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Author: Abdullah M. S. Al-Hatmi
Publisher: Frontiers Media SA
Published: 2022-08-01
Total Pages: 134
ISBN-13: 2889764117
DOWNLOAD EBOOKDownload or read book Molecular Epidemiology of Fungal Infections written by Abdullah M. S. Al-Hatmi and published by Frontiers Media SA. This book was released on 2022-08-01 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author: Christopher C. Kibbler
Publisher: Oxford University Press
Published: 2017-12-14
Total Pages: 401
ISBN-13: 0198755384
DOWNLOAD EBOOKThe Oxford Textbook of Medical Mycology is a comprehensive reference text which brings together the science and medicine of human fungal disease. Written by a leading group of international authors to bring a global expertise, it is divided into sections that deal with the principles of mycology, the organisms, a systems based approach to management, fungal disease in specific patient groups, diagnosis, and treatment. The detailed clinical chapters take account of recent international guidelines on the management of fungal disease. With chapters covering recent developments in taxonomy, fungal genetics and other 'omics', epidemiology, pathogenesis, and immunology, this textbook is well suited to aid both scientists and clinicians. The extensive illustrations, tables, and in-depth coverage of topics, including discussion of the non-infective aspects of allergic and toxin mediated fungal disease, are designed to aid the understanding of mechanisms and pathology, and extend the usual approach to fungal disease. This textbook is essential reading for microbiologists, research scientists, infectious diseases clinicians, respiratory physicians, and those managing immunocompromised patients. Part of the Oxford Textbook in Infectious Disease and Microbiology series, it is also a useful companion text for students and trainees looking to supplement mycology courses and microbiology training.
Download or read book Oxford Textbook of Medical Mycology written by Christopher C. Kibbler and published by Oxford University Press. This book was released on 2017-12-14 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Oxford Textbook of Medical Mycology is a comprehensive reference text which brings together the science and medicine of human fungal disease. Written by a leading group of international authors to bring a global expertise, it is divided into sections that deal with the principles of mycology, the organisms, a systems based approach to management, fungal disease in specific patient groups, diagnosis, and treatment. The detailed clinical chapters take account of recent international guidelines on the management of fungal disease. With chapters covering recent developments in taxonomy, fungal genetics and other 'omics', epidemiology, pathogenesis, and immunology, this textbook is well suited to aid both scientists and clinicians. The extensive illustrations, tables, and in-depth coverage of topics, including discussion of the non-infective aspects of allergic and toxin mediated fungal disease, are designed to aid the understanding of mechanisms and pathology, and extend the usual approach to fungal disease. This textbook is essential reading for microbiologists, research scientists, infectious diseases clinicians, respiratory physicians, and those managing immunocompromised patients. Part of the Oxford Textbook in Infectious Disease and Microbiology series, it is also a useful companion text for students and trainees looking to supplement mycology courses and microbiology training.
Download or read book Population Genetics and Molecular Epidemiology of Bacterial and Fungal Diseases and Spread of Resistance to Antimicrobial Agents written by Patrick Boerlin and published by . This book was released on 2003 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author: P.R. KALE
Publisher:
Published: 2017
Total Pages:
ISBN-13:
DOWNLOAD EBOOKMolecular epidemiology, risk factor analysis and Comparison of diagnostic methods for Rapid Diagnosis of Fungal Pneumonia in Critically ill CirrhoticsPratibha Kale1, Vikas Khillan1, L G Mitra2, S K Sarin3.1)Department of Microbiology, 2)Department of Critical Care Medicine, 3)Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi.Objectives:Liver cirrhosis is associated with dysregulation of the immune system and increased susceptibility to fungal infections. We aimed to study the major risk factors andmolecular epidemiology of fungal pneumonia in critically ill cirrhotic patients. Also compared the rapid diagnostic methods and biomarkers for fungal pneumonia. Methods:Single-center, prospective cohort study of 50critically ill cirrhotic patients with fungal pneumonia between January-September 2017.Demographics, comorbidities, and laboratory variables were recorded. Comparative analysis of culture, real time PCR and biomarkers; Bronchoalveolar lavage and serum galactomannan, serum procalcitoninwere measured by ELISA and chemiluminescence assay on day 1, day 3 and day 7. The final outcome considered were mortality within one month after diagnosis or discharge of the patient with stable parameters. Genotyping was done with amplified fragment length polymorphism of clinical and air sampling Aspergillus isolates.Results:Aspergillusflavus was the most common species (34/50,68%). The risk factors identified were, neutropenia (p 0.03), steroids prior to ICU admission (p 0.02), prolonged hospitalizations >21 days (p 0.05). Culture positivity was 80%. Culture was not inferior to real time PCR for diagnosis of fungal pneumonia. BAL Galactomannan was early and better prognostic marker with median rise above >1 index value on day 1. Combination of molecular test and galactomannan could detect invasive aspergillosis in 90% cases. The median PCT level was higher from day 1in the fungal pneumonianon-survivor group (3.29 vs. 0.8ng/ml) withhigher 30-day mortality (72%). There was an association was found between PCT concentration associated bacterial infection(48%),antibiotic(74%) and antifungal therapy and renal failure. Patients with higher PCT at admission had higher mortality.Genotyping revealed; in two clusters, clinical isolates recovered from patients matched those recovered from air. Conclusion:Fungal pneumonia is a serious complication in cirrhotics with neutropenia, prolonged hospitalization and steroids as major risk factors. Aspergillus species predominate in consanguity with Asian epidemiology. Culture methods are reliable for diagnosis and combination of molecular test with BAL galactomannan is useful for rapid diagnosis. Serum procalcitonin is raised in patients with fungal pneumonia. Higher procalcitonin values are associated with higher mortality and poor outcome in critically ill patients.In our study the baseline PCT at admission to ICU was higher in non- survivor group, levels on D3 and D7 were persistantly higher. High serum procalcitonin level is an independent prognostic biomarker of mortality risk, and itu2019s a promising biomarker of prognosis in critically ill patients with fungal pneumonia to step up therapeutic measures. The observation of genetic relatedness of clinical and environmental sample might open new perspectives in the development of infection control measures to prevent invasive aspergillosis in high-risk patients.
Download or read book Molecular Epidemiology, Risk Factor Analysis And Comparison Of Diagnostic Methods For Rapid Diagnosis Of Fungal Pneumonia In Critically Ill Cirrhotics written by P.R. KALE and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular epidemiology, risk factor analysis and Comparison of diagnostic methods for Rapid Diagnosis of Fungal Pneumonia in Critically ill CirrhoticsPratibha Kale1, Vikas Khillan1, L G Mitra2, S K Sarin3.1)Department of Microbiology, 2)Department of Critical Care Medicine, 3)Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi.Objectives:Liver cirrhosis is associated with dysregulation of the immune system and increased susceptibility to fungal infections. We aimed to study the major risk factors andmolecular epidemiology of fungal pneumonia in critically ill cirrhotic patients. Also compared the rapid diagnostic methods and biomarkers for fungal pneumonia. Methods:Single-center, prospective cohort study of 50critically ill cirrhotic patients with fungal pneumonia between January-September 2017.Demographics, comorbidities, and laboratory variables were recorded. Comparative analysis of culture, real time PCR and biomarkers; Bronchoalveolar lavage and serum galactomannan, serum procalcitoninwere measured by ELISA and chemiluminescence assay on day 1, day 3 and day 7. The final outcome considered were mortality within one month after diagnosis or discharge of the patient with stable parameters. Genotyping was done with amplified fragment length polymorphism of clinical and air sampling Aspergillus isolates.Results:Aspergillusflavus was the most common species (34/50,68%). The risk factors identified were, neutropenia (p 0.03), steroids prior to ICU admission (p 0.02), prolonged hospitalizations >21 days (p 0.05). Culture positivity was 80%. Culture was not inferior to real time PCR for diagnosis of fungal pneumonia. BAL Galactomannan was early and better prognostic marker with median rise above >1 index value on day 1. Combination of molecular test and galactomannan could detect invasive aspergillosis in 90% cases. The median PCT level was higher from day 1in the fungal pneumonianon-survivor group (3.29 vs. 0.8ng/ml) withhigher 30-day mortality (72%). There was an association was found between PCT concentration associated bacterial infection(48%),antibiotic(74%) and antifungal therapy and renal failure. Patients with higher PCT at admission had higher mortality.Genotyping revealed; in two clusters, clinical isolates recovered from patients matched those recovered from air. Conclusion:Fungal pneumonia is a serious complication in cirrhotics with neutropenia, prolonged hospitalization and steroids as major risk factors. Aspergillus species predominate in consanguity with Asian epidemiology. Culture methods are reliable for diagnosis and combination of molecular test with BAL galactomannan is useful for rapid diagnosis. Serum procalcitonin is raised in patients with fungal pneumonia. Higher procalcitonin values are associated with higher mortality and poor outcome in critically ill patients.In our study the baseline PCT at admission to ICU was higher in non- survivor group, levels on D3 and D7 were persistantly higher. High serum procalcitonin level is an independent prognostic biomarker of mortality risk, and itu2019s a promising biomarker of prognosis in critically ill patients with fungal pneumonia to step up therapeutic measures. The observation of genetic relatedness of clinical and environmental sample might open new perspectives in the development of infection control measures to prevent invasive aspergillosis in high-risk patients.
Author: Betsy Foxman
Publisher: Academic Press
Published: 2010-12-28
Total Pages: 228
ISBN-13: 0080920845
DOWNLOAD EBOOKMolecular Tools and Infectious Disease Epidemiology examines the opportunities and methodologic challenges in the application of modern molecular genetic and biologic techniques to infectious disease epidemiology. The application of these techniques dramatically improves the measurement of disease and putative risk factors, increasing our ability to detect and track outbreaks, identify risk factors and detect new infectious agents. However, integration of these techniques into epidemiologic studies also poses new challenges in the design, conduct, and analysis. This book presents the key points of consideration when integrating molecular biology and epidemiology; discusses how using molecular tools in epidemiologic research affects program design and conduct; considers the ethical concerns that arise in molecular epidemiologic studies; and provides a context for understanding and interpreting scientific literature as a foundation for subsequent practical experience in the laboratory and in the field. The book is recommended for graduate and advanced undergraduate students studying infectious disease epidemiology and molecular epidemiology; and for the epidemiologist wishing to integrate molecular techniques into his or her studies. Presents the key points of consideration when integrating molecular biology and epidemiology Discusses how using molecular tools in epidemiologic research affects program design and conduct Considers the ethical concerns that arise in molecular epidemiologic studies Provides a context for understanding and interpreting scientific literature as a foundation for subsequent practical experience in the laboratory and in the field
Download or read book Molecular Tools and Infectious Disease Epidemiology written by Betsy Foxman and published by Academic Press. This book was released on 2010-12-28 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Tools and Infectious Disease Epidemiology examines the opportunities and methodologic challenges in the application of modern molecular genetic and biologic techniques to infectious disease epidemiology. The application of these techniques dramatically improves the measurement of disease and putative risk factors, increasing our ability to detect and track outbreaks, identify risk factors and detect new infectious agents. However, integration of these techniques into epidemiologic studies also poses new challenges in the design, conduct, and analysis. This book presents the key points of consideration when integrating molecular biology and epidemiology; discusses how using molecular tools in epidemiologic research affects program design and conduct; considers the ethical concerns that arise in molecular epidemiologic studies; and provides a context for understanding and interpreting scientific literature as a foundation for subsequent practical experience in the laboratory and in the field. The book is recommended for graduate and advanced undergraduate students studying infectious disease epidemiology and molecular epidemiology; and for the epidemiologist wishing to integrate molecular techniques into his or her studies. Presents the key points of consideration when integrating molecular biology and epidemiology Discusses how using molecular tools in epidemiologic research affects program design and conduct Considers the ethical concerns that arise in molecular epidemiologic studies Provides a context for understanding and interpreting scientific literature as a foundation for subsequent practical experience in the laboratory and in the field
Author: Arunaloke Chakrabarti
Publisher: Springer Nature
Published: 2019-11-16
Total Pages: 339
ISBN-13: 9811394598
DOWNLOAD EBOOKThis book discusses the unique epidemiology of fungal infections in Asia, illustrating that the situation in these countries is different from that in Western countries in terms of the causative species, natural history and management strategies. Asia, the world’s largest continent and home to more than half the global population, has conditions that favor the growth of many fungi, including a number of unique species. Further, socio-economic conditions such as overcrowding, compromised health care facilities and lack of awareness add to the morbidity and mortality due to fungal diseases in this part of the world. Since the majority of Asian countries do not have good diagnostic mycology laboratories, antifungal management is often based on experience. The limited data from Asian countries suggest a very high incidence of fungal infections. This book addresses epidemiology of fungal infections in general and specific populations of Asia, fungal allergy, and diagnosis and management in resource-limited environments. The book is must read for busy clinicians, microbiologists and critical care providers.
Download or read book Clinical Practice of Medical Mycology in Asia written by Arunaloke Chakrabarti and published by Springer Nature. This book was released on 2019-11-16 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the unique epidemiology of fungal infections in Asia, illustrating that the situation in these countries is different from that in Western countries in terms of the causative species, natural history and management strategies. Asia, the world’s largest continent and home to more than half the global population, has conditions that favor the growth of many fungi, including a number of unique species. Further, socio-economic conditions such as overcrowding, compromised health care facilities and lack of awareness add to the morbidity and mortality due to fungal diseases in this part of the world. Since the majority of Asian countries do not have good diagnostic mycology laboratories, antifungal management is often based on experience. The limited data from Asian countries suggest a very high incidence of fungal infections. This book addresses epidemiology of fungal infections in general and specific populations of Asia, fungal allergy, and diagnosis and management in resource-limited environments. The book is must read for busy clinicians, microbiologists and critical care providers.
Author: Serge Morand
Publisher: Springer Science & Business Media
Published: 2011-09-08
Total Pages: 335
ISBN-13: 9400721145
DOWNLOAD EBOOKMolecular epidemiology has recently broaden its focuses due to the development of molecular tools but also by incorporating advances of other fields such as mathematical epidemiology, molecular ecology, population genetics and evolution. Facing new risks of emerging and re-emerging infectious diseases that are threats for humans and their livestock, the objectives of molecular epidemiology include: - the development of molecular tools, genotyping and gene expression - the incorporation of concepts and results of population genetics of infectious diseases - the integration of recent advances in theoretical epidemiology and evolutionary ecology of diseases - a better understanding of transmission for the development of risk factors analyses. This book will demonstrate how the latest developments in molecular tools and in epidemiology can be integrated with studies of host-pathogen interactions. Besides a strong theoretical component, there will also be an emphasis on applications in the fields of epidemiology, public health, veterinary medicine, and health ecology. Students and researchers in the fields of epidemiology, animal and human health, evolutionary ecology, parasitology are the main potential readers of the book, as well as a broader audience from veterinary medicine and conservation.
Download or read book New Frontiers of Molecular Epidemiology of Infectious Diseases written by Serge Morand and published by Springer Science & Business Media. This book was released on 2011-09-08 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular epidemiology has recently broaden its focuses due to the development of molecular tools but also by incorporating advances of other fields such as mathematical epidemiology, molecular ecology, population genetics and evolution. Facing new risks of emerging and re-emerging infectious diseases that are threats for humans and their livestock, the objectives of molecular epidemiology include: - the development of molecular tools, genotyping and gene expression - the incorporation of concepts and results of population genetics of infectious diseases - the integration of recent advances in theoretical epidemiology and evolutionary ecology of diseases - a better understanding of transmission for the development of risk factors analyses. This book will demonstrate how the latest developments in molecular tools and in epidemiology can be integrated with studies of host-pathogen interactions. Besides a strong theoretical component, there will also be an emphasis on applications in the fields of epidemiology, public health, veterinary medicine, and health ecology. Students and researchers in the fields of epidemiology, animal and human health, evolutionary ecology, parasitology are the main potential readers of the book, as well as a broader audience from veterinary medicine and conservation.
Author: Dongyou Liu
Publisher: CRC Press
Published: 2011-06-17
Total Pages: 961
ISBN-13: 1439812403
DOWNLOAD EBOOKThe large number of molecular protocols available creates a dilemma for those attempting to adopt the most appropriate for streamlined identification and detection of fungal pathogens of interest. Molecular Detection of Human Fungal Pathogens provides a reliable and comprehensive resource relating the molecular detection and identification of major human fungal pathogens. This volume contains expert contributions from international mycologists involved in fungal pathogen research and diagnosis. Following a similar format throughout, each chapter comprises: A brief review of the classification, epidemiology, clinical features, and diagnosis of one or a group of related fungal species An outline of clinical sample collection and preparation procedures A selection of representative stepwise molecular detection protocols A discussion on further research requirements for improving the diagnosis The book offers an indispensable tool for medical, veterinary, and industrial laboratory scientists working in the area of fungal determination. It also constitutes a convenient textbook for undergraduate and graduate students majoring in microbiology and is an essential guide for upcoming and experienced laboratory scientists wishing to acquire and polish their skills in molecular diagnosis of fungal diseases.
Download or read book Molecular Detection of Human Fungal Pathogens written by Dongyou Liu and published by CRC Press. This book was released on 2011-06-17 with total page 961 pages. Available in PDF, EPUB and Kindle. Book excerpt: The large number of molecular protocols available creates a dilemma for those attempting to adopt the most appropriate for streamlined identification and detection of fungal pathogens of interest. Molecular Detection of Human Fungal Pathogens provides a reliable and comprehensive resource relating the molecular detection and identification of major human fungal pathogens. This volume contains expert contributions from international mycologists involved in fungal pathogen research and diagnosis. Following a similar format throughout, each chapter comprises: A brief review of the classification, epidemiology, clinical features, and diagnosis of one or a group of related fungal species An outline of clinical sample collection and preparation procedures A selection of representative stepwise molecular detection protocols A discussion on further research requirements for improving the diagnosis The book offers an indispensable tool for medical, veterinary, and industrial laboratory scientists working in the area of fungal determination. It also constitutes a convenient textbook for undergraduate and graduate students majoring in microbiology and is an essential guide for upcoming and experienced laboratory scientists wishing to acquire and polish their skills in molecular diagnosis of fungal diseases.
Author: Mahmoud Ghannoum
Publisher: CRC Press
Published: 2016-04-19
Total Pages: 484
ISBN-13: 0849387868
DOWNLOAD EBOOKA concise one-stop-practical reference for the various physicians dealing with fungal infections, Antifungal Therapy appeals to infectious disease physicians, transplant surgeons, dermatologists, and intensivists, as well as basic scientists and pharmaceutical company researchers interested in the state of antifungal therapy. This book provides a c
Download or read book Antifungal Therapy written by Mahmoud Ghannoum and published by CRC Press. This book was released on 2016-04-19 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: A concise one-stop-practical reference for the various physicians dealing with fungal infections, Antifungal Therapy appeals to infectious disease physicians, transplant surgeons, dermatologists, and intensivists, as well as basic scientists and pharmaceutical company researchers interested in the state of antifungal therapy. This book provides a c
Author: Duane R. Hospenthal
Publisher: Springer Science & Business Media
Published: 2007-11-29
Total Pages: 424
ISBN-13: 1588298221
DOWNLOAD EBOOKDiagnosis and Treatment of Human Mycoses brings together globally-recognized mycoses experts to guide readers in the use of current knowledge in the field of medical mycology to manage those who suffer from fungal infections (mycoses). Often, diagnostic strategies and tests, including basic and directed culturing techniques, histopathology with standard and special stains, serological methods, and radiological studies all need to be considered and commonly combined to make the diagnosis of fungal infection. This volume first introduces and reviews these tools separately and then as they pertain to specific infections or groups of diseases. The volume consists of four parts. Parts I-III provide an overview of diagnostic and therapeutic tools, and part IV presents the human mycoses. Diagnosis and Treatment of Human Mycoses is meant to be a concise text that will provide the busy infectious disease, hematology–oncology, pulmonology, or critical care specialist a practical tool to diagnose and manage fungal infections. In addition, the depth of the material in the text will provide these and other medical specialists and trainees an excellent reference and learning resource.
Download or read book Diagnosis and Treatment of Human Mycoses written by Duane R. Hospenthal and published by Springer Science & Business Media. This book was released on 2007-11-29 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diagnosis and Treatment of Human Mycoses brings together globally-recognized mycoses experts to guide readers in the use of current knowledge in the field of medical mycology to manage those who suffer from fungal infections (mycoses). Often, diagnostic strategies and tests, including basic and directed culturing techniques, histopathology with standard and special stains, serological methods, and radiological studies all need to be considered and commonly combined to make the diagnosis of fungal infection. This volume first introduces and reviews these tools separately and then as they pertain to specific infections or groups of diseases. The volume consists of four parts. Parts I-III provide an overview of diagnostic and therapeutic tools, and part IV presents the human mycoses. Diagnosis and Treatment of Human Mycoses is meant to be a concise text that will provide the busy infectious disease, hematology–oncology, pulmonology, or critical care specialist a practical tool to diagnose and manage fungal infections. In addition, the depth of the material in the text will provide these and other medical specialists and trainees an excellent reference and learning resource.
