Molecular Hematology

Molecular Hematology

Author: Drew Provan

Publisher: John Wiley & Sons

Published: 2019-09-17

Total Pages: 814

ISBN-13: 1119252938

DOWNLOAD EBOOK

The new and fully-revised volume of hematologic molecular biology for practicing and trainee hematologists Molecular Hematology is a comprehensive resource for hematologists to increase their understanding of the molecular basis of various blood diseases, their pathogeneses, and current and emerging molecular research and therapies. The impact of molecular research on the field of hematology is significant—molecular techniques are continuing to play a central role in in the diagnosis and treatment of blood diseases. Molecular characterization of genes and proteins has increased our comprehension of the causes of hematological diseases and led to the development of new drug therapies and recombinant proteins. Now in its fourth edition, Molecular Hematology has been thoroughly revised and updated to reflect current advances in molecular research. Chapters introduce and summarize specific disorders, such as hemophilia, anemia, and multiple myeloma, and illustrate the impact of molecular research on their diagnoses and treatments. Contributions written by respected clinicians and researchers offer accessible coverage of topics including lymphoma genetics, molecular coagulation and thrombophilia, platelet disorders, pharmacogenomics, and many others. Demonstrates the clinical relevance of molecular biology in hematology Provides overviews of recent advances in cancer-cell biology, with an emphasis on leukemia and lymphoma Offers new and updated chapters written by an international team of experts in the field Presents new full-color charts, graphs, and illustrations Includes access to a Wiley Companion Digital Edition providing search across the book, downloadable illustrations and notation tools Molecular Hematology is an essential volume for both trainee and practicing hematologists and oncologists, molecular biologists, and research scientists working in the field of hematology.


Book Synopsis Molecular Hematology by : Drew Provan

Download or read book Molecular Hematology written by Drew Provan and published by John Wiley & Sons. This book was released on 2019-09-17 with total page 814 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new and fully-revised volume of hematologic molecular biology for practicing and trainee hematologists Molecular Hematology is a comprehensive resource for hematologists to increase their understanding of the molecular basis of various blood diseases, their pathogeneses, and current and emerging molecular research and therapies. The impact of molecular research on the field of hematology is significant—molecular techniques are continuing to play a central role in in the diagnosis and treatment of blood diseases. Molecular characterization of genes and proteins has increased our comprehension of the causes of hematological diseases and led to the development of new drug therapies and recombinant proteins. Now in its fourth edition, Molecular Hematology has been thoroughly revised and updated to reflect current advances in molecular research. Chapters introduce and summarize specific disorders, such as hemophilia, anemia, and multiple myeloma, and illustrate the impact of molecular research on their diagnoses and treatments. Contributions written by respected clinicians and researchers offer accessible coverage of topics including lymphoma genetics, molecular coagulation and thrombophilia, platelet disorders, pharmacogenomics, and many others. Demonstrates the clinical relevance of molecular biology in hematology Provides overviews of recent advances in cancer-cell biology, with an emphasis on leukemia and lymphoma Offers new and updated chapters written by an international team of experts in the field Presents new full-color charts, graphs, and illustrations Includes access to a Wiley Companion Digital Edition providing search across the book, downloadable illustrations and notation tools Molecular Hematology is an essential volume for both trainee and practicing hematologists and oncologists, molecular biologists, and research scientists working in the field of hematology.

Molecular Hematology

Molecular Hematology

Author: Drew Provan

Publisher: John Wiley & Sons

Published: 2024-03-05

Total Pages: 452

ISBN-13: 1394180470

DOWNLOAD EBOOK

Provides a core knowledgebase for those with minimal exposure to hematologic molecular biology, fully revised and updated Molecular Hematology brings together the most up-to-date and reliable information on the molecular basis of major hematologic diseases. Edited and authored by leading experts in the field, this volume demonstrates the clinical relevance of molecular biology in the diagnosis and treatment of blood disorders. Concise, accessible chapters address key topics in modern hematology, such as lymphoma genetics, molecular coagulation, thrombophilia, pharmacogenomics, platelet disorders, hemophilia, anemia, and multiple myeloma. Chapters introduce and summarize specific hematologic diseases, explore the pathogenesis of the disorder, highlight new and emerging molecular strategies, and more. Now in its fifth edition, Molecular Hematology is fully revised to incorporate contemporary hematology research and practice. Entirely new chapters cover topics such as CAR-T cell technology, COVID, cancer cell biology, gene therapy and gene editing in clinical practice, as well as the impact of molecular research on the diagnosis and treatment of various malignant hematologic diseases. This edition includes updated suggested readings and a wealth of new full-color charts, graphs, and illustrations throughout. Covers the molecular biology of different blood diseases, their pathogeneses, and current molecular research and therapies Illustrates the impact of molecular research on hematologic investigations and therapeutics Discusses how progress in basic science and therapeutics has improved the diagnosis and care of patients with various hematologic disorders Surveys recent developments in cancer-cell biology, with an emphasis on leukemia and lymphoma Includes access to a companion Digital Edition providing search across the book, downloadable illustrations, and notation tools Molecular Hematology is a must-have resource for established and trainee clinicians, clinical scientists and researchers, medical students, and upper-level undergraduates in the fields of hematology, oncology, and molecular biology.


Book Synopsis Molecular Hematology by : Drew Provan

Download or read book Molecular Hematology written by Drew Provan and published by John Wiley & Sons. This book was released on 2024-03-05 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a core knowledgebase for those with minimal exposure to hematologic molecular biology, fully revised and updated Molecular Hematology brings together the most up-to-date and reliable information on the molecular basis of major hematologic diseases. Edited and authored by leading experts in the field, this volume demonstrates the clinical relevance of molecular biology in the diagnosis and treatment of blood disorders. Concise, accessible chapters address key topics in modern hematology, such as lymphoma genetics, molecular coagulation, thrombophilia, pharmacogenomics, platelet disorders, hemophilia, anemia, and multiple myeloma. Chapters introduce and summarize specific hematologic diseases, explore the pathogenesis of the disorder, highlight new and emerging molecular strategies, and more. Now in its fifth edition, Molecular Hematology is fully revised to incorporate contemporary hematology research and practice. Entirely new chapters cover topics such as CAR-T cell technology, COVID, cancer cell biology, gene therapy and gene editing in clinical practice, as well as the impact of molecular research on the diagnosis and treatment of various malignant hematologic diseases. This edition includes updated suggested readings and a wealth of new full-color charts, graphs, and illustrations throughout. Covers the molecular biology of different blood diseases, their pathogeneses, and current molecular research and therapies Illustrates the impact of molecular research on hematologic investigations and therapeutics Discusses how progress in basic science and therapeutics has improved the diagnosis and care of patients with various hematologic disorders Surveys recent developments in cancer-cell biology, with an emphasis on leukemia and lymphoma Includes access to a companion Digital Edition providing search across the book, downloadable illustrations, and notation tools Molecular Hematology is a must-have resource for established and trainee clinicians, clinical scientists and researchers, medical students, and upper-level undergraduates in the fields of hematology, oncology, and molecular biology.

Small Molecules in Hematology

Small Molecules in Hematology

Author: Uwe M. Martens

Publisher: Springer

Published: 2018-08-01

Total Pages: 297

ISBN-13: 3319914391

DOWNLOAD EBOOK

This book, written by respected experts, discusses in detail the latest developments in targeted therapy for hematologic malignancies using small molecules. It covers a wide range of small molecules including tyrosine kinase inhibitors, immunomodulatory drugs, the IDH-2 inhibitor enasidenib, the BCL-2 inhibitor venetoclax, and the proteasome inhibitor carfilzomib. For each molecule, aspects such as the chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed. Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of precision cancer therapy is now growing rapidly, and the advances being made will mean significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. An accompanying volume addresses the use of small molecules in oncology, and the two volumes together represent the third edition of the book originally published under the same title.


Book Synopsis Small Molecules in Hematology by : Uwe M. Martens

Download or read book Small Molecules in Hematology written by Uwe M. Martens and published by Springer. This book was released on 2018-08-01 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, written by respected experts, discusses in detail the latest developments in targeted therapy for hematologic malignancies using small molecules. It covers a wide range of small molecules including tyrosine kinase inhibitors, immunomodulatory drugs, the IDH-2 inhibitor enasidenib, the BCL-2 inhibitor venetoclax, and the proteasome inhibitor carfilzomib. For each molecule, aspects such as the chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed. Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of precision cancer therapy is now growing rapidly, and the advances being made will mean significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. An accompanying volume addresses the use of small molecules in oncology, and the two volumes together represent the third edition of the book originally published under the same title.

Molecular Aspects of Hematologic Malignancies

Molecular Aspects of Hematologic Malignancies

Author: Michal Witt

Publisher: Springer Science & Business Media

Published: 2012-06-30

Total Pages: 468

ISBN-13: 3642294677

DOWNLOAD EBOOK

This book provides a state-of-the-art approach to the molecular basis of hematologic diseases and its translation into improved diagnostics and novel therapeutic strategies. Several representative hemato-oncologic malignancies are analyzed in detail: acute lymphoblastic leukemia, acute myeloid leukemia, B-cell Non-Hodgkin lymphomas, multiple myeloma, chronic lymphocytic leukemia, chronic myeloid leukemia, myelodysplastic syndromes, and myeloproliferative neoplasms. Experts in the field describe the molecular methods applied for modern diagnostics and therapies, such as hematopoietic stem cell transplantation, donor recipient matching, banking of biological material, analyses of post-transplant chimerism, and minimal residual disease monitoring. The volume concludes with an extensive section comprising thorough step-by-step protocols of molecular techniques in hematology, all of them validated in the authors’ own laboratories.


Book Synopsis Molecular Aspects of Hematologic Malignancies by : Michal Witt

Download or read book Molecular Aspects of Hematologic Malignancies written by Michal Witt and published by Springer Science & Business Media. This book was released on 2012-06-30 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a state-of-the-art approach to the molecular basis of hematologic diseases and its translation into improved diagnostics and novel therapeutic strategies. Several representative hemato-oncologic malignancies are analyzed in detail: acute lymphoblastic leukemia, acute myeloid leukemia, B-cell Non-Hodgkin lymphomas, multiple myeloma, chronic lymphocytic leukemia, chronic myeloid leukemia, myelodysplastic syndromes, and myeloproliferative neoplasms. Experts in the field describe the molecular methods applied for modern diagnostics and therapies, such as hematopoietic stem cell transplantation, donor recipient matching, banking of biological material, analyses of post-transplant chimerism, and minimal residual disease monitoring. The volume concludes with an extensive section comprising thorough step-by-step protocols of molecular techniques in hematology, all of them validated in the authors’ own laboratories.

Rodak's Hematology - E-Book

Rodak's Hematology - E-Book

Author: Elaine M. Keohane

Publisher: Elsevier Health Sciences

Published: 2019-02-22

Total Pages: 910

ISBN-13: 0323549632

DOWNLOAD EBOOK

**Selected for Doody’s Core Titles® 2024 in Laboratory Technology** Make sure you are thoroughly prepared to work in a clinical lab. Rodak’s Hematology: Clinical Principles and Applications, 6th Edition uses hundreds of full-color photomicrographs to help you understand the essentials of hematology. This new edition shows how to accurately identify cells, simplifies hemostasis and thrombosis concepts, and covers normal hematopoiesis through diseases of erythroid, myeloid, lymphoid, and megakaryocytic origins. Easy to follow and understand, this book also covers key topics including: working in a hematology lab; complementary testing areas such as flow cytometry, cytogenetics, and molecular diagnostics; the parts and functions of the cell; and laboratory testing of blood cells and body fluid cells. UPDATED nearly 700 full-color illustrations and photomicrographs make it easier for you to visualize hematology concepts and show what you’ll encounter in the lab, with images appearing near their mentions in the text to minimize flipping pages back and forth. UPDATED content throughout text reflects latest information on hematology. Instructions for lab procedures include sources of possible errors along with comments. Hematology instruments are described, compared, and contrasted. Case studies in each chapter provide opportunities to apply hematology concepts to real-life scenarios. Hematology/hemostasis reference ranges are listed on the inside front and back covers for quick reference. A bulleted summary makes it easy for you to review the important points in every chapter. Learning objectives begin each chapter and indicate what you should achieve, with review questions appearing at the end. A glossary of key terms makes it easy to find and learn definitions. NEW! Additional content on cell structure and receptors helps you learn to identify these organisms. NEW! New chapter on Introduction to Hematology Malignancies provides and overview of diagnostic technology and techniques used in the lab.


Book Synopsis Rodak's Hematology - E-Book by : Elaine M. Keohane

Download or read book Rodak's Hematology - E-Book written by Elaine M. Keohane and published by Elsevier Health Sciences. This book was released on 2019-02-22 with total page 910 pages. Available in PDF, EPUB and Kindle. Book excerpt: **Selected for Doody’s Core Titles® 2024 in Laboratory Technology** Make sure you are thoroughly prepared to work in a clinical lab. Rodak’s Hematology: Clinical Principles and Applications, 6th Edition uses hundreds of full-color photomicrographs to help you understand the essentials of hematology. This new edition shows how to accurately identify cells, simplifies hemostasis and thrombosis concepts, and covers normal hematopoiesis through diseases of erythroid, myeloid, lymphoid, and megakaryocytic origins. Easy to follow and understand, this book also covers key topics including: working in a hematology lab; complementary testing areas such as flow cytometry, cytogenetics, and molecular diagnostics; the parts and functions of the cell; and laboratory testing of blood cells and body fluid cells. UPDATED nearly 700 full-color illustrations and photomicrographs make it easier for you to visualize hematology concepts and show what you’ll encounter in the lab, with images appearing near their mentions in the text to minimize flipping pages back and forth. UPDATED content throughout text reflects latest information on hematology. Instructions for lab procedures include sources of possible errors along with comments. Hematology instruments are described, compared, and contrasted. Case studies in each chapter provide opportunities to apply hematology concepts to real-life scenarios. Hematology/hemostasis reference ranges are listed on the inside front and back covers for quick reference. A bulleted summary makes it easy for you to review the important points in every chapter. Learning objectives begin each chapter and indicate what you should achieve, with review questions appearing at the end. A glossary of key terms makes it easy to find and learn definitions. NEW! Additional content on cell structure and receptors helps you learn to identify these organisms. NEW! New chapter on Introduction to Hematology Malignancies provides and overview of diagnostic technology and techniques used in the lab.

Laboratory Hematology Practice

Laboratory Hematology Practice

Author: Kandice Kottke-Marchant

Publisher: John Wiley & Sons

Published: 2012-06-06

Total Pages: 777

ISBN-13: 1444398571

DOWNLOAD EBOOK

Expertly edited and endorsed by the International Society for Laboratory Hematology, this is the newest international textbook on all aspects of laboratory hematology. Covering both traditional and cutting-edge hematology laboratory technology this book emphasizes international recommendations for testing practices. Illustrative case studies on how technology can be used in patient diagnosis are included. Laboratory Hematology Practice is an invaluable resource for all those working in the field.


Book Synopsis Laboratory Hematology Practice by : Kandice Kottke-Marchant

Download or read book Laboratory Hematology Practice written by Kandice Kottke-Marchant and published by John Wiley & Sons. This book was released on 2012-06-06 with total page 777 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expertly edited and endorsed by the International Society for Laboratory Hematology, this is the newest international textbook on all aspects of laboratory hematology. Covering both traditional and cutting-edge hematology laboratory technology this book emphasizes international recommendations for testing practices. Illustrative case studies on how technology can be used in patient diagnosis are included. Laboratory Hematology Practice is an invaluable resource for all those working in the field.

Introduction to Molecular Immunohematology

Introduction to Molecular Immunohematology

Author: Tony S. Casina

Publisher:

Published: 2020

Total Pages:

ISBN-13: 9781563953668

DOWNLOAD EBOOK

"The book will be an approachable guide to learning about molecular testing as it relates to blood banking and Immunohematology. Methods will be discussed, allele tables explained, and nuances taught, so that the reader will feel comfortable understanding and using the resources that are available. It will be a useful tool to the SBB student or pathology resident studying for exams"--Provided by publisher.


Book Synopsis Introduction to Molecular Immunohematology by : Tony S. Casina

Download or read book Introduction to Molecular Immunohematology written by Tony S. Casina and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "The book will be an approachable guide to learning about molecular testing as it relates to blood banking and Immunohematology. Methods will be discussed, allele tables explained, and nuances taught, so that the reader will feel comfortable understanding and using the resources that are available. It will be a useful tool to the SBB student or pathology resident studying for exams"--Provided by publisher.

Hematologic Malignancies

Hematologic Malignancies

Author: Manorama Bhargava

Publisher: Springer Nature

Published: 2021-02-13

Total Pages: 246

ISBN-13: 9813347996

DOWNLOAD EBOOK

This book is a compendium of case studies in hematologic malignancies such as acute leukemias, myelodysplastic and myeloproliferative neoplasms, chronic leukemias and multiple myeloma covering cytogenetics (karyotyping Fluorescence in sitn hybridization (FISH)) and molecular studies in detail. The first few chapters describe the methodology employed for karyotyping, FISH and Real Time PCR technology conducive to establishment of these labs if required. Each case study is described in detail by including the clinical history of the patient, findings of peripheral blood, bone marrow aspirate and bone biopsy morphological details. This is then followed by flowcytometric immunophenotyping, cytogenetic and molecular observations leading collectively to a final diagnosis, A discussion follows based on the relevance of this data in informing the prognosis, treatment response and survival in these patients. Additionally, this data serves as a key determinant for clinical decision making involving evidence based rational management of patients including targeted therapy. For better understanding, each case study is accompanied by black and white or colour images as appropriate. This book is a source of learning and a valuable read for clinical hematologists, hematopathologists, medical oncologists, residents, interns, DM Hematology students and DNB Hematology students as well.


Book Synopsis Hematologic Malignancies by : Manorama Bhargava

Download or read book Hematologic Malignancies written by Manorama Bhargava and published by Springer Nature. This book was released on 2021-02-13 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a compendium of case studies in hematologic malignancies such as acute leukemias, myelodysplastic and myeloproliferative neoplasms, chronic leukemias and multiple myeloma covering cytogenetics (karyotyping Fluorescence in sitn hybridization (FISH)) and molecular studies in detail. The first few chapters describe the methodology employed for karyotyping, FISH and Real Time PCR technology conducive to establishment of these labs if required. Each case study is described in detail by including the clinical history of the patient, findings of peripheral blood, bone marrow aspirate and bone biopsy morphological details. This is then followed by flowcytometric immunophenotyping, cytogenetic and molecular observations leading collectively to a final diagnosis, A discussion follows based on the relevance of this data in informing the prognosis, treatment response and survival in these patients. Additionally, this data serves as a key determinant for clinical decision making involving evidence based rational management of patients including targeted therapy. For better understanding, each case study is accompanied by black and white or colour images as appropriate. This book is a source of learning and a valuable read for clinical hematologists, hematopathologists, medical oncologists, residents, interns, DM Hematology students and DNB Hematology students as well.

Biology of Multiple Myeloma

Biology of Multiple Myeloma

Author: P. Leif Bergsagel

Publisher:

Published: 2005-11

Total Pages: 400

ISBN-13: 9781588291387

DOWNLOAD EBOOK

discusses the advances in molecular and cellular biology that have affected all fields of biology and have had a tremendous impact on the understanding of the biology of myeloma;reviews the dramatic clinical response to novel agents that has prompted a re-evaluation of important signaling pathways in myeloma;covers bone marrow microenvionments, molecular genetics, and other various genetic changes.


Book Synopsis Biology of Multiple Myeloma by : P. Leif Bergsagel

Download or read book Biology of Multiple Myeloma written by P. Leif Bergsagel and published by . This book was released on 2005-11 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: discusses the advances in molecular and cellular biology that have affected all fields of biology and have had a tremendous impact on the understanding of the biology of myeloma;reviews the dramatic clinical response to novel agents that has prompted a re-evaluation of important signaling pathways in myeloma;covers bone marrow microenvionments, molecular genetics, and other various genetic changes.

Molecular Pathology in Clinical Practice

Molecular Pathology in Clinical Practice

Author: Debra G.B. Leonard

Publisher: Springer Science & Business Media

Published: 2007-11-25

Total Pages: 589

ISBN-13: 0387332278

DOWNLOAD EBOOK

This authoritative textbook embodies the current standard in molecular testing for practicing pathologists, and residents and fellows in training. The text is organized into eight sections: genetics, inherited cancers, infectious disease, neoplastic hematopathology, solid tumors, HLA typing, identity testing, and laboratory management. Discussion of each diagnostic test includes its clinical significance, available assays, quality control and lab issues, interpretation, and reasons for testing. Coverage extends to HIV, hepatitis, developmental disorders, bioterrorism, warfare organisms, lymphomas, breast cancer and melanoma, forensics, parentage, and much more. Includes 189 illustrations, 45 in full-color. This textbook is a classic in the making and a must-have reference.


Book Synopsis Molecular Pathology in Clinical Practice by : Debra G.B. Leonard

Download or read book Molecular Pathology in Clinical Practice written by Debra G.B. Leonard and published by Springer Science & Business Media. This book was released on 2007-11-25 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative textbook embodies the current standard in molecular testing for practicing pathologists, and residents and fellows in training. The text is organized into eight sections: genetics, inherited cancers, infectious disease, neoplastic hematopathology, solid tumors, HLA typing, identity testing, and laboratory management. Discussion of each diagnostic test includes its clinical significance, available assays, quality control and lab issues, interpretation, and reasons for testing. Coverage extends to HIV, hepatitis, developmental disorders, bioterrorism, warfare organisms, lymphomas, breast cancer and melanoma, forensics, parentage, and much more. Includes 189 illustrations, 45 in full-color. This textbook is a classic in the making and a must-have reference.