers will find contributions covering a broad range of topics, from the mathematical foundations of the diffusion process and signal generation, to new computational methods and estimation techniques for the in vivo recovery of microstructural and connectivity features, as well as diffusion-relaxometry and frontline applications in research and clinical practice. This edition includes invited works from high-profile researchers with a specific focus on three new and important topics that are gaining momentum within the diffusion MRI community, including diffusion MRI signal acquisition and processing strategies, machine learning for diffusion MRI, and diffusion MRI outside the brain and clinical applications.
Book Synopsis Computational Diffusion MRI by : Elisenda Bonet-Carne
Download or read book Computational Diffusion MRI written by Elisenda Bonet-Carne and published by Springer Nature. This book was released on 2020-11-06 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume gathers papers presented at the Workshop on Computational Diffusion MRI (CDMRI 2019), held under the auspices of the International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI), which took place in Shenzhen, China on October 17, 2019. This book presents the latest advances in the rapidly expanding field of diffusion MRI. It shares new perspectives on the latest research challenges for those currently working in the field, but also offers a valuable starting point for anyone interested in learning about computational techniques in diffusion MRI. The book includes rigorous mathematical derivations, a wealth of rich, full-colour visualisations and extensive clinically relevant results. As such, it will be of interest to researchers and practitioners in the fields of computer science, MRI physics and applied mathematics. Readers will find contributions covering a broad range of topics, from the mathematical foundations of the diffusion process and signal generation, to new computational methods and estimation techniques for the in vivo recovery of microstructural and connectivity features, as well as diffusion-relaxometry and frontline applications in research and clinical practice. This edition includes invited works from high-profile researchers with a specific focus on three new and important topics that are gaining momentum within the diffusion MRI community, including diffusion MRI signal acquisition and processing strategies, machine learning for diffusion MRI, and diffusion MRI outside the brain and clinical applications.
Glioblastoma is an aggressive incurable primary tumor of the central nervous system. Median overall survival is in the range of 1.5 years even in selected clinical trials populations. Many features contribute to this therapeutic challenge including high intratumoral and intertumoral heterogeneity, resistance to therapy, migration and invasion, immunosuppression. With the access of novel highthroughput technologies, significant progress has been made to understand molecular and immunological signatures underlying the pathology of glioblastoma. Clinical trial designs have shifted from investigating broad “one-for-all” treatment approaches to precision oncology designs. The collection of contributions in this book aim at providing researchers and clinicians an update on different aspects of glioblastoma, i.e. progress in basic, preclinical and clinical research.
Book Synopsis Glioblastoma: State of the Art and Future Perspectives by : Ghazaleh Tabatabai
Download or read book Glioblastoma: State of the Art and Future Perspectives written by Ghazaleh Tabatabai and published by MDPI. This book was released on 2020-12-10 with total page 784 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glioblastoma is an aggressive incurable primary tumor of the central nervous system. Median overall survival is in the range of 1.5 years even in selected clinical trials populations. Many features contribute to this therapeutic challenge including high intratumoral and intertumoral heterogeneity, resistance to therapy, migration and invasion, immunosuppression. With the access of novel highthroughput technologies, significant progress has been made to understand molecular and immunological signatures underlying the pathology of glioblastoma. Clinical trial designs have shifted from investigating broad “one-for-all” treatment approaches to precision oncology designs. The collection of contributions in this book aim at providing researchers and clinicians an update on different aspects of glioblastoma, i.e. progress in basic, preclinical and clinical research.
