New Chemistry And New Opportunities From The Expanding Protein Universe - Proceedings Of The 23rd International Solvay Conference On Chemistry

New Chemistry And New Opportunities From The Expanding Protein Universe - Proceedings Of The 23rd International Solvay Conference On Chemistry

Author: Donald Hilvert

Publisher: World Scientific

Published: 2014-11-10

Total Pages: 380

ISBN-13: 9814603848

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A select group of 40 eminent scientists from all parts of the world met to consider the current state of chemical and biological knowledge on the ever-expanding protein universe, and to discuss emerging opportunities for the foreseeable future. Scientific approaches to discover, characterize, and regulate protein functions were discussed over a range of disciplines, including natural product chemistry, microbiology, enzymology, biochemistry, structural biology, chemical biology, and glycobiology. Some notable highlights included discovery of new enzymatic pathways, innovative carbohydrate chemistry, design of proteins containing unnatural amino acids, structural elucidation of complex supramolecular machines, and design and application of small molecule drugs, biologics and biosimilars.This fascinating compendium of scientific presentations and in-depth discussions affords a unique perspective on today's protein chemistry and biology as well as on the challenges for tomorrow.


Book Synopsis New Chemistry And New Opportunities From The Expanding Protein Universe - Proceedings Of The 23rd International Solvay Conference On Chemistry by : Donald Hilvert

Download or read book New Chemistry And New Opportunities From The Expanding Protein Universe - Proceedings Of The 23rd International Solvay Conference On Chemistry written by Donald Hilvert and published by World Scientific. This book was released on 2014-11-10 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: A select group of 40 eminent scientists from all parts of the world met to consider the current state of chemical and biological knowledge on the ever-expanding protein universe, and to discuss emerging opportunities for the foreseeable future. Scientific approaches to discover, characterize, and regulate protein functions were discussed over a range of disciplines, including natural product chemistry, microbiology, enzymology, biochemistry, structural biology, chemical biology, and glycobiology. Some notable highlights included discovery of new enzymatic pathways, innovative carbohydrate chemistry, design of proteins containing unnatural amino acids, structural elucidation of complex supramolecular machines, and design and application of small molecule drugs, biologics and biosimilars.This fascinating compendium of scientific presentations and in-depth discussions affords a unique perspective on today's protein chemistry and biology as well as on the challenges for tomorrow.

New Chemistry and New Opportunities from the Expanding Protein Universe

New Chemistry and New Opportunities from the Expanding Protein Universe

Author: Kurt Wüthrich

Publisher: Imperial College Press

Published: 2014

Total Pages: 355

ISBN-13: 9789814603829

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A select group of 40 eminent scientists from all parts of the world met to consider the current state of chemical and biological knowledge on the ever-expanding protein universe, and to discuss emerging opportunities for the foreseeable future. Scientific approaches to discover, characterize, and regulate protein functions were discussed over a range of disciplines, including natural product chemistry, microbiology, enzymology, biochemistry, structural biology, chemical biology, and glycobiology. Some notable highlights included discovery of new enzymatic pathways, innovative carbohydrate chemistry, design of proteins containing unnatural amino acids, structural elucidation of complex supramolecular machines, and design and application of small molecule drugs, biologics and biosimilars.This fascinating compendium of scientific presentations and in-depth discussions affords a unique perspective on today's protein chemistry and biology as well as on the challenges for tomorrow.


Book Synopsis New Chemistry and New Opportunities from the Expanding Protein Universe by : Kurt Wüthrich

Download or read book New Chemistry and New Opportunities from the Expanding Protein Universe written by Kurt Wüthrich and published by Imperial College Press. This book was released on 2014 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: A select group of 40 eminent scientists from all parts of the world met to consider the current state of chemical and biological knowledge on the ever-expanding protein universe, and to discuss emerging opportunities for the foreseeable future. Scientific approaches to discover, characterize, and regulate protein functions were discussed over a range of disciplines, including natural product chemistry, microbiology, enzymology, biochemistry, structural biology, chemical biology, and glycobiology. Some notable highlights included discovery of new enzymatic pathways, innovative carbohydrate chemistry, design of proteins containing unnatural amino acids, structural elucidation of complex supramolecular machines, and design and application of small molecule drugs, biologics and biosimilars.This fascinating compendium of scientific presentations and in-depth discussions affords a unique perspective on today's protein chemistry and biology as well as on the challenges for tomorrow.

Exploring and Expanding the Protein Universe with Non-Canonical Amino Acids

Exploring and Expanding the Protein Universe with Non-Canonical Amino Acids

Author: Gustavo Fuertes

Publisher: Frontiers Media SA

Published: 2023-11-01

Total Pages: 123

ISBN-13: 2832538029

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The site-specific incorporation of unnatural or non-canonical amino acids (ncAAs) into proteins is a universally important tool for systems bioengineering at the interface of chemistry, biology, and biotechnology. The synergistic use of ncAA and related technologies (e.g. Xeno nucleic acids) should enable: i) New opportunities to manipulate, design and elucidate protein structure, dynamics, and function. ii) A deeper understanding of natural and evolved translational systems and their importance for artificial biology. iii) The synthesis of novel biopolymers, creating a solid basis for synthetic cells, which is also an important technology in the production of new classes of medically relevant protein-based scaffolds. Research on reprogrammed protein translation has now reached an experimental and intellectual maturity: more than 200 ncAA (i.e. more than ten times larger variety than standard amino acids) have been introduced into proteins using different routes: genetic code expansion (GCE), selective pressure incorporation (SPI), chemical mutagenesis, protein semi-synthesis, and peptide synthesis.


Book Synopsis Exploring and Expanding the Protein Universe with Non-Canonical Amino Acids by : Gustavo Fuertes

Download or read book Exploring and Expanding the Protein Universe with Non-Canonical Amino Acids written by Gustavo Fuertes and published by Frontiers Media SA. This book was released on 2023-11-01 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt: The site-specific incorporation of unnatural or non-canonical amino acids (ncAAs) into proteins is a universally important tool for systems bioengineering at the interface of chemistry, biology, and biotechnology. The synergistic use of ncAA and related technologies (e.g. Xeno nucleic acids) should enable: i) New opportunities to manipulate, design and elucidate protein structure, dynamics, and function. ii) A deeper understanding of natural and evolved translational systems and their importance for artificial biology. iii) The synthesis of novel biopolymers, creating a solid basis for synthetic cells, which is also an important technology in the production of new classes of medically relevant protein-based scaffolds. Research on reprogrammed protein translation has now reached an experimental and intellectual maturity: more than 200 ncAA (i.e. more than ten times larger variety than standard amino acids) have been introduced into proteins using different routes: genetic code expansion (GCE), selective pressure incorporation (SPI), chemical mutagenesis, protein semi-synthesis, and peptide synthesis.

Chemistry Challenges Of The 21st Century - Proceedings Of The 100th Anniversary Of The 26th International Solvay Conference On Chemistry

Chemistry Challenges Of The 21st Century - Proceedings Of The 100th Anniversary Of The 26th International Solvay Conference On Chemistry

Author: Kurt Wuthrich

Publisher: World Scientific

Published: 2023-12-28

Total Pages: 550

ISBN-13: 9811282331

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Chaired by K Wüthrich (Nobel Laureate in Chemistry, 2002) and co-chaired by B Feringa (Nobel Laureate in Chemistry, 2016), this by-invitation-only conference gathered around 40 participants, who are well-recognized leaders in the diverse field of Chemistry. The highlights of the Conference Proceedings include short prepared statements by all the participants, and the recordings of lively discussions on the current and future perspectives in the field of chemistry, with topics ranging from renewable energy and new materials to vaccines.


Book Synopsis Chemistry Challenges Of The 21st Century - Proceedings Of The 100th Anniversary Of The 26th International Solvay Conference On Chemistry by : Kurt Wuthrich

Download or read book Chemistry Challenges Of The 21st Century - Proceedings Of The 100th Anniversary Of The 26th International Solvay Conference On Chemistry written by Kurt Wuthrich and published by World Scientific. This book was released on 2023-12-28 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chaired by K Wüthrich (Nobel Laureate in Chemistry, 2002) and co-chaired by B Feringa (Nobel Laureate in Chemistry, 2016), this by-invitation-only conference gathered around 40 participants, who are well-recognized leaders in the diverse field of Chemistry. The highlights of the Conference Proceedings include short prepared statements by all the participants, and the recordings of lively discussions on the current and future perspectives in the field of chemistry, with topics ranging from renewable energy and new materials to vaccines.

Computational Modeling: From Chemistry To Materials To Biology - Proceedings Of The 25th Solvay Conference On Chemistry

Computational Modeling: From Chemistry To Materials To Biology - Proceedings Of The 25th Solvay Conference On Chemistry

Author: Kurt Wuthrich

Publisher: World Scientific

Published: 2020-12-21

Total Pages: 372

ISBN-13: 9811228221

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Chaired by K Wüthrich (Nobel Laureate in Chemistry, 2002) and co-chaired by B Weckhuysen, this by-invitation-only conference has gathered 39 participants — who are leaders in the field of computational modeling and its applications in Chemistry, Material Sciences and Biology. Highlights of the Conference Proceedings are short, prepared statements by all the participants and the records of lively discussions on the current and future perspectives in the field of computational modeling, from chemistry to materials to biology.


Book Synopsis Computational Modeling: From Chemistry To Materials To Biology - Proceedings Of The 25th Solvay Conference On Chemistry by : Kurt Wuthrich

Download or read book Computational Modeling: From Chemistry To Materials To Biology - Proceedings Of The 25th Solvay Conference On Chemistry written by Kurt Wuthrich and published by World Scientific. This book was released on 2020-12-21 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chaired by K Wüthrich (Nobel Laureate in Chemistry, 2002) and co-chaired by B Weckhuysen, this by-invitation-only conference has gathered 39 participants — who are leaders in the field of computational modeling and its applications in Chemistry, Material Sciences and Biology. Highlights of the Conference Proceedings are short, prepared statements by all the participants and the records of lively discussions on the current and future perspectives in the field of computational modeling, from chemistry to materials to biology.

Catalysis in Chemistry and Biology

Catalysis in Chemistry and Biology

Author: Wuthrich Kurt

Publisher: World Scientific

Published: 2018-06-19

Total Pages: 416

ISBN-13: 981323718X

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The Proceedings of the 24th International Solvay Conference on Chemistry comprise contributed short personal statements and transcripts of in-depth discussions on 'Catalysis in Chemistry and Biology' from a by-invitation-only select group of 48 eminent scientists, including four Nobel Laureates, from all parts of the world. The theme of the conference was presented in six sessions, along which the Proceedings are organized. The first session on 'Homogeneous Catalysis,' chaired by Professor Robert Grubbs, is devoted to basic research on catalysis in homogeneous solutions and applications thereof. 'Heterogeneous Catalysis and Characterization of Catalyst Surfaces,' chaired by Professor Gerhard Ertl, includes extensive references to industrial applications of catalysis on solid supports, and discussions on the experimental techniques used in this field. 'Catalysis by Microporous Materials,' chaired by Professor Mark E. Davis, is devoted to a detailed characterization of this particular class of solid support catalysts, with special emphasis on model analysis of the processes catalyzed by these materials. 'Catalysis under Extreme Conditions: Studies at High Pressure and High Temperatures -- Relations with Processes in Nature,' chaired by Professor Henk N W Lekkerkerker, broadens the scope of the two preceding sessions with exciting illustrations. The sessions on 'Catalysis by Protein Enzymes,' chaired by Prof. JoAnne Stubbe, and 'Catalysis by Ribozymes in Molecular Machines,' chaired by Prof. David Lilley, present at the same time an exciting extension of and a contrast to the initial four sessions. The combination of the six sessions provides an impressive overview, giving innovative insights into relationships between catalysis in chemical processes and in biological systems, and a unique outlook to anticipated developments in the coming years and the more distant future.


Book Synopsis Catalysis in Chemistry and Biology by : Wuthrich Kurt

Download or read book Catalysis in Chemistry and Biology written by Wuthrich Kurt and published by World Scientific. This book was released on 2018-06-19 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Proceedings of the 24th International Solvay Conference on Chemistry comprise contributed short personal statements and transcripts of in-depth discussions on 'Catalysis in Chemistry and Biology' from a by-invitation-only select group of 48 eminent scientists, including four Nobel Laureates, from all parts of the world. The theme of the conference was presented in six sessions, along which the Proceedings are organized. The first session on 'Homogeneous Catalysis,' chaired by Professor Robert Grubbs, is devoted to basic research on catalysis in homogeneous solutions and applications thereof. 'Heterogeneous Catalysis and Characterization of Catalyst Surfaces,' chaired by Professor Gerhard Ertl, includes extensive references to industrial applications of catalysis on solid supports, and discussions on the experimental techniques used in this field. 'Catalysis by Microporous Materials,' chaired by Professor Mark E. Davis, is devoted to a detailed characterization of this particular class of solid support catalysts, with special emphasis on model analysis of the processes catalyzed by these materials. 'Catalysis under Extreme Conditions: Studies at High Pressure and High Temperatures -- Relations with Processes in Nature,' chaired by Professor Henk N W Lekkerkerker, broadens the scope of the two preceding sessions with exciting illustrations. The sessions on 'Catalysis by Protein Enzymes,' chaired by Prof. JoAnne Stubbe, and 'Catalysis by Ribozymes in Molecular Machines,' chaired by Prof. David Lilley, present at the same time an exciting extension of and a contrast to the initial four sessions. The combination of the six sessions provides an impressive overview, giving innovative insights into relationships between catalysis in chemical processes and in biological systems, and a unique outlook to anticipated developments in the coming years and the more distant future.

RNA

RNA

Author: D. Söll

Publisher: Elsevier

Published: 2001-12-03

Total Pages: 354

ISBN-13: 9780080540627

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This publication summarizes the current status of our understanding of RNA, with particular emphasis on the chemistry of this key biological molecule. The various RNAs covered are messenger RNA, ribosomal RNA, transfer RNA and RNA enzymes (ribozymes). The different chapters detail biophysical and chemical methods to investigate RNA structure and function, the synthesis of native and modified RNAs and the latest advances in our understanding of the vast array of biological processes in which RNA is involved.


Book Synopsis RNA by : D. Söll

Download or read book RNA written by D. Söll and published by Elsevier. This book was released on 2001-12-03 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication summarizes the current status of our understanding of RNA, with particular emphasis on the chemistry of this key biological molecule. The various RNAs covered are messenger RNA, ribosomal RNA, transfer RNA and RNA enzymes (ribozymes). The different chapters detail biophysical and chemical methods to investigate RNA structure and function, the synthesis of native and modified RNAs and the latest advances in our understanding of the vast array of biological processes in which RNA is involved.

Humanity in a Creative Universe

Humanity in a Creative Universe

Author: Stuart A. Kauffman

Publisher: Oxford University Press

Published: 2016-02-02

Total Pages: 313

ISBN-13: 0199390479

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In the hard sciences, which can often feel out of grasp for many lay readers, there are "great thinkers" who go far beyond the equations, formulas, and research. Minds such as Stephen Hawking philosophize about the functions and nature of the universe, the implications of our existence, and other impossibly fascinating, yet difficult questions. Stuart A. Kauffman is one of those great thinkers. He has dedicated his lifetime to researching "complex systems" at prestigious institutions and now writes his treatise on the most complex system of all: our universe. A recent Scientific American article claims that "philosophy begins where physics ends, and physics begins where philosophy ends," and perhaps no better quote sums up what Kauffman's latest book offers. Grounded in his rigorous training and research background, Kauffman is inter-disciplinary in every sense of the word, sorting through the major questions and theories in biology, physics, and philosophy. Best known for his philosophy of evolutionary biology, Kauffman coined the term "prestatability" to call into question whether science can ever accurately and precisely predict the future development of biological features in organisms. As evidenced by the title's mention of creativity, the book refreshingly argues that our preoccupation to explain all things with scientific law has deadened our creative natures. In this fascinating read, Kauffman concludes that the development of life on earth is not entirely predictable, because no theory could ever fully account for the limitless variations of evolution. Sure to cause a stir, this book will be discussed for years to come and may even set the tone for the next "great thinker."


Book Synopsis Humanity in a Creative Universe by : Stuart A. Kauffman

Download or read book Humanity in a Creative Universe written by Stuart A. Kauffman and published by Oxford University Press. This book was released on 2016-02-02 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the hard sciences, which can often feel out of grasp for many lay readers, there are "great thinkers" who go far beyond the equations, formulas, and research. Minds such as Stephen Hawking philosophize about the functions and nature of the universe, the implications of our existence, and other impossibly fascinating, yet difficult questions. Stuart A. Kauffman is one of those great thinkers. He has dedicated his lifetime to researching "complex systems" at prestigious institutions and now writes his treatise on the most complex system of all: our universe. A recent Scientific American article claims that "philosophy begins where physics ends, and physics begins where philosophy ends," and perhaps no better quote sums up what Kauffman's latest book offers. Grounded in his rigorous training and research background, Kauffman is inter-disciplinary in every sense of the word, sorting through the major questions and theories in biology, physics, and philosophy. Best known for his philosophy of evolutionary biology, Kauffman coined the term "prestatability" to call into question whether science can ever accurately and precisely predict the future development of biological features in organisms. As evidenced by the title's mention of creativity, the book refreshingly argues that our preoccupation to explain all things with scientific law has deadened our creative natures. In this fascinating read, Kauffman concludes that the development of life on earth is not entirely predictable, because no theory could ever fully account for the limitless variations of evolution. Sure to cause a stir, this book will be discussed for years to come and may even set the tone for the next "great thinker."

Annual Reports in Computational Chemistry

Annual Reports in Computational Chemistry

Author: Ralph A. Wheeler

Publisher: Elsevier

Published: 2008-10-30

Total Pages: 271

ISBN-13: 0080932789

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Annual Reports in Computational Chemistry is a new periodical providing timely and critical reviews of important topics in computational chemistry as applied to all chemical disciplines. Topics covered include quantum chemistry, molecular mechanics, force fields, chemical education, and applications in academic and industrial settings. Each volume is organized into (thematic) sections with contributions written by experts. Focusing on the most recent literature and advances in the field, each article covers a specific topic of importance to computational chemists. Annual Reports in Computational Chemistry is a "must" for researchers and students wishing to stay up-to-date on current developments in computational chemistry. * Broad coverage of computational chemistry and up-to-date information * Topics covered include bioinformatics, drug discovery, protein NMR, simulation methodologies, and applications in academic and industrial settings * Each chapter reviews the most recent literature on a specific topic of interest to computational chemists


Book Synopsis Annual Reports in Computational Chemistry by : Ralph A. Wheeler

Download or read book Annual Reports in Computational Chemistry written by Ralph A. Wheeler and published by Elsevier. This book was released on 2008-10-30 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annual Reports in Computational Chemistry is a new periodical providing timely and critical reviews of important topics in computational chemistry as applied to all chemical disciplines. Topics covered include quantum chemistry, molecular mechanics, force fields, chemical education, and applications in academic and industrial settings. Each volume is organized into (thematic) sections with contributions written by experts. Focusing on the most recent literature and advances in the field, each article covers a specific topic of importance to computational chemists. Annual Reports in Computational Chemistry is a "must" for researchers and students wishing to stay up-to-date on current developments in computational chemistry. * Broad coverage of computational chemistry and up-to-date information * Topics covered include bioinformatics, drug discovery, protein NMR, simulation methodologies, and applications in academic and industrial settings * Each chapter reviews the most recent literature on a specific topic of interest to computational chemists

Plant Behaviour and Intelligence

Plant Behaviour and Intelligence

Author: Anthony Trewavas

Publisher: OUP Oxford

Published: 2014-08-21

Total Pages: 305

ISBN-13: 0191028916

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This book provides a convincing argument for the view that whole cells and whole plants growing in competitive wild conditions show aspects of plant behaviour that can be accurately described as 'intelligent'. Trewavas argues that behaviour, like intelligence, must be assessed within the constraints of the anatomical and physiological framework of the organism in question. The fact that plants do not have centralized nervous systems for example, does not exclude intelligent behaviour. Outside the human dimension, culture is thought largely absent and fitness is the biological property of value. Thus, solving environmental problems that threaten to reduce fitness is another way of viewing intelligent behaviour and has a similar meaning to adaptively variable behaviour. The capacity to solve these problems might be considered to vary in different organisms, but variation does not mean absence. By extending these ideas into a book that allows a critical and amplified discussion, the author hopes to raise an awareness of the concept of purposive behaviour in plants.


Book Synopsis Plant Behaviour and Intelligence by : Anthony Trewavas

Download or read book Plant Behaviour and Intelligence written by Anthony Trewavas and published by OUP Oxford. This book was released on 2014-08-21 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a convincing argument for the view that whole cells and whole plants growing in competitive wild conditions show aspects of plant behaviour that can be accurately described as 'intelligent'. Trewavas argues that behaviour, like intelligence, must be assessed within the constraints of the anatomical and physiological framework of the organism in question. The fact that plants do not have centralized nervous systems for example, does not exclude intelligent behaviour. Outside the human dimension, culture is thought largely absent and fitness is the biological property of value. Thus, solving environmental problems that threaten to reduce fitness is another way of viewing intelligent behaviour and has a similar meaning to adaptively variable behaviour. The capacity to solve these problems might be considered to vary in different organisms, but variation does not mean absence. By extending these ideas into a book that allows a critical and amplified discussion, the author hopes to raise an awareness of the concept of purposive behaviour in plants.