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While very useful for studying syntheses of molecular diversity, multi-component reactions also offer rapid access to a variety of complex molecules that are relevant for biological applications. Multi-component Reactions in Molecular Diversity analyzes these reactions, whether they are realized by organometallic, ionic or even radical processes. It highlights popular methods based on monotype reactions (cascade, tandem, domino) and their efficiency and academic industrial domain are illustrated. This book also investigates the most efficient ways to prepare complex molecules. Multi-component reactions are in tune with the concepts of atom and steps economy, which are of prior importance in all the reported processes ? from the laboratory to the pilot scale. The essential criteria for green chemistry are also examined in the book in detail.
Book Synopsis Multi-component Reactions in Molecular Diversity by : Jean-Philippe Goddard
Download or read book Multi-component Reactions in Molecular Diversity written by Jean-Philippe Goddard and published by John Wiley & Sons. This book was released on 2020-04-28 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: While very useful for studying syntheses of molecular diversity, multi-component reactions also offer rapid access to a variety of complex molecules that are relevant for biological applications. Multi-component Reactions in Molecular Diversity analyzes these reactions, whether they are realized by organometallic, ionic or even radical processes. It highlights popular methods based on monotype reactions (cascade, tandem, domino) and their efficiency and academic industrial domain are illustrated. This book also investigates the most efficient ways to prepare complex molecules. Multi-component reactions are in tune with the concepts of atom and steps economy, which are of prior importance in all the reported processes ? from the laboratory to the pilot scale. The essential criteria for green chemistry are also examined in the book in detail.
In the very first book on this hot topic, the expert editors andauthors present a comprehensive overview of these elegantreactions. From the contents: Organoboron compounds Free-radical mediated multicomponent coupling reactions Applications in drug discovery Metal catalyzed reactions Total synthesis of natural products Asymmetric isocyanide-based reactions The Biginelli reaction Asymmetric isocyanide-based reactions The Domino-Knoevenagel-Hetero-Diels-Alder Reaction and relatedtransformations Catalytic asymmetric reactions Algorithm based methods for discovering novel reactions Post-condensation modifications of the Passerini and Ugireactions An essential reference for organic and catalytic chemists, andthose working in organometallics both in academia and industry.
Book Synopsis Multicomponent Reactions by : Jieping Zhu
Download or read book Multicomponent Reactions written by Jieping Zhu and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the very first book on this hot topic, the expert editors andauthors present a comprehensive overview of these elegantreactions. From the contents: Organoboron compounds Free-radical mediated multicomponent coupling reactions Applications in drug discovery Metal catalyzed reactions Total synthesis of natural products Asymmetric isocyanide-based reactions The Biginelli reaction Asymmetric isocyanide-based reactions The Domino-Knoevenagel-Hetero-Diels-Alder Reaction and relatedtransformations Catalytic asymmetric reactions Algorithm based methods for discovering novel reactions Post-condensation modifications of the Passerini and Ugireactions An essential reference for organic and catalytic chemists, andthose working in organometallics both in academia and industry.
Generating molecular complexity and molecular diversity in a simple and rapid process has become one of the most challenging yet increasingly popular concepts in organic chemistry over the past few years. Taking this into consideration, the design of various types of chemical building blocks to prepare a small library of natural products or biological active molecules has become a significant objective. To fulfill these objectives, one can take advantage of multi component reactions (MCRs), in which three or more starting materials react to form a single product, where basically all or most of the atoms contribute to the newly formed product. MCRs have the ability of combining commercially available or readily accessible multiple starting materials with a variety of functionalities in one-step and then invoking post modification steps, like various kinds of ring formations and rearrangements. The experimental simplicity of one-pot procedures can give access to a diverse library of compounds rapidly, which makes the procedure more advantageous over multistep syntheses. All these important factors provide the opportunity to work on combinatorial chemistry which counts as a fundamental phenomenon in finding novel molecules for medicinal chemistry. The development and application of multicomponent reactions have attracted much attention in recent years since they are very useful synthetic tools for synthesize of potential pharmaceutically bioactive scaffolds. Post modified transformation of MCRs have great importance for accessing the synthetic building blocks for complex natural products and their analogues to investigate their possibility in treating various diseases. In the first project, we attempted the synthesis and biological study of Derivatives of the herbicide thaxtomin, through Ugi/keto-amide cyclization and Ugi/Dess-Martin/keto-amide cyclization sequences. The Ugi reaction was utilized with 3-nitrobenzaldehyde, indole-3-carboxaldehydes, phenyl lactic acid, methylamine, and methyl isocyanide to prepare dipeptides which then underwent oxidation to a- ketoamide intermediates followed by subsequent alkaline mediated keto-amide cyclization to syn and anti hemiaminal DKPs. In the second project, we reported a one-pot, two-step, total synthesis of naturally occurring Xenortides A, B, C and D, (Xens A-D) isolated from the bacterium Xenorhabdus nematophila, and an entire complimentary set of stereoisomers. The syntheses were accomplished utilizing an isocyanide-based Ugi 4-CR followed by facile N-Boc deprotection. The reaction sequence takes advantage of the chiral pool of N-Boc protected amino acids (L-Leu/Val and D-Leu/Val) with aryl isocyanides, phenyl acetaldehyde and methylamine giving the desired Xens A-D and all subsequent stereoisomers. Moreover, this focused library of naturally occurring Xens A-D and their subsequent stereoisomers were screened for cytotoxicity against a panel of epithelial cancer cell lines as well as normal cell lines.
Book Synopsis Synthesis of Biologically Active Compounds Via Multicomponent Reactions and Evaluation of Their Biological Activies by : Nasim Esmati
Download or read book Synthesis of Biologically Active Compounds Via Multicomponent Reactions and Evaluation of Their Biological Activies written by Nasim Esmati and published by . This book was released on 2018 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Generating molecular complexity and molecular diversity in a simple and rapid process has become one of the most challenging yet increasingly popular concepts in organic chemistry over the past few years. Taking this into consideration, the design of various types of chemical building blocks to prepare a small library of natural products or biological active molecules has become a significant objective. To fulfill these objectives, one can take advantage of multi component reactions (MCRs), in which three or more starting materials react to form a single product, where basically all or most of the atoms contribute to the newly formed product. MCRs have the ability of combining commercially available or readily accessible multiple starting materials with a variety of functionalities in one-step and then invoking post modification steps, like various kinds of ring formations and rearrangements. The experimental simplicity of one-pot procedures can give access to a diverse library of compounds rapidly, which makes the procedure more advantageous over multistep syntheses. All these important factors provide the opportunity to work on combinatorial chemistry which counts as a fundamental phenomenon in finding novel molecules for medicinal chemistry. The development and application of multicomponent reactions have attracted much attention in recent years since they are very useful synthetic tools for synthesize of potential pharmaceutically bioactive scaffolds. Post modified transformation of MCRs have great importance for accessing the synthetic building blocks for complex natural products and their analogues to investigate their possibility in treating various diseases. In the first project, we attempted the synthesis and biological study of Derivatives of the herbicide thaxtomin, through Ugi/keto-amide cyclization and Ugi/Dess-Martin/keto-amide cyclization sequences. The Ugi reaction was utilized with 3-nitrobenzaldehyde, indole-3-carboxaldehydes, phenyl lactic acid, methylamine, and methyl isocyanide to prepare dipeptides which then underwent oxidation to a- ketoamide intermediates followed by subsequent alkaline mediated keto-amide cyclization to syn and anti hemiaminal DKPs. In the second project, we reported a one-pot, two-step, total synthesis of naturally occurring Xenortides A, B, C and D, (Xens A-D) isolated from the bacterium Xenorhabdus nematophila, and an entire complimentary set of stereoisomers. The syntheses were accomplished utilizing an isocyanide-based Ugi 4-CR followed by facile N-Boc deprotection. The reaction sequence takes advantage of the chiral pool of N-Boc protected amino acids (L-Leu/Val and D-Leu/Val) with aryl isocyanides, phenyl acetaldehyde and methylamine giving the desired Xens A-D and all subsequent stereoisomers. Moreover, this focused library of naturally occurring Xens A-D and their subsequent stereoisomers were screened for cytotoxicity against a panel of epithelial cancer cell lines as well as normal cell lines.
Has the concept of Diversity Oriented Synthesis remained unchanged over these two decades, or do we observe improvements or deviations from the original guidelines drawn by the pioneers? The aim of this Research Topic is to collect contributions on the state-of-the-art and progress of Diversity Oriented Synthesis, and to foresee its shape in the next decade.
Book Synopsis Diversity Oriented Synthesis by : Andrea Basso
Download or read book Diversity Oriented Synthesis written by Andrea Basso and published by Frontiers Media SA. This book was released on 2019-03-22 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: Has the concept of Diversity Oriented Synthesis remained unchanged over these two decades, or do we observe improvements or deviations from the original guidelines drawn by the pioneers? The aim of this Research Topic is to collect contributions on the state-of-the-art and progress of Diversity Oriented Synthesis, and to foresee its shape in the next decade.
Book Synopsis Molecular Diversity and Combinatorial Synthesis Via Multiple-component Reactions by : Thomas Arthur Keating
Download or read book Molecular Diversity and Combinatorial Synthesis Via Multiple-component Reactions written by Thomas Arthur Keating and published by . This book was released on 1998 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Géraldine Masson, Luc Neuville ∙ Carine Bughin ∙ Aude Fayol ∙ Jieping Zhu Multicomponent Syntheses of Macrocycles Thomas J.J. Müller Palladium-Copper Catalyzed Alkyne Activation as an Entry to Multicomponent Syntheses of Heterocycles Rachel Scheffelaar ∙ Eelco Ruijter ∙ Romano V.A. Orru Multicomponent Reaction Design Strategies: Towards Scaffold and Stereochemical Diversity Nicola Kielland ∙ Rodolfo Lavilla Recent Developments in Reissert-Type Multicomponent Reactions Jitender B. Bariwal ∙ Jalpa C. Trivedi ∙ Erik V. Van der Eycken Microwave Irradiation and Multicomponent Reactions Irini Akritopoulou-Zanze ∙ Stevan W. Djuric Applications of MCR-Derived Heterocycles in Drug Discovery
Book Synopsis Synthesis of Heterocycles via Multicomponent Reactions II by : Romano V. A. Orru
Download or read book Synthesis of Heterocycles via Multicomponent Reactions II written by Romano V. A. Orru and published by Springer. This book was released on 2010-07-26 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Géraldine Masson, Luc Neuville ∙ Carine Bughin ∙ Aude Fayol ∙ Jieping Zhu Multicomponent Syntheses of Macrocycles Thomas J.J. Müller Palladium-Copper Catalyzed Alkyne Activation as an Entry to Multicomponent Syntheses of Heterocycles Rachel Scheffelaar ∙ Eelco Ruijter ∙ Romano V.A. Orru Multicomponent Reaction Design Strategies: Towards Scaffold and Stereochemical Diversity Nicola Kielland ∙ Rodolfo Lavilla Recent Developments in Reissert-Type Multicomponent Reactions Jitender B. Bariwal ∙ Jalpa C. Trivedi ∙ Erik V. Van der Eycken Microwave Irradiation and Multicomponent Reactions Irini Akritopoulou-Zanze ∙ Stevan W. Djuric Applications of MCR-Derived Heterocycles in Drug Discovery
Multi-component reactions warrant ever-increasing attention, as they are ideally suited for combinatorial synthesis (either on solid support or in solution) of libraries of products relevant to catalysis, such as agrochemicals or pharmaceuticals. Therefore, the study and implementation of MCRs possesses a wide range of appeal and applicability. A broad and expanding audience of scientists and students continues to apply the concepts of multi-component chemistry to an array of disciplines—this collection of research offers an angle for each and brings together the vast scope of possibilities within the greater community.
Book Synopsis MCR 2009 by : Maxim A. Mironov
Download or read book MCR 2009 written by Maxim A. Mironov and published by Springer Science & Business Media. This book was released on 2010-10-26 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multi-component reactions warrant ever-increasing attention, as they are ideally suited for combinatorial synthesis (either on solid support or in solution) of libraries of products relevant to catalysis, such as agrochemicals or pharmaceuticals. Therefore, the study and implementation of MCRs possesses a wide range of appeal and applicability. A broad and expanding audience of scientists and students continues to apply the concepts of multi-component chemistry to an array of disciplines—this collection of research offers an angle for each and brings together the vast scope of possibilities within the greater community.
Written for advanced undergraduate and graduate students, this textbook makes the main concepts of combinatorial chemistry accessible to the non-specialist.
Book Synopsis Molecular Diversity and Combinatorial Chemistry by : Michael C. Pirrung
Download or read book Molecular Diversity and Combinatorial Chemistry written by Michael C. Pirrung and published by Elsevier. This book was released on 2004-10-17 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written for advanced undergraduate and graduate students, this textbook makes the main concepts of combinatorial chemistry accessible to the non-specialist.
Book Synopsis Multicomponent Approaches to Molecular Diversity and Complexity by : Niels Elders
Download or read book Multicomponent Approaches to Molecular Diversity and Complexity written by Niels Elders and published by . This book was released on 2010 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Presents a wide-ranging overview of essential topics and recent advances in MCR chemistry Heterocycles are a central component in natural product chemistry, pharmaceuticals, agrochemicals, and material science. New synthetic methodologies integrating the sequencing of multicomponent reactions (MCRs) are today being used for the rapid synthesis of diversified heterocycles in just one step. Multicomponent Reactions towards Heterocycles presents an up-to-date summary MCR chemistry with a focus on the conjugation between modern synthetic methodologies and MCRs. Featuring contributions by leaders in the field, this comprehensive resource highlights applications of MCRs in natural products and intermediate synthesis, discusses current trends and future prospects in MCR chemistry, outlines novel multicomponent procedures, and more. The authors provide the practical information required for designing new reaction strategies and mechanisms, covering topics including MCR-based green synthetic methods, cyclization and cycloaddition reactions, heterocycle multicomponent syntheses in a continuous flow, catalytic alkynoyl generation, MCR synthesis of saturated heterocycles, and C–H functionalization and multicomponent reactions. Provides a thorough overview of heterocycles as input in multicomponent reactions Discusses recent advances in the field of MCR chemistry and progress in the synthesis and functionalization of heterocycles Demonstrates the use of MCRs to simplify synthetic design and achieve complexity and diversity in novel bioactive molecules Highlights examples of multicomponent polymerizations, target-oriented synthesis, and applications of MCR in medicinal chemistry Explains the methodology of using on-resin MCRs to produce heterocycle compounds Illustrating the key role of MCRs towards heterocycles in natural product synthesis, drug discovery, organic synthesis, and other applications, Multicomponent Reactions towards Heterocycles is required reading for synthetic chemists in academia and industry alike.
Book Synopsis Multicomponent Reactions towards Heterocycles by : Erik Van der Eycken
Download or read book Multicomponent Reactions towards Heterocycles written by Erik Van der Eycken and published by John Wiley & Sons. This book was released on 2022-03-21 with total page 626 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents a wide-ranging overview of essential topics and recent advances in MCR chemistry Heterocycles are a central component in natural product chemistry, pharmaceuticals, agrochemicals, and material science. New synthetic methodologies integrating the sequencing of multicomponent reactions (MCRs) are today being used for the rapid synthesis of diversified heterocycles in just one step. Multicomponent Reactions towards Heterocycles presents an up-to-date summary MCR chemistry with a focus on the conjugation between modern synthetic methodologies and MCRs. Featuring contributions by leaders in the field, this comprehensive resource highlights applications of MCRs in natural products and intermediate synthesis, discusses current trends and future prospects in MCR chemistry, outlines novel multicomponent procedures, and more. The authors provide the practical information required for designing new reaction strategies and mechanisms, covering topics including MCR-based green synthetic methods, cyclization and cycloaddition reactions, heterocycle multicomponent syntheses in a continuous flow, catalytic alkynoyl generation, MCR synthesis of saturated heterocycles, and C–H functionalization and multicomponent reactions. Provides a thorough overview of heterocycles as input in multicomponent reactions Discusses recent advances in the field of MCR chemistry and progress in the synthesis and functionalization of heterocycles Demonstrates the use of MCRs to simplify synthetic design and achieve complexity and diversity in novel bioactive molecules Highlights examples of multicomponent polymerizations, target-oriented synthesis, and applications of MCR in medicinal chemistry Explains the methodology of using on-resin MCRs to produce heterocycle compounds Illustrating the key role of MCRs towards heterocycles in natural product synthesis, drug discovery, organic synthesis, and other applications, Multicomponent Reactions towards Heterocycles is required reading for synthetic chemists in academia and industry alike.