Molecular Mechanisms of the Aging Process and Rejuvenation

Molecular Mechanisms of the Aging Process and Rejuvenation

Author: Naofumi Shiomi

Publisher: BoD – Books on Demand

Published: 2016-08-31

Total Pages: 128

ISBN-13: 9535125680

DOWNLOAD EBOOK

Numerous studies had been performed to elucidate the mechanisms of aging and to achieve rejuvenation, with some success reported in recent years. However, at present, the findings from those studies are not sufficient to resolve the issue of aging. This book presents an overview of recent topics on cellular aging and rejuvenation. In the early chapters, the molecular mechanisms of aging via the activities of clock and ion channel proteins, in addition to overall aspects, are discussed. In the latter part, the aging of the skin, immune system, and brain is discussed. This book will prove useful for those studying or developing new drugs to counter the aging process and will encourage the development of novel ideas for rejuvenation.


Book Synopsis Molecular Mechanisms of the Aging Process and Rejuvenation by : Naofumi Shiomi

Download or read book Molecular Mechanisms of the Aging Process and Rejuvenation written by Naofumi Shiomi and published by BoD – Books on Demand. This book was released on 2016-08-31 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Numerous studies had been performed to elucidate the mechanisms of aging and to achieve rejuvenation, with some success reported in recent years. However, at present, the findings from those studies are not sufficient to resolve the issue of aging. This book presents an overview of recent topics on cellular aging and rejuvenation. In the early chapters, the molecular mechanisms of aging via the activities of clock and ion channel proteins, in addition to overall aspects, are discussed. In the latter part, the aging of the skin, immune system, and brain is discussed. This book will prove useful for those studying or developing new drugs to counter the aging process and will encourage the development of novel ideas for rejuvenation.

Molecular Mechanisms of Skin Aging and Age-Related Diseases

Molecular Mechanisms of Skin Aging and Age-Related Diseases

Author: Taihao Quan

Publisher: CRC Press

Published: 2016-04-21

Total Pages: 263

ISBN-13: 1498704654

DOWNLOAD EBOOK

Our skin changes as we age. It becomes thinner and loses fat, making it less plump and smooth. Clinically, aged skin is characterized by wrinkles, sagging, age spots and dryness. Emphasizing laboratory and clinical research, this book comprehensively describes the molecular mechanisms of human skin-aging and age-related skin diseases. This includes molecular understanding of the development of aging skin and its prevention as well as mechanisms-based clinical rejuvenation. The book also focuses on research to develop mechanisms-based anti-skin-aging products.


Book Synopsis Molecular Mechanisms of Skin Aging and Age-Related Diseases by : Taihao Quan

Download or read book Molecular Mechanisms of Skin Aging and Age-Related Diseases written by Taihao Quan and published by CRC Press. This book was released on 2016-04-21 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our skin changes as we age. It becomes thinner and loses fat, making it less plump and smooth. Clinically, aged skin is characterized by wrinkles, sagging, age spots and dryness. Emphasizing laboratory and clinical research, this book comprehensively describes the molecular mechanisms of human skin-aging and age-related skin diseases. This includes molecular understanding of the development of aging skin and its prevention as well as mechanisms-based clinical rejuvenation. The book also focuses on research to develop mechanisms-based anti-skin-aging products.

Cell Aging: Molecular Mechanisms and Implications for Disease

Cell Aging: Molecular Mechanisms and Implications for Disease

Author: Christian Behl

Publisher: Springer Science & Business Media

Published: 2013-12-18

Total Pages: 113

ISBN-13: 3642451799

DOWNLOAD EBOOK

Aging represents a physiological and per se non-pathological and multifactorial process involving a set of key genes and mechanisms being triggered by different endogenous and exogenous factors. Since aging is a major risk factor in connection with a variety of human disorders, it is increasingly becoming a central topic in biochemical and medical research. The plethora of theories on aging – some of which have been discussed for decades – are neither isolated nor contradictory but instead can be connected in a network of pathways and processes at the cellular and molecular levels. This book summarizes the most prominent and important approaches, focusing on telomeres, DNA damage and oxidative stress as well as on the possible role of nutrition, the interplay between genes and environment (epigenetics) and intracellular protein homeostasis and introduces some genes that have actually extended life spans in animal models. Linking these different determinants of aging with disease, this volume aims to reveal their multiple interdependencies. We see that there is no single “perfect” theory of aging and that instead it is possible to define what the authors call the molecular aging matrix of the cell. A better knowledge of its key mechanisms and the mutual connections between its components will lead to a better understanding of age-associated disorders such as Alzheimer’s disease.


Book Synopsis Cell Aging: Molecular Mechanisms and Implications for Disease by : Christian Behl

Download or read book Cell Aging: Molecular Mechanisms and Implications for Disease written by Christian Behl and published by Springer Science & Business Media. This book was released on 2013-12-18 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aging represents a physiological and per se non-pathological and multifactorial process involving a set of key genes and mechanisms being triggered by different endogenous and exogenous factors. Since aging is a major risk factor in connection with a variety of human disorders, it is increasingly becoming a central topic in biochemical and medical research. The plethora of theories on aging – some of which have been discussed for decades – are neither isolated nor contradictory but instead can be connected in a network of pathways and processes at the cellular and molecular levels. This book summarizes the most prominent and important approaches, focusing on telomeres, DNA damage and oxidative stress as well as on the possible role of nutrition, the interplay between genes and environment (epigenetics) and intracellular protein homeostasis and introduces some genes that have actually extended life spans in animal models. Linking these different determinants of aging with disease, this volume aims to reveal their multiple interdependencies. We see that there is no single “perfect” theory of aging and that instead it is possible to define what the authors call the molecular aging matrix of the cell. A better knowledge of its key mechanisms and the mutual connections between its components will lead to a better understanding of age-associated disorders such as Alzheimer’s disease.

Times, Cells, and Aging

Times, Cells, and Aging

Author: Bernard Strihler

Publisher: Academic Press

Published: 1977-01-28

Total Pages: 480

ISBN-13:

DOWNLOAD EBOOK

Time, Cells, and Aging, 2nd Edition presents the mechanics of cell function and the relevant implications of the molecular-genetic view to the aging phenomena. This book explores the biology of the aging process. Comprised of 11 chapters, this edition starts with an overview of the causes and mechanisms underlying the gradual deterioration of structure and function characteristics of aging. This text then examines the two aspects of the behavior of man, including the reasoned conscious behavior and the greater dependence on reaction patterns predicted on the successful responses of the past. Other chapters explore the relationship between aging and mortality rate in animals, which is a result of an organism's deceasing ability to function optimally in carrying out his vital functions. The final chapter deals with the implementation of a research plan relevant to understanding the primary mechanisms of the aging process. This book is a valuable resource for gerontologists, biologists, and molecular biologists.


Book Synopsis Times, Cells, and Aging by : Bernard Strihler

Download or read book Times, Cells, and Aging written by Bernard Strihler and published by Academic Press. This book was released on 1977-01-28 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Time, Cells, and Aging, 2nd Edition presents the mechanics of cell function and the relevant implications of the molecular-genetic view to the aging phenomena. This book explores the biology of the aging process. Comprised of 11 chapters, this edition starts with an overview of the causes and mechanisms underlying the gradual deterioration of structure and function characteristics of aging. This text then examines the two aspects of the behavior of man, including the reasoned conscious behavior and the greater dependence on reaction patterns predicted on the successful responses of the past. Other chapters explore the relationship between aging and mortality rate in animals, which is a result of an organism's deceasing ability to function optimally in carrying out his vital functions. The final chapter deals with the implementation of a research plan relevant to understanding the primary mechanisms of the aging process. This book is a valuable resource for gerontologists, biologists, and molecular biologists.

Molecular Mechanisms of Aging

Molecular Mechanisms of Aging

Author: Konrad Beyreuther

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 327

ISBN-13: 3642842240

DOWNLOAD EBOOK


Book Synopsis Molecular Mechanisms of Aging by : Konrad Beyreuther

Download or read book Molecular Mechanisms of Aging written by Konrad Beyreuther and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cellular and Molecular Mechanisms of Aging in the Nervous System

Cellular and Molecular Mechanisms of Aging in the Nervous System

Author: Adler Brown

Publisher: American Medical Publishers

Published: 2023-09-26

Total Pages: 0

ISBN-13: 9781639279708

DOWNLOAD EBOOK

The nervous system is a highly complex network of nerves that coordinates actions and sensory information by transmitting signals to and from various parts of the body. Random molecular damage that steadily accumulates with age drives the ageing process at the cellular level. Many molecular mechanisms are involved and exogenous factors, like stress, also play a role in the aging process. The nervous system at the cellular level comprises a special cell called a neuron, which transmits signals to the other cells. Many physical, chemical, or biological changes in the status of neurons characterize brain aging. It is manifested in the form of deterioration in cognitive function and dementia. Dendritic regression in pyramidal neurons, synaptic atrophy, decrease of striatal dopamine receptors, accumulation of fluorescent pigments, cytoskeletal abnormalities, and reactive astrocytes and microglia are the common features of brain aging. The consequence of molecular and cellular alterations in brain aging is characterized by a plethora of anatomical changes, such as significant neuronal loss in hippocampus and neocortex. This book provides comprehensive insights on the molecular and cellular mechanisms of aging. The readers would gain knowledge that would broaden their perspective about this area of study.


Book Synopsis Cellular and Molecular Mechanisms of Aging in the Nervous System by : Adler Brown

Download or read book Cellular and Molecular Mechanisms of Aging in the Nervous System written by Adler Brown and published by American Medical Publishers. This book was released on 2023-09-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The nervous system is a highly complex network of nerves that coordinates actions and sensory information by transmitting signals to and from various parts of the body. Random molecular damage that steadily accumulates with age drives the ageing process at the cellular level. Many molecular mechanisms are involved and exogenous factors, like stress, also play a role in the aging process. The nervous system at the cellular level comprises a special cell called a neuron, which transmits signals to the other cells. Many physical, chemical, or biological changes in the status of neurons characterize brain aging. It is manifested in the form of deterioration in cognitive function and dementia. Dendritic regression in pyramidal neurons, synaptic atrophy, decrease of striatal dopamine receptors, accumulation of fluorescent pigments, cytoskeletal abnormalities, and reactive astrocytes and microglia are the common features of brain aging. The consequence of molecular and cellular alterations in brain aging is characterized by a plethora of anatomical changes, such as significant neuronal loss in hippocampus and neocortex. This book provides comprehensive insights on the molecular and cellular mechanisms of aging. The readers would gain knowledge that would broaden their perspective about this area of study.

Molecular Mechanisms and Models of Aging, Volume 1119

Molecular Mechanisms and Models of Aging, Volume 1119

Author: Efstathios S. Gonos

Publisher: Wiley-Blackwell

Published: 2008-01-14

Total Pages: 0

ISBN-13: 9781573316866

DOWNLOAD EBOOK

Aging is an inevitable consequence of life for nearly all organisms. It mostly reflects the outcome of complicated interactions between genetic factors along with the accumulation of a variety of deleterious stochastic changes over time. Thus, aging is an adaptive process, not caused by a single factor or process, but it is rather a multifactorial procedure modulated by the interplay among genetic and environmental factors. In the coming years, human aging will be one of the biggest challenges faced by industrialized countries as the average life expectancy is continuously increasing. This volume gathers together contributions from the top scientists and covers the whole range of modern research on aging. More specifically, the following topics are included: replicative senescence, telomeres and telomerase, cancer and aging, DNA repair, free radicals and oxidative stress, proteolysis and proteins maintenance, Immunity, neurodegeneration, model organisms, intervention as well as evolutional and epidemiological aspects. Overall, increasing our understanding of the aging process at the molecular level and applying available interventions will help to protect and preserve healthy aging. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member


Book Synopsis Molecular Mechanisms and Models of Aging, Volume 1119 by : Efstathios S. Gonos

Download or read book Molecular Mechanisms and Models of Aging, Volume 1119 written by Efstathios S. Gonos and published by Wiley-Blackwell. This book was released on 2008-01-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aging is an inevitable consequence of life for nearly all organisms. It mostly reflects the outcome of complicated interactions between genetic factors along with the accumulation of a variety of deleterious stochastic changes over time. Thus, aging is an adaptive process, not caused by a single factor or process, but it is rather a multifactorial procedure modulated by the interplay among genetic and environmental factors. In the coming years, human aging will be one of the biggest challenges faced by industrialized countries as the average life expectancy is continuously increasing. This volume gathers together contributions from the top scientists and covers the whole range of modern research on aging. More specifically, the following topics are included: replicative senescence, telomeres and telomerase, cancer and aging, DNA repair, free radicals and oxidative stress, proteolysis and proteins maintenance, Immunity, neurodegeneration, model organisms, intervention as well as evolutional and epidemiological aspects. Overall, increasing our understanding of the aging process at the molecular level and applying available interventions will help to protect and preserve healthy aging. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member

Skin Aging

Skin Aging

Author: Barbara A. Gilchrest

Publisher: Springer Science & Business Media

Published: 2006-04-20

Total Pages: 205

ISBN-13: 3540329536

DOWNLOAD EBOOK

The topic of skin aging is of growing importance to all working in the field of dermatology, aesthetic medicine and cosmetic medicine. Two internationally well-known and leading experts in the field present a comprehensive state-of-the-art review on all aspects of skin aging. With its clear, concise and reader-friendly format this book has all the potential to become the Bible of skin aging. Every specialist interested in dermatology, aesthetic medicine, cosmetic science, cutaneous biology and aging research will find indispensable information of great value for his or her daily work.


Book Synopsis Skin Aging by : Barbara A. Gilchrest

Download or read book Skin Aging written by Barbara A. Gilchrest and published by Springer Science & Business Media. This book was released on 2006-04-20 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: The topic of skin aging is of growing importance to all working in the field of dermatology, aesthetic medicine and cosmetic medicine. Two internationally well-known and leading experts in the field present a comprehensive state-of-the-art review on all aspects of skin aging. With its clear, concise and reader-friendly format this book has all the potential to become the Bible of skin aging. Every specialist interested in dermatology, aesthetic medicine, cosmetic science, cutaneous biology and aging research will find indispensable information of great value for his or her daily work.

Ending Aging

Ending Aging

Author: Aubrey de Grey

Publisher: Macmillan + ORM

Published: 2007-09-04

Total Pages: 452

ISBN-13: 1429931833

DOWNLOAD EBOOK

MUST WE AGE? A long life in a healthy, vigorous, youthful body has always been one of humanity's greatest dreams. Recent progress in genetic manipulations and calorie-restricted diets in laboratory animals hold forth the promise that someday science will enable us to exert total control over our own biological aging. Nearly all scientists who study the biology of aging agree that we will someday be able to substantially slow down the aging process, extending our productive, youthful lives. Dr. Aubrey de Grey is perhaps the most bullish of all such researchers. As has been reported in media outlets ranging from 60 Minutes to The New York Times, Dr. de Grey believes that the key biomedical technology required to eliminate aging-derived debilitation and death entirely—technology that would not only slow but periodically reverse age-related physiological decay, leaving us biologically young into an indefinite future—is now within reach. In Ending Aging, Dr. de Grey and his research assistant Michael Rae describe the details of this biotechnology. They explain that the aging of the human body, just like the aging of man-made machines, results from an accumulation of various types of damage. As with man-made machines, this damage can periodically be repaired, leading to indefinite extension of the machine's fully functional lifetime, just as is routinely done with classic cars. We already know what types of damage accumulate in the human body, and we are moving rapidly toward the comprehensive development of technologies to remove that damage. By demystifying aging and its postponement for the nonspecialist reader, de Grey and Rae systematically dismantle the fatalist presumption that aging will forever defeat the efforts of medical science.


Book Synopsis Ending Aging by : Aubrey de Grey

Download or read book Ending Aging written by Aubrey de Grey and published by Macmillan + ORM. This book was released on 2007-09-04 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: MUST WE AGE? A long life in a healthy, vigorous, youthful body has always been one of humanity's greatest dreams. Recent progress in genetic manipulations and calorie-restricted diets in laboratory animals hold forth the promise that someday science will enable us to exert total control over our own biological aging. Nearly all scientists who study the biology of aging agree that we will someday be able to substantially slow down the aging process, extending our productive, youthful lives. Dr. Aubrey de Grey is perhaps the most bullish of all such researchers. As has been reported in media outlets ranging from 60 Minutes to The New York Times, Dr. de Grey believes that the key biomedical technology required to eliminate aging-derived debilitation and death entirely—technology that would not only slow but periodically reverse age-related physiological decay, leaving us biologically young into an indefinite future—is now within reach. In Ending Aging, Dr. de Grey and his research assistant Michael Rae describe the details of this biotechnology. They explain that the aging of the human body, just like the aging of man-made machines, results from an accumulation of various types of damage. As with man-made machines, this damage can periodically be repaired, leading to indefinite extension of the machine's fully functional lifetime, just as is routinely done with classic cars. We already know what types of damage accumulate in the human body, and we are moving rapidly toward the comprehensive development of technologies to remove that damage. By demystifying aging and its postponement for the nonspecialist reader, de Grey and Rae systematically dismantle the fatalist presumption that aging will forever defeat the efforts of medical science.

DNA Repair

DNA Repair

Author: Maddalena Mognato

Publisher: BoD – Books on Demand

Published: 2019-06-05

Total Pages: 234

ISBN-13: 1838807829

DOWNLOAD EBOOK

This book offers a collection of chapters addressing different studies on DNA repair from a cellular and molecular point of view. The various contributions highlight the vastness of DNA repair process and the need for a deeper understanding. To this end, the recent considerations here presented can be a cue for scientists and students working on, or interested in, the subject of DNA repair in human cells. This book may suggest to readers new avenues of interplay between different kinds of DNA damage and cellular response for maintaining nuclear and mitochondrial genomic stability.


Book Synopsis DNA Repair by : Maddalena Mognato

Download or read book DNA Repair written by Maddalena Mognato and published by BoD – Books on Demand. This book was released on 2019-06-05 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a collection of chapters addressing different studies on DNA repair from a cellular and molecular point of view. The various contributions highlight the vastness of DNA repair process and the need for a deeper understanding. To this end, the recent considerations here presented can be a cue for scientists and students working on, or interested in, the subject of DNA repair in human cells. This book may suggest to readers new avenues of interplay between different kinds of DNA damage and cellular response for maintaining nuclear and mitochondrial genomic stability.